Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS5751 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- GPR50 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 345-390 of Human GPR50.
- Description
- G protein-coupled receptors (GPCRs) play a central role in mediating the intracellular effects of numerous neurotransmitters and hormones, including melatonin. GPR50, also designated Melatonin-related receptor, GPCR50 and H9, does not bind melatonin. It is a multi-pass membrane protein primarily detected in hypothalamus and pituitary. GPR50 is a 613 amino acid protein that contains the seven hydrophobic segments that are characteristic of GPCRs, as well as the distinguishing sequence motifs of the melatonin receptor GPCR family. The GPR50 protein is 45% identical to the melatonin receptors 1A and 1B and has an unusually long proline-rich C-terminal tail. Research suggests that a deletion variant within the GPR50 gene is a sex-specific risk factor for susceptibility to BPAD (bipolar affective disorder) and that other variants in the gene may be sex-specific risk factors in the development of schizophrenia.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of GPR50 pAb at 1:500 dilutionLane1:Hela cell lysateLane2:sp2/0 cell lysateLane3:PC12 cell lysate