Antibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 13301-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13301-1-AP, RRID:AB_2198214
- Product name
- Syntaxin 11 antibody
- Antibody type
- Polyclonal
- Description
- Syntaxin 11 antibody (Cat. #13301-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The septin cytoskeleton regulates natural killer cell lytic granule release.
Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing.
C2 Domains of Munc13-4 Are Crucial for Ca2+-Dependent Degranulation and Cytotoxicity in NK Cells.
Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis.
Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells.
Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.
An N-Terminal Missense Mutation in STX11 Causative of FHL4 Abrogates Syntaxin-11 Binding to Munc18-2.
Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.
Effect of glucocorticoid on the biosynthesis of growth hormone-containing secretory granules in pituitary cells.
STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America.
Phatarpekar PV, Overlee BL, Leehan A, Wilton KM, Ham H, Billadeau DD
The Journal of cell biology 2020 Nov 2;219(11)
The Journal of cell biology 2020 Nov 2;219(11)
Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing.
Lopez JA, Noori T, Minson A, Li Jovanoska L, Thia K, Hildebrand MS, Akhlaghi H, Darcy PK, Kershaw MH, Brown NJ, Grigg A, Trapani JA, Voskoboinik I
Frontiers in immunology 2018;9:529
Frontiers in immunology 2018;9:529
C2 Domains of Munc13-4 Are Crucial for Ca2+-Dependent Degranulation and Cytotoxicity in NK Cells.
Bin NR, Ma K, Tien CW, Wang S, Zhu D, Park S, Turlova E, Sugita K, Shirakawa R, van der Sluijs P, Horiuchi H, Sun HS, Monnier PP, Gaisano HY, Sugita S
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 15;201(2):700-713
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 15;201(2):700-713
Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis.
Bin NR, Jung CH, Kim B, Chandrasegram P, Turlova E, Zhu D, Gaisano HY, Sun HS, Sugita S
Journal of cell science 2015 May 15;128(10):1946-60
Journal of cell science 2015 May 15;128(10):1946-60
Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells.
Hellewell AL, Foresti O, Gover N, Porter MY, Hewitt EW
PloS one 2014;9(6):e98900
PloS one 2014;9(6):e98900
Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.
Cichocki F, Schlums H, Li H, Stache V, Holmes T, Lenvik TR, Chiang SC, Miller JS, Meeths M, Anderson SK, Bryceson YT
The Journal of experimental medicine 2014 Jun 2;211(6):1079-91
The Journal of experimental medicine 2014 Jun 2;211(6):1079-91
An N-Terminal Missense Mutation in STX11 Causative of FHL4 Abrogates Syntaxin-11 Binding to Munc18-2.
Müller ML, Chiang SC, Meeths M, Tesi B, Entesarian M, Nilsson D, Wood SM, Nordenskjöld M, Henter JI, Naqvi A, Bryceson YT
Frontiers in immunology 2014 Jan 14;4:515
Frontiers in immunology 2014 Jan 14;4:515
Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.
Bin NR, Jung CH, Piggott C, Sugita S
Proceedings of the National Academy of Sciences of the United States of America 2013 Mar 19;110(12):4610-5
Proceedings of the National Academy of Sciences of the United States of America 2013 Mar 19;110(12):4610-5
Effect of glucocorticoid on the biosynthesis of growth hormone-containing secretory granules in pituitary cells.
Kawashima R, Ikematsu K, Abe Y, Sato M, Tsuruya S, Nakasono I, Fukushima H, Inoue K, Tsuboi T
Biochemical and biophysical research communications 2010 Sep 17;400(2):225-9
Biochemical and biophysical research communications 2010 Sep 17;400(2):225-9
STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America.
Marsh RA, Satake N, Biroschak J, Jacobs T, Johnson J, Jordan MB, Bleesing JJ, Filipovich AH, Zhang K
Pediatric blood & cancer 2010 Jul 15;55(1):134-40
Pediatric blood & cancer 2010 Jul 15;55(1):134-40
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human placenta tissue were subjected to SDS PAGE followed by western blot with 13301-1-AP(STX11 antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Syntaxin 11 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Syntaxin 11. This antibody recognizes human,mouse,rat antigen. The Syntaxin 11 antibody has been validated for the following applications: ELISA, WB, IHC analysis.