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- Antibody Data
- Antigen structure
- References [89]
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- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 21920-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21920-1-AP, RRID:AB_11232223
- Product name
- NMDAR2B/GRIN2B antibody
- Antibody type
- Polyclonal
- Description
- NMDAR2B/GRIN2B antibody (Cat. #21920-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Epigenetic regulation by KDM5A mediates the effects of prenatal PM(2.5) exposure on hippocampal development and synaptic integrity through the Shh signaling pathway.
Alleviation of migraine related pain and anxiety by inhibiting calcium-stimulating AC1-dependent CGRP in the insula of adult rats.
Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome.
Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice.
Cognitive impairment in Alzheimer's disease FAD(4T) mouse model: Synaptic loss facilitated by activated microglia via C1qA.
Acupuncture Alleviates Chronic Ischemic White Matter Injury in SHR Rats via JNK-NMDAR Circuit.
Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy.
Ciprofol alleviates remifentanil-induced hyperalgesia by regulating α2GABAARs, NR2B, and P-CaMKIIα levels in the spinal cord and hippocampus.
METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.
Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory.
Integrin α3 is required for high-frequency repetitive transcranial magnetic stimulation-induced glutamatergic synaptic transmission in mice with ischemia.
Exercise attenuates the perioperative neurocognitive disorder induced by hyperhomocysteinemia in mice.
SorCS2 is involved in promoting periodontitis-induced depression-like behaviour in mice.
Dysfunction of inhibitory interneurons contributes to synaptic plasticity via GABABR-pNR2B signaling in a chronic migraine rat model.
Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.
Influence of bifenthrin exposure at different gestational stages on the neural development.
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes.
Cherry leaf decoction inhibits NMDAR expression and thereby ameliorates CUMS- induced depression-like behaviors through downregulation of α2δ-1.
Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors.
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons.
The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination.
RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG.
Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory.
The Apelin/APJ system modulates seizure activity and endocytosis of the NMDA receptor GluN2B subunit.
Infralimbic YTHDF1 is necessary for the beneficial effects of acute mild exercise on auditory fear extinction retention.
The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults.
Microglial Priming in Bilirubin-Induced Neurotoxicity.
CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice.
Complement C3a receptor antagonist alleviates tau pathology and ameliorates cognitive deficits in P301S mice.
PAG neuronal NMDARs activation mediated morphine-induced hyperalgesia by HMGB1-TLR4 dependent microglial inflammation.
Laparotomy-Induced Peripheral Inflammation Activates NR2B Receptors on the Brain Mast Cells and Results in Neuroinflammation in a Vagus Nerve-Dependent Manner.
KangPiLao decoction modulates cognitive and emotional disorders in rats with central fatigue through the GABA/Glu pathway.
Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity.
RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.
Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3β Overactivation-Induced Hyperphosphorylated Tau in Rats.
Down-regulation of NR2B receptors contributes to the analgesic and antianxiety effects of enriched environment mediated by endocannabinoid system in the inflammatory pain mice.
Protective effect of 3-n-butylphthalide against intrastriatal injection of malonic acid-induced neurotoxicity and biochemical alteration in rats.
Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia.
Single-Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury.
Ginkgo Biloba Extract Ameliorates Scopolamine-induced Memory Deficits via Rescuing Synaptic Damage.
The epigenetic reader PHF21B modulates murine social memory and synaptic plasticity-related genes.
Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF-κB Signaling-Mediated Neuroinflammation.
KIF17 Modulates Epileptic Seizures and Membrane Expression of the NMDA Receptor Subunit NR2B.
Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission.
Repeated maternal separation prolongs the critical period of ocular dominance plasticity in mouse visual cortex.
Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice.
Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity.
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine.
Transcranial direct current stimulation relieves visceral hypersensitivity via normalizing GluN2B expression and neural activity in anterior cingulate cortex.
Early and Delayed Impact of Nanosilver on the Glutamatergic NMDA Receptor Complex in Immature Rat Brain.
Maternal exposure to low doses of bisphenol A affects learning and memory in male rat offspring with abnormal N-methyl-d-aspartate receptors in the hippocampus.
Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model.
Phosphorylation of GluN2B subunits of N-methyl-d-aspartate receptors in the frontal association cortex involved in morphine-induced conditioned place preference in mice.
A high-throughput screen identifies inhibitors of lung cancer stem cells.
