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antibody from antibodies-online
Targeting: MRE11
ATLD, MRE11A
Western blot
Immunocytochemistry
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- Antibody Data
- Antigen structure
- References [150]
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- Western blot [2]
- Immunohistochemistry [1]
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- Product number
- ABIN151076 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody
- Antibody type
- Polyclonal
- Description
- Unpurified
- Reactivity
- Human, Mouse, Rat, Chicken/Avian, Hamster
- Host
- Rabbit
- Vial size
- 0.05 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages.
Efficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes.
PHF11 promotes DSB resection, ATR signaling, and HR.
Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.
DNA damage response during mouse oocyte maturation.
H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation.
DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.
Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.
PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.
Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer.
KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification.
Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection.
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.
Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks.
LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.
The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation.
DNA2 drives processing and restart of reversed replication forks in human cells.
Replication fork integrity and intra-S phase checkpoint suppress gene amplification.
MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex.
hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ.
Nijmegen breakage syndrome detected by newborn screening for T cell receptor excision circles (TRECs).
BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses.
DNA damage focus analysis in blood samples of minipigs reveals acute partial body irradiation.
Functional characterization of the TERRA transcriptome at damaged telomeres.
Inefficient export of viral late mRNA contributes to fastidiousness of human adenovirus type 41 (HAdV-41) in 293 cells.
Homologous recombination repair signaling in chemical carcinogenesis: prolonged particulate hexavalent chromium exposure suppresses the Rad51 response in human lung cells.
Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination.
Mutations in the FHA-domain of ectopically expressed NBS1 lead to radiosensitization and to no increase in somatic mutation rates via a partial suppression of homologous recombination.
PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.
Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors.
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance.
DNA damage to a single chromosome end delays anaphase onset.
Analysis of the Cullin binding sites of the E4orf6 proteins of human adenovirus E3 ubiquitin ligases.
SPOC1-mediated antiviral host cell response is antagonized early in human adenovirus type 5 infection.
MutS homologue hMSH5: recombinational DSB repair and non-synonymous polymorphic variants.
Mutation inactivation of Nijmegen breakage syndrome gene (NBS1) in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
A quantitative telomeric chromatin isolation protocol identifies different telomeric states.
BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids.
Targeting telomere-containing chromosome ends with a near-infrared femtosecond laser to study the activation of the DNA damage response and DNA damage repair pathways.
Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair.
siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.
Role of E1B55K in E4orf6/E1B55K E3 ligase complexes formed by different human adenovirus serotypes.
MutS homologue hMSH4: interaction with eIF3f and a role in NHEJ-mediated DSB repair.
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.
JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks.
The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability.
Inhibition of DNA damage repair by artificial activation of PARP with siDNA.
CBP and p300 histone acetyltransferases contribute to homologous recombination by transcriptionally activating the BRCA1 and RAD51 genes.
Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway.
Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism.
p21 promotes error-free replication-coupled DNA double-strand break repair.
Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.
A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons.
The human adenovirus type 5 E1B 55-kilodalton protein is phosphorylated by protein kinase CK2.
MutS homologue hMSH5: role in cisplatin-induced DNA damage response.
NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes.
Lycopene inhibits Helicobacter pylori-induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells.
Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection.
Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells.
Identifying novel protein complexes in cancer cells using epitope-tagging of endogenous human genes and affinity-purification mass spectrometry.
TIS21(/BTG2/PC3) accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2(T68)-p53(S20) pathway.
Functional cooperation between human adenovirus type 5 early region 4, open reading frame 6 protein, and cellular homeobox protein HoxB7.
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.
Functional connection between Rad51 and PML in homology-directed repair.
Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells.
NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.
Astrocyte dysfunction associated with cerebellar attrition in a Nijmegen breakage syndrome animal model.
Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.
Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.
The E3 ubiquitin ligase activity associated with the adenoviral E1B-55K-E4orf6 complex does not require CRM1-dependent export.
The E4orf6/E1B55K E3 ubiquitin ligase complexes of human adenoviruses exhibit heterogeneity in composition and substrate specificity.
Five dysfunctional telomeres predict onset of senescence in human cells.
Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis.
Rap1-independent telomere attachment and bouquet formation in mammalian meiosis.
The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection.
Biological dose estimation of UVA laser microirradiation utilizing charged particle-induced protein foci.
WRN participates in translesion synthesis pathway through interaction with NBS1.
Proteasome-dependent degradation of Daxx by the viral E1B-55K protein in human adenovirus-infected cells.
A common gain of function of p53 cancer mutants in inducing genetic instability.
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
A 49-kilodalton isoform of the adenovirus type 5 early region 1B 55-kilodalton protein is sufficient to support virus replication.
Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.
Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway.
Identification of integrin alpha3 as a new substrate of the adenovirus E4orf6/E1B 55-kilodalton E3 ubiquitin ligase complex.
A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation.
Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis.
ATM activation and signaling under hypoxic conditions.
Human MutL-complexes monitor homologous recombination independently of mismatch repair.
A proteomic approach to identify candidate substrates of human adenovirus E4orf6-E1B55K and other viral cullin-based E3 ubiquitin ligases.
Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex.
ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.
Control of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activity.
Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells.
Adenovirus type 5 early region 1B 55-kDa oncoprotein can promote cell transformation by a mechanism independent from blocking p53-activated transcription.
Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.
A role for E1B-AP5 in ATR signaling pathways during adenovirus infection.
Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 protein.
Mdm2 promotes genetic instability and transformation independent of p53.
Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres.
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling.
ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication.
Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation.
Dimerization of the Rad50 protein is independent of the conserved hook domain.
BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges.
Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein.
A role for MRE11, NBS1, and recombination junctions in replication and stable maintenance of EBV episomes.
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Mre11-Rad50-Nbs1 complex is activated by hypertonicity.
Nijmegen breakage syndrome (NBS) with neurological abnormalities and without chromosomal instability.
Active role for nibrin in the kinetics of atm activation.
Mild Nijmegen breakage syndrome phenotype due to alternative splicing.
