ABIN197027

antibody from antibodies-online

Targeting: EGFR ERBB, ERBB1

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN197027

Provider

antibodies-online

Product name

anti-Epidermal Growth Factor Receptor (EGFR) (pTyr1110) antibody

Antibody type

Polyclonal

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

pTyr1110

Vial size

50 μL

Storage

-20°C

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells.

Erjala K, Sundvall M, Junttila TT, Zhang N, Savisalo M, Mali P, Kulmala J, Pulkkinen J, Grenman R, Elenius K
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Jul 1;12(13):4103-11

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ZD1839, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER2-overexpressing breast cancer cells.

Anido J, Matar P, Albanell J, Guzmán M, Rojo F, Arribas J, Averbuch S, Baselga J
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Apr;9(4):1274-83

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Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade.

Andreev J, Galisteo ML, Kranenburg O, Logan SK, Chiu ES, Okigaki M, Cary LA, Moolenaar WH, Schlessinger J
The Journal of biological chemistry 2001 Jun 8;276(23):20130-5