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca(2+)-Activin A circuit in chronic cerebral hypoperfusion rats.
Enriched Environment Promotes Cognitive Function Recovery following Cerebral Ischemic Injury via Upregulating GABAergic and Glutamatergic Systems in the Contralateral Hippocampus.
Effects of Xiaoyaosan on Depressive-Like Behaviors in Rats With Chronic Unpredictable Mild Stress Through HPA Axis Induced Astrocytic Activities.
Involvement of NMDAR/PSD-95/nNOS-NO-cGMP pathway in embryonic exposure to BPA induced learning and memory dysfunction of rats.
Up-regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine.
STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
EphrinB/EphB Signaling Contributes to the Synaptic Plasticity of Chronic Migraine Through NR2B Phosphorylation.
CCL2-CCR2 Axis Potentiates NMDA Receptor Signaling to Aggravate Neuropathic Pain Induced by Brachial Plexus Avulsion.
SAP102 contributes to hyperalgesia formation in the cancer induced bone pain rat model by anchoring NMDA receptors.
Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice.
TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation.
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system.
Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy.
Inhibition of CB1 receptor ameliorates spatial learning and memory impairment in mice with traumatic brain injury.
Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X.
CAMK2-Dependent Signaling in Neurons Is Essential for Survival.
The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors.
NR2B-Tyr phosphorylation regulates synaptic plasticity in central sensitization in a chronic migraine rat model.
Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnS(2) nanoflowers.
N-methyl D-aspartate receptor subtype 2B antagonist, Ro 25-6981, attenuates neuropathic pain by inhibiting postsynaptic density 95 expression.
Effects of intrathecal bupivacaine on the NR2B/CaMKIIα/CREB signaling pathway in the rat lumbar spinal cord.
Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex.
HCN2 contributes to oxaliplatin-induced neuropathic pain through activation of the CaMKII/CREB cascade in spinal neurons.
Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats.
Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age.
Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice.
Protective effects of Bushen Tiansui decoction on hippocampal synapses in a rat model of Alzheimer's disease.
Beneficial Effects of a CaMKIIα Inhibitor TatCN21 Peptide in Global Cerebral Ischemia.
Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction.
Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.
A lasting effect of postnatal sevoflurane anesthesia on the composition of NMDA receptor subunits in rat prefrontal cortex.
NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.
Dopamine D3 receptor-regulated NR2B subunits of N-methyl-d-aspartate receptors in the nucleus accumbens involves in morphine-induced locomotor activity.
Huang J, Song C, Liu Y, Zhang T, Wang T, Liu X, Yu L
Ecotoxicology and environmental safety 2024 May;276:116311
Ecotoxicology and environmental safety 2024 May;276:116311
Alleviation of migraine related pain and anxiety by inhibiting calcium-stimulating AC1-dependent CGRP in the insula of adult rats.
Li Y, Li C, Chen QY, Hao S, Mao J, Zhang W, Han X, Dong Z, Liu R, Tang W, Zhuo M, Yu S, Liu Y
The journal of headache and pain 2024 May 17;25(1):81
The journal of headache and pain 2024 May 17;25(1):81
Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome.
Fu Y, Yuan P, Zeng M, Zhang Q, Hou Y, Gao L, Wei Y, Zheng Y, Feng W, Zheng X
Heliyon 2024 May 15;10(9):e29807
Heliyon 2024 May 15;10(9):e29807
Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice.
Zhou S, Cui X, Chen J, Luo M, Ouyang W, Tong J, Xie Z, Le Y
Free radical biology & medicine 2024 Mar;214:184-192
Free radical biology & medicine 2024 Mar;214:184-192
Cognitive impairment in Alzheimer's disease FAD(4T) mouse model: Synaptic loss facilitated by activated microglia via C1qA.
Zhang C, Qi H, Jia D, Zhao J, Xu C, Liu J, Cui Y, Zhang J, Wang M, Chen M, Tang B
Life sciences 2024 Mar 1;340:122457
Life sciences 2024 Mar 1;340:122457
Acupuncture Alleviates Chronic Ischemic White Matter Injury in SHR Rats via JNK-NMDAR Circuit.
Dong A, Gao Z, Wang H, Wu R, Wang W, Jin X, Ji Y, Yang F, Zhu T, Jiang Z, Xu Y, Guo J, Ji L
Molecular neurobiology 2024 Jun;61(6):3144-3160
Molecular neurobiology 2024 Jun;61(6):3144-3160
Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy.