Physical and functional interaction between hMSH5 and c-Abl.
Rapid activation of ATR by ionizing radiation requires ATM and Mre11.
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.
Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.
Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination.
Nibrin functions in Ig class-switch recombination.
Expression of the adenovirus E4 34k oncoprotein inhibits repair of double strand breaks in the cellular genome of a 293-based inducible cell line.
A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts.
Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.
Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53.
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks.
Notch and Schwann cell transformation.
Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks.
Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation.
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation.
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Deficient regulation of DNA double-strand break repair in Fanconi anemia fibroblasts.
Evidence for a direct association of hMRE11 with the human mismatch repair protein hMLH1.
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.
PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage.
SV40 large T-antigen disturbs the formation of nuclear DNA-repair foci containing MRE11.
UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization.
Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation.
Interaction of FANCD2 and NBS1 in the DNA damage response.
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.
DNA replication arrest in XP variant cells after UV exposure is diverted into an Mre11-dependent recombination pathway by the kinase inhibitor wortmannin.
Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein.
Role of poly(ADP-ribosyl)ation in DNA-PKcs- independent V(D)J recombination.
Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest.
The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity.
NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres.
Polymerase eta deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair.
Metabolism of recombination coding ends in scid cells.
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Morales AJ, Carrero JA, Hung PJ, Tubbs AT, Andrews JM, Edelson BT, Calderon B, Innes CL, Paules RS, Payton JE, Sleckman BP
eLife 2017 Mar 31;6
eLife 2017 Mar 31;6
Efficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes.
Speiseder T, Hofmann-Sieber H, Rodríguez E, Schellenberg A, Akyüz N, Dierlamm J, Spruss T, Lange C, Dobner T
Journal of virology 2017 Jan 1;91(1)
Journal of virology 2017 Jan 1;91(1)
PHF11 promotes DSB resection, ATR signaling, and HR.
Gong Y, Handa N, Kowalczykowski SC, de Lange T
Genes & development 2017 Jan 1;31(1):46-58
Genes & development 2017 Jan 1;31(1):46-58
Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.
Cirilli M, Bereshchenko O, Ermakova O, Nerlov C
Biochimica et biophysica acta. General subjects 2017 Feb;1861(2):467-476
Biochimica et biophysica acta. General subjects 2017 Feb;1861(2):467-476
DNA damage response during mouse oocyte maturation.
Mayer A, Baran V, Sakakibara Y, Brzakova A, Ferencova I, Motlik J, Kitajima TS, Schultz RM, Solc P
Cell cycle (Georgetown, Tex.) 2016;15(4):546-58
Cell cycle (Georgetown, Tex.) 2016;15(4):546-58
H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation.
Xu Z, Song Z, Li G, Tu H, Liu W, Liu Y, Wang P, Wang Y, Cui X, Liu C, Shang Y, de Rooij DG, Gao F, Li W
Nucleic acids research 2016 Nov 16;44(20):9681-9697
Nucleic acids research 2016 Nov 16;44(20):9681-9697
DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.
Hampp S, Kiessling T, Buechle K, Mansilla SF, Thomale J, Rall M, Ahn J, Pospiech H, Gottifredi V, Wiesmüller L
Proceedings of the National Academy of Sciences of the United States of America 2016 Jul 26;113(30):E4311-9
Proceedings of the National Academy of Sciences of the United States of America 2016 Jul 26;113(30):E4311-9
Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.
Obermeier K, Sachsenweger J, Friedl TW, Pospiech H, Winqvist R, Wiesmüller L
Oncogene 2016 Jul 21;35(29):3796-806
Oncogene 2016 Jul 21;35(29):3796-806
PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.
Wimmer P, Berscheminski J, Blanchette P, Groitl P, Branton PE, Hay RT, Dobner T, Schreiner S
Oncogene 2016 Jan 7;35(1):69-82
Oncogene 2016 Jan 7;35(1):69-82
Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer.
Choi YE, Meghani K, Brault ME, Leclerc L, He YJ, Day TA, Elias KM, Drapkin R, Weinstock DM, Dao F, Shih KK, Matulonis U, Levine DA, Konstantinopoulos PA, Chowdhury D
Cell reports 2016 Jan 26;14(3):429-439
Cell reports 2016 Jan 26;14(3):429-439
KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification.
Bürck C, Mund A, Berscheminski J, Kieweg L, Müncheberg S, Dobner T, Schreiner S
Journal of virology 2016 Jan 15;90(2):930-46
Journal of virology 2016 Jan 15;90(2):930-46
Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection.
Parameswaran B, Chiang HC, Lu Y, Coates J, Deng CX, Baer R, Lin HK, Li R, Paull TT, Hu Y
Cell cycle (Georgetown, Tex.) 2015;14(3):437-48
Cell cycle (Georgetown, Tex.) 2015;14(3):437-48
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.
Kijas AW, Lim YC, Bolderson E, Cerosaletti K, Gatei M, Jakob B, Tobias F, Taucher-Scholz G, Gueven N, Oakley G, Concannon P, Wolvetang E, Khanna KK, Wiesmüller L, Lavin MF
Nucleic acids research 2015 Sep 30;43(17):8352-67
Nucleic acids research 2015 Sep 30;43(17):8352-67
Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks.
Muraki K, Han L, Miller D, Murnane JP
Nucleic acids research 2015 Sep 18;43(16):7911-30
Nucleic acids research 2015 Sep 18;43(16):7911-30
LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.
Liu XS, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP
Nature communications 2015 Oct 8;6:8325
Nature communications 2015 Oct 8;6:8325
The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation.
Iannascoli C, Palermo V, Murfuni I, Franchitto A, Pichierri P
Nucleic acids research 2015 Nov 16;43(20):9788-803
Nucleic acids research 2015 Nov 16;43(20):9788-803
DNA2 drives processing and restart of reversed replication forks in human cells.
