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- Antibody Data
- Antigen structure
- References [7]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 20574-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20574-1-AP, RRID:AB_10696316
- Product name
- DOC2B antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DOC2B antibody (Cat. #20574-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release.
Double C-2 like domain beta (DOC2B) induces calcium dependent oxidative stress to promote lipotoxicity and mitochondrial dysfunction for its tumor suppressive function.
A Novel Role for DOC2B in Ameliorating Palmitate-Induced Glucose Uptake Dysfunction in Skeletal Muscle Cells via a Mechanism Involving β-AR Agonism and Cofilin.
DOC2B is a negative regulator of Wnt/β-catenin signaling pathway in cervical cancer.
Metastatic suppression by DOC2B is mediated by inhibition of epithelial-mesenchymal transition and induction of senescence.
Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function.
DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer.
Zhang H, Lei M, Zhang Y, Li H, He Z, Xie S, Zhu L, Wang S, Liu J, Li Y, Lu Y, Ma C
Science advances 2024 May 17;10(20):eadi7024
Science advances 2024 May 17;10(20):eadi7024
Double C-2 like domain beta (DOC2B) induces calcium dependent oxidative stress to promote lipotoxicity and mitochondrial dysfunction for its tumor suppressive function.
Adiga D, Bhat S, Shukla V, Shah HV, Kuthethur R, Chakrabarty S, Kabekkodu SP
Free radical biology & medicine 2023 May 20;201:1-13
Free radical biology & medicine 2023 May 20;201:1-13
A Novel Role for DOC2B in Ameliorating Palmitate-Induced Glucose Uptake Dysfunction in Skeletal Muscle Cells via a Mechanism Involving β-AR Agonism and Cofilin.
Hwang J, Balakrishnan R, Oh E, Veluthakal R, Thurmond DC
International journal of molecular sciences 2023 Dec 21;25(1)
International journal of molecular sciences 2023 Dec 21;25(1)
DOC2B is a negative regulator of Wnt/β-catenin signaling pathway in cervical cancer.
Adiga D, Bhat S, Chakrabarty S, Kabekkodu SP
Pharmacological research 2022 Jun;180:106239
Pharmacological research 2022 Jun;180:106239
Metastatic suppression by DOC2B is mediated by inhibition of epithelial-mesenchymal transition and induction of senescence.
Bhat S, Adiga D, Shukla V, Guruprasad KP, Kabekkodu SP, Satyamoorthy K
Cell biology and toxicology 2022 Apr;38(2):237-258
Cell biology and toxicology 2022 Apr;38(2):237-258
Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function.
Aslamy A, Oh E, Olson EM, Zhang J, Ahn M, Moin ASM, Tunduguru R, Salunkhe VA, Veluthakal R, Thurmond DC
Diabetes 2018 Jul;67(7):1332-1344
Diabetes 2018 Jul;67(7):1332-1344
DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer.
Kabekkodu SP, Bhat S, Radhakrishnan R, Aithal A, Mascarenhas R, Pandey D, Rai L, Kushtagi P, Mundyat GP, Satyamoorthy K
The Journal of biological chemistry 2014 Apr 11;289(15):10637-10649
The Journal of biological chemistry 2014 Apr 11;289(15):10637-10649
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse kidney tissue were subjected to SDS PAGE followed by western blot with 20574-1-AP(DOC2B antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using DOC2B antibody 20574-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