Ban Y, Yang X, Tan D, Gong C, Gao Y, Yuan J, Chen Y, Wang Y, Xu T
Neurochemistry international 2024 Jun;176:105727
Neurochemistry international 2024 Jun;176:105727
Ciprofol alleviates remifentanil-induced hyperalgesia by regulating α2GABAARs, NR2B, and P-CaMKIIα levels in the spinal cord and hippocampus.
Yang Y, Yang C, Shi Y, Tang C, Wang H, Tan M, Xing R, Gao C, Zhang M, Xie Y
The Journal of pharmacy and pharmacology 2024 Jun 1;76(6):736-745
The Journal of pharmacy and pharmacology 2024 Jun 1;76(6):736-745
METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.
Lu W, Yang X, Zhong W, Chen G, Guo X, Ye Q, Xu Y, Qi Z, Ye Y, Zhang J, Wang Y, Wang X, Wang S, Zhao Q, Zeng W, Huang J, Ma H, Xie J
The Journal of clinical investigation 2024 Feb 6;134(6)
The Journal of clinical investigation 2024 Feb 6;134(6)
Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory.
Chen CC, Han J, Chinn CA, Rounds JS, Li X, Nikan M, Myszka M, Tong L, Passalacqua LFM, Bredy T, Wood MA, Luptak A
eLife 2024 Feb 6;13
eLife 2024 Feb 6;13
Integrin α3 is required for high-frequency repetitive transcranial magnetic stimulation-induced glutamatergic synaptic transmission in mice with ischemia.
Liu L, Hu H, Wu J, Koleske AJ, Chen H, Wang N, Yu K, Wu Y, Xiao X, Zhang Q
CNS neuroscience & therapeutics 2024 Apr;30(4):e14498
CNS neuroscience & therapeutics 2024 Apr;30(4):e14498
Exercise attenuates the perioperative neurocognitive disorder induced by hyperhomocysteinemia in mice.
Zhang Q, Cong P, Tian L, Wu T, Huang X, Zhang Y, Wu H, Liang H, Xiong L
Brain research bulletin 2024 Apr;209:110913
Brain research bulletin 2024 Apr;209:110913
SorCS2 is involved in promoting periodontitis-induced depression-like behaviour in mice.
Li Y, Yang Y, Guan X, Liu Z, Pan L, Wang Y, Jia X, Yang J, Hou T
Oral diseases 2024 Apr 3;
Oral diseases 2024 Apr 3;
Dysfunction of inhibitory interneurons contributes to synaptic plasticity via GABABR-pNR2B signaling in a chronic migraine rat model.
Zeng X, Niu Y, Qin G, Zhang D, Chen L
Frontiers in molecular neuroscience 2023;16:1142072
Frontiers in molecular neuroscience 2023;16:1142072
Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.
Zhang L, Huang J, Dai L, Zhu G, Yang XL, He Z, Li YH, Yang H, Zhang CQ, Shen KF, Liang P
Frontiers in neurology 2023;14:1255097
Frontiers in neurology 2023;14:1255097
Influence of bifenthrin exposure at different gestational stages on the neural development.
Xi C, Shi X, Wang Y, He J, Jiang S, Niu B, Chen Y, Zhao F, Cao Z
Ecotoxicology and environmental safety 2023 Sep 15;263:115365
Ecotoxicology and environmental safety 2023 Sep 15;263:115365
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes.
Li SJ, Ma MH, Li JM, Lu XY, Lu CB, Zhou SF, Zhang LX, Li MQ, Shao TZ, Bai SP, Yan XX, Li F, Li CQ
Aging and disease 2023 Oct 1;14(5):1853-1869
Aging and disease 2023 Oct 1;14(5):1853-1869
Cherry leaf decoction inhibits NMDAR expression and thereby ameliorates CUMS- induced depression-like behaviors through downregulation of α2δ-1.
Jiang C, Wang C, Qu W, Wang Y, Wang H, Wei X, Wang M, He Q, Wang Y, Yuan L, Gao Y
Heliyon 2023 Nov;9(11):e21743
Heliyon 2023 Nov;9(11):e21743
Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors.
Li W, Shen Z, Yin X, Chang W, Chen X, Yu J, Xu S
Translational psychiatry 2023 Nov 22;13(1):359
Translational psychiatry 2023 Nov 22;13(1):359
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons.