Thangavel S, Berti M, Levikova M, Pinto C, Gomathinayagam S, Vujanovic M, Zellweger R, Moore H, Lee EH, Hendrickson EA, Cejka P, Stewart S, Lopes M, Vindigni A
The Journal of cell biology 2015 Mar 2;208(5):545-62
The Journal of cell biology 2015 Mar 2;208(5):545-62
Replication fork integrity and intra-S phase checkpoint suppress gene amplification.
Kondratova A, Watanabe T, Marotta M, Cannon M, Segall AM, Serre D, Tanaka H
Nucleic acids research 2015 Mar 11;43(5):2678-90
Nucleic acids research 2015 Mar 11;43(5):2678-90
MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex.
Lee KY, Im JS, Shibata E, Park J, Handa N, Kowalczykowski SC, Dutta A
Nature communications 2015 Jul 28;6:7744
Nature communications 2015 Jul 28;6:7744
hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ.
Xu Y, Wu X, Her C
The Journal of biological chemistry 2015 Jul 24;290(30):18545-58
The Journal of biological chemistry 2015 Jul 24;290(30):18545-58
Nijmegen breakage syndrome detected by newborn screening for T cell receptor excision circles (TRECs).
Patel JP, Puck JM, Srinivasan R, Brown C, Sunderam U, Kundu K, Brenner SE, Gatti RA, Church JA
Journal of clinical immunology 2015 Feb;35(2):227-33
Journal of clinical immunology 2015 Feb;35(2):227-33
BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
Badie S, Carlos AR, Folio C, Okamoto K, Bouwman P, Jonkers J, Tarsounas M
The EMBO journal 2015 Feb 3;34(3):410-24
The EMBO journal 2015 Feb 3;34(3):410-24
Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses.
Kobayashi J, Saito Y, Okui M, Miwa N, Komatsu K
Mutation research. Genetic toxicology and environmental mutagenesis 2015 Apr;782:42-50
Mutation research. Genetic toxicology and environmental mutagenesis 2015 Apr;782:42-50
DNA damage focus analysis in blood samples of minipigs reveals acute partial body irradiation.
Lamkowski A, Forcheron F, Agay D, Ahmed EA, Drouet M, Meineke V, Scherthan H
PloS one 2014;9(2):e87458
PloS one 2014;9(2):e87458
Functional characterization of the TERRA transcriptome at damaged telomeres.
Porro A, Feuerhahn S, Delafontaine J, Riethman H, Rougemont J, Lingner J
Nature communications 2014 Oct 31;5:5379
Nature communications 2014 Oct 31;5:5379
Inefficient export of viral late mRNA contributes to fastidiousness of human adenovirus type 41 (HAdV-41) in 293 cells.
Zou XH, Li WJ, Guo XJ, Qu JG, Wang M, Si HL, Lu ZZ, Hung T
Virology 2014 Nov;468-470:388-396
Virology 2014 Nov;468-470:388-396
Homologous recombination repair signaling in chemical carcinogenesis: prolonged particulate hexavalent chromium exposure suppresses the Rad51 response in human lung cells.
Qin Q, Xie H, Wise SS, Browning CL, Thompson KN, Holmes AL, Wise JP Sr
Toxicological sciences : an official journal of the Society of Toxicology 2014 Nov;142(1):117-25
Toxicological sciences : an official journal of the Society of Toxicology 2014 Nov;142(1):117-25
Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination.
Gao M, Wei W, Li MM, Wu YS, Ba Z, Jin KX, Li MM, Liao YQ, Adhikari S, Chong Z, Zhang T, Guo CX, Tang TS, Zhu BT, Xu XZ, Mailand N, Yang YG, Qi Y, Rendtlew Danielsen JM
Cell research 2014 May;24(5):532-41
Cell research 2014 May;24(5):532-41
Mutations in the FHA-domain of ectopically expressed NBS1 lead to radiosensitization and to no increase in somatic mutation rates via a partial suppression of homologous recombination.
Ohara M, Funyu Y, Ebara S, Sakamoto Y, Seki R, Iijima K, Ohishi A, Kobayashi J, Komatsu K, Tachibana A, Tauchi H
Journal of radiation research 2014 Jul;55(4):690-8
Journal of radiation research 2014 Jul;55(4):690-8
PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.
Illuzzi G, Fouquerel E, Amé JC, Noll A, Rehmet K, Nasheuer HP, Dantzer F, Schreiber V
Nucleic acids research 2014 Jul;42(12):7776-92
Nucleic acids research 2014 Jul;42(12):7776-92
Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors.
Boichuk S, Lee DJ, Mehalek KR, Makielski KR, Wozniak A, Seneviratne DS, Korzeniewski N, Cuevas R, Parry JA, Brown MF, Zewe J, Taguchi T, Kuan SF, Schöffski P, Debiec-Rychter M, Duensing A
Cancer research 2014 Feb 15;74(4):1200-13
Cancer research 2014 Feb 15;74(4):1200-13
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance.
Khongkow P, Karunarathna U, Khongkow M, Gong C, Gomes AR, Yagüe E, Monteiro LJ, Kongsema M, Zona S, Man EP, Tsang JW, Coombes RC, Wu KJ, Khoo US, Medema RH, Freire R, Lam EW
Oncogene 2014 Aug 7;33(32):4144-55
Oncogene 2014 Aug 7;33(32):4144-55
DNA damage to a single chromosome end delays anaphase onset.
Silva BA, Stambaugh JR, Yokomori K, Shah JV, Berns MW
The Journal of biological chemistry 2014 Aug 15;289(33):22771-84
The Journal of biological chemistry 2014 Aug 15;289(33):22771-84
Analysis of the Cullin binding sites of the E4orf6 proteins of human adenovirus E3 ubiquitin ligases.
Gilson T, Cheng CY, Hur WS, Blanchette P, Branton PE
Journal of virology 2014 Apr;88(7):3885-97
Journal of virology 2014 Apr;88(7):3885-97
SPOC1-mediated antiviral host cell response is antagonized early in human adenovirus type 5 infection.
Schreiner S, Kinkley S, Bürck C, Mund A, Wimmer P, Schubert T, Groitl P, Will H, Dobner T
PLoS pathogens 2013;9(11):e1003775
PLoS pathogens 2013;9(11):e1003775
MutS homologue hMSH5: recombinational DSB repair and non-synonymous polymorphic variants.
