Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- AP08710PU-N - Provider product page
- Provider
- Acris Antibodies GmbH
- Proper citation
- Acris Antibodies GmbH Cat#AP08710PU-N, RRID:AB_1975632
- Product name
- anti NMDAR2B pTyr1472
- Antibody type
- Polyclonal
- Antigen
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Tyr1472 of NMDA NR2B.
- Reactivity
- Human, Mouse, Rat, Bovine, Canine, Chicken/Avian, Zebrafish
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
Submitted references Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model.
Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity.
Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase.
Gladding CM, Sepers MD, Xu J, Zhang LY, Milnerwood AJ, Lombroso PJ, Raymond LA
Human molecular genetics 2012 Sep 1;21(17):3739-52
Human molecular genetics 2012 Sep 1;21(17):3739-52
Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity.
Xu J, Kurup P, Bartos JA, Patriarchi T, Hell JW, Lombroso PJ
The Journal of biological chemistry 2012 Jun 15;287(25):20942-56
The Journal of biological chemistry 2012 Jun 15;287(25):20942-56
Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase.
Hicklin TR, Wu PH, Radcliffe RA, Freund RK, Goebel-Goody SM, Correa PR, Proctor WR, Lombroso PJ, Browning MD
Proceedings of the National Academy of Sciences of the United States of America 2011 Apr 19;108(16):6650-5
Proceedings of the National Academy of Sciences of the United States of America 2011 Apr 19;108(16):6650-5
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Supportive validation
- Submitted by
- Acris Antibodies GmbH (provider)
- Main image
- Experimental details
- Figure 1. Western blot of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2B subunit of the NMDAR phosphorylated at Tyr1472 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase). The blot is identical to the control except that it was incubated in lambda-Ptase (1200 units for 30 min) before being exposed to the phospho-Tyr1472 NMDA NR2B antibody. The immunolabeling is completely eliminated by treatment with lambda-Ptase.