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Protein structure
FGR
FGR proto-oncogene, Src family tyrosine kinasec-fgr, p55c-fgr, SRC2
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| LSBio |  LS-C133192 |
Monoclonal |
WB
EL
IHC
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| OriGene | TA590200 |
1 references | Polyclonal |
WB
EL
ICC
IHC
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| Abgent | AP7707a |
2 references | Polyclonal |
WB
ICC
IHC
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| Invitrogen Antibodies | H00002268-M01 |
Monoclonal |
WB
EL
IHC
OA
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| Novus Biologicals | H00002268-M03 |
1 references | Monoclonal |
WB
EL
IHC
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