Wu X, Xu Y, Feng K, Tompkins JD, Her C
PloS one 2013;8(9):e73284
PloS one 2013;8(9):e73284
Mutation inactivation of Nijmegen breakage syndrome gene (NBS1) in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Wang Y, Hong Y, Li M, Long J, Zhao YP, Zhang JX, Li Q, You H, Tong WM, Jia JD, Huang J
PloS one 2013;8(12):e82426
PloS one 2013;8(12):e82426
A quantitative telomeric chromatin isolation protocol identifies different telomeric states.
Grolimund L, Aeby E, Hamelin R, Armand F, Chiappe D, Moniatte M, Lingner J
Nature communications 2013;4:2848
Nature communications 2013;4:2848
BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids.
Chandramouly G, Kwok A, Huang B, Willis NA, Xie A, Scully R
Nature communications 2013;4:2404
Nature communications 2013;4:2404
Targeting telomere-containing chromosome ends with a near-infrared femtosecond laser to study the activation of the DNA damage response and DNA damage repair pathways.
Silva BA, Stambaugh JR, Berns MW
Journal of biomedical optics 2013 Sep;18(9):095003
Journal of biomedical optics 2013 Sep;18(9):095003
Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair.
Goldstein M, Derheimer FA, Tait-Mulder J, Kastan MB
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 15;110(42):16874-9
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 15;110(42):16874-9
siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.
Böhringer M, Obermeier K, Griner N, Waldraff D, Dickinson E, Eirich K, Schindler D, Hagen M, Jerry DJ, Wiesmüller L
Oncogene 2013 Nov 28;32(48):5458-70
Oncogene 2013 Nov 28;32(48):5458-70
Role of E1B55K in E4orf6/E1B55K E3 ligase complexes formed by different human adenovirus serotypes.
Cheng CY, Gilson T, Wimmer P, Schreiner S, Ketner G, Dobner T, Branton PE, Blanchette P
Journal of virology 2013 Jun;87(11):6232-45
Journal of virology 2013 Jun;87(11):6232-45
MutS homologue hMSH4: interaction with eIF3f and a role in NHEJ-mediated DSB repair.
Chu YL, Wu X, Xu Y, Her C
Molecular cancer 2013 Jun 2;12:51
Molecular cancer 2013 Jun 2;12:51
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.
Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB
Nature 2013 Jun 13;498(7453):246-50
Nature 2013 Jun 13;498(7453):246-50
JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks.
Watanabe S, Watanabe K, Akimov V, Bartkova J, Blagoev B, Lukas J, Bartek J
Nature structural & molecular biology 2013 Dec;20(12):1425-33
Nature structural & molecular biology 2013 Dec;20(12):1425-33
The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability.
Mason JM, Das I, Arlt M, Patel N, Kraftson S, Glover TW, Sekiguchi JM
Human molecular genetics 2013 Dec 15;22(24):4901-13
Human molecular genetics 2013 Dec 15;22(24):4901-13
Inhibition of DNA damage repair by artificial activation of PARP with siDNA.
Croset A, Cordelières FP, Berthault N, Buhler C, Sun JS, Quanz M, Dutreix M
Nucleic acids research 2013 Aug;41(15):7344-55
Nucleic acids research 2013 Aug;41(15):7344-55
CBP and p300 histone acetyltransferases contribute to homologous recombination by transcriptionally activating the BRCA1 and RAD51 genes.
Ogiwara H, Kohno T
PloS one 2012;7(12):e52810
PloS one 2012;7(12):e52810
Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway.
Kobayashi J, Fujimoto H, Sato J, Hayashi I, Burma S, Matsuura S, Chen DJ, Komatsu K
PloS one 2012;7(11):e49245
PloS one 2012;7(11):e49245
Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism.
Sohn SY, Hearing P
Journal of virology 2012 Sep;86(18):9656-65
Journal of virology 2012 Sep;86(18):9656-65
p21 promotes error-free replication-coupled DNA double-strand break repair.
Mauro M, Rego MA, Boisvert RA, Esashi F, Cavallo F, Jasin M, Howlett NG
Nucleic acids research 2012 Sep 1;40(17):8348-60
Nucleic acids research 2012 Sep 1;40(17):8348-60
Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.
Oplustilova L, Wolanin K, Mistrik M, Korinkova G, Simkova D, Bouchal J, Lenobel R, Bartkova J, Lau A, O'Connor MJ, Lukas J, Bartek J
Cell cycle (Georgetown, Tex.) 2012 Oct 15;11(20):3837-50
Cell cycle (Georgetown, Tex.) 2012 Oct 15;11(20):3837-50
A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons.
Li R, Yang YG, Gao Y, Wang ZQ, Tong WM
Cell research 2012 May;22(5):859-72
Cell research 2012 May;22(5):859-72
The human adenovirus type 5 E1B 55-kilodalton protein is phosphorylated by protein kinase CK2.
Ching W, Dobner T, Koyuncu E
Journal of virology 2012 Mar;86(5):2400-15
Journal of virology 2012 Mar;86(5):2400-15
MutS homologue hMSH5: role in cisplatin-induced DNA damage response.
Tompkins JD, Wu X, Her C
Molecular cancer 2012 Mar 8;11:10
Molecular cancer 2012 Mar 8;11:10
NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes.
Volcic M, Karl S, Baumann B, Salles D, Daniel P, Fulda S, Wiesmüller L
Nucleic acids research 2012 Jan;40(1):181-95
Nucleic acids research 2012 Jan;40(1):181-95
Lycopene inhibits Helicobacter pylori-induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells.
Jang SH, Lim JW, Morio T, Kim H
Free radical biology & medicine 2012 Feb 1;52(3):607-615
Free radical biology & medicine 2012 Feb 1;52(3):607-615
Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection.
