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- Antibody Data
- Antigen structure
- References [147]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 18986-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18986-1-AP, RRID:AB_10596476
- Product name
- EGFR-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated EGFR-Specific antibody (Cat. #18986-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: FC, IF, IP, WB,ELISA.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references METTL3 inhibitor STM2457 impairs tumor progression and enhances sensitivity to anlotinib in OSCC.
Interferon-induced transmembrane protein-1 competitively blocks Ephrin receptor A2-mediated Epstein-Barr virus entry into epithelial cells.
Deacetylation of ATG7 drives the induction of macroautophagy and LC3-associated microautophagy.
Dihydroartemisinin-driven selective anti-lung cancer proliferation by binding to EGFR and inhibition of NRAS signaling pathway-induced DNA damage.
TMED2 promotes glioma tumorigenesis by being involved in EGFR recycling transport.
PD-L1 on large extracellular vesicles is a predictive biomarker for therapy response in tissue PD-L1-low and -negative patients with non-small cell lung cancer.
UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5.
Lysophospholipid acyltransferase-mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation.
Brain Metastasis from EGFR-Mutated Non-Small Cell Lung Cancer: Secretion of IL11 from Astrocytes Up-Regulates PDL1 and Promotes Immune Escape.
KBTBD2 promotes proliferation and migration of gastric cancer via activating EGFR signaling pathway.
Anti-EGFR ScFv functionalized exosomes delivering LPCAT1 specific siRNAs for inhibition of lung cancer brain metastases.
Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion.
The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats.
YAP1 synergize with YY1 transcriptional co-repress DUSP1 to induce osimertinib resistant by activating the EGFR/MAPK pathway and abrogating autophagy in non-small cell lung cancer.
Fraxin represses NF-κB pathway via inhibiting the activation of epidermal growth factor receptor to ameliorate diabetic renal tubulointerstitial fibrosis.
Fibromodulin overexpression drives oral squamous cell carcinoma via activating downstream EGFR signaling.
TRIP13 overexpression promotes gefitinib resistance in non‑small cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway.
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.
NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer.
Exosomes derived from MDR cells induce cetuximab resistance in CRC via PI3K/AKT signaling‑mediated Sox2 and PD‑L1 expression.
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma.
Systematic Pharmacology-Based Strategy to Explore the Mechanism of Bufei Huoxue Capsule in the Treatment of Chronic Obstructive Pulmonary Disease.
Aldolase A promotes cell proliferation and cisplatin resistance via the EGFR pathway in gastric cancer.
Identifying Candidate Genes for Short Gestation Length Trait in Chinese Qingping Pigs by Whole-Genome Resequencing and RNA Sequencing.
Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-A(Thr288)-geminin dual signaling pathways.
Guishaozichuan granules can attenuate asthma in rats via the MUC5AC/EGFR signaling pathway.
Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway.
S645C Point Mutation Suppresses Degradation of EGFR to Promote Progression of Glioblastoma.
Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma.
Fucoidan inhibits EGFR redistribution and potentiates sorafenib to overcome sorafenib-resistant hepatocellular carcinoma.
Cellular Hypoxia Mitigation by Dandelion-like Nanoparticles for Synergistic Photodynamic Therapy of Oral Squamous Cell Carcinoma.
MicroRNA-122a aggravates intestinal ischemia/reperfusion injury by promoting pyroptosis via targeting EGFR-NLRP3 signaling pathway.
Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system.
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Serine protease inhibitor Kazal type 1 (SPINK1) promotes proliferation, migration, invasion and radiation resistance in rectal cancer patients receiving concurrent chemoradiotherapy: a potential target for precision medicine.
Evolution of the ErbB gene family and analysis of regulators of Egfr expression during development of the rat spinal cord.
In Silico Exploration and Biological Evaluation of Bispecific Peptides Derived from Anti-HER2 Antibodies and Peptide-Camptothecin Conjugates for HER2-Positive Breast Cancer.
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
Circular dorsal ruffles disturb the growth factor-induced PI3K-AKT pathway in hepatocellular carcinoma Hep3B cells.
Microneedle patches integrated with lateral flow cassettes for blood-free chronic kidney disease point-of-care testing during a pandemic.
Grb2 interacts with necrosome components and is involved in rasfonin-induced necroptosis.
Increasing astrogenesis in the developing hippocampus induces autistic-like behavior in mice via enhancing inhibitory synaptic transmission.
DLX6 promotes cell proliferation and survival in oral squamous cell carcinoma.
Regulatory role of melatonin on epidermal growth factor receptor, Type I collagen α1 chain, and caveolin 1 in granulosa cells of sheep antral follicles.
The unique Akt inhibitor SC66 suppressed AMPK activity and abolished autophagy through the EGFR-p62 pathway.
A Dual-Reporter Platform for Screening Tumor-Targeted Extracellular Vesicles.
Targeted Disruption of a Proximal Tubule-Specific TMEM174 Gene in Mice Causes Hyperphosphatemia and Vascular Calcification.
Phosphorylated STYK1 restrains the inhibitory role of EGFR in autophagy initiation and EGFR-TKIs sensitivity.
MicroRNA-222 Transferred From Semen Extracellular Vesicles Inhibits Sperm Apoptosis by Targeting BCL2L11.
Lysophosphatidic Acid-Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase.
In Silico and In Vivo Studies on the Mechanisms of Chinese Medicine Formula (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis.
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
Prognostic and Predictive Value of Immune-Related Gene Pair Signature in Primary Lower-Grade Glioma Patients.
MiR-338-5p Inhibits EGF-Induced EMT in Pancreatic Cancer Cells by Targeting EGFR/ERK Signaling.
A network pharmacology strategy to investigate the anti-osteoarthritis mechanism of main lignans components of Schisandrae Fructus.
Remarkable inhibition effects of afatinib alone or combining with paclitaxel in esophageal squamous cell carcinoma.
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
Investigation on the clinical efficacy and mechanism of compound kushen injection in treating esophageal cancer based on multi-dimensional network meta-analysis and in vitro experiment.
Identification and validation of a hypoxia-related prognostic and immune microenvironment signature in bladder cancer.
On-Chip Replication of Extremely Early-Stage Tumor Behavior.
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics.
Ketoplatin in triple-negative breast cancer cells MDA-MB-231: High efficacy and low toxicity, and positive impact on inflammatory microenvironment.
Construction of autophagy prognostic signature and analysis of prospective molecular mechanisms in skin cutaneous melanoma patients.
A metabolic data-driven systems pharmacology strategy for decoding and validating the mechanism of Compound Kushen Injection against HCC.
LncRNA LPAL2/miR-1287-5p/EGFR Axis Modulates TED-Derived Orbital Fibroblast Activation Through Cell Adhesion Factors.
GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
lncRNA SOX2-OT ceRNA network enhances the malignancy of long-term PM(2.5)-exposed human bronchial epithelia.
Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma.
Elevated ZBTB7A expression in the tumor invasive front correlates with more tumor budding formation in gastric adenocarcinoma.
Effects of ER-resident and secreted AGR2 on cell proliferation, migration, invasion, and survival in PANC-1 pancreatic cancer cells.
Cell membrane-encapsulated magnetic nanoparticles for enhancing natural killer cell-mediated cancer immunotherapy.
CALM1 promotes progression and dampens chemosensitivity to EGFR inhibitor in esophageal squamous cell carcinoma.
Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma.
[6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling.
