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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Product number
- ABIN362028 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Epidermal Growth Factor Receptor (EGFR) (pTyr1092) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around phosphorylation site of pTyr1092 (P-E-Y (p) -I-N) derived from Human EGFR. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- pTyr1092
- Isotype
- IgG
- Vial size
- 100 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF.
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.
Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.
Ganglioside GM3 blocks the activation of epidermal growth factor receptor induced by integrin at specific tyrosine sites.
Saito T, Okada S, Ohshima K, Yamada E, Sato M, Uehara Y, Shimizu H, Pessin JE, Mori M
Endocrinology 2004 Sep;145(9):4232-43
Endocrinology 2004 Sep;145(9):4232-43
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.
Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, Mardis E, Kupfer D, Wilson R, Kris M, Varmus H
Proceedings of the National Academy of Sciences of the United States of America 2004 Sep 7;101(36):13306-11
Proceedings of the National Academy of Sciences of the United States of America 2004 Sep 7;101(36):13306-11
Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.
Buerger C, Nagel-Wolfrum K, Kunz C, Wittig I, Butz K, Hoppe-Seyler F, Groner B
The Journal of biological chemistry 2003 Sep 26;278(39):37610-21
The Journal of biological chemistry 2003 Sep 26;278(39):37610-21
Ganglioside GM3 blocks the activation of epidermal growth factor receptor induced by integrin at specific tyrosine sites.
Wang XQ, Sun P, Paller AS
The Journal of biological chemistry 2003 Dec 5;278(49):48770-8
The Journal of biological chemistry 2003 Dec 5;278(49):48770-8
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