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- Antibody Data
- Antigen structure
- References [145]
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- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 21920-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21920-1-AP, RRID:AB_11232223
- Product name
- NMDAR2B/GRIN2B antibody
- Antibody type
- Polyclonal
- Description
- NMDAR2B/GRIN2B antibody (Cat. #21920-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression.
HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer's disease.
Anxiety and abnormal hippocampal neurogenesis in adult rat offspring after high-speed train indoor pressure exposure during early pregnancy.
NR2B-CaMKII signaling in the dentate gyrus driven by astrocytic P2Y1Rs mediates the antidepressant effect of low-dose LPS.
The dynamic impairment of synaptic transmission in the PCx-IL engram circuit contributes to early olfactory memory decline in Alzheimer's disease.
n-3 polyunsaturated fatty acids inhibit the IL-1β/SP positive feedback loop in intervertebral disc endplate and low back pain-related behaviors in mice.
Abnormal FKN-CX3CR1-NR signal triggers hippocampal synaptic dysfunction in rheumatoid arthritis-related depression.
Exercise-induced extracellular vesicles derived from platelet-rich plasma improved recovery after ischemic stroke.
Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs.
Acupuncture Modulates Neurotransmitter-Related Molecules in the Amygdala to Ameliorate Generalized Anxiety Disorder.
Targeting ApoE-KCC2 Signaling Rescues GABAergic Synaptic Dysfunction and Depression-like Behaviors in Mice.
The role of DAAO in cognitive impairment of offspring mice induced by arsenic exposure during early developmental stage.
NMDAR inhibitor preconditioned mesenchymal stromal cell-derived extracellular vesicles enhance post-stroke recovery by targeting excitotoxicity and neuronal regeneration.
GluN2B influences the progression of status epilepticus by modulating calcium ion homeostasis through its interaction with CaMKIIα.
Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy.
The endogenous glutamatergic transmitter system promotes collagen synthesis in cardiac fibroblasts under hypoxia.
IRF1 ameliorates synaptic dysfunction through the modulation of O-GlcNAcylation on GluN1 subunit of NMDAR.
USP47 Regulates Excitatory Synaptic Plasticity and Modulates Seizures in Murine Models by Blocking Ubiquitinated AMPAR Degradation.
Spinal p38 MAPK/PGC-1α/SIRT3 signaling pathway mediates remifentanil-induced hyperalgesia in rats via ROS release and NR2B activation.
Prenatal PM(2.)(5) exposure impairs hippocampal synaptic development in offspring via KDM5A-mediated epigenetic derepression of Pin1.
Paternal scrotal heat stress epigenetically impairs spatial memory in F1 male offspring in mice.
Exogenous α-Synuclein Induces Oxidative Damage to Dopaminergic Neurons Through p-NMDAR2B/Nur77.
Ventral Hippocampal CA1 GADD45B Regulates Susceptibility to Social Stress by Influencing NMDA Receptor-Mediated Synaptic Plasticity.
α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice.
The Frmpd3 Protein Regulates Susceptibility to Epilepsy by Combining with GRIP and GluA2.
Mechanistic insights into retinoic-acid treatment for autism in the improvement of social behavior: Evidence from a multi omics study in rats.
Neurotransmitter imbalance and amygdala synaptic plasticity in lumbar disc herniation-induced chronic pain and related emotional Disturbances:A multi-omics analysis.
Anticonvulsant effect of Stachydrine on pentylenetetrazole-induced kindling seizure mouse model via Notch and NMDAR signaling pathways.
Jujuboside A in ameliorating insomnia in mice via GABAergic modulation of the PVT.
Deciphering the CREB-NR2B axis: Unraveling the crosstalk of insulin and TGF-β signalling in ameliorating postoperative cognitive dysfunction.
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
TREM2 alleviates long-term cognitive dysfunction after subarachnoid hemorrhage in mice by attenuating hippocampal neuroinflammation via PI3K/Akt signaling pathway.
Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice.
Geniposide Improves Corticosterone-induced Toxicity in PC12 Cells through the NMDARs and BDNF Pathway.
Tat-NR2B9c prevent cognitive dysfunction in mice modeling Alzheimer's Disease induced by Aβ(1-42) via perturbing PSD-95 interactions with NR2B-subtype receptors.
Microglial-derived nitric oxide regulates amygdala synaptic plasticity to drive chronic pain and depression induced by lumbar disc herniation.
CMTR1-catalyzed 2'-O-methylation promotes NMDA receptor signaling, long-term potentiation and memory.
Deletion of SH2D5 alleviates epileptic seizures and NMDAR expression via autophagic degradation of STAT1.
Direct reprogramming of fibroblasts into spiral ganglion neurons by defined transcription factors.
Tumor cell-derived N-acetyl-aspartyl-glutamate reshapes the tumor microenvironment to facilitate breast cancer metastasis.
SIRT1-regulated ROS generation activates NMDAR2B phosphorylation to promote central sensitization and allodynia in a male chronic migraine rat model.
Prenatal LPS leads to increases in RAS expression within the PVN and overactivation of sympathetic outflow in offspring rats.
Dysregulation of parvalbumin expression and neurotransmitter imbalance in the auditory cortex of the BTBR mouse model of autism spectrum disorder.
Scavenger Receptor Class B Type I Modulates Epileptic Seizures and Receptor α2δ-1 Expression.
Rhythmic gamma frequency light flickering ameliorates stress-related behaviors and cognitive deficits by modulating neuroinflammatory response through IL-12-Mediated cytokines production in chronic stress-induced mice.
Small Molecule Hydrogels Loading Small Molecule Drugs from Chinese Medicine for the Enhanced Treatment of Traumatic Brain Injury.
Astrocyte TrkB.T1 deficiency disrupts glutamatergic synaptogenesis and astrocyte-synapse interactions.
SorCS2 is involved in promoting periodontitis-induced depression-like behaviour in mice.
LASP1 in the nucleus accumbens modulates methamphetamine-induced conditioned place preference in mice.
Oral edaravone ameliorates behavioral deficits and pathologies in a valproic acid-induced rat model of autism spectrum disorder.
Epigenetic regulation by KDM5A mediates the effects of prenatal PM(2.5) exposure on hippocampal development and synaptic integrity through the Shh signaling pathway.
Alleviation of migraine related pain and anxiety by inhibiting calcium-stimulating AC1-dependent CGRP in the insula of adult rats.
Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome.
Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice.
Cognitive impairment in Alzheimer's disease FAD(4T) mouse model: Synaptic loss facilitated by activated microglia via C1qA.
Acupuncture Alleviates Chronic Ischemic White Matter Injury in SHR Rats via JNK-NMDAR Circuit.
Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy.
Ciprofol alleviates remifentanil-induced hyperalgesia by regulating α2GABAARs, NR2B, and P-CaMKIIα levels in the spinal cord and hippocampus.
Activation of GPER1 by G1 prevents PTSD-like behaviors in mice: Illustrating the mechanisms from BDNF/TrkB to mitochondria and synaptic connection.
METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.
Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory.
Translational Approach to Social Isolation During a Global Pandemic: Hippocampal Somatic Mutation and Stress.
A tiered toxicity testing strategy for assessing early life stage toxicity in estuarine fish (Mugilogobius chulae): A case study on tris (1-chloro-2-propyl) phosphate ester.
A refined formula derived from Jiawei-Xiaoyao pill exerts rapid antidepressant-like effects in LPS-induced depression by reducing neuroinflammation and restoring neuroplasticity signaling.
Mahuang Fuzi Xixin decoction: A potent analgesic for neuropathic pain targeting the NMDAR2B/CaMKIIα/ERK/CREB pathway.
Postsynaptic lncRNA Sera/Pkm2 pathway orchestrates the transition from social competition to rank by remodeling the neural ensemble in mPFC.