Exosomal miR-27 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS.
Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect.
JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling.
Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth.
RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro.
METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner.
α1,6-Fucosyltransferase (FUT8) regulates the cancer-promoting capacity of cancer-associated fibroblasts (CAFs) by modifying EGFR core fucosylation (CF) in non-small cell lung cancer (NSCLC).
EGFR/FOXO3A/LXR-α Axis Promotes Prostate Cancer Proliferation and Metastasis and Dual-Targeting LXR-α/EGFR Shows Synthetic Lethality.
Lapatinib‑induced inhibition of ovarian function is counteracted by the STAT3 pathway both in vivo and in vitro.
ΔNp63α is a super enhancer-enriched master factor controlling the basal-to-luminal differentiation transcriptional program and gene regulatory networks in nasopharyngeal carcinoma.
FUT4siRNA augments the chemosensitivity of non-small cell lung cancer to cisplatin through activation of FOXO1-induced apoptosis.
Down-regulation of NTSR3 inhibits cell growth and metastasis, as well as the PI3K-AKT and MAPK signaling pathways in colorectal cancer.
Hypoxia Alters the Response to Anti-EGFR Therapy by Regulating EGFR Expression and Downstream Signaling in a DNA Methylation-Specific and HIF-Dependent Manner.
EGFR-targeted CAR-T cells are potent and specific in suppressing triple-negative breast cancer both in vitro and in vivo.
Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer.
HUWE1 promotes EGFR ubiquitination and degradation to protect against renal tubulointerstitial fibrosis.
Preclinical Evaluation of the Novel Small-Molecule MSI-N1014 for Treating Drug-Resistant Colon Cancer via the LGR5/β-catenin/miR-142-3p Network and Reducing Cancer-Associated Fibroblast Transformation.
Serine Protease Imbalance in the Small Airways and Development of Centrilobular Emphysema in Chronic Obstructive Pulmonary Disease.
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
EGFR-PKM2 signaling promotes the metastatic potential of nasopharyngeal carcinoma through induction of FOSL1 and ANTXR2.
Human Neutrophil Elastase Induces MUC5AC Overexpression in Chronic Rhinosinusitis Through miR-146a.
[High expression of STAT2 in ovarian cancer and its effect on metastasis of ovarian cancer cells].
VPS33B negatively modulated by nicotine functions as a tumor suppressor in colorectal cancer.
DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2α- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation.
Exploration of the Effects of Substrate Stiffness on Biological Responses of Neural Cells and Their Mechanisms.
MiR-30a-5p inhibits proliferation and metastasis of hydatidiform mole by regulating B3GNT5 through ERK/AKT pathways.
ZEB1-Mediated Transcriptional Upregulation of circWWC3 Promotes Breast Cancer Progression through Activating Ras Signaling Pathway.
Prolonged siRNA expression in mammalian cells using an Epstein-Barr virus-based plasmid expression system.
DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas.
CAPE-pNO(2) Inhibited the Growth and Metastasis of Triple-Negative Breast Cancer via the EGFR/STAT3/Akt/E-Cadherin Signaling Pathway.
SEMA3C Promotes Cervical Cancer Growth and Is Associated With Poor Prognosis.
DpdtbA-Induced Growth Inhibition in Human Esophageal Cancer Cells Involved Inactivation of the p53/EGFR/AKT Pathway.
Verteporfin suppresses the proliferation, epithelial-mesenchymal transition and stemness of head and neck squamous carcinoma cells via inhibiting YAP1.
Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration.
Erlotinib overcomes paclitaxel-resistant cancer stem cells by blocking the EGFR-CREB/GRβ-IL-6 axis in MUC1-positive cervical cancer.
The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking.
An in vivo anti-tumor effect of eckol from marine brown algae by improving the immune response.
miR-323-3p regulates the steroidogenesis and cell apoptosis in polycystic ovary syndrome (PCOS) by targeting IGF-1.
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
Prognostic significance of contactin 3 expression and associated genes in glioblastoma multiforme.
The anti-androgenic effects of cypermethrin mediated by non-classical testosterone pathway activation of mitogen-activated protein kinase cascade in mouse Sertoli cells.
Adaptive EGF expression sensitizes pancreatic cancer cells to ionizing radiation through activation of the cyclin D1/P53/PARP pathway.
Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner.
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells.
Sensitisation of Cancer Cells to MLN8237, an Aurora-A Inhibitor, by YAP/TAZ Inactivation.
Relationship of Epidermal Growth Factor Receptor Expression with Clinical Symptoms and Metastasis of Invasive Breast Cancer.
Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snail1 pathway.
Porphyromonas gingivalis and its lipopolysaccharide differently modulate epidermal growth factor-dependent signaling in human gingival epithelial cells.
miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury.
Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells.
ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats.
S100P is associated with proliferation and migration in nasopharyngeal carcinoma.
Propofol enhances the cisplatin-induced apoptosis on cervical cancer cells via EGFR/JAK2/STAT3 pathway.
Induction of apoptosis by FFJ-5, a novel naphthoquinone compound, occurs via downregulation of PKM2 in A549 and HepG2 cells.
Hyperthermia with different temperatures inhibits proliferation and promotes apoptosis through the EGFR/STAT3 pathway in C6 rat glioma cells.
EGFR expression in patients with stage III colorectal cancer after adjuvant chemotherapy and on cancer cell function.
Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.
Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome.
Gingerol Reverses the Cancer-Promoting Effect of Capsaicin by Increased TRPV1 Level in a Urethane-Induced Lung Carcinogenic Model.
Wnt signaling regulation of stem-like properties in human lung adenocarcinoma cell lines.
Enoyl-coenzyme A hydratase short chain 1 silencing attenuates the proliferation of hepatocellular carcinoma by inhibiting epidermal growth factor signaling in vitro and in vivo.
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Eupolyphaga sinensis Walker inhibits human chronic myeloid leukemia cell K562 growth by inducing G2-M phase cell cycle arrest and targeting EGFR signaling pathway and in S180 tumor-bearing mice.
Identification of miR-133b and RB1CC1 as independent predictors for biochemical recurrence and potential therapeutic targets for prostate cancer.
High transfection efficiency of quantum dot-antisense oligonucleotide nanoparticles in cancer cells through dual-receptor synergistic targeting.
Lentiviral vector-mediated RBM5 overexpression downregulates EGFR expression in human non-small cell lung cancer cells.
miR-7 inhibits the invasion and metastasis of gastric cancer cells by suppressing epidermal growth factor receptor expression.
Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats.
Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB.
Wentilactone B from Aspergillus wentii induces apoptosis and inhibits proliferation and migration of human hepatoma SMMC-7721 cells.
Histone deacetylase inhibitor trichostatin A enhances anti-tumor effects of docetaxel or erlotinib in A549 cell line.
Liu L, Zhao T, Zheng S, Tang D, Han H, Yang C, Zheng X, Wang J, Ma J, Wei W, Wang Z, He S, He Q
Oral diseases 2024 Oct;30(7):4243-4254
Oral diseases 2024 Oct;30(7):4243-4254
Interferon-induced transmembrane protein-1 competitively blocks Ephrin receptor A2-mediated Epstein-Barr virus entry into epithelial cells.