Serwach K, Nurowska E, Klukowska M, Zablocka B, Gruszczynska-Biegala J
Cellular and molecular life sciences : CMLS 2023 Nov 21;80(12):368
Cellular and molecular life sciences : CMLS 2023 Nov 21;80(12):368
The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination.
Zhang YY, Yang XY, Liu HQ, Zhang Z, Hu CP, Peng J, Luo XJ
Molecular neurobiology 2023 Mar;60(3):1563-1579
Molecular neurobiology 2023 Mar;60(3):1563-1579
RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG.
Zhang L, Luo L, Xue L, Ran D, Yang F, Tang Q, Jiang W
Experimental neurology 2023 Mar;361:114299
Experimental neurology 2023 Mar;361:114299
Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory.
Chen CC, Han J, Chinn CA, Rounds JS, Li X, Nikan M, Myszka M, Tong L, Passalacqua LFM, Bredy TW, Wood MA, Lupták A
bioRxiv : the preprint server for biology 2023 Jun 9;
bioRxiv : the preprint server for biology 2023 Jun 9;
The Apelin/APJ system modulates seizure activity and endocytosis of the NMDA receptor GluN2B subunit.
Zhang X, Gu Y, Ma Y, Wu J, Chen Y, Tao K, Sun H, Liu Z, Wang X, Tian X
Neurochemistry international 2023 Jul;167:105545
Neurochemistry international 2023 Jul;167:105545
Infralimbic YTHDF1 is necessary for the beneficial effects of acute mild exercise on auditory fear extinction retention.
Li SJ, Zhang LX, Zou GJ, Ma MH, Zhou SF, Lu XY, Li F, Li CQ
Cerebral cortex (New York, N.Y. : 1991) 2023 Feb 20;33(5):1814-1825
Cerebral cortex (New York, N.Y. : 1991) 2023 Feb 20;33(5):1814-1825
The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults.
Guo B, Song H, Fan J, Wang B, Chen L, Hu Q, Yin Y
Experimental brain research 2023 Dec;241(11-12):2735-2750
Experimental brain research 2023 Dec;241(11-12):2735-2750
Microglial Priming in Bilirubin-Induced Neurotoxicity.
Huang H, Li S, Zhang Y, He C, Hua Z
Neurotoxicity research 2023 Aug;41(4):338-348
Neurotoxicity research 2023 Aug;41(4):338-348
CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice.
Zhang L, Zeng Z, Lu X, Li M, Yao J, Zou G, Chen Z, Li Q, Li C, Li F
Neurotoxicity research 2023 Aug;41(4):324-337
Neurotoxicity research 2023 Aug;41(4):324-337
Complement C3a receptor antagonist alleviates tau pathology and ameliorates cognitive deficits in P301S mice.
Yao Y, Chang Y, Li S, Zhu J, Wu Y, Jiang X, Li L, Liu R, Ma R, Li G
Brain research bulletin 2023 Aug;200:110685
Brain research bulletin 2023 Aug;200:110685
PAG neuronal NMDARs activation mediated morphine-induced hyperalgesia by HMGB1-TLR4 dependent microglial inflammation.
Mo J, Lu Z, Peng J, Li XP, Lan L, Wang H, Peng Y
Journal of psychiatric research 2023 Aug;164:150-161
Journal of psychiatric research 2023 Aug;164:150-161
Laparotomy-Induced Peripheral Inflammation Activates NR2B Receptors on the Brain Mast Cells and Results in Neuroinflammation in a Vagus Nerve-Dependent Manner.
Yang J, Dong HQ, Liu YH, Ji MH, Zhang X, Dai HY, Sun ZC, Liu L, Zhou J, Sha HH, Qian YN, Li QG, Yao H, Li NN
Frontiers in cellular neuroscience 2022;16:771156
Frontiers in cellular neuroscience 2022;16:771156
KangPiLao decoction modulates cognitive and emotional disorders in rats with central fatigue through the GABA/Glu pathway.
Xu Y, Lian Y, Li J, Zhang Y, Liu Y, Wang X, Ma J, Li F
Frontiers in pharmacology 2022;13:939169
Frontiers in pharmacology 2022;13:939169
Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity.
Du J, Chen X, Zhao Y, Zhao T, Wang D, Chen Z, Wang C, Meng Q, Yao J, Sun H, Liu K, Wu J
Frontiers in pharmacology 2022;13:1046814
Frontiers in pharmacology 2022;13:1046814
RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.
