HPA002997

antibody from Atlas Antibodies

Targeting: LAMTOR1 C11orf59, FLJ20625, p18, p27RF-Rho, Pdro, Ragulator1

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA002997

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA002997, RRID:AB_1845531

Product name

Anti-LAMTOR1

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human LAMTOR1, Gene description: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1, Alternative Gene Names: C11orf59, FLJ20625, p18, p27RF-Rho, Pdro, Ragulator1, Validated applications: IHC, Uniprot ID: Q6IAA8, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.2 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

The lysosomal LAMTOR / Ragulator complex is essential for nutrient homeostasis in brown adipose tissue.

Liebscher G, Vujic N, Schreiber R, Heine M, Krebiehl C, Duta-Mare M, Lamberti G, de Smet CH, Hess MW, Eichmann TO, Hölzl S, Scheja L, Heeren J, Kratky D, Huber LA
Molecular metabolism 2023 May;71:101705

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Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo

Singh J, Elhabashy H, Muthukottiappan P, Stepath M, Eisenacher M, Kohlbacher O, Gieselmann V, Winter D
Nature Communications 2022;13(1)

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UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

Sun J, Liu Y, Jia Y, Hao X, Lin W, Tran J, Lynch G, Baudry M, Bi X
eLife 2018;7

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LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning.

Filipek PA, de Araujo MEG, Vogel GF, De Smet CH, Eberharter D, Rebsamen M, Rudashevskaya EL, Kremser L, Yordanov T, Tschaikner P, Fürnrohr BG, Lechner S, Dunzendorfer-Matt T, Scheffzek K, Bennett KL, Superti-Furga G, Lindner HH, Stasyk T, Huber LA
The Journal of cell biology 2017 Dec 4;216(12):4199-4215

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mTOR activates the VPS 34– UVRAG complex to regulate autolysosomal tubulation and cell survival

Munson M, Allen G, Toth R, Campbell D, Lucocq J, Ganley I
The EMBO Journal 2015;34(17):2272-2290

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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

Martina J, Chen Y, Gucek M, Puertollano R
Autophagy 2014;8(6):903-914

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The late endosomal adaptor p14 is a macrophage host defense factor against Salmonella Typhimurium infection

Taub N, Nairz M, Hilber D, Hess M, Weiss G, Huber L
Journal of Cell Science 2012

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Proteomic analysis of endosomes from genetically modified p14/MP1 mouse embryonic fibroblasts

Stasyk T, Holzmann J, Stumberger S, Ebner H, Hess M, Bonn G, Mechtler K, Huber L
PROTEOMICS 2010;10(22):4117-4127