Integrin α3 is required for high-frequency repetitive transcranial magnetic stimulation-induced glutamatergic synaptic transmission in mice with ischemia.
Exercise attenuates the perioperative neurocognitive disorder induced by hyperhomocysteinemia in mice.
Dysfunction of inhibitory interneurons contributes to synaptic plasticity via GABABR-pNR2B signaling in a chronic migraine rat model.
Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.
Influence of bifenthrin exposure at different gestational stages on the neural development.
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes.
Cherry leaf decoction inhibits NMDAR expression and thereby ameliorates CUMS- induced depression-like behaviors through downregulation of α2δ-1.
Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors.
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons.
The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination.
RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG.
Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory.
The Apelin/APJ system modulates seizure activity and endocytosis of the NMDA receptor GluN2B subunit.
Effects of Prolonged High-Fat Diet Consumption Starting at Different Ages on Behavioral Parameters and Hippocampal Neuroplasticity in Male Mice.
Infralimbic YTHDF1 is necessary for the beneficial effects of acute mild exercise on auditory fear extinction retention.
The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults.
Microglial Priming in Bilirubin-Induced Neurotoxicity.
CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice.
Complement C3a receptor antagonist alleviates tau pathology and ameliorates cognitive deficits in P301S mice.
PAG neuronal NMDARs activation mediated morphine-induced hyperalgesia by HMGB1-TLR4 dependent microglial inflammation.
Laparotomy-Induced Peripheral Inflammation Activates NR2B Receptors on the Brain Mast Cells and Results in Neuroinflammation in a Vagus Nerve-Dependent Manner.
KangPiLao decoction modulates cognitive and emotional disorders in rats with central fatigue through the GABA/Glu pathway.
Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity.
RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.
Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3β Overactivation-Induced Hyperphosphorylated Tau in Rats.
Down-regulation of NR2B receptors contributes to the analgesic and antianxiety effects of enriched environment mediated by endocannabinoid system in the inflammatory pain mice.
Protective effect of 3-n-butylphthalide against intrastriatal injection of malonic acid-induced neurotoxicity and biochemical alteration in rats.
Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia.
Single-Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury.
Ginkgo Biloba Extract Ameliorates Scopolamine-induced Memory Deficits via Rescuing Synaptic Damage.
The epigenetic reader PHF21B modulates murine social memory and synaptic plasticity-related genes.
Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF-κB Signaling-Mediated Neuroinflammation.
KIF17 Modulates Epileptic Seizures and Membrane Expression of the NMDA Receptor Subunit NR2B.
Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission.
Repeated maternal separation prolongs the critical period of ocular dominance plasticity in mouse visual cortex.
Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice.
Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity.
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine.
Transcranial direct current stimulation relieves visceral hypersensitivity via normalizing GluN2B expression and neural activity in anterior cingulate cortex.
Early and Delayed Impact of Nanosilver on the Glutamatergic NMDA Receptor Complex in Immature Rat Brain.
Maternal exposure to low doses of bisphenol A affects learning and memory in male rat offspring with abnormal N-methyl-d-aspartate receptors in the hippocampus.
Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model.
Phosphorylation of GluN2B subunits of N-methyl-d-aspartate receptors in the frontal association cortex involved in morphine-induced conditioned place preference in mice.
A high-throughput screen identifies inhibitors of lung cancer stem cells.
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca(2+)-Activin A circuit in chronic cerebral hypoperfusion rats.
Enriched Environment Promotes Cognitive Function Recovery following Cerebral Ischemic Injury via Upregulating GABAergic and Glutamatergic Systems in the Contralateral Hippocampus.
Effects of Xiaoyaosan on Depressive-Like Behaviors in Rats With Chronic Unpredictable Mild Stress Through HPA Axis Induced Astrocytic Activities.
Involvement of NMDAR/PSD-95/nNOS-NO-cGMP pathway in embryonic exposure to BPA induced learning and memory dysfunction of rats.
Up-regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine.
STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
EphrinB/EphB Signaling Contributes to the Synaptic Plasticity of Chronic Migraine Through NR2B Phosphorylation.
CCL2-CCR2 Axis Potentiates NMDA Receptor Signaling to Aggravate Neuropathic Pain Induced by Brachial Plexus Avulsion.
SAP102 contributes to hyperalgesia formation in the cancer induced bone pain rat model by anchoring NMDA receptors.
Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice.
TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation.
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system.
Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy.
Inhibition of CB1 receptor ameliorates spatial learning and memory impairment in mice with traumatic brain injury.
Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X.
CAMK2-Dependent Signaling in Neurons Is Essential for Survival.
The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors.
NR2B-Tyr phosphorylation regulates synaptic plasticity in central sensitization in a chronic migraine rat model.
Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnS(2) nanoflowers.
N-methyl D-aspartate receptor subtype 2B antagonist, Ro 25-6981, attenuates neuropathic pain by inhibiting postsynaptic density 95 expression.
Effects of intrathecal bupivacaine on the NR2B/CaMKIIα/CREB signaling pathway in the rat lumbar spinal cord.
Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex.
HCN2 contributes to oxaliplatin-induced neuropathic pain through activation of the CaMKII/CREB cascade in spinal neurons.
Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats.
Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age.
Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice.
Protective effects of Bushen Tiansui decoction on hippocampal synapses in a rat model of Alzheimer's disease.
Beneficial Effects of a CaMKIIα Inhibitor TatCN21 Peptide in Global Cerebral Ischemia.
Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction.
Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.
A lasting effect of postnatal sevoflurane anesthesia on the composition of NMDA receptor subunits in rat prefrontal cortex.
NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.
Dopamine D3 receptor-regulated NR2B subunits of N-methyl-d-aspartate receptors in the nucleus accumbens involves in morphine-induced locomotor activity.
Yao X, Chen R, Zhu J, Hou R, Xiang S, Jia T, Gu Y, Wang Z, Hu H, Chen H, Wang H, Feng J, Robbins TW, Wang Y, Higley MJ, Koleske AJ, Xiao X
Molecular psychiatry 2026 May;31(5):2542-2560
Molecular psychiatry 2026 May;31(5):2542-2560
HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer's disease.
Yu H, Wang F, Yuan JQ, Chen J, Zhang KY, Jia D, Gong J, Mao Y, Bi S, Zhang YQ, Lan ZC, Yu HY, Chai GS
Experimental & molecular medicine 2026 Mar;58(3):813-831
Experimental & molecular medicine 2026 Mar;58(3):813-831
Anxiety and abnormal hippocampal neurogenesis in adult rat offspring after high-speed train indoor pressure exposure during early pregnancy.
Zhang X, Deng Y, Zhang W, Wang T, Qian B, Dai L
International journal of environmental health research 2026 Mar;36(3):541-553
International journal of environmental health research 2026 Mar;36(3):541-553
NR2B-CaMKII signaling in the dentate gyrus driven by astrocytic P2Y1Rs mediates the antidepressant effect of low-dose LPS.
Ye M, Huang C, Gu Y, Lu X, Zhu T, Zhang Y
Brain, behavior, and immunity 2026 Mar 6;135:106529
Brain, behavior, and immunity 2026 Mar 6;135:106529
The dynamic impairment of synaptic transmission in the PCx-IL engram circuit contributes to early olfactory memory decline in Alzheimer's disease.
Yan Y, Song D, Li G, Li J, Tang Y, Li D, Mao J, Li H, Liu X, Yu D, Ma F, Pang Y, Jin Y, Deng Y, Qiu Y, Quan Z, Ni J, Cheng Y, Wang Z, Dong Z, Hong Q
Molecular psychiatry 2026 Mar 25;
Molecular psychiatry 2026 Mar 25;
n-3 polyunsaturated fatty acids inhibit the IL-1β/SP positive feedback loop in intervertebral disc endplate and low back pain-related behaviors in mice.