Yang H, Zheng Z, Zhao LY, Li Q, Liao D
Cell cycle (Georgetown, Tex.) 2012 Feb 1;11(3):582-93
Cell cycle (Georgetown, Tex.) 2012 Feb 1;11(3):582-93
Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells.
Zou Z, Yuan Z, Zhang Q, Long Z, Chen J, Tang Z, Zhu Y, Chen S, Xu J, Yan M, Wang J, Liu Q
Autophagy 2012 Dec;8(12):1798-810
Autophagy 2012 Dec;8(12):1798-810
Identifying novel protein complexes in cancer cells using epitope-tagging of endogenous human genes and affinity-purification mass spectrometry.
Song J, Hao Y, Du Z, Wang Z, Ewing RM
Journal of proteome research 2012 Dec 7;11(12):5630-41
Journal of proteome research 2012 Dec 7;11(12):5630-41
TIS21(/BTG2/PC3) accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2(T68)-p53(S20) pathway.
Choi KS, Kim JY, Lim SK, Choi YW, Kim YH, Kang SY, Park TJ, Lim IK
DNA repair 2012 Dec 1;11(12):965-75
DNA repair 2012 Dec 1;11(12):965-75
Functional cooperation between human adenovirus type 5 early region 4, open reading frame 6 protein, and cellular homeobox protein HoxB7.
Müller D, Schreiner S, Schmid M, Groitl P, Winkler M, Dobner T
Journal of virology 2012 Aug;86(15):8296-308
Journal of virology 2012 Aug;86(15):8296-308
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.
Wohlbold L, Merrick KA, De S, Amat R, Kim JH, Larochelle S, Allen JJ, Zhang C, Shokat KM, Petrini JH, Fisher RP
PLoS genetics 2012 Aug;8(8):e1002935
PLoS genetics 2012 Aug;8(8):e1002935
Functional connection between Rad51 and PML in homology-directed repair.
Boichuk S, Hu L, Makielski K, Pandolfi PP, Gjoerup OV
PloS one 2011;6(10):e25814
PloS one 2011;6(10):e25814
Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells.
Schreiner S, Wimmer P, Groitl P, Chen SY, Blanchette P, Branton PE, Dobner T
Journal of virology 2011 Sep;85(17):8752-65
Journal of virology 2011 Sep;85(17):8752-65
NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.
Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K
Molecular cell 2011 Sep 2;43(5):788-97
Molecular cell 2011 Sep 2;43(5):788-97
Astrocyte dysfunction associated with cerebellar attrition in a Nijmegen breakage syndrome animal model.
Galron R, Gruber R, Lifshitz V, Lu H, Kirshner M, Ziv N, Wang ZQ, Shiloh Y, Barzilai A, Frenkel D
Journal of molecular neuroscience : MN 2011 Oct;45(2):202-11
Journal of molecular neuroscience : MN 2011 Oct;45(2):202-11
Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.
Zolner AE, Abdou I, Ye R, Mani RS, Fanta M, Yu Y, Douglas P, Tahbaz N, Fang S, Dobbs T, Wang C, Morrice N, Hendzel MJ, Weinfeld M, Lees-Miller SP
Nucleic acids research 2011 Nov;39(21):9224-37
Nucleic acids research 2011 Nov;39(21):9224-37
Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.
Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, Tahara H, Oku S, Hiramoto A, Shiiki T, Fujisawa Y, Ohashi H, Sakemi Y, Matsuura S
DNA repair 2011 Mar 7;10(3):314-21
DNA repair 2011 Mar 7;10(3):314-21
The E3 ubiquitin ligase activity associated with the adenoviral E1B-55K-E4orf6 complex does not require CRM1-dependent export.
Schmid M, Kindsmüller K, Wimmer P, Groitl P, Gonzalez RA, Dobner T
Journal of virology 2011 Jul;85(14):7081-94
Journal of virology 2011 Jul;85(14):7081-94
The E4orf6/E1B55K E3 ubiquitin ligase complexes of human adenoviruses exhibit heterogeneity in composition and substrate specificity.
Cheng CY, Gilson T, Dallaire F, Ketner G, Branton PE, Blanchette P
Journal of virology 2011 Jan;85(2):765-75
Journal of virology 2011 Jan;85(2):765-75
Five dysfunctional telomeres predict onset of senescence in human cells.
Kaul Z, Cesare AJ, Huschtscha LI, Neumann AA, Reddel RR
EMBO reports 2011 Dec 23;13(1):52-9
EMBO reports 2011 Dec 23;13(1):52-9
Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis.
Mohapatra S, Kawahara M, Khan IS, Yannone SM, Povirk LF
Nucleic acids research 2011 Aug;39(15):6500-10
Nucleic acids research 2011 Aug;39(15):6500-10
Rap1-independent telomere attachment and bouquet formation in mammalian meiosis.
Scherthan H, Sfeir A, de Lange T
Chromosoma 2011 Apr;120(2):151-7
Chromosoma 2011 Apr;120(2):151-7
The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection.
Coleman KA, Greenberg RA
The Journal of biological chemistry 2011 Apr 15;286(15):13669-80
The Journal of biological chemistry 2011 Apr 15;286(15):13669-80
Biological dose estimation of UVA laser microirradiation utilizing charged particle-induced protein foci.
Splinter J, Jakob B, Lang M, Yano K, Engelhardt J, Hell SW, Chen DJ, Durante M, Taucher-Scholz G
Mutagenesis 2010 May;25(3):289-97
Mutagenesis 2010 May;25(3):289-97
WRN participates in translesion synthesis pathway through interaction with NBS1.
Kobayashi J, Okui M, Asaithamby A, Burma S, Chen BP, Tanimoto K, Matsuura S, Komatsu K, Chen DJ
Mechanisms of ageing and development 2010 Jun;131(6):436-44
Mechanisms of ageing and development 2010 Jun;131(6):436-44
Proteasome-dependent degradation of Daxx by the viral E1B-55K protein in human adenovirus-infected cells.
Schreiner S, Wimmer P, Sirma H, Everett RD, Blanchette P, Groitl P, Dobner T
Journal of virology 2010 Jul;84(14):7029-38
Journal of virology 2010 Jul;84(14):7029-38
A common gain of function of p53 cancer mutants in inducing genetic instability.
