14903-1-AP

antibody from Proteintech Group

Targeting: SNAP25 bA416N4.2, dJ1068F16.2, RIC-4, RIC4, SEC9, SNAP, SNAP-25

Provider product page for 14903-1-AP

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Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [35]
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Western blot [1]

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Product number: 14903-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14903-1-AP, RRID:AB_2192051
Product name: SNAP25 antibody
Antibody type: Polyclonal
Description: SNAP25 antibody (Cat. #14903-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SNAP25 protein structure - 14903-1-AP shown in red.

Submitted references Spiky Nanoparticle-Gel Composite for Efficient Intravesical Botulinum Toxin A Delivery and Treatment of Overactive Bladder.

Zhou Y, Liu Q, Wang L, Sun H, Liu Y, Xiang T, Zhu M, Liu X, Liu T, Cong H, Liao L
Advanced healthcare materials 2026 Mar 27;:e05843

Methyl 3-chloroasterric acid exerted anti-neuroinflammatory and antidepressant effects through the downregulation of P2Y1R.

Zhang Y, Sun M, Zhang Z, Jia Y, Xiao H, Xu X, Pan X, Li Z
International immunopharmacology 2026 Jul 15;181:116689

Buyang Huanwu decoction facilitates the repair of red nucleus neurons subsequent to spinal cord injury in rats via autophagy.

Deng J, Zhang Y, Xie W, Li L, Li Q
The journal of spinal cord medicine 2026 Jan;49(1):95-106

Nicotinamide Riboside Alleviates the Neurotoxic Injury of Dendritic Spine Plasticity Mediated by Hypoxic Microglial Activation.

Hou J, Zhang H, Huo X, Guan R, Wang B, Wang Y, Zhao F, Liu X, Hu Y, Zhuang C, Zou Y
Biomolecules 2025 Sep 30;15(10)

Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons.

Chen C, He Q, Tombesi G, Napier E, Jaconelli M, Moreno-Ramos OA, Serio H, Naaldijk Y, Promes V, Schneeweis A, Quinn K, Nasios C, Greggio E, Kozorovitskiy Y, Arango D, Khan AR, Alessi DR, Dombeck DA, Hilfiker S, Awatramani R, Parisiadou L
bioRxiv : the preprint server for biology 2025 Sep 3;

MicroRNA-502-3p Modulates the GABA A Subunits, Synaptic Proteins, and Mitochondrial Morphology in Hippocampal Neurons.

Sharma B, Rodarte D, Goyal G, Rodriguez S, Kumar S
Molecular neurobiology 2025 Oct;62(10):13479-13499

SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes.

Ding Z, Liu Q, Zhang J
Molecular neurobiology 2025 Oct;62(10):12523-12538

Muscone Protects Against Ferroptosis-Induced Injury in Models of Acute Ischemic Stroke by Modulating Snap25 Protein.

You R, Sun B, Luo J, Hu G, Shao N, Si W
Journal of integrative neuroscience 2025 Jun 19;24(6):39116

High-frequency repetitive transcranial magnetic stimulation upregulates BDNF expression and promotes synaptogenesis in mouse models of Parkinson's disease.

Chen D, Jiang Y, Ge F, Liu X, Huang Q, Gong Y
Neuroscience 2025 Jul 23;579:129-143

Deficiency of Rab26 causes behavioral defects in mice through impaired trafficking of serotonin (5-HT) transporter.

Ren Y, Wang Z, Wei Z, Zhuang R, Zhang Y, Liu X, Jiang C, Liu X, Yun Y, Li Y, Hong W, Wang T
iScience 2025 Jul 18;28(7):112931

Phlorizin ameliorates cognitive and behavioral impairments via the microbiota-gut-brain axis in high-fat and high-fructose diet-induced obese male mice.

Zhang S, Wang X, Liu S, Hu C, Meng Y
Brain, behavior, and immunity 2025 Jan;123:193-210

Clinical and functional characterization of a novel KCNJ11 (c.101G > A, p.R34H) mutation associated with maturity-onset diabetes mellitus of the young type 13.

Lv X, Gao J, Yang J, Zou Y, Chen J, Sun Y, Song J, Liu Y, Wang L, Xia L, Yu S, Wei Z, Chen L, Hou X
Endocrine 2024 Nov;86(2):515-527

Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway.

Huang G, Yang X, Yu Q, Luo Q, Ju C, Zhang B, Chen Y, Liang Z, Xia S, Wang X, Xiang D, Zhong N, Tang XX
Signal transduction and targeted therapy 2024 Nov 11;9(1):306

Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release.

Zhang H, Lei M, Zhang Y, Li H, He Z, Xie S, Zhu L, Wang S, Liu J, Li Y, Lu Y, Ma C
Science advances 2024 May 17;10(20):eadi7024

Bavachin ameliorates neuroinflammation and depressive-like behaviors in streptozotocin-induced diabetic mice through the inhibition of PKCδ.

Zhang Z, Sun L, Guo Y, Zhao J, Li J, Pan X, Li Z
Free radical biology & medicine 2024 Mar;213:52-64

L116 Deletion in CSPα Promotes α-Synuclein Aggregation and Neurodegeneration.

Guo T, Xiong J, Feng H, Bu L, Xiao T, Zhou L, He J, Deng M, Liu Y, Zhang Z, Zhang Z
Molecular neurobiology 2024 Jan;61(1):15-27

Optimization of protocols for immunohistochemical assessment of enteric nervous system in formalin fixed human tissue.

