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Immunocytochemistry
Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [8]
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- Validations
- Chromatin Immunoprecipitation [1]
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- Product number
- HPA012672 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA012672, RRID:AB_1847466
- Product name
- Anti-DACH1
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human DACH1, Gene description: dachshund family transcription factor 1, Alternative Gene Names: DACH, Validated applications: ChIP, ICC, IHC, Uniprot ID: , Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.1 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references The classical pathway triggers pathogenic complement activation in membranous nephropathy
Deep learning–based molecular morphometrics for kidney biopsies
DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity
Decoding myofibroblast origins in human kidney fibrosis
Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis
DACH1 , a Zona Glomerulosa Selective Gene in the Human Adrenal, Activates Transforming Growth Factor-β Signaling and Suppresses Aldosterone Secretion
DACH1: Its Role as a Classifier of Long Term Good Prognosis in Luminal Breast Cancer
A comprehensive look at transcription factor gene expression changes in colorectal adenomas
Seifert L, Zahner G, Meyer-Schwesinger C, Hickstein N, Dehde S, Wulf S, Köllner S, Lucas R, Kylies D, Froembling S, Zielinski S, Kretz O, Borodovsky A, Biniaminov S, Wang Y, Cheng H, Koch-Nolte F, Zipfel P, Hopfer H, Puelles V, Panzer U, Huber T, Wiech T, Tomas N
Nature Communications 2023;14(1)
Nature Communications 2023;14(1)
Deep learning–based molecular morphometrics for kidney biopsies
Zimmermann M, Klaus M, Wong M, Thebille A, Gernhold L, Kuppe C, Halder M, Kranz J, Wanner N, Braun F, Wulf S, Wiech T, Panzer U, Krebs C, Hoxha E, Kramann R, Huber T, Bonn S, Puelles V
JCI Insight 2021;6(7)
JCI Insight 2021;6(7)
DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity
Cao A, Li J, Asadi M, Basgen J, Zhu B, Yi Z, Jiang S, Doke T, El Shamy O, Patel N, Cravedi P, Azeloglu E, Campbell K, Menon M, Coca S, Zhang W, Wang H, Zen K, Liu Z, Murphy B, He J, D’Agati V, Susztak K, Kaufman L
Journal of Clinical Investigation 2021;131(10)
Journal of Clinical Investigation 2021;131(10)
Decoding myofibroblast origins in human kidney fibrosis
Kuppe C, Ibrahim M, Kranz J, Zhang X, Ziegler S, Perales-Patón J, Jansen J, Reimer K, Smith J, Dobie R, Wilson-Kanamori J, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles V, Huber T, Boor P, Menzel S, Hoogenboezem R, Bindels E, Steffens J, Floege J, Schneider R, Saez-Rodriguez J, Henderson N, Kramann R
Nature 2020;589(7841):281-286
Nature 2020;589(7841):281-286
Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis
Miesen L, Eymael J, Sharma S, Loeven M, Willemsen B, Bakker-van Bebber M, Mooren F, Meyer-Schwesinger C, Dijkman H, Wetzels J, Jansen J, van der Vlag J, Smeets B
Scientific Reports 2020;10(1)
Scientific Reports 2020;10(1)
DACH1 , a Zona Glomerulosa Selective Gene in the Human Adrenal, Activates Transforming Growth Factor-β Signaling and Suppresses Aldosterone Secretion
Zhou J, Shaikh L, Neogi S, McFarlane I, Zhao W, Figg N, Brighton C, Maniero C, Teo A, Azizan E, Brown M
Hypertension 2015;65(5):1103-1110
Hypertension 2015;65(5):1103-1110
DACH1: Its Role as a Classifier of Long Term Good Prognosis in Luminal Breast Cancer
Rishi A, Powe D, Dhondalay G, Lemetre C, Allen T, Habashy H, Ellis I, Rees R, Ball G
PLoS ONE 2014;9(1):e84428
PLoS ONE 2014;9(1):e84428
A comprehensive look at transcription factor gene expression changes in colorectal adenomas
Vonlanthen J, Okoniewski M, Menigatti M, Cattaneo E, Pellegrini-Ochsner D, Haider R, Jiricny J, Staiano T, Buffoli F, Marra G
BMC Cancer 2014;14(1)
BMC Cancer 2014;14(1)
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- ChIP-Exo-Seq composite graph for Anti-DACH1 (HPA012672, Lot 000019467) tested in K562 cells. Strand-specific reads (blue: forward, red: reverse) and IgG controls (black: forward, grey: reverse) are plotted against the distance from a composite set of reference binding sites. The antibody exhibits robust target enrichment compared to a non-specific IgG control and precisely reveals its structural organization around the binding site. Data generated by Prof. B. F. Pugh´s Lab at Cornell University.