Yang Y, Ding T, Cong Y, Luo X, Liu C, Gong T, Zhao M, Zheng X, Li C, Zhang Y, Zhou J, Ni C, Zhang X, Ji Z, Wu T, Yang S, Zhou Q, Wu D, Gong X, Zheng Q, Li X
Nature microbiology 2024 May;9(5):1256-1270
Nature microbiology 2024 May;9(5):1256-1270
Deacetylation of ATG7 drives the induction of macroautophagy and LC3-associated microautophagy.
Xu Y, Qian C, Wang Q, Song L, He Z, Liu W, Wan W
Autophagy 2024 May;20(5):1134-1146
Autophagy 2024 May;20(5):1134-1146
Dihydroartemisinin-driven selective anti-lung cancer proliferation by binding to EGFR and inhibition of NRAS signaling pathway-induced DNA damage.
Li LG, Peng XC, Yang ZY, Han N, Gou CL, Shi J, Yu LL, Chen NN, Yu TT, Li TF, Li XY, Hu J
Scientific reports 2024 May 22;14(1):11704
Scientific reports 2024 May 22;14(1):11704
TMED2 promotes glioma tumorigenesis by being involved in EGFR recycling transport.
Sun C, Zhang Y, Wang Z, Chen J, Zhang J, Gu Y
International journal of biological macromolecules 2024 Mar;262(Pt 2):130055
International journal of biological macromolecules 2024 Mar;262(Pt 2):130055
PD-L1 on large extracellular vesicles is a predictive biomarker for therapy response in tissue PD-L1-low and -negative patients with non-small cell lung cancer.
Schöne N, Kemper M, Menck K, Evers G, Krekeler C, Schulze AB, Lenz G, Wardelmann E, Binder C, Bleckmann A
Journal of extracellular vesicles 2024 Mar;13(3):e12418
Journal of extracellular vesicles 2024 Mar;13(3):e12418
UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5.
Li J, Liang Y, Zhou S, Chen J, Wu C
Breast cancer research : BCR 2024 Mar 11;26(1):44
Breast cancer research : BCR 2024 Mar 11;26(1):44
Lysophospholipid acyltransferase-mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation.
Li Q, Xia Z, Wu Y, Ma Y, Zhang D, Wang S, Fan J, Xu P, Li X, Bai L, Zhou X, Xue M
The FEBS journal 2024 Jul;291(14):3191-3210
The FEBS journal 2024 Jul;291(14):3191-3210
Brain Metastasis from EGFR-Mutated Non-Small Cell Lung Cancer: Secretion of IL11 from Astrocytes Up-Regulates PDL1 and Promotes Immune Escape.
Tang M, Xu M, Wang J, Liu Y, Liang K, Jin Y, Duan W, Xia S, Li G, Chu H, Liu W, Wang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(26):e2306348
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(26):e2306348
KBTBD2 promotes proliferation and migration of gastric cancer via activating EGFR signaling pathway.
Ding J, Gao W, Yang H, Duan L, Sun D, Liu L, Qu X, Yu H, Xu B, Zhao S, Wang L, Chai J
Pathology, research and practice 2024 Feb;254:155095
Pathology, research and practice 2024 Feb;254:155095
Anti-EGFR ScFv functionalized exosomes delivering LPCAT1 specific siRNAs for inhibition of lung cancer brain metastases.
Jiang J, Lu Y, Chu J, Zhang X, Xu C, Liu S, Wan Z, Wang J, Zhang L, Liu K, Liu Z, Yang A, Ren X, Zhang R
Journal of nanobiotechnology 2024 Apr 8;22(1):159
Journal of nanobiotechnology 2024 Apr 8;22(1):159
Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion.
Ye F, Yuan Z, Tang Y, Li J, Liu X, Sun X, Chen S, Ye X, Zeng Z, Zhang XK, Zhou H
Cell reports 2024 Apr 23;43(4):114002
Cell reports 2024 Apr 23;43(4):114002
The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats.
Cao T, Wang L, Jiao S, Chen H, Lin C, Zhang B, Cai H
Neuropsychobiology 2023;82(6):346-358
Neuropsychobiology 2023;82(6):346-358
YAP1 synergize with YY1 transcriptional co-repress DUSP1 to induce osimertinib resistant by activating the EGFR/MAPK pathway and abrogating autophagy in non-small cell lung cancer.
Ning Y, Zheng H, Yang Y, Zang H, Wang W, Zhan Y, Wang H, Luo J, Wen Q, Peng J, Xiang J, Fan S
International journal of biological sciences 2023;19(8):2458-2474
International journal of biological sciences 2023;19(8):2458-2474
Fraxin represses NF-κB pathway via inhibiting the activation of epidermal growth factor receptor to ameliorate diabetic renal tubulointerstitial fibrosis.
Zeng J, Liang L, Chen R, Li C, Pan L, Wen M, Lv D, Liu M, Xu Z, Huang H
European journal of pharmacology 2023 Sep 15;955:175915
European journal of pharmacology 2023 Sep 15;955:175915
Fibromodulin overexpression drives oral squamous cell carcinoma via activating downstream EGFR signaling.
Xia L, Zhang T, Yao J, Lu K, Hu Z, Gu X, Chen Y, Qin S, Leng W
iScience 2023 Nov 17;26(11):108201
iScience 2023 Nov 17;26(11):108201
TRIP13 overexpression promotes gefitinib resistance in non‑small cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway.
Xiao Z, Li M, Zhang X, Rong X, Xu H
Oncology reports 2023 May;49(5)
Oncology reports 2023 May;49(5)
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.
Wu JC, Wang XJ, Zhu JH, Huang XY, Liu M, Qiao Z, Zhang Y, Sun Y, Wang ZY, Zhan P, Zhang T, Hu HL, Liu H, Tang W, Yi F
Acta pharmacologica Sinica 2023 Jun;44(6):1206-1216
Acta pharmacologica Sinica 2023 Jun;44(6):1206-1216
NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer.
Wei W, Zhang S, Han H, Wang X, Zheng S, Wang Z, Yang C, Wang L, Ma J, Guo S, Wang J, Liu L, Choe J, Lin S
Cell reports 2023 Jul 25;42(7):112810
Cell reports 2023 Jul 25;42(7):112810
Exosomes derived from MDR cells induce cetuximab resistance in CRC via PI3K/AKT signaling‑mediated Sox2 and PD‑L1 expression.
Wei Z, Wang Z, Chai Q, Li Z, Zhang M, Zhang Y, Zhang L, Tang Q, Zhu H, Sui H
Experimental and therapeutic medicine 2023 Feb;25(2):86
Experimental and therapeutic medicine 2023 Feb;25(2):86
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Wang Z, Li L, Chu C, Wei X, Liu Q, Wang R, Zhang G, Wu G, Wang Y, An L, Li X
International journal of oncology 2023 Dec;63(6)
International journal of oncology 2023 Dec;63(6)
Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma.
Cui X, Zhao J, Li G, Yang C, Yang S, Zhan Q, Zhou J, Wang Y, Xiao M, Hong B, Yi K, Tong F, Tan Y, Wang H, Wang Q, Jiang T, Fang C, Kang C
Cancer communications (London, England) 2023 Dec;43(12):1326-1353
Cancer communications (London, England) 2023 Dec;43(12):1326-1353
Systematic Pharmacology-Based Strategy to Explore the Mechanism of Bufei Huoxue Capsule in the Treatment of Chronic Obstructive Pulmonary Disease.
Shi L, Yan J, Meng Y, Wang G, Du J, Feng C
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1129567
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1129567
Aldolase A promotes cell proliferation and cisplatin resistance via the EGFR pathway in gastric cancer.