Li K, Luo L, Lai W, Lian Z, Pu P, Zhang Z, Ao X, Huang M
Molecular and cellular endocrinology 2026 Jul;617:112776
Molecular and cellular endocrinology 2026 Jul;617:112776
Abnormal FKN-CX3CR1-NR signal triggers hippocampal synaptic dysfunction in rheumatoid arthritis-related depression.
Yao SX, Luo SY, Zhao HQ, Tan H, Liu PA, Liu J
International immunopharmacology 2026 Jul 15;181:116693
International immunopharmacology 2026 Jul 15;181:116693
Exercise-induced extracellular vesicles derived from platelet-rich plasma improved recovery after ischemic stroke.
Miyauchi Y, Miyamoto N, Inaba T, Xu HB, Kijima C, Hira K, Hattori N, Ueno Y
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 Feb;46(2):359-376
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 Feb;46(2):359-376
Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs.
Cai Y, Zheng Z, Xu H, Zhu Y, Zepeda JC, Grueter BA, Wang X, Ku T, Duan Y, Tsang HWS, Fu WY, Fu AKY, Mellios N, Wong HH, Lai KO, Ip JPK
Science advances 2026 Feb 13;12(7):eads7509
Science advances 2026 Feb 13;12(7):eads7509
Acupuncture Modulates Neurotransmitter-Related Molecules in the Amygdala to Ameliorate Generalized Anxiety Disorder.
Sun Z, Wang Y, Kang X, Ran B, Wu Q, Huang L, Li J, Kan L, Long H, Liang J, Shen W
CNS neuroscience & therapeutics 2026 Apr;32(4):e70847
CNS neuroscience & therapeutics 2026 Apr;32(4):e70847
Targeting ApoE-KCC2 Signaling Rescues GABAergic Synaptic Dysfunction and Depression-like Behaviors in Mice.
Xu C, Liu J, Guo M, Wang J, Bai X, Zhang C, Luan X, Pei H, Liu H, Lv X, Ye X, Tang B, Chen M
Research (Washington, D.C.) 2025;8:0746
Research (Washington, D.C.) 2025;8:0746
The role of DAAO in cognitive impairment of offspring mice induced by arsenic exposure during early developmental stage.
Niu Z, Xie X, Jin X, Yu H, Jin G, Wang Y
PloS one 2025;20(9):e0333414
PloS one 2025;20(9):e0333414
NMDAR inhibitor preconditioned mesenchymal stromal cell-derived extracellular vesicles enhance post-stroke recovery by targeting excitotoxicity and neuronal regeneration.
Zhang X, Tian H, Bo H, Zhong L
Frontiers in cellular neuroscience 2025;19:1608615
Frontiers in cellular neuroscience 2025;19:1608615
GluN2B influences the progression of status epilepticus by modulating calcium ion homeostasis through its interaction with CaMKIIα.
Zhang L, Meng Y, Liu C, Wei L, Lu Y, Zheng S, Zou D, Wu Y
Frontiers in pharmacology 2025;16:1550879
Frontiers in pharmacology 2025;16:1550879
Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy.
Xu P, Zhou W, Wang S, Wang L, Bai Y, Xing S, Xue W, Li M, Shi J, Wu H
Theranostics 2025;15(18):9415-9446
Theranostics 2025;15(18):9415-9446
The endogenous glutamatergic transmitter system promotes collagen synthesis in cardiac fibroblasts under hypoxia.
Wang R, Yuan X, Xie T, Zhao X, Li J, Zhang X, Lv C
Frontiers in cardiovascular medicine 2025;12:1638650
Frontiers in cardiovascular medicine 2025;12:1638650
IRF1 ameliorates synaptic dysfunction through the modulation of O-GlcNAcylation on GluN1 subunit of NMDAR.
Fan X, Wang H, Guo C, Huang S, Xia L, Zhou Z, Tao R, Li M, Wang X, Qian W
Alzheimer's research & therapy 2025 Sep 30;17(1):205
Alzheimer's research & therapy 2025 Sep 30;17(1):205
USP47 Regulates Excitatory Synaptic Plasticity and Modulates Seizures in Murine Models by Blocking Ubiquitinated AMPAR Degradation.
Yang J, Zhang H, Wang Y, Luo Y, Zheng W, Liu Y, Jiang Q, Deng J, Liu Q, Zhang P, Huang H, Yu C, Xu Z, Chen Y
Neuroscience bulletin 2025 Oct;41(10):1805-1823
Neuroscience bulletin 2025 Oct;41(10):1805-1823
Spinal p38 MAPK/PGC-1α/SIRT3 signaling pathway mediates remifentanil-induced hyperalgesia in rats via ROS release and NR2B activation.
Feng G, Song F, Wang A, Wang L, Zhang H, Wang S, Hou H, Zhang L, Deng L
Neurochemistry international 2025 Nov;190:106061
Neurochemistry international 2025 Nov;190:106061
Prenatal PM(2.)(5) exposure impairs hippocampal synaptic development in offspring via KDM5A-mediated epigenetic derepression of Pin1.
Song C, Zhou L, Wang S, Nie W, Yu H, Lv E, Liu Y, Sun L, Li W, Li D, Yu L
Ecotoxicology and environmental safety 2025 Nov 15;307:119391
Ecotoxicology and environmental safety 2025 Nov 15;307:119391
Paternal scrotal heat stress epigenetically impairs spatial memory in F1 male offspring in mice.
Huang J, Huang Z, Chen N, Li Q, Fu Y, Jin X, Xie X, Li H, Wan X
Ecotoxicology and environmental safety 2025 Nov 1;306:119304
Ecotoxicology and environmental safety 2025 Nov 1;306:119304
Exogenous α-Synuclein Induces Oxidative Damage to Dopaminergic Neurons Through p-NMDAR2B/Nur77.
Lai X, Wu J, Kou X, Zhang Y, Shen M, Yu M, Zhai Y, Yan J
Molecular neurobiology 2025 May;62(5):5664-5678
Molecular neurobiology 2025 May;62(5):5664-5678
Ventral Hippocampal CA1 GADD45B Regulates Susceptibility to Social Stress by Influencing NMDA Receptor-Mediated Synaptic Plasticity.
Huang M, Bao J, Tao X, Niu Y, Li K, Wang J, Gong X, Yang R, Gui Y, Zhou H, Xia Y, Yang Y, Sun B, Liu W, Shu X
Neuroscience bulletin 2025 Mar;41(3):406-420
Neuroscience bulletin 2025 Mar;41(3):406-420
α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice.
Xu W, Wang M, Li X, He R, Ding RB, Bao J, Zhangsun D, Luo S
Marine drugs 2025 Mar 4;23(3)
Marine drugs 2025 Mar 4;23(3)
The Frmpd3 Protein Regulates Susceptibility to Epilepsy by Combining with GRIP and GluA2.
Jia Y, Zhan J, Huang P, Li X, Hong D, Lu X
Current issues in molecular biology 2025 Mar 26;47(4)
Current issues in molecular biology 2025 Mar 26;47(4)
Mechanistic insights into retinoic-acid treatment for autism in the improvement of social behavior: Evidence from a multi omics study in rats.
Zhu J, Liu H, Hu Y, Liu J, Dai C, Liang J, Cheng B, Tan M, Zhang Y, Cao Q, Lai X
Neuropharmacology 2025 Mar 1;265:110244
Neuropharmacology 2025 Mar 1;265:110244
Neurotransmitter imbalance and amygdala synaptic plasticity in lumbar disc herniation-induced chronic pain and related emotional Disturbances:A multi-omics analysis.
Huang Z, Tan H, Fu Y, Xie H, Tan H, Gao K, Lou H
Neuropharmacology 2025 Jun 15;271:110405
Neuropharmacology 2025 Jun 15;271:110405
Anticonvulsant effect of Stachydrine on pentylenetetrazole-induced kindling seizure mouse model via Notch and NMDAR signaling pathways.
