MAB8321

antibody from Abnova Corporation

Targeting: TYK2 JTK1

Western blot (Supportive data in Antibodypedia)

Antibody Data

Product number

MAB8321

Provider

Abnova Corporation

Proper citation

Abnova Corporation Cat#MAB8321, RRID:AB_10616783

Product name

TYK2 monoclonal antibody, clone 8G8E9,8G9H5

Antibody type

Monoclonal

Description

Mouse monoclonal antibody raised against partial recombinant TYK2.

Isotype

IgG

Antibody clone number

8G8E9,8G9H5

Storage

Store at -20°C.Aliquot to avoid repeated freezing and thawing.

References

Submitted references

Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation.

Shaw MH, Freeman GJ, Scott MF, Fox BA, Bzik DJ, Belkaid Y, Yap GS
Journal of immunology (Baltimore, Md. : 1950) 2006 Jun 15;176(12):7263-71

---

TYK2 is a key regulator of the surveillance of B lymphoid tumors.

Stoiber D, Kovacic B, Schuster C, Schellack C, Karaghiosoff M, Kreibich R, Weisz E, Artwohl M, Kleine OC, Muller M, Baumgartner-Parzer S, Ghysdael J, Freissmuth M, Sexl V
The Journal of clinical investigation 2004 Dec;114(11):1650-8

---

Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice.

Seto Y, Nakajima H, Suto A, Shimoda K, Saito Y, Nakayama KI, Iwamoto I
Journal of immunology (Baltimore, Md. : 1950) 2003 Jan 15;170(2):1077-83

Western blot

Supportive validation

Submitted by

Abnova Corporation (provider)

Main image

Experimental details

Western blot analyssi using TYK2 monoclonal antibody, clone 8G8E9, 8G9H5 (Cat # MAB8321) against trucated TYK2 recombinant protein (Lane 1) and Jurkat cell lysate (Lane 2).