Ma P, Wan LP, Li Y, He CH, Song NN, Zhao S, Wang H, Ding YQ, Mao B, Sheng N
Science advances 2022 Sep 30;8(39):eabq4736
Science advances 2022 Sep 30;8(39):eabq4736
Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3β Overactivation-Induced Hyperphosphorylated Tau in Rats.
Liu X, Song W, Yu Y, Su J, Shi X, Yang X, Wang H, Liu P, Zou L
Neurotoxicity research 2022 Oct;40(5):1163-1173
Neurotoxicity research 2022 Oct;40(5):1163-1173
Down-regulation of NR2B receptors contributes to the analgesic and antianxiety effects of enriched environment mediated by endocannabinoid system in the inflammatory pain mice.
Jiang S, Zheng C, Wen G, Bu B, Zhao S, Xu X
Behavioural brain research 2022 Oct 28;435:114062
Behavioural brain research 2022 Oct 28;435:114062
Protective effect of 3-n-butylphthalide against intrastriatal injection of malonic acid-induced neurotoxicity and biochemical alteration in rats.
Yuan C, Zheng L, Zhao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113664
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113664
Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia.
Zhang X, Wang M, Feng B, Zhang Q, Tong J, Wang M, Lu C, Peng S
International journal of molecular sciences 2022 May 17;23(10)
International journal of molecular sciences 2022 May 17;23(10)
Single-Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury.
Shi Y, Wu X, Zhou J, Cui W, Wang J, Hu Q, Zhang S, Han L, Zhou M, Luo J, Wang Q, Liu H, Feng D, Ge S, Qu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(7):e2104112
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(7):e2104112
Ginkgo Biloba Extract Ameliorates Scopolamine-induced Memory Deficits via Rescuing Synaptic Damage.
Zhang GJ, Zheng D, Yu H, Luo XP, Wu W
Current medical science 2022 Jun;42(3):474-482
Current medical science 2022 Jun;42(3):474-482
The epigenetic reader PHF21B modulates murine social memory and synaptic plasticity-related genes.
Chin EW, Ma Q, Ruan H, Chin C, Somasundaram A, Zhang C, Liu C, Lewis MD, White M, Smith TL, Battersby M, Yao WD, Lu XY, Arap W, Licinio J, Wong ML
JCI insight 2022 Jul 22;7(14)
JCI insight 2022 Jul 22;7(14)
Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF-κB Signaling-Mediated Neuroinflammation.
Peng X, Wang J, Peng J, Jiang H, Le K
Journal of molecular neuroscience : MN 2022 Jan;72(1):113-125
Journal of molecular neuroscience : MN 2022 Jan;72(1):113-125
KIF17 Modulates Epileptic Seizures and Membrane Expression of the NMDA Receptor Subunit NR2B.
Liu Y, Tian X, Ke P, Gu J, Ma Y, Guo Y, Xu X, Chen Y, Yang M, Wang X, Xiao F
Neuroscience bulletin 2022 Aug;38(8):841-856
Neuroscience bulletin 2022 Aug;38(8):841-856
Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission.
Liang W, Hou Y, Huang W, Wang Y, Jiang T, Huang X, Wang Z, Wu F, Zheng J, Zhang J, Ou H, Li S, Ping J, Zhang Y, Ye J, Li Z, Yang Q, Zhang J, Zheng X, Li S, Zhu XH, Chen R, Zhao C
Science advances 2022 Aug 19;8(33):eabn7357
Science advances 2022 Aug 19;8(33):eabn7357
Repeated maternal separation prolongs the critical period of ocular dominance plasticity in mouse visual cortex.
Li S, Zhang X, Liu Y, Shan Z, Liu H, Wu W, Yang Y
Neuroscience letters 2022 Apr 17;776:136577
Neuroscience letters 2022 Apr 17;776:136577
Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice.
Chang Y, Yao Y, Ma R, Wang Z, Hu J, Wu Y, Jiang X, Li L, Li G
Frontiers in neuroscience 2021;15:620176
Frontiers in neuroscience 2021;15:620176
Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity.
Qi CC, Chen XX, Gao XR, Xu JX, Liu S, Ge JF
Frontiers in aging neuroscience 2021;13:633495
Frontiers in aging neuroscience 2021;13:633495
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Zhang Q, Zhang J, Ye J, Li X, Liu H, Ma X, Wang C, He K, Zhang W, Yuan J, Zhao Y, Xu H, Liu Q
Molecular neurodegeneration 2021 Sep 22;16(1):66
Molecular neurodegeneration 2021 Sep 22;16(1):66
Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine.