Gu M, Jiang B, Li H, Zhu D, Jiang Y, Xu W
American journal of translational research 2022;14(9):6586-6595
American journal of translational research 2022;14(9):6586-6595
Identifying Candidate Genes for Short Gestation Length Trait in Chinese Qingping Pigs by Whole-Genome Resequencing and RNA Sequencing.
Liu Z, Yang J, Li H, Zhong Z, Huang J, Fu J, Zhao H, Liu X, Jiang S
Frontiers in genetics 2022;13:857705
Frontiers in genetics 2022;13:857705
Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-A(Thr288)-geminin dual signaling pathways.
Zhao H, Jia P, Nanding K, Wu M, Bai X, Morigen M, Fan L
Frontiers in pharmacology 2022;13:1046269
Frontiers in pharmacology 2022;13:1046269
Guishaozichuan granules can attenuate asthma in rats via the MUC5AC/EGFR signaling pathway.
Gao Q, Feng C, Shi Q, Wang Q, Ding Z, Chu H, Kong D, Yin X, Ni J, Sun W, Li Y
Frontiers in pharmacology 2022;13:1011751
Frontiers in pharmacology 2022;13:1011751
Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway.
Islam MT, Chen FZ, Chen HC, Wahid A
Frontiers in oncology 2022;12:923270
Frontiers in oncology 2022;12:923270
S645C Point Mutation Suppresses Degradation of EGFR to Promote Progression of Glioblastoma.
Huang W, Zou L, Hao Z, Wang B, Mao F, Duan Q, Guo D
Frontiers in oncology 2022;12:904383
Frontiers in oncology 2022;12:904383
Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma.
Li M, Liu G, Jin X, Guo H, Setrerrahmane S, Xu X, Li T, Lin Y, Xu H
Molecular cancer 2022 Sep 19;21(1):181
Molecular cancer 2022 Sep 19;21(1):181
Fucoidan inhibits EGFR redistribution and potentiates sorafenib to overcome sorafenib-resistant hepatocellular carcinoma.
Luo J, Li L, Zhu Z, Chang B, Deng F, Wang D, Lu X, Zuo D, Chen Q, Zhou J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113602
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113602
Cellular Hypoxia Mitigation by Dandelion-like Nanoparticles for Synergistic Photodynamic Therapy of Oral Squamous Cell Carcinoma.
Tao Y, Liu Y, Dong Z, Chen X, Wang Y, Li T, Li J, Zang S, He X, Chen D, Zhao Z, Li M
ACS applied materials & interfaces 2022 Oct 5;14(39):44039-44053
ACS applied materials & interfaces 2022 Oct 5;14(39):44039-44053
MicroRNA-122a aggravates intestinal ischemia/reperfusion injury by promoting pyroptosis via targeting EGFR-NLRP3 signaling pathway.
Wang F, Gu L, Wang Y, Sun D, Zhao Y, Meng Q, Yin L, Xu L, Lu X, Peng J, Lin Y, Sun P
Life sciences 2022 Oct 15;307:120863
Life sciences 2022 Oct 15;307:120863
Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system.
Guo H, Wang J, Ren S, Zheng LF, Zhuang YX, Li DL, Sun HH, Liu LY, Xie C, Wu YY, Wang HR, Deng X, Li P, Zhao TJ
Nature communications 2022 Oct 12;13(1):6004
Nature communications 2022 Oct 12;13(1):6004
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Wang T, Liu J, Huang X, Zhang C, Shangguan M, Chen J, Wu S, Chen M, Yang Z, Zhao S
Oncology reports 2022 Nov;48(5)
Oncology reports 2022 Nov;48(5)
Serine protease inhibitor Kazal type 1 (SPINK1) promotes proliferation, migration, invasion and radiation resistance in rectal cancer patients receiving concurrent chemoradiotherapy: a potential target for precision medicine.
Chen YT, Tseng TT, Tsai HP, Kuo SH, Huang MY, Wang JY, Chai CY
Human cell 2022 Nov;35(6):1912-1927
Human cell 2022 Nov;35(6):1912-1927
Evolution of the ErbB gene family and analysis of regulators of Egfr expression during development of the rat spinal cord.
Zhang Y, Zhang T, Xu L, Zhu Y, Zhao LL, Li XD, Yang WW, Chen J, Gu M, Gu XS, Yang J
Neural regeneration research 2022 Nov;17(11):2484-2490
Neural regeneration research 2022 Nov;17(11):2484-2490
In Silico Exploration and Biological Evaluation of Bispecific Peptides Derived from Anti-HER2 Antibodies and Peptide-Camptothecin Conjugates for HER2-Positive Breast Cancer.
Zhou J, Bian X, Kan Z, Cai Z, Jiang Y, Wang Z, Li Y, Shi W, Qian H
Journal of medicinal chemistry 2022 Nov 24;65(22):15123-15139
Journal of medicinal chemistry 2022 Nov 24;65(22):15123-15139
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
Zhang JJ, Cao CX, Wan LL, Zhang W, Liu ZJ, Wang JL, Guo Q, Tang H
World journal of gastroenterology 2022 May 7;28(17):1781-1797
World journal of gastroenterology 2022 May 7;28(17):1781-1797
Circular dorsal ruffles disturb the growth factor-induced PI3K-AKT pathway in hepatocellular carcinoma Hep3B cells.
Sun X, Liu Y, Zhou S, Wang L, Wei J, Hua R, Shen Z, Yoshida S
Cell communication and signaling : CCS 2022 Jul 7;20(1):102
Cell communication and signaling : CCS 2022 Jul 7;20(1):102
Microneedle patches integrated with lateral flow cassettes for blood-free chronic kidney disease point-of-care testing during a pandemic.
Chen YJ, Hsu YP, Tain YL, Li NS, Pang HH, Kuo SW, Yang HW
Biosensors & bioelectronics 2022 Jul 15;208:114234
Biosensors & bioelectronics 2022 Jul 15;208:114234
Grb2 interacts with necrosome components and is involved in rasfonin-induced necroptosis.
Hou B, Huang H, Li Y, Liang J, Xi Z, Jiang X, Liu L, Li E
Cell death discovery 2022 Jul 13;8(1):319
Cell death discovery 2022 Jul 13;8(1):319
Increasing astrogenesis in the developing hippocampus induces autistic-like behavior in mice via enhancing inhibitory synaptic transmission.
Chen J, Ma XL, Zhao H, Wang XY, Xu MX, Wang H, Yang TQ, Peng C, Liu SS, Huang M, Zhou YD, Shen Y
Glia 2022 Jan;70(1):106-122
Glia 2022 Jan;70(1):106-122
DLX6 promotes cell proliferation and survival in oral squamous cell carcinoma.
Liang J, Liu J, Deng Z, Liu Z, Liang L
Oral diseases 2022 Jan;28(1):87-96
Oral diseases 2022 Jan;28(1):87-96
Regulatory role of melatonin on epidermal growth factor receptor, Type I collagen α1 chain, and caveolin 1 in granulosa cells of sheep antral follicles.
Wang W, Lv J, Duan H, Ding Z, Zeng J, Lv C, Hu J, Zhang Y, Zhao X
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13760
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13760
The unique Akt inhibitor SC66 suppressed AMPK activity and abolished autophagy through the EGFR-p62 pathway.