Liu DP, Song H, Xu Y
Oncogene 2010 Feb 18;29(7):949-56
Oncogene 2010 Feb 18;29(7):949-56
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
Boichuk S, Hu L, Hein J, Gjoerup OV
Journal of virology 2010 Aug;84(16):8007-20
Journal of virology 2010 Aug;84(16):8007-20
A 49-kilodalton isoform of the adenovirus type 5 early region 1B 55-kilodalton protein is sufficient to support virus replication.
Kindsmüller K, Schreiner S, Leinenkugel F, Groitl P, Kremmer E, Dobner T
Journal of virology 2009 Sep;83(18):9045-56
Journal of virology 2009 Sep;83(18):9045-56
Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.
Yan T, Seo Y, Kinsella TJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Nov 15;15(22):6912-20
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Nov 15;15(22):6912-20
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.
Karen KA, Hoey PJ, Young CS, Hearing P
Journal of virology 2009 May;83(9):4565-73
Journal of virology 2009 May;83(9):4565-73
Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Nahas SA, Butch AW, Du L, Gatti RA
Clinical chemistry 2009 Mar;55(3):463-72
Clinical chemistry 2009 Mar;55(3):463-72
Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway.
Shimada M, Sagae R, Kobayashi J, Habu T, Komatsu K
Cancer research 2009 Mar 1;69(5):1768-75
Cancer research 2009 Mar 1;69(5):1768-75
Identification of integrin alpha3 as a new substrate of the adenovirus E4orf6/E1B 55-kilodalton E3 ubiquitin ligase complex.
Dallaire F, Blanchette P, Groitl P, Dobner T, Branton PE
Journal of virology 2009 Jun;83(11):5329-38
Journal of virology 2009 Jun;83(11):5329-38
A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation.
Yu Z, Chen T, Hébert J, Li E, Richard S
Molecular and cellular biology 2009 Jun;29(11):2982-96
Molecular and cellular biology 2009 Jun;29(11):2982-96
Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis.
Shao L, Fujii H, Colmegna I, Oishi H, Goronzy JJ, Weyand CM
The Journal of experimental medicine 2009 Jun 8;206(6):1435-49
The Journal of experimental medicine 2009 Jun 8;206(6):1435-49
ATM activation and signaling under hypoxic conditions.
Bencokova Z, Kaufmann MR, Pires IM, Lecane PS, Giaccia AJ, Hammond EM
Molecular and cellular biology 2009 Jan;29(2):526-37
Molecular and cellular biology 2009 Jan;29(2):526-37
Human MutL-complexes monitor homologous recombination independently of mismatch repair.
Siehler SY, Schrauder M, Gerischer U, Cantor S, Marra G, Wiesmüller L
DNA repair 2009 Feb 1;8(2):242-52
DNA repair 2009 Feb 1;8(2):242-52
A proteomic approach to identify candidate substrates of human adenovirus E4orf6-E1B55K and other viral cullin-based E3 ubiquitin ligases.
Dallaire F, Blanchette P, Branton PE
Journal of virology 2009 Dec;83(23):12172-84
Journal of virology 2009 Dec;83(23):12172-84
Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex.
Guirouilh-Barbat J, Redon C, Pommier Y
Molecular biology of the cell 2008 Sep;19(9):3969-81
Molecular biology of the cell 2008 Sep;19(9):3969-81
ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.
Ewald B, Sampath D, Plunkett W
Cancer research 2008 Oct 1;68(19):7947-55
Cancer research 2008 Oct 1;68(19):7947-55
Control of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activity.
Blanchette P, Kindsmüller K, Groitl P, Dallaire F, Speiseder T, Branton PE, Dobner T
Journal of virology 2008 Mar;82(6):2642-51
Journal of virology 2008 Mar;82(6):2642-51
Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells.
Zhao X, Madden-Fuentes RJ, Lou BX, Pipas JM, Gerhardt J, Rigell CJ, Fanning E
Journal of virology 2008 Jun;82(11):5316-28
Journal of virology 2008 Jun;82(11):5316-28
Adenovirus type 5 early region 1B 55-kDa oncoprotein can promote cell transformation by a mechanism independent from blocking p53-activated transcription.
Härtl B, Zeller T, Blanchette P, Kremmer E, Dobner T
Oncogene 2008 Jun 12;27(26):3673-84
Oncogene 2008 Jun 12;27(26):3673-84
Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.
Bartkova J, Tommiska J, Oplustilova L, Aaltonen K, Tamminen A, Heikkinen T, Mistrik M, Aittomäki K, Blomqvist C, Heikkilä P, Lukas J, Nevanlinna H, Bartek J
Molecular oncology 2008 Dec;2(4):296-316
Molecular oncology 2008 Dec;2(4):296-316
A role for E1B-AP5 in ATR signaling pathways during adenovirus infection.
Blackford AN, Bruton RK, Dirlik O, Stewart GS, Taylor AM, Dobner T, Grand RJ, Turnell AS
Journal of virology 2008 Aug;82(15):7640-52
Journal of virology 2008 Aug;82(15):7640-52
Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 protein.
Ullman AJ, Hearing P
Journal of virology 2008 Aug;82(15):7325-35
Journal of virology 2008 Aug;82(15):7325-35
Mdm2 promotes genetic instability and transformation independent of p53.
Bouska A, Lushnikova T, Plaza S, Eischen CM
Molecular and cellular biology 2008 Aug;28(15):4862-74
Molecular and cellular biology 2008 Aug;28(15):4862-74
Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres.
Zhong ZH, Jiang WQ, Cesare AJ, Neumann AA, Wadhwa R, Reddel RR
The Journal of biological chemistry 2007 Oct 5;282(40):29314-22
The Journal of biological chemistry 2007 Oct 5;282(40):29314-22
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling.
Stewart GS, Stankovic T, Byrd PJ, Wechsler T, Miller ES, Huissoon A, Drayson MT, West SC, Elledge SJ, Taylor AM
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 23;104(43):16910-5
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 23;104(43):16910-5
ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication.