Li Q, Li R, Ge B, Luo X, Xu J, Fu L, Kong Y, Yang JY, Li S
Journal of ethnopharmacology 2025 Jun 12;349:119975
Journal of ethnopharmacology 2025 Jun 12;349:119975
Jujuboside A in ameliorating insomnia in mice via GABAergic modulation of the PVT.
Wang M, Wang G, Zhao M, Hou L, Ma D, Yang H, Luo Z, Mi B, Lv S
Journal of ethnopharmacology 2025 Jun 12;349:119939
Journal of ethnopharmacology 2025 Jun 12;349:119939
Deciphering the CREB-NR2B axis: Unraveling the crosstalk of insulin and TGF-β signalling in ameliorating postoperative cognitive dysfunction.
Zhou J, Han X, Wei Z, Liu Y, Xu J, Xu M, Xia T, Cheng X, Gu X
Life sciences 2025 Jun 1;370:123574
Life sciences 2025 Jun 1;370:123574
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Fan Y, Wu H, Yin D, Liu Q, Yuan C, Zhong T, Xia B, Xiong L, Li Y, Zeng L, Li Y, Li Y, Tang L
Bioorganic chemistry 2025 Jul 1;161:108547
Bioorganic chemistry 2025 Jul 1;161:108547
TREM2 alleviates long-term cognitive dysfunction after subarachnoid hemorrhage in mice by attenuating hippocampal neuroinflammation via PI3K/Akt signaling pathway.
Tang S, Xing W, Yan J, Wang L, Li Z, Wang Y, Gu N, Sun X
Brain research 2025 Jan 1;1846:149235
Brain research 2025 Jan 1;1846:149235
Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice.
Wang J, Zhang J, Li J, Gao Q, Chen J, Jia C, Gu X
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Feb 26;45(9)
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Feb 26;45(9)
Geniposide Improves Corticosterone-induced Toxicity in PC12 Cells through the NMDARs and BDNF Pathway.
Ma Q, Ma Y, Sun S, Yang L, Shi T, Zhang B, Shang B, Zhou R, Liu J, He J, Hu J, Cao Y
Cell biochemistry and biophysics 2025 Dec;83(4):5387-5400
Cell biochemistry and biophysics 2025 Dec;83(4):5387-5400
Tat-NR2B9c prevent cognitive dysfunction in mice modeling Alzheimer's Disease induced by Aβ(1-42) via perturbing PSD-95 interactions with NR2B-subtype receptors.
Huang Y, Lei W, Shen J, Sun J
IBRO neuroscience reports 2025 Dec;19:317-322
IBRO neuroscience reports 2025 Dec;19:317-322
Microglial-derived nitric oxide regulates amygdala synaptic plasticity to drive chronic pain and depression induced by lumbar disc herniation.
Huang Z, Sun J, Li H, Hu Z, Tan H, Fu Y, Gao L, Peng X, Lou H
Neuropharmacology 2025 Dec 1;280:110662
Neuropharmacology 2025 Dec 1;280:110662
CMTR1-catalyzed 2'-O-methylation promotes NMDA receptor signaling, long-term potentiation and memory.
Azeem S, Chang TT, Peng C, Lee YL, Yeh NH, Huang YS
Progress in neurobiology 2025 Aug;251:102802
Progress in neurobiology 2025 Aug;251:102802
Deletion of SH2D5 alleviates epileptic seizures and NMDAR expression via autophagic degradation of STAT1.
Guo H, Zhang H, Zhang C, Shen Y, Jiang L, Yang M, Zhang Y, Zhang N, Zhang R, Yu R, Yang Y, Tian X
JCI insight 2025 Aug 22;10(16)
JCI insight 2025 Aug 22;10(16)
Direct reprogramming of fibroblasts into spiral ganglion neurons by defined transcription factors.
Huang Y, Chen Z, Chen J, Liu J, Qiu C, Liu Q, Zhang L, Zhu GJ, Ma X, Sun S, Shi YS, Wan G
Cell proliferation 2025 Apr;58(4):e13775
Cell proliferation 2025 Apr;58(4):e13775
Tumor cell-derived N-acetyl-aspartyl-glutamate reshapes the tumor microenvironment to facilitate breast cancer metastasis.
Xia J, Zhang L, Zhu W, Tu J, Peng X, Deng Q, Li S, He X, Dong H, Liu C, Chen X, Xu J, Ma W, Xiao Y, Liu W, Hu G, Jiang YZ, Chen C, Bian XW, Shao ZM, Liu S
Science bulletin 2025 Apr 15;70(7):1126-1138
Science bulletin 2025 Apr 15;70(7):1126-1138
SIRT1-regulated ROS generation activates NMDAR2B phosphorylation to promote central sensitization and allodynia in a male chronic migraine rat model.
Zhang X, Zhang W, Wang Y, Zhang Y, Zhang D, Qin G, Zhou J, Chen L
Frontiers in molecular neuroscience 2024;17:1387481
Frontiers in molecular neuroscience 2024;17:1387481
Prenatal LPS leads to increases in RAS expression within the PVN and overactivation of sympathetic outflow in offspring rats.
Hao X, Long X, Fan L, Gou J, Liu Y, Fu Y, Zhao H, Xie X, Wang D, Liang G, Ye Y, Wang J, Li S, Zeng C
Hypertension research : official journal of the Japanese Society of Hypertension 2024 Sep;47(9):2363-2376
Hypertension research : official journal of the Japanese Society of Hypertension 2024 Sep;47(9):2363-2376
Dysregulation of parvalbumin expression and neurotransmitter imbalance in the auditory cortex of the BTBR mouse model of autism spectrum disorder.
Tang B, Zhao J, Zhang C, Qi P, Zheng S, Xu C, Chen M, Ye X
Developmental neurobiology 2024 Oct;84(4):251-263
Developmental neurobiology 2024 Oct;84(4):251-263
Scavenger Receptor Class B Type I Modulates Epileptic Seizures and Receptor α2δ-1 Expression.
Huang Y, Gao Y, Huang Z, Liang M, Chen Y
Neurochemical research 2024 Oct;49(10):2842-2853
Neurochemical research 2024 Oct;49(10):2842-2853
Rhythmic gamma frequency light flickering ameliorates stress-related behaviors and cognitive deficits by modulating neuroinflammatory response through IL-12-Mediated cytokines production in chronic stress-induced mice.
Yao J, Zhang L, Zhang C, Chen X, Bao K, Hou S, Yin Y, Liu K, Wen Q, Huang X, Song L
Brain, behavior, and immunity 2024 Oct;121:213-228
Brain, behavior, and immunity 2024 Oct;121:213-228
Small Molecule Hydrogels Loading Small Molecule Drugs from Chinese Medicine for the Enhanced Treatment of Traumatic Brain Injury.
Luo W, Yang Z, Zheng J, Cai Z, Li X, Liu J, Guo X, Luo M, Fan X, Cheng M, Tang T, Liu J, Wang Y
ACS nano 2024 Oct 22;18(42):28894-28909
ACS nano 2024 Oct 22;18(42):28894-28909
Astrocyte TrkB.T1 deficiency disrupts glutamatergic synaptogenesis and astrocyte-synapse interactions.
Pinkston BTC, Browning JL, Olsen ML
bioRxiv : the preprint server for biology 2024 Oct 22;
bioRxiv : the preprint server for biology 2024 Oct 22;
SorCS2 is involved in promoting periodontitis-induced depression-like behaviour in mice.
Li Y, Yang Y, Guan X, Liu Z, Pan L, Wang Y, Jia X, Yang J, Hou T
Oral diseases 2024 Nov;30(8):5408-5420
Oral diseases 2024 Nov;30(8):5408-5420
LASP1 in the nucleus accumbens modulates methamphetamine-induced conditioned place preference in mice.