Hou B, Li E, Liang J, Liu S, Yang H, Liu L, Jiang X
Cell biology international 2022 Feb;46(2):311-322
Cell biology international 2022 Feb;46(2):311-322
A Dual-Reporter Platform for Screening Tumor-Targeted Extracellular Vesicles.
Kanada M, Linenfelser L, Cox E, Gilad AA
Pharmaceutics 2022 Feb 22;14(3)
Pharmaceutics 2022 Feb 22;14(3)
Targeted Disruption of a Proximal Tubule-Specific TMEM174 Gene in Mice Causes Hyperphosphatemia and Vascular Calcification.
Miyazaki-Anzai S, Keenan AL, Blaine J, Miyazaki M
Journal of the American Society of Nephrology : JASN 2022 Aug;33(8):1477-1486
Journal of the American Society of Nephrology : JASN 2022 Aug;33(8):1477-1486
Phosphorylated STYK1 restrains the inhibitory role of EGFR in autophagy initiation and EGFR-TKIs sensitivity.
Zhou C, Dong X, Wang M, Qian X, Hu M, Liang K, Liang Y, Zhang R, Huang Y, Lyu H, Xiao S, Tang Y, Ali DW, Michalak M, Chen XZ, Tang J
Cell insight 2022 Aug;1(4):100045
Cell insight 2022 Aug;1(4):100045
MicroRNA-222 Transferred From Semen Extracellular Vesicles Inhibits Sperm Apoptosis by Targeting BCL2L11.
Ding Y, Ding N, Zhang Y, Xie S, Huang M, Ding X, Dong W, Zhang Q, Jiang L
Frontiers in cell and developmental biology 2021;9:736864
Frontiers in cell and developmental biology 2021;9:736864
Lysophosphatidic Acid-Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase.
Zhao H, Gezi G, Tian X, Jia P, Morigen M, Fan L
Frontiers in pharmacology 2021;12:706240
Frontiers in pharmacology 2021;12:706240
In Silico and In Vivo Studies on the Mechanisms of Chinese Medicine Formula (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis.
Liu X, Fan Y, Du L, Mei Z, Fu Y
Frontiers in pharmacology 2021;12:665102
Frontiers in pharmacology 2021;12:665102
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
Cao T, Tang M, Jiang P, Zhang B, Wu X, Chen Q, Zeng C, Li N, Zhang S, Cai H
Frontiers in pharmacology 2021;12:612083
Frontiers in pharmacology 2021;12:612083
Prognostic and Predictive Value of Immune-Related Gene Pair Signature in Primary Lower-Grade Glioma Patients.
Lei K, Li J, Tu Z, Liu F, Ye M, Wu M, Zhu Y, Luo M, Lin L, Tao C, Huang K, Zhu X
Frontiers in oncology 2021;11:665870
Frontiers in oncology 2021;11:665870
MiR-338-5p Inhibits EGF-Induced EMT in Pancreatic Cancer Cells by Targeting EGFR/ERK Signaling.
Sun J, Chen L, Dong M
Frontiers in oncology 2021;11:616481
Frontiers in oncology 2021;11:616481
A network pharmacology strategy to investigate the anti-osteoarthritis mechanism of main lignans components of Schisandrae Fructus.
Min L, Wu Y, Cao G, Mi D, Chen C
International immunopharmacology 2021 Sep;98:107873
International immunopharmacology 2021 Sep;98:107873
Remarkable inhibition effects of afatinib alone or combining with paclitaxel in esophageal squamous cell carcinoma.
Yang LY, Cheng ZJ, Liu Z, Wang D, Zhang N, Fan ZL, Cai HQ, Zhang Y, Cai Y, Xu X, Wang JH, Du GH, Hao JJ, Wang MR
Journal of gastroenterology and hepatology 2021 Sep;36(9):2513-2522
Journal of gastroenterology and hepatology 2021 Sep;36(9):2513-2522
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
Shopit A, Li X, Wang S, Awsh M, Safi M, Chu P, Jia J, Al-Radhi M, Baldi S, Wang F, Fang J, Peng J, Ma X, Tang Z, Shu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153711
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153711
Investigation on the clinical efficacy and mechanism of compound kushen injection in treating esophageal cancer based on multi-dimensional network meta-analysis and in vitro experiment.
Zhou W, Huang Z, Wu C, Lu S, Fu C, Ye P, Tan Y, Wu Z, Fan X, Zhang J, Guo S, Jia S, Stalin A, Wang H, Zhang X, Wang M, Wu J
Journal of ethnopharmacology 2021 Oct 28;279:114386
Journal of ethnopharmacology 2021 Oct 28;279:114386
Identification and validation of a hypoxia-related prognostic and immune microenvironment signature in bladder cancer.
Sun X, Zhou Z, Zhang Y, Wang J, Zhao X, Jin L, Zhai T, Liu X, Zhang J, Mei W, Zhang B, Luo M, Yao X, Ye L
Cancer cell international 2021 May 7;21(1):251
Cancer cell international 2021 May 7;21(1):251
On-Chip Replication of Extremely Early-Stage Tumor Behavior.
Li C, Li S, Du K, Li P, Qiu B, Ding W
ACS applied materials & interfaces 2021 May 5;13(17):19768-19777
ACS applied materials & interfaces 2021 May 5;13(17):19768-19777
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics.
Fu Z, Zhang X, Zhou X, Ur-Rehman U, Yu M, Liang H, Guo H, Guo X, Kong Y, Su Y, Ye Y, Hu X, Cheng W, Wu J, Wang Y, Gu Y, Lu SF, Wu D, Zen K, Li J, Yan C, Zhang CY, Chen X
Cell research 2021 Jun;31(6):631-648
Cell research 2021 Jun;31(6):631-648
Ketoplatin in triple-negative breast cancer cells MDA-MB-231: High efficacy and low toxicity, and positive impact on inflammatory microenvironment.
Ma ZY, Song XQ, Hu JJ, Wang DB, Ding XJ, Liu RP, Dai ML, Meng FY, Xu JY
Biochemical pharmacology 2021 Jun;188:114523
Biochemical pharmacology 2021 Jun;188:114523
Construction of autophagy prognostic signature and analysis of prospective molecular mechanisms in skin cutaneous melanoma patients.
Liao S, He J, Liu C, Zhang Z, Liao H, Liao Z, Yu C, Guan J, Mo H, Yuan Z, Liang T, Lu Z, Xu G, Wang Z, Chen J, Jiang J, Zhan X
Medicine 2021 Jun 4;100(22):e26219
Medicine 2021 Jun 4;100(22):e26219
A metabolic data-driven systems pharmacology strategy for decoding and validating the mechanism of Compound Kushen Injection against HCC.
Wang KX, Chen YP, Lu AP, Du GH, Qin XM, Guan DG, Gao L
Journal of ethnopharmacology 2021 Jun 28;274:114043
Journal of ethnopharmacology 2021 Jun 28;274:114043
LncRNA LPAL2/miR-1287-5p/EGFR Axis Modulates TED-Derived Orbital Fibroblast Activation Through Cell Adhesion Factors.
Wang N, Hou SY, Qi X, Deng M, Cao JM, Tong BD, Xiong W
The Journal of clinical endocrinology and metabolism 2021 Jul 13;106(8):e2866-e2886
The Journal of clinical endocrinology and metabolism 2021 Jul 13;106(8):e2866-e2886
GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
Wang W, Sun R, Zeng L, Chen Y, Zhang N, Cao S, Deng S, Meng X, Yang S
Life sciences 2021 Jul 1;276:119439
Life sciences 2021 Jul 1;276:119439
lncRNA SOX2-OT ceRNA network enhances the malignancy of long-term PM(2.5)-exposed human bronchial epithelia.