Lin JJ, Dutta A
The Journal of biological chemistry 2007 Oct 19;282(42):30357-62
The Journal of biological chemistry 2007 Oct 19;282(42):30357-62
Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation.
Baker A, Rohleder KJ, Hanakahi LA, Ketner G
Journal of virology 2007 Jul;81(13):7034-40
Journal of virology 2007 Jul;81(13):7034-40
Dimerization of the Rad50 protein is independent of the conserved hook domain.
Cahill D, Carney JP
Mutagenesis 2007 Jul;22(4):269-74
Mutagenesis 2007 Jul;22(4):269-74
BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges.
Chan KL, North PS, Hickson ID
The EMBO journal 2007 Jul 25;26(14):3397-409
The EMBO journal 2007 Jul 25;26(14):3397-409
Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein.
Krüger L, Demuth I, Neitzel H, Varon R, Sperling K, Chrzanowska KH, Seemanova E, Digweed M
Carcinogenesis 2007 Jan;28(1):107-11
Carcinogenesis 2007 Jan;28(1):107-11
A role for MRE11, NBS1, and recombination junctions in replication and stable maintenance of EBV episomes.
Dheekollu J, Deng Z, Wiedmer A, Weitzman MD, Lieberman PM
PloS one 2007 Dec 5;2(12):e1257
PloS one 2007 Dec 5;2(12):e1257
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y
The Journal of biological chemistry 2006 Oct 13;281(41):30814-23
The Journal of biological chemistry 2006 Oct 13;281(41):30814-23
Mre11-Rad50-Nbs1 complex is activated by hypertonicity.
Sheen MR, Kim SW, Jung JY, Ahn JY, Rhee JG, Kwon HM, Woo SK
American journal of physiology. Renal physiology 2006 Nov;291(5):F1014-20
American journal of physiology. Renal physiology 2006 Nov;291(5):F1014-20
Nijmegen breakage syndrome (NBS) with neurological abnormalities and without chromosomal instability.
Seemanová E, Sperling K, Neitzel H, Varon R, Hadac J, Butova O, Schröck E, Seeman P, Digweed M
Journal of medical genetics 2006 Mar;43(3):218-24
Journal of medical genetics 2006 Mar;43(3):218-24
Active role for nibrin in the kinetics of atm activation.
Cerosaletti K, Wright J, Concannon P
Molecular and cellular biology 2006 Mar;26(5):1691-9
Molecular and cellular biology 2006 Mar;26(5):1691-9
Mild Nijmegen breakage syndrome phenotype due to alternative splicing.
Varon R, Dutrannoy V, Weikert G, Tanzarella C, Antoccia A, Stöckl L, Spadoni E, Krüger LA, di Masi A, Sperling K, Digweed M, Maraschio P
Human molecular genetics 2006 Mar 1;15(5):679-89
Human molecular genetics 2006 Mar 1;15(5):679-89
Physical and functional interaction between hMSH5 and c-Abl.
Yi W, Lee TH, Tompkins JD, Zhu F, Wu X, Her C
Cancer research 2006 Jan 1;66(1):151-8
Cancer research 2006 Jan 1;66(1):151-8
Rapid activation of ATR by ionizing radiation requires ATM and Mre11.
Myers JS, Cortez D
The Journal of biological chemistry 2006 Apr 7;281(14):9346-50
The Journal of biological chemistry 2006 Apr 7;281(14):9346-50
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.
Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J
The Journal of cell biology 2006 Apr 24;173(2):195-206
The Journal of cell biology 2006 Apr 24;173(2):195-206
Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.
Alt JR, Bouska A, Fernandez MR, Cerny RL, Xiao H, Eischen CM
The Journal of biological chemistry 2005 May 13;280(19):18771-81
The Journal of biological chemistry 2005 May 13;280(19):18771-81
Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination.
Restle A, Janz C, Wiesmüller L
Oncogene 2005 Jun 23;24(27):4380-7
Oncogene 2005 Jun 23;24(27):4380-7
Nibrin functions in Ig class-switch recombination.
Kracker S, Bergmann Y, Demuth I, Frappart PO, Hildebrand G, Christine R, Wang ZQ, Sperling K, Digweed M, Radbruch A
Proceedings of the National Academy of Sciences of the United States of America 2005 Feb 1;102(5):1584-9
Proceedings of the National Academy of Sciences of the United States of America 2005 Feb 1;102(5):1584-9
Expression of the adenovirus E4 34k oncoprotein inhibits repair of double strand breaks in the cellular genome of a 293-based inducible cell line.
Mohammadi ES, Ketner EA, Johns DC, Ketner G
Nucleic acids research 2004;32(8):2652-9
Nucleic acids research 2004;32(8):2652-9
A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts.
Donahue SL, Campbell C
Nucleic acids research 2004;32(10):3248-57
Nucleic acids research 2004;32(10):3248-57
Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.
Cerosaletti K, Concannon P
The Journal of biological chemistry 2004 Sep 10;279(37):38813-9
The Journal of biological chemistry 2004 Sep 10;279(37):38813-9
Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53.
Blanchette P, Cheng CY, Yan Q, Ketner G, Ornelles DA, Dobner T, Conaway RC, Conaway JW, Branton PE
Molecular and cellular biology 2004 Nov;24(21):9619-29
Molecular and cellular biology 2004 Nov;24(21):9619-29
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.
Cheng WH, von Kobbe C, Opresko PL, Arthur LM, Komatsu K, Seidman MM, Carney JP, Bohr VA
The Journal of biological chemistry 2004 May 14;279(20):21169-76
The Journal of biological chemistry 2004 May 14;279(20):21169-76
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks.
Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu NC, Bonner WM, Barrett JC
Nature cell biology 2004 Feb;6(2):168-70
Nature cell biology 2004 Feb;6(2):168-70
Notch and Schwann cell transformation.