Li MQ, Lu XY, Yao JY, Zou GJ, Zeng ZH, Zhang LX, Zhou SF, Chen ZR, Zhao TS, Guo ZR, Cui YH, Li F, Li CQ
Neurochemistry international 2024 Nov;180:105884
Neurochemistry international 2024 Nov;180:105884
Oral edaravone ameliorates behavioral deficits and pathologies in a valproic acid-induced rat model of autism spectrum disorder.
Lu XY, Li MQ, Li YT, Yao JY, Zhang LX, Zeng ZH, Yu-Liu, Chen ZR, Li CQ, Zhou XF, Li F
Neuropharmacology 2024 Nov 1;258:110089
Neuropharmacology 2024 Nov 1;258:110089
Epigenetic regulation by KDM5A mediates the effects of prenatal PM(2.5) exposure on hippocampal development and synaptic integrity through the Shh signaling pathway.
Huang J, Song C, Liu Y, Zhang T, Wang T, Liu X, Yu L
Ecotoxicology and environmental safety 2024 May;276:116311
Ecotoxicology and environmental safety 2024 May;276:116311
Alleviation of migraine related pain and anxiety by inhibiting calcium-stimulating AC1-dependent CGRP in the insula of adult rats.
Li Y, Li C, Chen QY, Hao S, Mao J, Zhang W, Han X, Dong Z, Liu R, Tang W, Zhuo M, Yu S, Liu Y
The journal of headache and pain 2024 May 17;25(1):81
The journal of headache and pain 2024 May 17;25(1):81
Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome.
Fu Y, Yuan P, Zeng M, Zhang Q, Hou Y, Gao L, Wei Y, Zheng Y, Feng W, Zheng X
Heliyon 2024 May 15;10(9):e29807
Heliyon 2024 May 15;10(9):e29807
Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice.
Zhou S, Cui X, Chen J, Luo M, Ouyang W, Tong J, Xie Z, Le Y
Free radical biology & medicine 2024 Mar;214:184-192
Free radical biology & medicine 2024 Mar;214:184-192
Cognitive impairment in Alzheimer's disease FAD(4T) mouse model: Synaptic loss facilitated by activated microglia via C1qA.
Zhang C, Qi H, Jia D, Zhao J, Xu C, Liu J, Cui Y, Zhang J, Wang M, Chen M, Tang B
Life sciences 2024 Mar 1;340:122457
Life sciences 2024 Mar 1;340:122457
Acupuncture Alleviates Chronic Ischemic White Matter Injury in SHR Rats via JNK-NMDAR Circuit.
Dong A, Gao Z, Wang H, Wu R, Wang W, Jin X, Ji Y, Yang F, Zhu T, Jiang Z, Xu Y, Guo J, Ji L
Molecular neurobiology 2024 Jun;61(6):3144-3160
Molecular neurobiology 2024 Jun;61(6):3144-3160
Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy.
Ban Y, Yang X, Tan D, Gong C, Gao Y, Yuan J, Chen Y, Wang Y, Xu T
Neurochemistry international 2024 Jun;176:105727
Neurochemistry international 2024 Jun;176:105727
Ciprofol alleviates remifentanil-induced hyperalgesia by regulating α2GABAARs, NR2B, and P-CaMKIIα levels in the spinal cord and hippocampus.
Yang Y, Yang C, Shi Y, Tang C, Wang H, Tan M, Xing R, Gao C, Zhang M, Xie Y
The Journal of pharmacy and pharmacology 2024 Jun 1;76(6):736-745
The Journal of pharmacy and pharmacology 2024 Jun 1;76(6):736-745
Activation of GPER1 by G1 prevents PTSD-like behaviors in mice: Illustrating the mechanisms from BDNF/TrkB to mitochondria and synaptic connection.
Chen L, Zhang Y, Wang Z, Zhang Z, Wang J, Zhu G, Yang S
CNS neuroscience & therapeutics 2024 Jul;30(7):e14855
CNS neuroscience & therapeutics 2024 Jul;30(7):e14855
METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.
Lu W, Yang X, Zhong W, Chen G, Guo X, Ye Q, Xu Y, Qi Z, Ye Y, Zhang J, Wang Y, Wang X, Wang S, Zhao Q, Zeng W, Huang J, Ma H, Xie J
The Journal of clinical investigation 2024 Feb 6;134(6)
The Journal of clinical investigation 2024 Feb 6;134(6)
Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory.
Chen CC, Han J, Chinn CA, Rounds JS, Li X, Nikan M, Myszka M, Tong L, Passalacqua LFM, Bredy T, Wood MA, Luptak A
eLife 2024 Feb 6;13
eLife 2024 Feb 6;13
Translational Approach to Social Isolation During a Global Pandemic: Hippocampal Somatic Mutation and Stress.
Lee B, Maeng S, Seo Y, Jung S, Im S, Choi HJ, Bae JN, Kim Y
Psychiatry investigation 2024 Dec;21(12):1360-1371
Psychiatry investigation 2024 Dec;21(12):1360-1371
A tiered toxicity testing strategy for assessing early life stage toxicity in estuarine fish (Mugilogobius chulae): A case study on tris (1-chloro-2-propyl) phosphate ester.
Ren J, Peng Y, She L, Yan L, Li J, Gao C, Wang C, Wang Y, Nie X, Zhang X
Journal of hazardous materials 2024 Dec 5;480:136108
Journal of hazardous materials 2024 Dec 5;480:136108
A refined formula derived from Jiawei-Xiaoyao pill exerts rapid antidepressant-like effects in LPS-induced depression by reducing neuroinflammation and restoring neuroplasticity signaling.
Wu Z, Yin Y, Liu R, Li X, Sun Y, Yau SY, Wu L, Liu Y, Adzic M, Zhang H, Chen G
Journal of ethnopharmacology 2024 Dec 5;335:118647
Journal of ethnopharmacology 2024 Dec 5;335:118647
Mahuang Fuzi Xixin decoction: A potent analgesic for neuropathic pain targeting the NMDAR2B/CaMKIIα/ERK/CREB pathway.
Chai Y, He S, Liang D, Gu C, Gong Q, Long L, Chen P, Wang L
Heliyon 2024 Aug 30;10(16):e35970
Heliyon 2024 Aug 30;10(16):e35970
Postsynaptic lncRNA Sera/Pkm2 pathway orchestrates the transition from social competition to rank by remodeling the neural ensemble in mPFC.
Zhu LS, Lai C, Zhou CW, Chen HY, Liu ZQ, Guo Z, Man H, Du HY, Lu Y, Hu F, Chen Z, Shu K, Zhu LQ, Liu D
Cell discovery 2024 Aug 20;10(1):87
Cell discovery 2024 Aug 20;10(1):87
Integrin α3 is required for high-frequency repetitive transcranial magnetic stimulation-induced glutamatergic synaptic transmission in mice with ischemia.
Liu L, Hu H, Wu J, Koleske AJ, Chen H, Wang N, Yu K, Wu Y, Xiao X, Zhang Q
CNS neuroscience & therapeutics 2024 Apr;30(4):e14498
CNS neuroscience & therapeutics 2024 Apr;30(4):e14498
Exercise attenuates the perioperative neurocognitive disorder induced by hyperhomocysteinemia in mice.
Zhang Q, Cong P, Tian L, Wu T, Huang X, Zhang Y, Wu H, Liang H, Xiong L
Brain research bulletin 2024 Apr;209:110913
Brain research bulletin 2024 Apr;209:110913
Dysfunction of inhibitory interneurons contributes to synaptic plasticity via GABABR-pNR2B signaling in a chronic migraine rat model.
Zeng X, Niu Y, Qin G, Zhang D, Chen L
Frontiers in molecular neuroscience 2023;16:1142072
Frontiers in molecular neuroscience 2023;16:1142072
Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.
Zhang L, Huang J, Dai L, Zhu G, Yang XL, He Z, Li YH, Yang H, Zhang CQ, Shen KF, Liang P
Frontiers in neurology 2023;14:1255097
Frontiers in neurology 2023;14:1255097
Influence of bifenthrin exposure at different gestational stages on the neural development.