Fu Y, Li B, Yun J, Xu J, Meng Q, Li X, Chen R
Ecotoxicology and environmental safety 2021 Jul 1;217:112242
Ecotoxicology and environmental safety 2021 Jul 1;217:112242
Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma.
Jiang F, Ren S, Chen Y, Zhang A, Zhu Y, Zhang Z, Li Z, Piao D
Oncology reports 2021 Jan;45(1):139-150
Oncology reports 2021 Jan;45(1):139-150
Elevated ZBTB7A expression in the tumor invasive front correlates with more tumor budding formation in gastric adenocarcinoma.
Sun Y, He J, Shi DB, Zhang H, Chen X, Xing AY, Gao P
Journal of cancer research and clinical oncology 2021 Jan;147(1):105-115
Journal of cancer research and clinical oncology 2021 Jan;147(1):105-115
Effects of ER-resident and secreted AGR2 on cell proliferation, migration, invasion, and survival in PANC-1 pancreatic cancer cells.
Hong X, Li ZX, Hou J, Zhang HY, Zhang CY, Zhang J, Sun H, Pang LH, Wang T, Deng ZH
BMC cancer 2021 Jan 7;21(1):33
BMC cancer 2021 Jan 7;21(1):33
Cell membrane-encapsulated magnetic nanoparticles for enhancing natural killer cell-mediated cancer immunotherapy.
Wu D, Shou X, Zhang Y, Li Z, Wu G, Wu D, Wu J, Shi S, Wang S
Nanomedicine : nanotechnology, biology, and medicine 2021 Feb;32:102333
Nanomedicine : nanotechnology, biology, and medicine 2021 Feb;32:102333
CALM1 promotes progression and dampens chemosensitivity to EGFR inhibitor in esophageal squamous cell carcinoma.
Liu T, Han X, Zheng S, Liu Q, Tuerxun A, Zhang Q, Yang L, Lu X
Cancer cell international 2021 Feb 18;21(1):121
Cancer cell international 2021 Feb 18;21(1):121
Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma.
Chen T, Liu L, Zou Y, Hu X, Zhang W, Zhou T, Luo X, Fu W, Xu J
Cancer biology & medicine 2021 Feb 15;18(1):227-244
Cancer biology & medicine 2021 Feb 15;18(1):227-244
[6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling.
Jiang X, Wang J, Chen P, He Z, Xu J, Chen Y, Liu X, Jiang J
Cancer cell international 2021 Aug 10;21(1):420
Cancer cell international 2021 Aug 10;21(1):420
Exosomal miR-27 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS.
Liu K, Yang W, Hu M, Xie W, Huang J, Cui M, He X, Nie X
Journal of cellular and molecular medicine 2021 Apr;25(8):3976-3990
Journal of cellular and molecular medicine 2021 Apr;25(8):3976-3990
Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect.
Zhu D, Li S, Chen C, Wang S, Zhu J, Kong L, Luo J
Pharmacological research 2021 Apr;166:105523
Pharmacological research 2021 Apr;166:105523
JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling.
Ren Y, Chen D, Zhai Z, Chen J, Li A, Liang Y, Zhou J
Cell death discovery 2021 Apr 19;7(1):85
Cell death discovery 2021 Apr 19;7(1):85
Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth.
Zhang J, Sun Y, Zhong LY, Yu NN, Ouyang L, Fang RD, Wang Y, He QY
Computational and structural biotechnology journal 2020;18:3936-3946
Computational and structural biotechnology journal 2020;18:3936-3946
RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro.
Yu X, Yang F, Jiang H, Fan L
Drug design, development and therapy 2020;14:121-128
Drug design, development and therapy 2020;14:121-128
METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner.
Shi Y, Zhuang Y, Zhang J, Chen M, Wu S
Cancer management and research 2020;12:13173-13184
Cancer management and research 2020;12:13173-13184
α1,6-Fucosyltransferase (FUT8) regulates the cancer-promoting capacity of cancer-associated fibroblasts (CAFs) by modifying EGFR core fucosylation (CF) in non-small cell lung cancer (NSCLC).
Li F, Zhao S, Cui Y, Guo T, Qiang J, Xie Q, Yu W, Guo W, Deng W, Gu C, Wu T
American journal of cancer research 2020;10(3):816-837
American journal of cancer research 2020;10(3):816-837
EGFR/FOXO3A/LXR-α Axis Promotes Prostate Cancer Proliferation and Metastasis and Dual-Targeting LXR-α/EGFR Shows Synthetic Lethality.
Chen T, Xu J, Fu W
Frontiers in oncology 2020;10:1688
Frontiers in oncology 2020;10:1688
Lapatinib‑induced inhibition of ovarian function is counteracted by the STAT3 pathway both in vivo and in vitro.
Liao Q, Feng X, Li X, Chen G, Chen J, Yang B, Li K, Ai J
Oncology reports 2020 Sep;44(3):1127-1135
Oncology reports 2020 Sep;44(3):1127-1135
ΔNp63α is a super enhancer-enriched master factor controlling the basal-to-luminal differentiation transcriptional program and gene regulatory networks in nasopharyngeal carcinoma.
Cai J, Chen S, Yi M, Tan Y, Peng Q, Ban Y, Yang J, Li X, Zeng Z, Xiong W, McCarthy JB, Li G, Li X, Xiang B
Carcinogenesis 2020 Sep 24;41(9):1282-1293
Carcinogenesis 2020 Sep 24;41(9):1282-1293
FUT4siRNA augments the chemosensitivity of non-small cell lung cancer to cisplatin through activation of FOXO1-induced apoptosis.
Gao W, Liang J, Ye Y, Lu J, Lin T, Wang N, Dong J, Pan J
BMC cancer 2020 Sep 18;20(1):895
BMC cancer 2020 Sep 18;20(1):895
Down-regulation of NTSR3 inhibits cell growth and metastasis, as well as the PI3K-AKT and MAPK signaling pathways in colorectal cancer.
Liu A, Zuo Z, Liu L, Liu L
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Oct;98(5):548-555
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Oct;98(5):548-555
Hypoxia Alters the Response to Anti-EGFR Therapy by Regulating EGFR Expression and Downstream Signaling in a DNA Methylation-Specific and HIF-Dependent Manner.
Mamo M, Ye IC, DiGiacomo JW, Park JY, Downs B, Gilkes DM
Cancer research 2020 Nov 15;80(22):4998-5010
Cancer research 2020 Nov 15;80(22):4998-5010
EGFR-targeted CAR-T cells are potent and specific in suppressing triple-negative breast cancer both in vitro and in vivo.
Xia L, Zheng ZZ, Liu JY, Chen YJ, Ding JC, Xia NS, Luo WX, Liu W
Clinical & translational immunology 2020 May;9(5):e01135
Clinical & translational immunology 2020 May;9(5):e01135
Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer.
Ryu WJ, Lee JD, Park JC, Cha PH, Cho YH, Kim JY, Sohn JH, Paik S, Choi KY
Experimental & molecular medicine 2020 May;52(5):832-842
Experimental & molecular medicine 2020 May;52(5):832-842
HUWE1 promotes EGFR ubiquitination and degradation to protect against renal tubulointerstitial fibrosis.
