Antibody data

Product number
11-8052 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-Spi-B Antibody
Antibody type
Polyclonal
Description
Spi-B belongs to the ETS family transcription containing a conserved ETS domain which specifically binds to a purine-rich DNA sequence called the PU-box (5'-GAGGAA-3'). Spi-B has two known isoforms (28 and 18 kDa) localized in nucleus and cytoplasm. Spi-B contains two transactivation domains (TAD) at the N- terminal end which may be required for transcriptional activation of the target genes. Spi-B is involved in development of plasmacytoid dendritic cells (natural interferon producing cells) and B-cell development. Spi-B acts as a lymphoid specific enhancer. Spi-B is highly expressed in plasmacytoid dendritic cells (pDCs), B-cells and stem cell populations of the liver.
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant Spi-B
protein (amino acids 50-260) was us
ed as the immunogen for this antibo
dy.
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
SPIB protein structure - 11-8052 shown in red.