Xi C, Shi X, Wang Y, He J, Jiang S, Niu B, Chen Y, Zhao F, Cao Z
Ecotoxicology and environmental safety 2023 Sep 15;263:115365
Ecotoxicology and environmental safety 2023 Sep 15;263:115365
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes.
Li SJ, Ma MH, Li JM, Lu XY, Lu CB, Zhou SF, Zhang LX, Li MQ, Shao TZ, Bai SP, Yan XX, Li F, Li CQ
Aging and disease 2023 Oct 1;14(5):1853-1869
Aging and disease 2023 Oct 1;14(5):1853-1869
Cherry leaf decoction inhibits NMDAR expression and thereby ameliorates CUMS- induced depression-like behaviors through downregulation of α2δ-1.
Jiang C, Wang C, Qu W, Wang Y, Wang H, Wei X, Wang M, He Q, Wang Y, Yuan L, Gao Y
Heliyon 2023 Nov;9(11):e21743
Heliyon 2023 Nov;9(11):e21743
Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors.
Li W, Shen Z, Yin X, Chang W, Chen X, Yu J, Xu S
Translational psychiatry 2023 Nov 22;13(1):359
Translational psychiatry 2023 Nov 22;13(1):359
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons.
Serwach K, Nurowska E, Klukowska M, Zablocka B, Gruszczynska-Biegala J
Cellular and molecular life sciences : CMLS 2023 Nov 21;80(12):368
Cellular and molecular life sciences : CMLS 2023 Nov 21;80(12):368
The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination.
Zhang YY, Yang XY, Liu HQ, Zhang Z, Hu CP, Peng J, Luo XJ
Molecular neurobiology 2023 Mar;60(3):1563-1579
Molecular neurobiology 2023 Mar;60(3):1563-1579
RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG.
Zhang L, Luo L, Xue L, Ran D, Yang F, Tang Q, Jiang W
Experimental neurology 2023 Mar;361:114299
Experimental neurology 2023 Mar;361:114299
Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory.
Chen CC, Han J, Chinn CA, Rounds JS, Li X, Nikan M, Myszka M, Tong L, Passalacqua LFM, Bredy TW, Wood MA, Lupták A
bioRxiv : the preprint server for biology 2023 Jun 9;
bioRxiv : the preprint server for biology 2023 Jun 9;
The Apelin/APJ system modulates seizure activity and endocytosis of the NMDA receptor GluN2B subunit.
Zhang X, Gu Y, Ma Y, Wu J, Chen Y, Tao K, Sun H, Liu Z, Wang X, Tian X
Neurochemistry international 2023 Jul;167:105545
Neurochemistry international 2023 Jul;167:105545
Effects of Prolonged High-Fat Diet Consumption Starting at Different Ages on Behavioral Parameters and Hippocampal Neuroplasticity in Male Mice.
Yang C, Yao X, Zhang H, Wang C, Zhao J, Xu D, Xiao Y, Li Q, Zhuang H, Kang X, Sun C, Liu L
Journal of integrative neuroscience 2023 Jan 13;22(1):16
Journal of integrative neuroscience 2023 Jan 13;22(1):16
Infralimbic YTHDF1 is necessary for the beneficial effects of acute mild exercise on auditory fear extinction retention.
Li SJ, Zhang LX, Zou GJ, Ma MH, Zhou SF, Lu XY, Li F, Li CQ
Cerebral cortex (New York, N.Y. : 1991) 2023 Feb 20;33(5):1814-1825
Cerebral cortex (New York, N.Y. : 1991) 2023 Feb 20;33(5):1814-1825
The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults.
Guo B, Song H, Fan J, Wang B, Chen L, Hu Q, Yin Y
Experimental brain research 2023 Dec;241(11-12):2735-2750
Experimental brain research 2023 Dec;241(11-12):2735-2750
Microglial Priming in Bilirubin-Induced Neurotoxicity.
Huang H, Li S, Zhang Y, He C, Hua Z
Neurotoxicity research 2023 Aug;41(4):338-348
Neurotoxicity research 2023 Aug;41(4):338-348
CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice.
Zhang L, Zeng Z, Lu X, Li M, Yao J, Zou G, Chen Z, Li Q, Li C, Li F
Neurotoxicity research 2023 Aug;41(4):324-337
Neurotoxicity research 2023 Aug;41(4):324-337
Complement C3a receptor antagonist alleviates tau pathology and ameliorates cognitive deficits in P301S mice.
Yao Y, Chang Y, Li S, Zhu J, Wu Y, Jiang X, Li L, Liu R, Ma R, Li G
Brain research bulletin 2023 Aug;200:110685
Brain research bulletin 2023 Aug;200:110685
PAG neuronal NMDARs activation mediated morphine-induced hyperalgesia by HMGB1-TLR4 dependent microglial inflammation.
Mo J, Lu Z, Peng J, Li XP, Lan L, Wang H, Peng Y
Journal of psychiatric research 2023 Aug;164:150-161
Journal of psychiatric research 2023 Aug;164:150-161
Laparotomy-Induced Peripheral Inflammation Activates NR2B Receptors on the Brain Mast Cells and Results in Neuroinflammation in a Vagus Nerve-Dependent Manner.
Yang J, Dong HQ, Liu YH, Ji MH, Zhang X, Dai HY, Sun ZC, Liu L, Zhou J, Sha HH, Qian YN, Li QG, Yao H, Li NN
Frontiers in cellular neuroscience 2022;16:771156
Frontiers in cellular neuroscience 2022;16:771156
KangPiLao decoction modulates cognitive and emotional disorders in rats with central fatigue through the GABA/Glu pathway.
Xu Y, Lian Y, Li J, Zhang Y, Liu Y, Wang X, Ma J, Li F
Frontiers in pharmacology 2022;13:939169
Frontiers in pharmacology 2022;13:939169
Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity.
Du J, Chen X, Zhao Y, Zhao T, Wang D, Chen Z, Wang C, Meng Q, Yao J, Sun H, Liu K, Wu J
Frontiers in pharmacology 2022;13:1046814
Frontiers in pharmacology 2022;13:1046814
RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.
Ma P, Wan LP, Li Y, He CH, Song NN, Zhao S, Wang H, Ding YQ, Mao B, Sheng N
Science advances 2022 Sep 30;8(39):eabq4736
Science advances 2022 Sep 30;8(39):eabq4736
Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3β Overactivation-Induced Hyperphosphorylated Tau in Rats.
Liu X, Song W, Yu Y, Su J, Shi X, Yang X, Wang H, Liu P, Zou L
Neurotoxicity research 2022 Oct;40(5):1163-1173
Neurotoxicity research 2022 Oct;40(5):1163-1173
Down-regulation of NR2B receptors contributes to the analgesic and antianxiety effects of enriched environment mediated by endocannabinoid system in the inflammatory pain mice.
Jiang S, Zheng C, Wen G, Bu B, Zhao S, Xu X
Behavioural brain research 2022 Oct 28;435:114062
Behavioural brain research 2022 Oct 28;435:114062
Protective effect of 3-n-butylphthalide against intrastriatal injection of malonic acid-induced neurotoxicity and biochemical alteration in rats.
Yuan C, Zheng L, Zhao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113664
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113664
Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia.
Zhang X, Wang M, Feng B, Zhang Q, Tong J, Wang M, Lu C, Peng S
International journal of molecular sciences 2022 May 17;23(10)
International journal of molecular sciences 2022 May 17;23(10)
Single-Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury.
Shi Y, Wu X, Zhou J, Cui W, Wang J, Hu Q, Zhang S, Han L, Zhou M, Luo J, Wang Q, Liu H, Feng D, Ge S, Qu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(7):e2104112
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(7):e2104112
Ginkgo Biloba Extract Ameliorates Scopolamine-induced Memory Deficits via Rescuing Synaptic Damage.