Zhang X, You L, Zhang X, Wang F, Wang Y, Zhou J, Liu C, Qu F
Chinese medicine 2021 Oct 2;16(1):97
Chinese medicine 2021 Oct 2;16(1):97
Transcranial direct current stimulation relieves visceral hypersensitivity via normalizing GluN2B expression and neural activity in anterior cingulate cortex.
Xiao Y, Xie L, Xu QY, Chen L, Chen H, Xu GY, Zhang PA
Journal of neurophysiology 2021 May 1;125(5):1787-1797
Journal of neurophysiology 2021 May 1;125(5):1787-1797
Early and Delayed Impact of Nanosilver on the Glutamatergic NMDA Receptor Complex in Immature Rat Brain.
Dąbrowska-Bouta B, Sulkowski G, Sałek M, Frontczak-Baniewicz M, Strużyńska L
International journal of molecular sciences 2021 Mar 17;22(6)
International journal of molecular sciences 2021 Mar 17;22(6)
Maternal exposure to low doses of bisphenol A affects learning and memory in male rat offspring with abnormal N-methyl-d-aspartate receptors in the hippocampus.
Wang C, Shu Y, Xu L, Liu Q, Zhang B, Zhang H
Toxicology and industrial health 2021 Jun;37(6):303-313
Toxicology and industrial health 2021 Jun;37(6):303-313
Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model.
Wang Y, Pan Q, Tian R, Wen Q, Qin G, Zhang D, Chen L, Zhang Y, Zhou J
The journal of headache and pain 2021 Jul 27;22(1):84
The journal of headache and pain 2021 Jul 27;22(1):84
Phosphorylation of GluN2B subunits of N-methyl-d-aspartate receptors in the frontal association cortex involved in morphine-induced conditioned place preference in mice.
Chen G, Han W, Li A, Wang J, Xiao J, Huang X, Nazir KA, Shang Q, Qian H, Qiao C, Liu X, Li T
Neuroscience letters 2021 Jan 10;741:135470
Neuroscience letters 2021 Jan 10;741:135470
A high-throughput screen identifies inhibitors of lung cancer stem cells.
She X, Gao Y, Zhao Y, Yin Y, Dong Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug;140:111748
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug;140:111748
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca(2+)-Activin A circuit in chronic cerebral hypoperfusion rats.
Zhang X, Shi X, Wang J, Xu Z, He J
Aging 2021 Aug 30;13(16):20748-20761
Aging 2021 Aug 30;13(16):20748-20761
Enriched Environment Promotes Cognitive Function Recovery following Cerebral Ischemic Injury via Upregulating GABAergic and Glutamatergic Systems in the Contralateral Hippocampus.
Wang Y, Wu J, Xie H, Wang L, Wang C, Wu Y
Evidence-based complementary and alternative medicine : eCAM 2020;2020:8850119
Evidence-based complementary and alternative medicine : eCAM 2020;2020:8850119
Effects of Xiaoyaosan on Depressive-Like Behaviors in Rats With Chronic Unpredictable Mild Stress Through HPA Axis Induced Astrocytic Activities.
Song M, Zhang J, Li X, Liu Y, Wang T, Yan Z, Chen J
Frontiers in psychiatry 2020;11:545823
Frontiers in psychiatry 2020;11:545823
Involvement of NMDAR/PSD-95/nNOS-NO-cGMP pathway in embryonic exposure to BPA induced learning and memory dysfunction of rats.
Yu H, Ma L, Liu D, Wang Y, Pei X, Duan Z, Ma M, Zhang Y
Environmental pollution (Barking, Essex : 1987) 2020 Nov;266(Pt 1):115055
Environmental pollution (Barking, Essex : 1987) 2020 Nov;266(Pt 1):115055
Up-regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine.
Zhou X, Liang J, Wang J, Fei Z, Qin G, Zhang D, Zhou J, Chen L
Journal of neurochemistry 2020 Nov;155(4):370-389
Journal of neurochemistry 2020 Nov;155(4):370-389
STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
Gruszczynska-Biegala J, Strucinska K, Maciag F, Majewski L, Sladowska M, Kuznicki J
Cells 2020 Jan 9;9(1)
Cells 2020 Jan 9;9(1)
EphrinB/EphB Signaling Contributes to the Synaptic Plasticity of Chronic Migraine Through NR2B Phosphorylation.
Wang J, Fei Z, Liang J, Zhou X, Qin G, Zhang D, Zhou J, Chen L
Neuroscience 2020 Jan 21;428:178-191
Neuroscience 2020 Jan 21;428:178-191
CCL2-CCR2 Axis Potentiates NMDA Receptor Signaling to Aggravate Neuropathic Pain Induced by Brachial Plexus Avulsion.
Xian H, Jiang Y, Zhang H, Ma SB, Zhao R, Cong R
Neuroscience 2020 Jan 15;425:29-38
Neuroscience 2020 Jan 15;425:29-38
SAP102 contributes to hyperalgesia formation in the cancer induced bone pain rat model by anchoring NMDA receptors.
He QL, Deng HS, Xu LS, Zhu JJ, Ni HD, Wang TT, Wang YG, Shen H, Pan H, Yao M
Neuroscience letters 2020 Jan 1;714:134595
Neuroscience letters 2020 Jan 1;714:134595
Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice.
Qi F, Liu T, Zhang X, Gao X, Li Z, Chen L, Lin C, Wang L, Wang ZJ, Tang H, Chen Z
Neuropharmacology 2020 Jan 1;162:107783
Neuropharmacology 2020 Jan 1;162:107783
TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation.
Zhang H, Tian X, Lu X, Xu D, Guo Y, Dong Z, Li Y, Ma Y, Chen C, Yang Y, Yang M, Yang Y, Liu F, Zhou R, He M, Xiao F, Wang X
The Journal of clinical investigation 2019 Sep 3;129(9):3864-3876
The Journal of clinical investigation 2019 Sep 3;129(9):3864-3876
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
Wang X, Luo C, Mao XY, Li X, Yin JY, Zhang W, Zhou HH, Liu ZQ
Brain research 2019 Sep 15;1719:30-39
Brain research 2019 Sep 15;1719:30-39
Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system.
Chen K, Sun D, Qu S, Chen Y, Wang J, Zhou L, Jose PA, Yang Y, Zeng C
Clinical science (London, England : 1979) 2019 May 31;133(9):1097-1113
Clinical science (London, England : 1979) 2019 May 31;133(9):1097-1113
Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy.
Wen Y, Wu K, Xie Y, Dan W, Zhan Y, Shi Q
Biochemical and biophysical research communications 2019 Mar 26;511(1):79-86
Biochemical and biophysical research communications 2019 Mar 26;511(1):79-86
Inhibition of CB1 receptor ameliorates spatial learning and memory impairment in mice with traumatic brain injury.
Xu X, Jiang S, Xu E, Wu X, Zhao R
Neuroscience letters 2019 Mar 23;696:127-131
Neuroscience letters 2019 Mar 23;696:127-131
Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X.
So LY, Munger SJ, Miller JE
Behavioural brain research 2019 Mar 15;360:103-112
Behavioural brain research 2019 Mar 15;360:103-112
CAMK2-Dependent Signaling in Neurons Is Essential for Survival.
Kool MJ, Proietti Onori M, Borgesius NZ, van de Bree JE, Elgersma-Hooisma M, Nio E, Bezstarosti K, Buitendijk GHS, Aghadavoud Jolfaei M, Demmers JAA, Elgersma Y, van Woerden GM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 10;39(28):5424-5439
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 10;39(28):5424-5439
The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors.
Lu X, Zhang Q, Wang T
Biochemical and biophysical research communications 2019 Aug 13;516(1):63-67
Biochemical and biophysical research communications 2019 Aug 13;516(1):63-67
NR2B-Tyr phosphorylation regulates synaptic plasticity in central sensitization in a chronic migraine rat model.
Wang XY, Zhou HR, Wang S, Liu CY, Qin GC, Fu QQ, Zhou JY, Chen LX
The journal of headache and pain 2018 Nov 6;19(1):102
The journal of headache and pain 2018 Nov 6;19(1):102
Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnS(2) nanoflowers.
Bai D, Li Q, Wang J, Zhao J, Deng X, Yuan L, Wu P
Toxicology research 2018 Nov 1;7(6):1267-1279
Toxicology research 2018 Nov 1;7(6):1267-1279
N-methyl D-aspartate receptor subtype 2B antagonist, Ro 25-6981, attenuates neuropathic pain by inhibiting postsynaptic density 95 expression.
