Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 24546-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- SHP1 antibody
- Antibody type
- Polyclonal
- Description
- SHP1 antibody (Cat. #24546-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors.
CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway.
RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination.
Anticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1.
A thiazole-derived oridonin analogue exhibits antitumor activity by directly and allosterically inhibiting STAT3.
Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.
Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death.
Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.
Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling.
Xu X, Masubuchi T, Cai Q, Zhao Y, Hui E
eLife 2021 Nov 4;10
eLife 2021 Nov 4;10
CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway.
Chi D, Wang D, Zhang M, Ma H, Chen F, Sun Y
Experimental cell research 2021 Dec 15;409(2):112914
Experimental cell research 2021 Dec 15;409(2):112914
RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination.
Ren Y, Xu X, Mao CY, Han KK, Xu YJ, Cao BY, Zhang ZB, Sethi G, Tang XW, Mao XL
Acta pharmacologica Sinica 2020 Mar;41(3):394-403
Acta pharmacologica Sinica 2020 Mar;41(3):394-403
Anticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1.
Zhang H, Tan YP, Zhao L, Wang L, Fu NJ, Zheng SP, Shen XF
Cell death & disease 2020 Jan 24;11(1):63
Cell death & disease 2020 Jan 24;11(1):63
A thiazole-derived oridonin analogue exhibits antitumor activity by directly and allosterically inhibiting STAT3.
Shen X, Zhao L, Chen P, Gong Y, Liu D, Zhang X, Dai L, Sun Q, Lou J, Jin Z, Zhang B, Niu D, Chen C, Qi X, Jia D
The Journal of biological chemistry 2019 Nov 15;294(46):17471-17486
The Journal of biological chemistry 2019 Nov 15;294(46):17471-17486
Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.
Maryam A, Mehmood T, Yan Q, Li Y, Khan M, Ma T
Oxidative medicine and cellular longevity 2018;2018:3853409
Oxidative medicine and cellular longevity 2018;2018:3853409
Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death.
Xie L, Zeng Y, Dai Z, He W, Ke H, Lin Q, Chen Y, Bu J, Lin D, Zheng M
International journal of biological sciences 2018;14(5):577-585
International journal of biological sciences 2018;14(5):577-585
Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.
Igbe I, Shen XF, Jiao W, Qiang Z, Deng T, Li S, Liu WL, Liu HW, Zhang GL, Wang F
Oncotarget 2017 Dec 26;8(69):113734-113748
Oncotarget 2017 Dec 26;8(69):113734-113748
Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling.
Xiang M, Su H, Hong Z, Yang T, Shu G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jun;80:62-71
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jun;80:62-71
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 24546-1-AP( PTPN6 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SHP1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SHP1. This antibody recognizes human antigen. The SHP1 antibody has been validated for the following applications: ELISA, WB, IF analysis.