Zhu Q, Dong H, Bukhari AA, Zhao A, Li M, Sun Y, Zhang X, Cao C, Su D, Liang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4591-4601
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4591-4601
Preclinical Evaluation of the Novel Small-Molecule MSI-N1014 for Treating Drug-Resistant Colon Cancer via the LGR5/β-catenin/miR-142-3p Network and Reducing Cancer-Associated Fibroblast Transformation.
Yadav VK, Huang YJ, George TA, Wei PL, Sumitra MR, Ho CL, Chang TH, Wu ATH, Huang HS
Cancers 2020 Jun 16;12(6)
Cancers 2020 Jun 16;12(6)
Serine Protease Imbalance in the Small Airways and Development of Centrilobular Emphysema in Chronic Obstructive Pulmonary Disease.
Uemasu K, Tanabe N, Tanimura K, Hasegawa K, Mizutani T, Hamakawa Y, Sato S, Ogawa E, Thomas MJ, Ikegami M, Muro S, Hirai T, Sato A
American journal of respiratory cell and molecular biology 2020 Jul;63(1):67-78
American journal of respiratory cell and molecular biology 2020 Jul;63(1):67-78
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
Li J, Ma J, Tian Y, Zhao P, Liu X, Dong H, Zheng W, Feng S, Zhang L, Wu M, Zhu L, Liu S, Zhao D
Journal of ethnopharmacology 2020 Jul 15;257:112796
Journal of ethnopharmacology 2020 Jul 15;257:112796
EGFR-PKM2 signaling promotes the metastatic potential of nasopharyngeal carcinoma through induction of FOSL1 and ANTXR2.
Chen S, Youhong T, Tan Y, He Y, Ban Y, Cai J, Li X, Xiong W, Zeng Z, Li G, Yi M, Liu W, Xiang B
Carcinogenesis 2020 Jul 10;41(6):723-733
Carcinogenesis 2020 Jul 10;41(6):723-733
Human Neutrophil Elastase Induces MUC5AC Overexpression in Chronic Rhinosinusitis Through miR-146a.
Yan D, Ye Y, Zhang J, Zhao J, Yu J, Luo Q
American journal of rhinology & allergy 2020 Jan;34(1):59-69
American journal of rhinology & allergy 2020 Jan;34(1):59-69
[High expression of STAT2 in ovarian cancer and its effect on metastasis of ovarian cancer cells].
Chen X, Huang J, Lü Y
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2020 Jan 30;40(1):34-41
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2020 Jan 30;40(1):34-41
VPS33B negatively modulated by nicotine functions as a tumor suppressor in colorectal cancer.
Chen Y, Liu Z, Wang H, Tang Z, Liu Y, Liang Z, Deng X, Zhao M, Fu Q, Li L, Cai H, Xie W, Fang W
International journal of cancer 2020 Jan 15;146(2):496-509
International journal of cancer 2020 Jan 15;146(2):496-509
DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2α- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation.
Evagelou SL, Bebenek O, Specker EJ, Uniacke J
Molecular and cellular biology 2020 Feb 27;40(6)
Molecular and cellular biology 2020 Feb 27;40(6)
Exploration of the Effects of Substrate Stiffness on Biological Responses of Neural Cells and Their Mechanisms.
Zhang C, Tan Y, Feng J, Huang C, Liu B, Fan Z, Xu B, Lu T
ACS omega 2020 Dec 8;5(48):31115-31125
ACS omega 2020 Dec 8;5(48):31115-31125
MiR-30a-5p inhibits proliferation and metastasis of hydatidiform mole by regulating B3GNT5 through ERK/AKT pathways.
Guo Z, Sun Q, Liao Y, Liu C, Zhao W, Li X, Liu H, Dong M, Shang Y, Sui L, Kong Y
Journal of cellular and molecular medicine 2020 Aug;24(15):8350-8362
Journal of cellular and molecular medicine 2020 Aug;24(15):8350-8362
ZEB1-Mediated Transcriptional Upregulation of circWWC3 Promotes Breast Cancer Progression through Activating Ras Signaling Pathway.
Meng L, Liu S, Liu F, Sang M, Ju Y, Fan X, Gu L, Li Z, Geng C, Sang M
Molecular therapy. Nucleic acids 2020 Aug 19;22:124-137
Molecular therapy. Nucleic acids 2020 Aug 19;22:124-137
Prolonged siRNA expression in mammalian cells using an Epstein-Barr virus-based plasmid expression system.
Wu Y, Song T, Chen P, Jiang X, Wang Q, Chen Q
Biochemical and biophysical research communications 2020 Aug 13;529(1):51-56
Biochemical and biophysical research communications 2020 Aug 13;529(1):51-56
DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas.
Yang MQ, Bai LL, Lei L, Zheng YW, Wang Z, Li ZH, Liu CC, Huang WJ, Xu HT
Oncology reports 2020 Apr;43(4):1338-1348
Oncology reports 2020 Apr;43(4):1338-1348
CAPE-pNO(2) Inhibited the Growth and Metastasis of Triple-Negative Breast Cancer via the EGFR/STAT3/Akt/E-Cadherin Signaling Pathway.
Huang Q, Li S, Zhang L, Qiao X, Zhang Y, Zhao X, Xiao G, Li Z
Frontiers in oncology 2019;9:461
Frontiers in oncology 2019;9:461
SEMA3C Promotes Cervical Cancer Growth and Is Associated With Poor Prognosis.
Liu R, Shuai Y, Luo J, Zhang Z
Frontiers in oncology 2019;9:1035
Frontiers in oncology 2019;9:1035
DpdtbA-Induced Growth Inhibition in Human Esophageal Cancer Cells Involved Inactivation of the p53/EGFR/AKT Pathway.
Wang Z, Li C, Li Y, Guo X, Yan Z, Gao F, Li C
Oxidative medicine and cellular longevity 2019;2019:5414670
Oxidative medicine and cellular longevity 2019;2019:5414670
Verteporfin suppresses the proliferation, epithelial-mesenchymal transition and stemness of head and neck squamous carcinoma cells via inhibiting YAP1.
Liu K, Du S, Gao P, Zheng J
Journal of Cancer 2019;10(18):4196-4207
Journal of Cancer 2019;10(18):4196-4207
Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration.
Wang K, Zhu TN, Zhao RJ
Molecular medicine reports 2019 Oct;20(4):3671-3678
Molecular medicine reports 2019 Oct;20(4):3671-3678
Erlotinib overcomes paclitaxel-resistant cancer stem cells by blocking the EGFR-CREB/GRβ-IL-6 axis in MUC1-positive cervical cancer.
Lv Y, Cang W, Li Q, Liao X, Zhan M, Deng H, Li S, Jin W, Pang Z, Qiu X, Zhao K, Chen G, Qiu L, Huang L
Oncogenesis 2019 Nov 26;8(12):70
Oncogenesis 2019 Nov 26;8(12):70
The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking.
Mao Y, Tu R, Huang Y, Mao D, Yang Z, Lau PK, Wang J, Ni J, Guo Y, Xie T
Development (Cambridge, England) 2019 Jun 28;146(13)
Development (Cambridge, England) 2019 Jun 28;146(13)
An in vivo anti-tumor effect of eckol from marine brown algae by improving the immune response.
