RA0196

antibody from Oursmab

Targeting: EGFR ERBB, ERBB1

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Validation data

Product number: RA0196 - Provider product page
Provider: Oursmab
Product name: Depatuxizumab (Biosimilar Reference Antibody) (EGFR)
Antibody type: Monoclonal
Description: Depatuxizumab mafodotin (also known as ABT-414) was an investigational antibody-drug conjugate (ADC) developed for the treatment of glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor. It combined a humanized monoclonal antibody with a potent cytotoxic payload, designed to selectively target and kill tumor cells overexpressing a specific receptor. Clinical trials evaluated its efficacy, both as monotherapy and in combination with standard chemoradiotherapy (temozolomide), in patients with newly diagnosed or recurrent EGFR-amplified glioblastoma. Despite showing signs of activity, its development was ultimately discontinued after Phase III trials failed to demonstrate a statistically significant improvement in overall survival compared to standard of care.
Reactivity: Human
Isotype: IgG
Vial size: 100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg
Concentration: Bottled at the concentration indicated on the vial.
Storage: Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

EGFR protein structure - RA0196 shown in red.