Zhang GJ, Zheng D, Yu H, Luo XP, Wu W
Current medical science 2022 Jun;42(3):474-482
Current medical science 2022 Jun;42(3):474-482
The epigenetic reader PHF21B modulates murine social memory and synaptic plasticity-related genes.
Chin EW, Ma Q, Ruan H, Chin C, Somasundaram A, Zhang C, Liu C, Lewis MD, White M, Smith TL, Battersby M, Yao WD, Lu XY, Arap W, Licinio J, Wong ML
JCI insight 2022 Jul 22;7(14)
JCI insight 2022 Jul 22;7(14)
Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF-κB Signaling-Mediated Neuroinflammation.
Peng X, Wang J, Peng J, Jiang H, Le K
Journal of molecular neuroscience : MN 2022 Jan;72(1):113-125
Journal of molecular neuroscience : MN 2022 Jan;72(1):113-125
KIF17 Modulates Epileptic Seizures and Membrane Expression of the NMDA Receptor Subunit NR2B.
Liu Y, Tian X, Ke P, Gu J, Ma Y, Guo Y, Xu X, Chen Y, Yang M, Wang X, Xiao F
Neuroscience bulletin 2022 Aug;38(8):841-856
Neuroscience bulletin 2022 Aug;38(8):841-856
Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission.
Liang W, Hou Y, Huang W, Wang Y, Jiang T, Huang X, Wang Z, Wu F, Zheng J, Zhang J, Ou H, Li S, Ping J, Zhang Y, Ye J, Li Z, Yang Q, Zhang J, Zheng X, Li S, Zhu XH, Chen R, Zhao C
Science advances 2022 Aug 19;8(33):eabn7357
Science advances 2022 Aug 19;8(33):eabn7357
Repeated maternal separation prolongs the critical period of ocular dominance plasticity in mouse visual cortex.
Li S, Zhang X, Liu Y, Shan Z, Liu H, Wu W, Yang Y
Neuroscience letters 2022 Apr 17;776:136577
Neuroscience letters 2022 Apr 17;776:136577
Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice.
Chang Y, Yao Y, Ma R, Wang Z, Hu J, Wu Y, Jiang X, Li L, Li G
Frontiers in neuroscience 2021;15:620176
Frontiers in neuroscience 2021;15:620176
Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity.
Qi CC, Chen XX, Gao XR, Xu JX, Liu S, Ge JF
Frontiers in aging neuroscience 2021;13:633495
Frontiers in aging neuroscience 2021;13:633495
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Zhang Q, Zhang J, Ye J, Li X, Liu H, Ma X, Wang C, He K, Zhang W, Yuan J, Zhao Y, Xu H, Liu Q
Molecular neurodegeneration 2021 Sep 22;16(1):66
Molecular neurodegeneration 2021 Sep 22;16(1):66
Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine.
Zhang X, You L, Zhang X, Wang F, Wang Y, Zhou J, Liu C, Qu F
Chinese medicine 2021 Oct 2;16(1):97
Chinese medicine 2021 Oct 2;16(1):97
Transcranial direct current stimulation relieves visceral hypersensitivity via normalizing GluN2B expression and neural activity in anterior cingulate cortex.
Xiao Y, Xie L, Xu QY, Chen L, Chen H, Xu GY, Zhang PA
Journal of neurophysiology 2021 May 1;125(5):1787-1797
Journal of neurophysiology 2021 May 1;125(5):1787-1797
Early and Delayed Impact of Nanosilver on the Glutamatergic NMDA Receptor Complex in Immature Rat Brain.
Dąbrowska-Bouta B, Sulkowski G, Sałek M, Frontczak-Baniewicz M, Strużyńska L
International journal of molecular sciences 2021 Mar 17;22(6)
International journal of molecular sciences 2021 Mar 17;22(6)
Maternal exposure to low doses of bisphenol A affects learning and memory in male rat offspring with abnormal N-methyl-d-aspartate receptors in the hippocampus.
Wang C, Shu Y, Xu L, Liu Q, Zhang B, Zhang H
Toxicology and industrial health 2021 Jun;37(6):303-313
Toxicology and industrial health 2021 Jun;37(6):303-313
Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model.
Wang Y, Pan Q, Tian R, Wen Q, Qin G, Zhang D, Chen L, Zhang Y, Zhou J
The journal of headache and pain 2021 Jul 27;22(1):84
The journal of headache and pain 2021 Jul 27;22(1):84
Phosphorylation of GluN2B subunits of N-methyl-d-aspartate receptors in the frontal association cortex involved in morphine-induced conditioned place preference in mice.
Chen G, Han W, Li A, Wang J, Xiao J, Huang X, Nazir KA, Shang Q, Qian H, Qiao C, Liu X, Li T
Neuroscience letters 2021 Jan 10;741:135470
Neuroscience letters 2021 Jan 10;741:135470
A high-throughput screen identifies inhibitors of lung cancer stem cells.
She X, Gao Y, Zhao Y, Yin Y, Dong Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug;140:111748
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug;140:111748
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca(2+)-Activin A circuit in chronic cerebral hypoperfusion rats.
Zhang X, Shi X, Wang J, Xu Z, He J
Aging 2021 Aug 30;13(16):20748-20761
Aging 2021 Aug 30;13(16):20748-20761
Enriched Environment Promotes Cognitive Function Recovery following Cerebral Ischemic Injury via Upregulating GABAergic and Glutamatergic Systems in the Contralateral Hippocampus.
Wang Y, Wu J, Xie H, Wang L, Wang C, Wu Y
Evidence-based complementary and alternative medicine : eCAM 2020;2020:8850119
Evidence-based complementary and alternative medicine : eCAM 2020;2020:8850119
Effects of Xiaoyaosan on Depressive-Like Behaviors in Rats With Chronic Unpredictable Mild Stress Through HPA Axis Induced Astrocytic Activities.
Song M, Zhang J, Li X, Liu Y, Wang T, Yan Z, Chen J
Frontiers in psychiatry 2020;11:545823
Frontiers in psychiatry 2020;11:545823
Involvement of NMDAR/PSD-95/nNOS-NO-cGMP pathway in embryonic exposure to BPA induced learning and memory dysfunction of rats.
Yu H, Ma L, Liu D, Wang Y, Pei X, Duan Z, Ma M, Zhang Y
Environmental pollution (Barking, Essex : 1987) 2020 Nov;266(Pt 1):115055
Environmental pollution (Barking, Essex : 1987) 2020 Nov;266(Pt 1):115055
Up-regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine.
Zhou X, Liang J, Wang J, Fei Z, Qin G, Zhang D, Zhou J, Chen L
Journal of neurochemistry 2020 Nov;155(4):370-389
Journal of neurochemistry 2020 Nov;155(4):370-389
STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
Gruszczynska-Biegala J, Strucinska K, Maciag F, Majewski L, Sladowska M, Kuznicki J
Cells 2020 Jan 9;9(1)
Cells 2020 Jan 9;9(1)
EphrinB/EphB Signaling Contributes to the Synaptic Plasticity of Chronic Migraine Through NR2B Phosphorylation.
Wang J, Fei Z, Liang J, Zhou X, Qin G, Zhang D, Zhou J, Chen L
Neuroscience 2020 Jan 21;428:178-191
Neuroscience 2020 Jan 21;428:178-191
CCL2-CCR2 Axis Potentiates NMDA Receptor Signaling to Aggravate Neuropathic Pain Induced by Brachial Plexus Avulsion.
Xian H, Jiang Y, Zhang H, Ma SB, Zhao R, Cong R
Neuroscience 2020 Jan 15;425:29-38
Neuroscience 2020 Jan 15;425:29-38
SAP102 contributes to hyperalgesia formation in the cancer induced bone pain rat model by anchoring NMDA receptors.
