24546-1-AP

antibody from Proteintech Group

Targeting: PTPN6 HCP, HCPH, PTP-1C, SHP-1, SHP1

Provider product page for 24546-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [17]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 24546-1-AP - Provider product page
Provider: Proteintech Group
Product name: SHP1 antibody
Antibody type: Polyclonal
Description: SHP1 antibody (Cat. #24546-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PTPN6 protein structure - 24546-1-AP shown in red.

Submitted references Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.

Qian B, Lu R, Mao S, Chen Y, Yang M, Zhang W, Zhang M, Zhu D, Liu Z, Zen K, Li L
Cell reports 2024 May 28;43(5):114249

5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects of AG490 against Primary Effusion Lymphoma Cells.

Di Crosta M, Arena A, Benedetti R, Gilardini Montani MS, Cirone M
Current issues in molecular biology 2024 Mar 14;46(3):2468-2479

cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity.

Ma D, Yang M, Sun C, Cui X, Xiong G, Wang Q, Jing W, Chen H, Lv X, Liu S, Li T, Zhao Y, Han L
Cell death and differentiation 2024 Jun;31(6):722-737

Postbiotics Prepared Using Lactobacillus reuteri Ameliorates Ethanol-Induced Liver Injury by Regulating the FXR/SHP/SREBP-1c Axis.

Liu C, Cai T, Cheng Y, Bai J, Li M, Gu B, Huang M, Fu W
Molecular nutrition & food research 2024 Jul;68(14):e2300927

1-Pyrroline-5-carboxylate inhibit T cell glycolysis in prostate cancer microenvironment by SHP1/PKM2/LDHB axis.

Chang L, Li G, Jiang S, Li J, Yang J, Shah K, Zhou L, Song H, Deng L, Luo Z, Guo Y, Yan Y
Cell communication and signaling : CCS 2024 Feb 8;22(1):101

Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance.

Gao X, Wu Y, Chick JM, Abbott A, Jiang B, Wang DJ, Comte-Walters S, Johnson RH, Oberholtzer N, Nishimura MI, Gygi SP, Mehta A, Guttridge DC, Ball L, Mehrotra S, Sicinski P, Yu XZ, Wang H
Cell reports 2023 Apr 25;42(4):112314

Host MKRN1-Mediated Mycobacterial PPE Protein Ubiquitination Suppresses Innate Immune Response.

Dou Y, Xie Y, Zhang L, Liu S, Xu D, Wei Y, Li Y, Zhang XL
Frontiers in immunology 2022;13:880315

Src-homology domain 2 containing protein tyrosine phosphatase-1 (SHP-1) directly binds to proto-oncogene tyrosine-protein kinase Src (c-Src) and promotes the transcriptional activation of connexin 43 (Cx43).

Liu Y, Dai M, Yang P, Cao L, Lu L
Bioengineered 2022 May;13(5):13534-13543

Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors.

Xu X, Masubuchi T, Cai Q, Zhao Y, Hui E
eLife 2021 Nov 4;10

CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway.

Chi D, Wang D, Zhang M, Ma H, Chen F, Sun Y
Experimental cell research 2021 Dec 15;409(2):112914

RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination.

Ren Y, Xu X, Mao CY, Han KK, Xu YJ, Cao BY, Zhang ZB, Sethi G, Tang XW, Mao XL
Acta pharmacologica Sinica 2020 Mar;41(3):394-403

Anticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1.

Zhang H, Tan YP, Zhao L, Wang L, Fu NJ, Zheng SP, Shen XF
Cell death & disease 2020 Jan 24;11(1):63

A thiazole-derived oridonin analogue exhibits antitumor activity by directly and allosterically inhibiting STAT3.

Shen X, Zhao L, Chen P, Gong Y, Liu D, Zhang X, Dai L, Sun Q, Lou J, Jin Z, Zhang B, Niu D, Chen C, Qi X, Jia D
The Journal of biological chemistry 2019 Nov 15;294(46):17471-17486

Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.

Maryam A, Mehmood T, Yan Q, Li Y, Khan M, Ma T
Oxidative medicine and cellular longevity 2018;2018:3853409

Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death.

Xie L, Zeng Y, Dai Z, He W, Ke H, Lin Q, Chen Y, Bu J, Lin D, Zheng M
International journal of biological sciences 2018;14(5):577-585

Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.

Igbe I, Shen XF, Jiao W, Qiang Z, Deng T, Li S, Liu WL, Liu HW, Zhang GL, Wang F
Oncotarget 2017 Dec 26;8(69):113734-113748

Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling.

Xiang M, Su H, Hong Z, Yang T, Shu G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jun;80:62-71

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 24546-1-AP( PTPN6 Antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SHP1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SHP1. This antibody recognizes human antigen. The SHP1 antibody has been validated for the following applications: ELISA, WB, IF analysis.
Appendix: 24546-1-AP.pdf

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