67411-1-Ig

antibody from Proteintech Group

Targeting: TYK2 JTK1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

67411-1-Ig

Provider

Proteintech Group

Product name

TYK2 antibody

Antibody type

Monoclonal

Description

TYK2 antibody (Cat. #67411-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1E1A10

Vial size

20ul, 150ul

References

Submitted references

Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling.

Botman M, Huisman JMA, Drakaki A, Maas SL, Witalisz-Siepracka A, Stoiber D, van der Vorst EPC, Siebeler R, Hoeksema MA
Cell reports 2026 Feb 24;45(2):116985

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Protocatechuic aldehyde inactivates STAT3 through disrupting the STAT3-JAK1 interaction in epidermal keratinocyte and improves atopic dermatitis-like skin inflammation.

Yang X, Zhou Q, Liang L, Kang L, Yang J, Li X, Li F, Deng Y
International immunopharmacology 2025 Oct 30;164:115403

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Discovery of a Proteolysis-Targeting Chimera Degrader of JAK2 as a Potential Therapeutic Agent for JAK2-Mediated Myeloproliferative Neoplasms.

Wang C, Chen Z, Wang S, Wang J, Yu P, Huang C, Wu Y, Zhao Z, Mei W, Li H, Zhu L
Journal of medicinal chemistry 2025 Jun 12;68(11):12085-12099

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African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity.

Yao M, Li P, Li X, Li W, Qian P
Veterinary research 2025 Jul 5;56(1):137

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Discovery of a Highly Potent and Selective Tyrosine Kinase 2 (TYK2) Degrader with In Vivo Therapeutic Efficacy in a Murine Psoriasis Model.

Xiong S, Yang J, Yang M, Xiao M, Ha S, Tao W, Ma L, Ji C, Xiang H, Luo G
Journal of medicinal chemistry 2025 Apr 10;68(7):7560-7578

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Effectiveness of tofacitinib monotherapy for patients with IgG4-RD or idiopathic retroperitoneal fibrosis.

Cao X, Li S, Wan J, Yu Z, Dong G, Zhou W
Clinical and experimental rheumatology 2024 Sep;42(9):1736-1743

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pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infection.

Huang Z, Kong C, Zhang W, You J, Gao C, Yi J, Mai Z, Chen X, Zhou P, Gong L, Zhang G, Wang H
PLoS pathogens 2024 Oct;20(10):e1012613

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Picroside II promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2(-/-) mice by polarizing M1 macrophages and balancing immune responses.

Jia K, Ma Z, Zhang Y, Xie K, Li J, Wu J, Qu J, Li F, Li X
Chinese journal of natural medicines 2024 Jul;22(7):582-598

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Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses.

Duan S, Li X, Han J, Yang Y, Luo R, Cai Y, Li X, Zheng Q, Guo J, Liu R
Antioxidants (Basel, Switzerland) 2024 Feb 20;13(3)

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HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.

Sun X, Zhang K, Peng X, Zhou P, Qu C, Yang L, Shen L
Cancer letters 2023 May 28;562:216158

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IL-10 contributes to gemcitabine resistance in extranodal NK/T-cell lymphoma cells via ABCC4.

Huo J, Fu L, Jin M, Li Z, Zhang M
Investigational new drugs 2022 Jun;40(3):537-545

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SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway.

Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Fuchs SY, Connor JH, Douam F, Emili A, Saeed M
Journal of virology 2021 Sep 9;95(19):e0086221

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SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway.

Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M
bioRxiv : the preprint server for biology 2020 Oct 28;