Huang LE, Guo SH, Thitiseranee L, Yang Y, Zhou YF, Yao YX
Scientific reports 2018 May 18;8(1):7848
Scientific reports 2018 May 18;8(1):7848
Effects of intrathecal bupivacaine on the NR2B/CaMKIIα/CREB signaling pathway in the rat lumbar spinal cord.
Zhao L, Zhang Y, Yang F, Zhu D, Li N, Zhao L, Li N, Yu J, Ma H
Molecular medicine reports 2018 Mar;17(3):4508-4514
Molecular medicine reports 2018 Mar;17(3):4508-4514
Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex.
Li Y, Wang L, Zhang X, Huang M, Li S, Wang X, Chen L, Jiang B, Yang Y
Neuropharmacology 2018 Jan;128:207-220
Neuropharmacology 2018 Jan;128:207-220
HCN2 contributes to oxaliplatin-induced neuropathic pain through activation of the CaMKII/CREB cascade in spinal neurons.
Liu X, Zhang L, Jin L, Tan Y, Li W, Tang J
Molecular pain 2018 Jan-Dec;14:1744806918778490
Molecular pain 2018 Jan-Dec;14:1744806918778490
Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats.
Cao M, Fang J, Wang X, Wang Y, Duan K, Ye F, Ouyang W, Tong J
Brain research 2018 Apr 1;1684:21-29
Brain research 2018 Apr 1;1684:21-29
Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age.
Tang Y, Wang X, Zhang S, Duan S, Qing W, Chen G, Ye F, Le Y, Ouyang W
PloS one 2017;12(8):e0182471
PloS one 2017;12(8):e0182471
Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice.
Zhang S, Wang X, Ai S, Ouyang W, Le Y, Tong J
PloS one 2017;12(11):e0188273
PloS one 2017;12(11):e0188273
Protective effects of Bushen Tiansui decoction on hippocampal synapses in a rat model of Alzheimer's disease.
Hui S, Yang Y, Peng WJ, Sheng CX, Gong W, Chen S, Xu PP, Wang Z
Neural regeneration research 2017 Oct;12(10):1680-1686
Neural regeneration research 2017 Oct;12(10):1680-1686
Beneficial Effects of a CaMKIIα Inhibitor TatCN21 Peptide in Global Cerebral Ischemia.
Ahmed ME, Dong Y, Lu Y, Tucker D, Wang R, Zhang Q
Journal of molecular neuroscience : MN 2017 Jan;61(1):42-51
Journal of molecular neuroscience : MN 2017 Jan;61(1):42-51
Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction.
Wen Y, Fu P, Wu K, Si K, Xie Y, Dan W, Zhan Y, Shi Q
Neurochemical research 2017 Aug;42(8):2154-2166
Neurochemical research 2017 Aug;42(8):2154-2166
Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.
Tang L, Zhang Y, Chen G, Xiong Y, Wang X, Zhu B
Neurochemical research 2017 Apr;42(4):1211-1218
Neurochemical research 2017 Apr;42(4):1211-1218
A lasting effect of postnatal sevoflurane anesthesia on the composition of NMDA receptor subunits in rat prefrontal cortex.
Zhang X, Shen F, Xu D, Zhao X
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2016 Nov;54:62-69
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2016 Nov;54:62-69
NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.
Zhang Y, Chen G, Gao B, Li Y, Liang S, Wang X, Wang X, Zhu B
Scientific reports 2016 Nov 23;6:37713
Scientific reports 2016 Nov 23;6:37713
Dopamine D3 receptor-regulated NR2B subunits of N-methyl-d-aspartate receptors in the nucleus accumbens involves in morphine-induced locomotor activity.
Liu XS, Hou Y, Yan TL, Guo YY, Han W, Guan FL, Chen T, Li T
CNS neuroscience & therapeutics 2014 Sep;20(9):823-9
CNS neuroscience & therapeutics 2014 Sep;20(9):823-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 21920-1-AP(GRIN2B antibody) at dilution of 1:5000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-GRIN2B (IP:21920-1-AP, 3ug; Detection:21920-1-AP 1:2000) with mouse brain tissue lysate 6000ug.
- Sample type
- tissue
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NMDAR2B antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human NMDAR2B. This antibody recognizes human,mouse,rat antigen. The NMDAR2B antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 21920-1-AP(GRIN2B antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