Zhang MY, Guo J, Hu XM, Zhao SQ, Li SL, Wang J
Food & function 2019 Jul 17;10(7):4361-4371
Food & function 2019 Jul 17;10(7):4361-4371
miR-323-3p regulates the steroidogenesis and cell apoptosis in polycystic ovary syndrome (PCOS) by targeting IGF-1.
Wang T, Liu Y, Lv M, Xing Q, Zhang Z, He X, Xu Y, Wei Z, Cao Y
Gene 2019 Jan 30;683:87-100
Gene 2019 Jan 30;683:87-100
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, Qian M, Guo J, Xu J, Cao L, Chin YE, Coppé JP, Lam EW, Campisi J, Sun Y
Aging cell 2019 Dec;18(6):e13027
Aging cell 2019 Dec;18(6):e13027
Prognostic significance of contactin 3 expression and associated genes in glioblastoma multiforme.
Zhu YF, Guo YB, Zhang HY, Yang P, Wei DF, Zhang TT, Pan BR, Liu L
Oncology letters 2019 Aug;18(2):1863-1871
Oncology letters 2019 Aug;18(2):1863-1871
The anti-androgenic effects of cypermethrin mediated by non-classical testosterone pathway activation of mitogen-activated protein kinase cascade in mouse Sertoli cells.
Wang Q, Wang HX, Shen JY, Zhang R, Hong JW, Li Z, Chen G, Li MX, Ding Z, Li J, Zhang JP, Zhang MR, Xu LC
Ecotoxicology and environmental safety 2019 Aug 15;177:58-65
Ecotoxicology and environmental safety 2019 Aug 15;177:58-65
Adaptive EGF expression sensitizes pancreatic cancer cells to ionizing radiation through activation of the cyclin D1/P53/PARP pathway.
Liu X, Chen H, Hou Y, Ma X, Ye M, Huang R, Hu B, Cao H, Xu L, Liu M, Li L, Gao J, Bai Y
International journal of oncology 2019 Apr;54(4):1466-1480
International journal of oncology 2019 Apr;54(4):1466-1480
Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner.
Qin Z, Xiang C, Zhong F, Liu Y, Dong Q, Li K, Shi W, Ding C, Qin L, He F
Journal of experimental & clinical cancer research : CR 2019 Apr 11;38(1):154
Journal of experimental & clinical cancer research : CR 2019 Apr 11;38(1):154
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Gao Y, Yu H, Liu Y, Liu X, Zheng J, Ma J, Gong W, Chen J, Zhao L, Tian Y, Xue Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(1):131-147
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(1):131-147
Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells.
Lai X, Su W, Zhao H, Yang S, Zeng T, Wu W, Wang D
FEBS open bio 2018 May;8(5):743-750
FEBS open bio 2018 May;8(5):743-750
Sensitisation of Cancer Cells to MLN8237, an Aurora-A Inhibitor, by YAP/TAZ Inactivation.
Oku Y, Nishiya N, Sugiyama S, Sato H, Uehara Y
Anticancer research 2018 Jun;38(6):3471-3476
Anticancer research 2018 Jun;38(6):3471-3476
Relationship of Epidermal Growth Factor Receptor Expression with Clinical Symptoms and Metastasis of Invasive Breast Cancer.
Han L, Li L, Wang N, Xiong Y, Li Y, Gu Y
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2018 Dec;38(12):578-582
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2018 Dec;38(12):578-582
Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snail1 pathway.
Wu D, Zhao B, Qi X, Peng F, Fu H, Chi X, Miao QR, Shao S
Cancer letters 2018 Apr 1;418:135-146
Cancer letters 2018 Apr 1;418:135-146
Porphyromonas gingivalis and its lipopolysaccharide differently modulate epidermal growth factor-dependent signaling in human gingival epithelial cells.
Elkaim R, Bugueno-Valdebenito IM, Benkirane-Jessel N, Tenenbaum H
Journal of oral microbiology 2017;9(1):1334503
Journal of oral microbiology 2017;9(1):1334503
miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury.
Shi J, Bei Y, Kong X, Liu X, Lei Z, Xu T, Wang H, Xuan Q, Chen P, Xu J, Che L, Liu H, Zhong J, Sluijter JP, Li X, Rosenzweig A, Xiao J
Theranostics 2017;7(3):664-676
Theranostics 2017;7(3):664-676
Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells.
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OncoTargets and therapy 2017;10:3971-3978
OncoTargets and therapy 2017;10:3971-3978
ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats.
Zheng Q, Li Y, Zhang D, Cui X, Dai K, Yang Y, Liu S, Tan J, Yan Q
Cell death & disease 2017 Oct 26;8(10):e3145
Cell death & disease 2017 Oct 26;8(10):e3145
S100P is associated with proliferation and migration in nasopharyngeal carcinoma.
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Oncology letters 2017 Jul;14(1):525-532
Oncology letters 2017 Jul;14(1):525-532
Propofol enhances the cisplatin-induced apoptosis on cervical cancer cells via EGFR/JAK2/STAT3 pathway.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Feb;86:324-333
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Feb;86:324-333
Induction of apoptosis by FFJ-5, a novel naphthoquinone compound, occurs via downregulation of PKM2 in A549 and HepG2 cells.
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Oncology letters 2017 Feb;13(2):791-799
Oncology letters 2017 Feb;13(2):791-799
Hyperthermia with different temperatures inhibits proliferation and promotes apoptosis through the EGFR/STAT3 pathway in C6 rat glioma cells.
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Molecular medicine reports 2017 Dec;16(6):9401-9408
Molecular medicine reports 2017 Dec;16(6):9401-9408
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Oncotarget 2017 Dec 29;8(70):114663-114676
Oncotarget 2017 Dec 29;8(70):114663-114676
Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.
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Journal of experimental & clinical cancer research : CR 2016 Sep 22;35(1):149
Journal of experimental & clinical cancer research : CR 2016 Sep 22;35(1):149
Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome.
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Scientific reports 2016 Nov 15;6:37200
Scientific reports 2016 Nov 15;6:37200
Gingerol Reverses the Cancer-Promoting Effect of Capsaicin by Increased TRPV1 Level in a Urethane-Induced Lung Carcinogenic Model.
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Journal of agricultural and food chemistry 2016 Aug 10;64(31):6203-11
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Molecular medicine reports 2015 Jul;12(1):1421-8
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Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
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Eupolyphaga sinensis Walker inhibits human chronic myeloid leukemia cell K562 growth by inducing G2-M phase cell cycle arrest and targeting EGFR signaling pathway and in S180 tumor-bearing mice.
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Environmental toxicology and pharmacology 2014 May;37(3):1177-85
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Nanotechnology 2014 Jun 27;25(25):255102
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World journal of surgical oncology 2014 Dec 2;12:367
World journal of surgical oncology 2014 Dec 2;12:367
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PloS one 2013;8(12):e83429
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Current biology : CB 2013 Mar 18;23(6):453-61
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Biological & pharmaceutical bulletin 2012;35(11):1964-71
Biological & pharmaceutical bulletin 2012;35(11):1964-71
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Asian Pacific journal of cancer prevention : APJCP 2012;13(7):3471-6
Asian Pacific journal of cancer prevention : APJCP 2012;13(7):3471-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 18986-1-AP(EGFR-Specific antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using EGFR antibody 189861-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-EGFR-Specific (IP:18986-1-AP, 3ug; Detection:18986-1-AP 1:500) with MCF-7 cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 18986-1-AP(EGFR-Specific antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 18986-1-AP(EGFR-Specific antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
