XAGE3

This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]

Description

X antigen family member 3

Tissue specificity

Tissue enriched (placenta)

Subcell location

Vesicles, Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

X (52862525 - 52868083)

Ensembl ID

ENSG00000171402  (ver. 103.38)

Orthologs

-

UniProt

Q8WTP9

neXtProt

NX_Q8WTP9

Human splice variants

Protein structure