He QL, Deng HS, Xu LS, Zhu JJ, Ni HD, Wang TT, Wang YG, Shen H, Pan H, Yao M
Neuroscience letters 2020 Jan 1;714:134595
Neuroscience letters 2020 Jan 1;714:134595
Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice.
Qi F, Liu T, Zhang X, Gao X, Li Z, Chen L, Lin C, Wang L, Wang ZJ, Tang H, Chen Z
Neuropharmacology 2020 Jan 1;162:107783
Neuropharmacology 2020 Jan 1;162:107783
TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation.
Zhang H, Tian X, Lu X, Xu D, Guo Y, Dong Z, Li Y, Ma Y, Chen C, Yang Y, Yang M, Yang Y, Liu F, Zhou R, He M, Xiao F, Wang X
The Journal of clinical investigation 2019 Sep 3;129(9):3864-3876
The Journal of clinical investigation 2019 Sep 3;129(9):3864-3876
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
Wang X, Luo C, Mao XY, Li X, Yin JY, Zhang W, Zhou HH, Liu ZQ
Brain research 2019 Sep 15;1719:30-39
Brain research 2019 Sep 15;1719:30-39
Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system.
Chen K, Sun D, Qu S, Chen Y, Wang J, Zhou L, Jose PA, Yang Y, Zeng C
Clinical science (London, England : 1979) 2019 May 31;133(9):1097-1113
Clinical science (London, England : 1979) 2019 May 31;133(9):1097-1113
Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy.
Wen Y, Wu K, Xie Y, Dan W, Zhan Y, Shi Q
Biochemical and biophysical research communications 2019 Mar 26;511(1):79-86
Biochemical and biophysical research communications 2019 Mar 26;511(1):79-86
Inhibition of CB1 receptor ameliorates spatial learning and memory impairment in mice with traumatic brain injury.
Xu X, Jiang S, Xu E, Wu X, Zhao R
Neuroscience letters 2019 Mar 23;696:127-131
Neuroscience letters 2019 Mar 23;696:127-131
Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X.
So LY, Munger SJ, Miller JE
Behavioural brain research 2019 Mar 15;360:103-112
Behavioural brain research 2019 Mar 15;360:103-112
CAMK2-Dependent Signaling in Neurons Is Essential for Survival.
Kool MJ, Proietti Onori M, Borgesius NZ, van de Bree JE, Elgersma-Hooisma M, Nio E, Bezstarosti K, Buitendijk GHS, Aghadavoud Jolfaei M, Demmers JAA, Elgersma Y, van Woerden GM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 10;39(28):5424-5439
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 10;39(28):5424-5439
The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors.
Lu X, Zhang Q, Wang T
Biochemical and biophysical research communications 2019 Aug 13;516(1):63-67
Biochemical and biophysical research communications 2019 Aug 13;516(1):63-67
NR2B-Tyr phosphorylation regulates synaptic plasticity in central sensitization in a chronic migraine rat model.
Wang XY, Zhou HR, Wang S, Liu CY, Qin GC, Fu QQ, Zhou JY, Chen LX
The journal of headache and pain 2018 Nov 6;19(1):102
The journal of headache and pain 2018 Nov 6;19(1):102
Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnS(2) nanoflowers.
Bai D, Li Q, Wang J, Zhao J, Deng X, Yuan L, Wu P
Toxicology research 2018 Nov 1;7(6):1267-1279
Toxicology research 2018 Nov 1;7(6):1267-1279
N-methyl D-aspartate receptor subtype 2B antagonist, Ro 25-6981, attenuates neuropathic pain by inhibiting postsynaptic density 95 expression.
Huang LE, Guo SH, Thitiseranee L, Yang Y, Zhou YF, Yao YX
Scientific reports 2018 May 18;8(1):7848
Scientific reports 2018 May 18;8(1):7848
Effects of intrathecal bupivacaine on the NR2B/CaMKIIα/CREB signaling pathway in the rat lumbar spinal cord.
Zhao L, Zhang Y, Yang F, Zhu D, Li N, Zhao L, Li N, Yu J, Ma H
Molecular medicine reports 2018 Mar;17(3):4508-4514
Molecular medicine reports 2018 Mar;17(3):4508-4514
Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex.
Li Y, Wang L, Zhang X, Huang M, Li S, Wang X, Chen L, Jiang B, Yang Y
Neuropharmacology 2018 Jan;128:207-220
Neuropharmacology 2018 Jan;128:207-220
HCN2 contributes to oxaliplatin-induced neuropathic pain through activation of the CaMKII/CREB cascade in spinal neurons.
Liu X, Zhang L, Jin L, Tan Y, Li W, Tang J
Molecular pain 2018 Jan-Dec;14:1744806918778490
Molecular pain 2018 Jan-Dec;14:1744806918778490
Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats.
Cao M, Fang J, Wang X, Wang Y, Duan K, Ye F, Ouyang W, Tong J
Brain research 2018 Apr 1;1684:21-29
Brain research 2018 Apr 1;1684:21-29
Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age.
Tang Y, Wang X, Zhang S, Duan S, Qing W, Chen G, Ye F, Le Y, Ouyang W
PloS one 2017;12(8):e0182471
PloS one 2017;12(8):e0182471
Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice.
Zhang S, Wang X, Ai S, Ouyang W, Le Y, Tong J
PloS one 2017;12(11):e0188273
PloS one 2017;12(11):e0188273
Protective effects of Bushen Tiansui decoction on hippocampal synapses in a rat model of Alzheimer's disease.
Hui S, Yang Y, Peng WJ, Sheng CX, Gong W, Chen S, Xu PP, Wang Z
Neural regeneration research 2017 Oct;12(10):1680-1686
Neural regeneration research 2017 Oct;12(10):1680-1686
Beneficial Effects of a CaMKIIα Inhibitor TatCN21 Peptide in Global Cerebral Ischemia.
Ahmed ME, Dong Y, Lu Y, Tucker D, Wang R, Zhang Q
Journal of molecular neuroscience : MN 2017 Jan;61(1):42-51
Journal of molecular neuroscience : MN 2017 Jan;61(1):42-51
Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction.
Wen Y, Fu P, Wu K, Si K, Xie Y, Dan W, Zhan Y, Shi Q
Neurochemical research 2017 Aug;42(8):2154-2166
Neurochemical research 2017 Aug;42(8):2154-2166
Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.
Tang L, Zhang Y, Chen G, Xiong Y, Wang X, Zhu B
Neurochemical research 2017 Apr;42(4):1211-1218
Neurochemical research 2017 Apr;42(4):1211-1218
A lasting effect of postnatal sevoflurane anesthesia on the composition of NMDA receptor subunits in rat prefrontal cortex.
Zhang X, Shen F, Xu D, Zhao X
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2016 Nov;54:62-69
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2016 Nov;54:62-69
NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.
Zhang Y, Chen G, Gao B, Li Y, Liang S, Wang X, Wang X, Zhu B
Scientific reports 2016 Nov 23;6:37713
Scientific reports 2016 Nov 23;6:37713
Dopamine D3 receptor-regulated NR2B subunits of N-methyl-d-aspartate receptors in the nucleus accumbens involves in morphine-induced locomotor activity.
Liu XS, Hou Y, Yan TL, Guo YY, Han W, Guan FL, Chen T, Li T
CNS neuroscience & therapeutics 2014 Sep;20(9):823-9
CNS neuroscience & therapeutics 2014 Sep;20(9):823-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 21920-1-AP(GRIN2B antibody) at dilution of 1:5000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-GRIN2B (IP:21920-1-AP, 3ug; Detection:21920-1-AP 1:2000) with mouse brain tissue lysate 6000ug.
- Sample type
- tissue
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NMDAR2B antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human NMDAR2B. This antibody recognizes human,mouse,rat antigen. The NMDAR2B antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 21920-1-AP(GRIN2B antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
