615202

antibody from BioLegend

Targeting: SHC1 p66, SHC, ShcA

Western blot (Data presented on provider website)

Antibody Data

Product number

615202

Provider

BioLegend

Product name

Purified anti-Shc

Antibody type

Polyclonal

Antigen

Recombinant (partial), N-terminal

Description

Shc (Src homology 2 containing protein) was originally identified as a protooncogene involved in growth factor signaling. A cytoplasmic protein, Shc becomes phosphorylated by tyrosine kinases involved in growth factor signaling, antigen receptor signaling, hormone receptor signaling, cytokine receptor signaling, G-coupled receptor signaling, and integrin signaling. Shc functions as an adaptor molecule in signal transduction pathways by virtue of its SH2, SH3, PTB domains. Three isoforms of Shc exist with apparent molecular weights of 46 kD, 52 kD, and 66 kD. Shc facilitates activation of Ras proteins in response to a variety of stimuli and can form stable complexes with receptor tyrosine kinases and receptors devoid of intrinsic kinase activity. Shc has been shown to interact with Grb2 and SOS, receptor tyrosine kinases associated with the receptors for EGF, PDGF, HGF, erbB-2, insulin, and the cytoplasmic tyrosine kinases Lck, Src, and Sea. The Poly6152 antibody recognizes the N-terminal region of human Shc and is useful for Western blotting.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

200 µl

Storage

Upon receipt, store frozen at -20° C.