Li Y, Rao PK, Wen R, Song Y, Muir D, Wallace P, van Horne SJ, Tennekoon GI, Kadesch T
Oncogene 2004 Feb 5;23(5):1146-52
Oncogene 2004 Feb 5;23(5):1146-52
Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks.
Robison JG, Elliott J, Dixon K, Oakley GG
The Journal of biological chemistry 2004 Aug 13;279(33):34802-10
The Journal of biological chemistry 2004 Aug 13;279(33):34802-10
Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation.
Udayakumar D, Bladen CL, Hudson FZ, Dynan WS
The Journal of biological chemistry 2003 Oct 24;278(43):41631-5
The Journal of biological chemistry 2003 Oct 24;278(43):41631-5
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y
The Journal of biological chemistry 2003 May 30;278(22):20303-12
The Journal of biological chemistry 2003 May 30;278(22):20303-12
Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation.
Cerosaletti KM, Concannon P
The Journal of biological chemistry 2003 Jun 13;278(24):21944-51
The Journal of biological chemistry 2003 Jun 13;278(24):21944-51
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Siwicki JK, Degerman S, Chrzanowska KH, Roos G
Experimental cell research 2003 Jul 1;287(1):178-89
Experimental cell research 2003 Jul 1;287(1):178-89
Deficient regulation of DNA double-strand break repair in Fanconi anemia fibroblasts.
Donahue SL, Lundberg R, Saplis R, Campbell C
The Journal of biological chemistry 2003 Aug 8;278(32):29487-95
The Journal of biological chemistry 2003 Aug 8;278(32):29487-95
Evidence for a direct association of hMRE11 with the human mismatch repair protein hMLH1.
Her C, Vo AT, Wu X
DNA repair 2002 Sep 4;1(9):719-29
DNA repair 2002 Sep 4;1(9):719-29
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.
Kobayashi J, Tauchi H, Sakamoto S, Nakamura A, Morishima K, Matsuura S, Kobayashi T, Tamai K, Tanimoto K, Komatsu K
Current biology : CB 2002 Oct 29;12(21):1846-51
Current biology : CB 2002 Oct 29;12(21):1846-51
PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage.
Carbone R, Pearson M, Minucci S, Pelicci PG
Oncogene 2002 Mar 7;21(11):1633-40
Oncogene 2002 Mar 7;21(11):1633-40
SV40 large T-antigen disturbs the formation of nuclear DNA-repair foci containing MRE11.
Digweed M, Demuth I, Rothe S, Scholz R, Jordan A, Grötzinger C, Schindler D, Grompe M, Sperling K
Oncogene 2002 Jul 25;21(32):4873-8
Oncogene 2002 Jul 25;21(32):4873-8
UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization.
Limoli CL, Giedzinski E, Bonner WM, Cleaver JE
Proceedings of the National Academy of Sciences of the United States of America 2002 Jan 8;99(1):233-8
Proceedings of the National Academy of Sciences of the United States of America 2002 Jan 8;99(1):233-8
Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation.
Cleaver JE, Bartholomew J, Char D, Crowley E, Feeney L, Limoli CL
DNA repair 2002 Jan 22;1(1):41-57
DNA repair 2002 Jan 22;1(1):41-57
Interaction of FANCD2 and NBS1 in the DNA damage response.
Nakanishi K, Taniguchi T, Ranganathan V, New HV, Moreau LA, Stotsky M, Mathew CG, Kastan MB, Weaver DT, D'Andrea AD
Nature cell biology 2002 Dec;4(12):913-20
Nature cell biology 2002 Dec;4(12):913-20
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.
Heffernan TP, Simpson DA, Frank AR, Heinloth AN, Paules RS, Cordeiro-Stone M, Kaufmann WK
Molecular and cellular biology 2002 Dec;22(24):8552-61
Molecular and cellular biology 2002 Dec;22(24):8552-61
DNA replication arrest in XP variant cells after UV exposure is diverted into an Mre11-dependent recombination pathway by the kinase inhibitor wortmannin.
Limoli CL, Laposa R, Cleaver JE
Mutation research 2002 Dec 29;510(1-2):121-9
Mutation research 2002 Dec 29;510(1-2):121-9
Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein.
Naka K, Ikeda K, Motoyama N
Biochemical and biophysical research communications 2002 Dec 20;299(5):863-71
Biochemical and biophysical research communications 2002 Dec 20;299(5):863-71
Role of poly(ADP-ribosyl)ation in DNA-PKcs- independent V(D)J recombination.
Brown ML, Franco D, Burkle A, Chang Y
Proceedings of the National Academy of Sciences of the United States of America 2002 Apr 2;99(7):4532-7
Proceedings of the National Academy of Sciences of the United States of America 2002 Apr 2;99(7):4532-7
Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest.
Franchitto A, Pichierri P
The Journal of cell biology 2002 Apr 1;157(1):19-30
The Journal of cell biology 2002 Apr 1;157(1):19-30
The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity.
Tauchi H, Kobayashi J, Morishima K, Matsuura S, Nakamura A, Shiraishi T, Ito E, Masnada D, Delia D, Komatsu K
The Journal of biological chemistry 2001 Jan 5;276(1):12-5
The Journal of biological chemistry 2001 Jan 5;276(1):12-5
NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres.
Wu G, Lee WH, Chen PL
The Journal of biological chemistry 2000 Sep 29;275(39):30618-22
The Journal of biological chemistry 2000 Sep 29;275(39):30618-22
Polymerase eta deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair.
Limoli CL, Giedzinski E, Morgan WF, Cleaver JE
Proceedings of the National Academy of Sciences of the United States of America 2000 Jul 5;97(14):7939-46
Proceedings of the National Academy of Sciences of the United States of America 2000 Jul 5;97(14):7939-46
Metabolism of recombination coding ends in scid cells.
Brown ML, Chang Y
Journal of immunology (Baltimore, Md. : 1950) 2000 Apr 15;164(8):4135-42
Journal of immunology (Baltimore, Md. : 1950) 2000 Apr 15;164(8):4135-42
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J
Genes & development 2000 Apr 15;14(8):927-39
Genes & development 2000 Apr 15;14(8):927-39
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