Hong SM, Qian X, Deshpande V, Kulkarni S
bioRxiv : the preprint server for biology 2024 Dec 17;

γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.

Chen XQ, Becker A, Albay R, Nguyen PD, Karachentsev D, Roberts AJ, Rynearson KD, Tanzi RE, Mobley WC
Annals of neurology 2024 Aug;96(2):390-404

Psoralen protects neurons and alleviates neuroinflammation by regulating microglial M1/M2 polarization via inhibition of the Fyn-PKCδ pathway.

Guo Y, Xu S, Pan X, Xin W, Cao W, Ma W, Li L, Shen Q, Li Z
International immunopharmacology 2024 Aug 20;137:112493

Intrathecal Injection of Botulinum Toxin Type A has an Analgesic Effect in Male Rats CCI Model by Inhibiting the Activation of Spinal P2X4R.

Zhou WM, Lei ZY, Shi YQ, Gong CY, Kai Z, Wei N, Wang LN, Zhang CJ, Zhang HH
Neurochemical research 2023 Oct;48(10):3099-3112

Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.

Chen XQ, Zuo X, Becker A, Head E, Mobley WC
Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 May;19(5):2095-2116

Comparative study of PRPH2 D2 loop mutants reveals divergent disease mechanism in rods and cones.

Ikelle L, Makia M, Lewis T, Crane R, Kakakhel M, Conley SM, Birtley JR, Arshavsky VY, Al-Ubaidi MR, Naash MI
Cellular and molecular life sciences : CMLS 2023 Jul 19;80(8):214

Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis.

Li T, Cheng Q, Wang S, Ma C
eLife 2022 Sep 29;11

Chrysin alleviates lipopolysaccharide-induced neuron damage and behavioral deficits in mice through inhibition of Fyn.

Wang Q, Yang Z, Wu X, Zhang X, Geng F, Wang Q, Geng Z, Yu C, Li Z
International immunopharmacology 2022 Oct;111:109118

METTL3-mediated m(6)A RNA methylation regulates dorsal lingual epithelium homeostasis.

Xiong Q, Liu C, Zheng X, Zhou X, Lei K, Zhang X, Wang Q, Lin W, Tong R, Xu R, Yuan Q
International journal of oral science 2022 May 17;14(1):26

RUNDC3A regulates SNAP25-mediated chemotherapy resistance by binding AKT in gastric neuroendocrine carcinoma (GNEC).

Chen P, Wang W, Wong SW, Li J, Wu Q, Zhang SD, Lin Y, Kwok HF
Cell death discovery 2022 Jun 25;8(1):296

Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.

Zhang Q, Zhang J, Ye J, Li X, Liu H, Ma X, Wang C, He K, Zhang W, Yuan J, Zhao Y, Xu H, Liu Q
Molecular neurodegeneration 2021 Sep 22;16(1):66

Neuromodulation Induced by Sitagliptin: A New Strategy for Treating Diabetic Retinopathy.

Ramos H, Bogdanov P, Sabater D, Huerta J, Valeri M, Hernández C, Simó R
Biomedicines 2021 Nov 26;9(12)

Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells.

Chen J, Wang F, Zhou Y, Jiang J, Ksimu S, Zhang X, Li JZ, Niu J, Wang Q
Clinical science (London, England : 1979) 2020 Mar 13;134(5):529-542

SNAP25/syntaxin4/VAMP2/Munc18-1 Complexes in Spinal Dorsal Horn Contributed to Inflammatory Pain.

Duan XL, Guo Z, He YT, Li YX, Liu YN, Bai HH, Li HL, Hu XD, Suo ZW
Neuroscience 2020 Mar 1;429:203-212

Absence of BBSome function leads to astrocyte reactivity in the brain.

Singh M, Garrison JE, Wang K, Sheffield VC
Molecular brain 2019 May 9;12(1):48

Structural and Functional Analysis of the CAPS SNARE-Binding Domain Required for SNARE Complex Formation and Exocytosis.

Zhou H, Wei Z, Wang S, Yao D, Zhang R, Ma C
Cell reports 2019 Mar 19;26(12):3347-3359.e6

miR‑153 promotes neural differentiation in the mouse hippocampal HT‑22 cell line and increases the expression of neuron‑specific enolase.

Xu C, Wang C, Meng Q, Gu Y, Wang Q, Xu W, Han Y, Qin Y, Li J, Jia S, Xu J, Zhou Y
Molecular medicine reports 2019 Aug;20(2):1725-1735

MicroRNA-210-5p Contributes to Cognitive Impairment in Early Vascular Dementia Rat Model Through Targeting Snap25.

Ren Z, Yu J, Wu Z, Si W, Li X, Liu Y, Zhou J, Deng R, Chen D
Frontiers in molecular neuroscience 2018;11:388

Comparison of the Expression Changes after Botulinum Toxin Type A and Minocycline Administration in Lipopolysaccharide-Stimulated Rat Microglial and Astroglial Cultures.

Piotrowska A, Popiolek-Barczyk K, Pavone F, Mika J
Frontiers in cellular and infection microbiology 2017;7:141

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SNAP25 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SNAP25. This antibody recognizes human,mouse,rat antigen. The SNAP25 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14903-1-AP.pdf

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