Antibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10054-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10054-1-AP, RRID:AB_513584
- Product name
- SHC antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SHC antibody (Cat. #10054-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization in liver cirrhosis and hepatocellular carcinoma rat model via the MK/integrin signaling pathway.
p66Shc in sheep preimplantation embryos: Expression and regulation of oxidative stress through the manganese superoxide dismutase-reactive oxygen species metabolic pathway.
Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling.
Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.
Ketamine ameliorates hypoxia-induced endothelial injury in human umbilical vein endothelial cells.
RNA-seq analysis of the key long noncoding RNAs and mRNAs related to cognitive impairment after cardiac arrest and cardiopulmonary resuscitation.
Targeting of miR-96-5p by catalpol ameliorates oxidative stress and hepatic steatosis in LDLr-/- mice via p66shc/cytochrome C cascade.
Protocatechuic Acid-Mediated miR-219a-5p Activation Inhibits the p66shc Oxidant Pathway to Alleviate Alcoholic Liver Injury.
p66Shc is associated with hydrogen peroxide-induced oxidative stress in preimplantation sheep embryos.
Oxidative stress induces B lymphocyte DNA damage and apoptosis by upregulating p66shc.
Fu C, Zhang Y, Xi WJ, Xu K, Meng F, Ma T, Li W, Wu L, Chen Z
Journal of ethnopharmacology 2023 May 23;308:116191
Journal of ethnopharmacology 2023 May 23;308:116191
p66Shc in sheep preimplantation embryos: Expression and regulation of oxidative stress through the manganese superoxide dismutase-reactive oxygen species metabolic pathway.
Zhang T, Zhang J, Li R
Animal bioscience 2023 Jul;36(7):1022-1033
Animal bioscience 2023 Jul;36(7):1022-1033
Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling.
Zhou J, Yang J, Dong Y, Shi Y, Zhu E, Yuan H, Li X, Wang B
Stem cell research & therapy 2022 Jun 28;13(1):278
Stem cell research & therapy 2022 Jun 28;13(1):278
Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.
Liu AD, Zhou J, Bi XY, Hou GQ, Li SS, Chen Q, Xu H, Cao X
Clinical and translational medicine 2021 Mar;11(3):e337
Clinical and translational medicine 2021 Mar;11(3):e337
Ketamine ameliorates hypoxia-induced endothelial injury in human umbilical vein endothelial cells.
Zhou X, Liu J, Yang S, Su Y, Meng Z, Hu Y
Clinics (Sao Paulo, Brazil) 2020;75:e1865
Clinics (Sao Paulo, Brazil) 2020;75:e1865
RNA-seq analysis of the key long noncoding RNAs and mRNAs related to cognitive impairment after cardiac arrest and cardiopulmonary resuscitation.
Chen C, Liu C, Niu Z, Li M, Zhang Y, Gao R, Chen H, Wang Q, Zhang S, Zhou R, Gan L, Zhang Z, Zhu T, Yu H, Liu J
Aging 2020 Jul 21;12(14):14490-14505
Aging 2020 Jul 21;12(14):14490-14505
Targeting of miR-96-5p by catalpol ameliorates oxidative stress and hepatic steatosis in LDLr-/- mice via p66shc/cytochrome C cascade.
Zhang Y, Wang C, Lu J, Jin Y, Xu C, Meng Q, Liu Q, Dong D, Ma X, Liu K, Sun H
Aging 2020 Feb 5;12(3):2049-2069
Aging 2020 Feb 5;12(3):2049-2069
Protocatechuic Acid-Mediated miR-219a-5p Activation Inhibits the p66shc Oxidant Pathway to Alleviate Alcoholic Liver Injury.
Fu R, Zhou J, Wang R, Sun R, Feng D, Wang Z, Zhao Y, Lv L, Tian X, Yao J
Oxidative medicine and cellular longevity 2019;2019:3527809
Oxidative medicine and cellular longevity 2019;2019:3527809
p66Shc is associated with hydrogen peroxide-induced oxidative stress in preimplantation sheep embryos.
Zhang T, Zhao X, Hai R, Li R, Zhang W, Zhang J
Molecular reproduction and development 2019 Mar;86(3):342-350
Molecular reproduction and development 2019 Mar;86(3):342-350
Oxidative stress induces B lymphocyte DNA damage and apoptosis by upregulating p66shc.
Lang JY, Ma K, Guo JX, Sun H
European review for medical and pharmacological sciences 2018 Feb;22(4):1051-1060
European review for medical and pharmacological sciences 2018 Feb;22(4):1051-1060
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10054-1-AP(SHC1 antibody) at dilution of 1:200
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using SHC1 antibody 10054-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 10054-1-AP(SHC1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue