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- Product number
- 18243-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- TXNIP antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TXNIP antibody (Cat. #18243-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Yigan mingmu decoction treats diabetic retinopathy via Müller cell autophagy: A network pharmacology study.
HIF3A-mediated aberrant activation of TXNIP promotes Alzheimer's disease progression.
Punicalagin Ameliorates Diabetic Cognitive Dysfunction by Inhibiting Neuroinflammation via the CX3CL1/CX3CR1 Axis.
A bioactive protein from Dioscorea polystachya residue alleviates hydrocortisone-induced erectile dysfunction in rats via TXNIP/NLRP3 pathway inhibition.
Differential Toxicity of Water-Soluble Versus Water-Insoluble Components of Cowshed PM2.5 on Ovarian Granulosa Cells and the Regulatory Role of Txnip in Overall Toxicity.
Rhodiola rosea-derived exosome-like nanovesicles inhibit vascular endothelial pyroptosis in the treatment of limb skeletal muscle ischemic injury through the TXNIP/NLNP3 pathway.
Targeting MondoA-TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment.
Overexpression of PBX1 attenuates oxidative stress and apoptosis in diabetic cardiomyopathy by transcriptionally inhibiting TXNIP.
Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.
Molecular interplay between TXNIP and GLUT9 underlies uric acid transport dysregulation in vitro under hyperuricemic stress.
LncRNA MIR17HG accelerates the development of atherosclerosis by promoting macrophage pyroptosis through the miR-301a-3p/TXNIP pathway.
IGFBP2 plays a key role in aerobic exercise-mediated inhibition of ferroptosis in cardiac ischemia/reperfusion (I/R) injury.
Peroxynitrite is key to Cylindrospermopsin-mediated MASLD to MASH progression via triggering TXNIP binding to NLRP3 and subsequent inflammasome activation.
Protocatechuic aldehyde restrains NLRP3 inflammasome activation to alleviate inflammatory response in sepsis.
AMSC-EVs attenuate acute kidney injury through TXNIP-IKKα/NFκB signaling-mediated renal CX3CR1(+) macrophage polarization.
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
Ginsenoside Rg1 attenuates T2DM-induced renal damage and fibrosis by inhibiting TRPC6-ChREBP-TXNIP signaling.
Atractylenolide I Inhibits Nicotine-Induced Macrophage Pyroptosis and Alleviates Atherogenesis by Suppressing the TLR4/ROS/TXNIP/NLRP3 Pathway.
PDIA4 targets IRE1α/sXBP1 to alleviate NLRP3 inflammasome activation and renal tubular injury in diabetic kidney disease.
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
HNMT Promotes the Occurrence and Progression of Nasopharyngeal Carcinoma by Inhibiting the IFN/TXNIP/p53 Axis.
Unfolded protein response-activated NLRP3 inflammasome contributes to pyroptotic and apoptotic podocyte injury in diabetic kidney disease via the CHOP-TXNIP axis.
Txnip/Trx Is a Potential Element in Regulating O-GlcNAc Modification in Photoreceptors to Alleviate Diabetic Retinopathy.
Emodin delays rheumatoid arthritis progression by inhibiting the ROS/TXNIP/NLRP3 signaling pathway.
M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the TXNIP/NLRP3 axis.
UCP2 inhibition exaggerates diabetic cardiomyopathy by facilitating the activation of NLRP3 and pyroptosis.
Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore.
Ginsenoside Rg1 improves hypoxia-induced pulmonary vascular endothelial dysfunction through TXNIP/NLRP3 pathway-modulated mitophagy.
E3 ubiquitination ligase XIAP lightens diabetes-induced cognitive impairment by inactivating TXNIP-ERS-mediated neuronal injury.
Single-cell RNA sequencing of the carotid artery and femoral artery of rats exposed to hindlimb unloading.
Puerarin reduces diabetic nephropathy-induced podocyte pyroptosis by modulating the SIRT1/NLRP3/caspase-1 pathway.
Bioinformatics analysis and validation of novel biomarkers and competitive endogenous RNA networks involved in pyroptosis in diabetic nephropathy.
KLF5 drives granulosa cell apoptosis and inflammatory injury in polycystic ovary syndrome via transcriptional activation of TXNIP.
Cadmium exposure upregulates TXNIP and aggravates calcium oxalate kidney stone formation by promoting cell-crystal adhesion, apoptosis and macrophage M1 polarization.
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein m(6)A methylation.
Metformin Nanodelivery System Alleviates Morphine-Induced Analgesic Tolerance via Inhibiting the TXNIP/NLRP3/GSDMD Axis.
HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition.
Lipid metabolism analysis reveals that DGAT1 regulates Th17 survival by controlling lipid peroxidation in uveitis.
Swietenolide inhibits the TXNIP/NLRP3 pathways via Nrf2 activation to ameliorate cognitive dysfunction in diabetic mice.
Identification of immune-related endoplasmic reticulum stress genes in proliferative diabetic retinopathy using bioinformatics analysis.
piR112710 attenuates diabetic cardiomyopathy through inhibiting Txnip/NLRP3-mediated pyroptosis in db/db mice.
Sesamol Alleviated Lipotoxicity-Induced Dysfunction in MIN6 Cells via Facilitating Cellular Senescence Caused by Endoplasmic Reticulum Stress.
BAP1 inactivation promotes lactate production by leveraging the subcellular localization of LDHA in melanoma.
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis.
Molecular Regulation of Transforming Growth Factor-β1-induced Thioredoxin-interacting Protein Ubiquitination and Proteasomal Degradation in Lung Fibroblasts: Implication in Pulmonary Fibrosis.
Shexiang Tongxin dropping pills protect against ischemic stroke-induced cerebral microvascular dysfunction via suppressing TXNIP/NLRP3 signaling pathway.
Punicalagin Ameliorates Diabetic Liver Injury by Inhibiting Pyroptosis and Promoting Autophagy via Modulation of the FoxO1/TXNIP Signaling Pathway.
O-GlcNAc Modification Is a Promising Therapeutic Target for Diabetic Retinopathy.
Circ6834 suppresses non-small cell lung cancer progression by destabilizing ANHAK and regulating miR-873-5p/TXNIP axis.
Diagnostic and predictive significance of the ferroptosis-related gene TXNIP in lung adenocarcinoma stem cells based on multi-omics.
TXNIP knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis.
The downregulation of SCGN induced by lipotoxicity promotes NLRP3-mediated β-cell pyroptosis.
Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering.
KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling.
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease.
Aminoadipic acid aggravates atherosclerotic vascular inflammation through ROS/TXNIP/NLRP3 pathway, a harmful microbial metabolite reduced by paeonol.
Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation.
Atorvastatin inhibits glioma glycolysis and immune escape by modulating the miR-125a-5p/TXLNA axis.
Betaine improves METH-induced depressive-like behavior and cognitive impairment by alleviating neuroinflammation via NLRP3 inflammasome inhibition.
Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy.
Comparison of Endoplasmic Reticulum Stress and Pyroptosis Induced by Pathogenic Calcium Oxalate Monohydrate and Physiologic Calcium Oxalate Dihydrate Crystals in HK-2 Cells: Insights into Kidney Stone Formation.
Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury.
Upregulation of UHRF1 Promotes PINK1-mediated Mitophagy to Alleviates Ferroptosis in Diabetic Nephropathy.
Exosome-based WTAP siRNA delivery ameliorates myocardial ischemia-reperfusion injury.
A novel cuproptosis pattern and tumor immune microenvironment characterization in urothelial carcinoma of the bladder.
BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2.
Tremella fuciformis polysaccharides alleviates UV-provoked skin cell damage via regulation of thioredoxin interacting protein and thioredoxin reductase 2.
PIAS3 promotes ferroptosis by regulating TXNIP via TGF-β signaling pathway in hepatocellular carcinoma.
Glycosides of Buyang Huanwu decoction inhibits pyroptosis associated with cerebral ischemia-reperfusion through Nrf2-mediated antioxidant signaling pathway both in vivo and in vitro.
Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis.
The PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells.
SIRT1 Inhibits High Glucose-Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation.
Synergistic effects of combined treatment of 1,2-dichloroethane and high-dose ethanol on liver damage in mice and the related mechanisms.
Dihydrotanshinone Triggers Porimin-Dependent Oncosis by ROS-Mediated Mitochondrial Dysfunction in Non-Small-Cell Lung Cancer.
Salidroside protects pancreatic β-cells against pyroptosis by regulating the NLRP3/GSDMD pathway in diabetic conditions.
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein.
ChREBP-β/TXNIP aggravates frucose-induced renal injury through triggering ferroptosis of renal tubular epithelial cells.
Attenuation of ROS/Chloride Efflux-Mediated NLRP3 Inflammasome Activation Contributes to Alleviation of Diabetic Cardiomyopathy in Rats after Sleeve Gastrectomy.
Downregulation of Inflammatory Response via Nrf2/Trx1/TXNIP Axis in Oxidative Stress-Induced ARPE-19 Cells and Mouse Model of AMD.
PPARγ Alleviates Sepsis-Induced Liver Injury by Inhibiting Hepatocyte Pyroptosis via Inhibition of the ROS/TXNIP/NLRP3 Signaling Pathway.
Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model.
MicroRNA-25-5p negatively regulates TXNIP expression and relieves inflammatory responses of brain induced by lipopolysaccharide.
Embryonic Deletion of TXNIP in GABAergic Neurons Enhanced Oxidative Stress in PV+ Interneurons in Primary Somatosensory Cortex of Aging Mice: Relevance to Schizophrenia.
Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension.
Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways.
Localization of Thioredoxin-Interacting Protein in Aging and Alzheimer's Disease Brains.
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats.
A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker.
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication.
Artificial Intelligence-Assisted Bioinformatics, Microneedle, and Diabetic Wound Healing: A "New Deal" of an Old Drug.
Identification of a novel mechanism for reversal of doxorubicin-induced chemotherapy resistance by TXNIP in triple-negative breast cancer via promoting reactive oxygen-mediated DNA damage.
Bletilla striata Polysaccharide Promotes Diabetic Wound Healing Through Inhibition of the NLRP3 Inflammasome.
Downregulation of miR-135b-5p Suppresses Progression of Esophageal Cancer and Contributes to the Effect of Cisplatin.
Upregulation of thioredoxin contributes to inhibiting diabetic hearing impairment.
Ceramide induces the apoptosis of non‑small cell lung cancer cells through the Txnip/Trx1 complex.
MondoA Is Required for Normal Myogenesis and Regulation of the Skeletal Muscle Glycogen Content in Mice.
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.
Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration.
Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells.
The piperine derivative HJ105 inhibits Aβ(1-42)-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.
MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment.
Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes.
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis.
Rosmarinic acid alleviates di-2-ethylhexyl phthalate (DEHP) -induced thyroid dysfunction via multiple inflammasomes activation.
Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats.
Epigenetic repression of miR-17 contributed to di(2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal muscle.
HPV 16 E6/E7 Promote the Glucose Uptake of GLUT1 in Lung Cancer Through Downregulation of TXNIP Due to Inhibition of PTEN Phosphorylation.
Thioredoxin interacting protein (TXNIP) acts as a tumor suppressor in human prostate cancer.
Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway.
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
PSMD12 promotes breast cancer growth via inhibiting the expression of pro-apoptotic genes.
HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.
High Glucose-Aggravated Hepatic Insulin Resistance: Role of the NLRP3 Inflammasome in Kupffer Cells.
Endoplasmic reticulum stress and oxidative stress contribute to neuronal pyroptosis caused by cerebral venous sinus thrombosis in rats: Involvement of TXNIP/peroxynitrite-NLRP3 inflammasome activation.
NecroX-5 alleviate lipopolysaccharide-induced acute respiratory distress syndrome by inhibiting TXNIP/NLRP3 and NF-κB.
Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes.
Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury.
Effects of Hypobaric Hypoxia on Rat Retina and Protective Response of Resveratrol to the Stress.
Thioredoxin plays a key role in retinal neuropathy prior to endothelial damage in diabetic mice.
Thioredoxin is implicated in the anti‑apoptotic effects of grape seed proanthocyanidin extract during hyperglycemia.
Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease.
Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas.
Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes.
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways.
Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.
FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer.
Wang X, Hu ZY, Hu Q, Liu ZM, Chen XD
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158002
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158002
HIF3A-mediated aberrant activation of TXNIP promotes Alzheimer's disease progression.
Xue M, Zheng W, Li F, Gao L, Jia X, Pang S
Scientific reports 2026 Mar 10;16(1)
Scientific reports 2026 Mar 10;16(1)
Punicalagin Ameliorates Diabetic Cognitive Dysfunction by Inhibiting Neuroinflammation via the CX3CL1/CX3CR1 Axis.
Zhang R, Tan X, Zhang Y, Ma Y, You Z, Huang Y, Yang L
Phytotherapy research : PTR 2026 Jan;40(1):334-350
Phytotherapy research : PTR 2026 Jan;40(1):334-350
A bioactive protein from Dioscorea polystachya residue alleviates hydrocortisone-induced erectile dysfunction in rats via TXNIP/NLRP3 pathway inhibition.
Yu S, Zhang Y, Xi J, Feng J, Xie T, Pan D, Zhao D, Ren J, Dong Z, Liu M, Wang S
International journal of biological macromolecules 2026 Jan;335(Pt 1):149351
International journal of biological macromolecules 2026 Jan;335(Pt 1):149351
Differential Toxicity of Water-Soluble Versus Water-Insoluble Components of Cowshed PM2.5 on Ovarian Granulosa Cells and the Regulatory Role of Txnip in Overall Toxicity.
Ma Z, Zhang X, Du X, Zhao C, Jia Y, Wang Y, Li X, Yu X, Gao Y
Antioxidants (Basel, Switzerland) 2026 Jan 21;15(1)
Antioxidants (Basel, Switzerland) 2026 Jan 21;15(1)
Rhodiola rosea-derived exosome-like nanovesicles inhibit vascular endothelial pyroptosis in the treatment of limb skeletal muscle ischemic injury through the TXNIP/NLNP3 pathway.
Liu D, Zhang Z, Wang Y, Liang X, Chang Y, Wang C, Guo Y, Zhang S, Zhou J, Zhang M, Shen H, Zhang X, Gao W
Regenerative biomaterials 2025;12:rbaf113
Regenerative biomaterials 2025;12:rbaf113
Targeting MondoA-TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment.
Xu N, Zhu Y, Han Y, Liu Q, Tong L, Li Y, Chen Z, Shao S, He W, Li M, Wang Y, Qiang S, Chai P, Du P, Zhao W, Wu L, Zhang P, He J, Li H, Cheng J, Jia R, Li B, Lu Y, Tong X
Nature metabolism 2025 Sep;7(9):1889-1904
Nature metabolism 2025 Sep;7(9):1889-1904
Overexpression of PBX1 attenuates oxidative stress and apoptosis in diabetic cardiomyopathy by transcriptionally inhibiting TXNIP.
Zhou R, Wang X, Li N
The international journal of biochemistry & cell biology 2025 Sep;186:106828
The international journal of biochemistry & cell biology 2025 Sep;186:106828
Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.
Li S, Wang J, Chen Y, Cheng Y, Wang Y, Xu N, Wang H, Wang L, Chi Y, Ye X, Shi Y, Fang J, Yao X, Huang J, Xia Q, Bai T, Zhu B
Inflammation 2025 Oct;48(5):3180-3193
Inflammation 2025 Oct;48(5):3180-3193
Molecular interplay between TXNIP and GLUT9 underlies uric acid transport dysregulation in vitro under hyperuricemic stress.
Zhu Y, Zhang B, He Y, Du M, Chen W, Chen X, Yang Q, Kahaer M, Sun Y
European journal of medical research 2025 Oct 9;30(1):942
European journal of medical research 2025 Oct 9;30(1):942
LncRNA MIR17HG accelerates the development of atherosclerosis by promoting macrophage pyroptosis through the miR-301a-3p/TXNIP pathway.
Wang YP, Liu X, Xu XD, Hui L, Xu GH, Ma MQ, Zhu L, Ren K
International immunopharmacology 2025 Oct 30;164:115407
International immunopharmacology 2025 Oct 30;164:115407
IGFBP2 plays a key role in aerobic exercise-mediated inhibition of ferroptosis in cardiac ischemia/reperfusion (I/R) injury.
Yang C, Meng X, Xia C, Sun Y, Ren Y, Wang J, Li Y, Wang X
Journal of translational medicine 2025 Oct 13;23(1):1080
Journal of translational medicine 2025 Oct 13;23(1):1080
Peroxynitrite is key to Cylindrospermopsin-mediated MASLD to MASH progression via triggering TXNIP binding to NLRP3 and subsequent inflammasome activation.
Saha P, Bose D, Roy S, More M, Trivedi A, Brooks BW, Xiao S, Syn WK, Diehl AM, Chatterjee S
Toxicology and applied pharmacology 2025 Nov;504:117527
Toxicology and applied pharmacology 2025 Nov;504:117527
Protocatechuic aldehyde restrains NLRP3 inflammasome activation to alleviate inflammatory response in sepsis.
Li YF, Sun A, Miao Y, Wang HX, Zhang LL
Journal of pharmacological sciences 2025 Nov;159(3):172-183
Journal of pharmacological sciences 2025 Nov;159(3):172-183
AMSC-EVs attenuate acute kidney injury through TXNIP-IKKα/NFκB signaling-mediated renal CX3CR1(+) macrophage polarization.
Deng WJ, Tang R, Ma MQ, Zhang H, Cao CC
Stem cell research & therapy 2025 Nov 14;16(1):639
Stem cell research & therapy 2025 Nov 14;16(1):639
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
Zhu Y, Yang S, Su S, Huang Y, Chen Y, Liang H, Miao J, Wu Z, Li X, Xiao J, Wang X
Phytotherapy research : PTR 2025 May;39(5):2091-2109
Phytotherapy research : PTR 2025 May;39(5):2091-2109
Ginsenoside Rg1 attenuates T2DM-induced renal damage and fibrosis by inhibiting TRPC6-ChREBP-TXNIP signaling.
Zhang H, Liang H, Fan L, Zhu X, Ji P, Su Y, Li W, Li W
Journal of ethnopharmacology 2025 May 28;348:119863
Journal of ethnopharmacology 2025 May 28;348:119863
Atractylenolide I Inhibits Nicotine-Induced Macrophage Pyroptosis and Alleviates Atherogenesis by Suppressing the TLR4/ROS/TXNIP/NLRP3 Pathway.
Li HH, Liu X, Wang YP, Xu X, Zhu L, Zhang W, Ren K
Metabolites 2025 May 15;15(5)
Metabolites 2025 May 15;15(5)
PDIA4 targets IRE1α/sXBP1 to alleviate NLRP3 inflammasome activation and renal tubular injury in diabetic kidney disease.
Liu X, Zhou D, Su Y, Liu H, Su Q, Shen T, Zhang M, Mi X, Zhang Y, Yue S, Zhang Z, Wang D, Tan X
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167645
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167645
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Fu X, Zhang Q, Chen Y, Li Y, Wang H
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
HNMT Promotes the Occurrence and Progression of Nasopharyngeal Carcinoma by Inhibiting the IFN/TXNIP/p53 Axis.
Cheng S, Wu XF, Sun WD, Zhai H, Liu X, Jiang CW, Ruan B
Current medical science 2025 Jun;45(3):661-670
Current medical science 2025 Jun;45(3):661-670
Unfolded protein response-activated NLRP3 inflammasome contributes to pyroptotic and apoptotic podocyte injury in diabetic kidney disease via the CHOP-TXNIP axis.
Cao Y, Hu L, Chen R, Chen Y, Liu H, Wei J
Cellular signalling 2025 Jun;130:111702
Cellular signalling 2025 Jun;130:111702
Txnip/Trx Is a Potential Element in Regulating O-GlcNAc Modification in Photoreceptors to Alleviate Diabetic Retinopathy.
Imdad L, Xu S, Meng Y, Bao K, Dong W, Yin X, Tong Y, Zhang W, Ren X, Kong L
International journal of molecular sciences 2025 Jun 4;26(11)
International journal of molecular sciences 2025 Jun 4;26(11)
Emodin delays rheumatoid arthritis progression by inhibiting the ROS/TXNIP/NLRP3 signaling pathway.
Zhou L, Liu J, Yang K, Cai C, Cheng L, Du D, He H, Hua X, Rong X
International immunopharmacology 2025 Jun 17;158:114861
International immunopharmacology 2025 Jun 17;158:114861
M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the TXNIP/NLRP3 axis.
Zhang H, Jiang N, Xu M, Jing D, Dong T, Liu Q, Lv Q, Huo R, Chen P, Li L, Wang X
Life sciences 2025 Jun 1;370:123561
Life sciences 2025 Jun 1;370:123561
UCP2 inhibition exaggerates diabetic cardiomyopathy by facilitating the activation of NLRP3 and pyroptosis.
Zhang L, Ai C, Guo C, Li S, Niu J, Meng X, Zhang Z
Diabetology & metabolic syndrome 2025 Jul 16;17(1):267
Diabetology & metabolic syndrome 2025 Jul 16;17(1):267
Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore.
Zhao B, Ban F, Li Y, Shi Q, Guo S, Yi X, Wang H, Gao T, Li C, Zhu G
Cell death & disease 2025 Jul 1;16(1):482
Cell death & disease 2025 Jul 1;16(1):482
Ginsenoside Rg1 improves hypoxia-induced pulmonary vascular endothelial dysfunction through TXNIP/NLRP3 pathway-modulated mitophagy.
Zhang R, Lu M, Ran C, Niu L, Qi Q, Wang H
Journal of ginseng research 2025 Jan;49(1):80-91
Journal of ginseng research 2025 Jan;49(1):80-91
E3 ubiquitination ligase XIAP lightens diabetes-induced cognitive impairment by inactivating TXNIP-ERS-mediated neuronal injury.
Zhang Q, Huang HJ, Zhang JL, Tian Y, Hu Y
The Kaohsiung journal of medical sciences 2025 Jan;41(1):e12913
The Kaohsiung journal of medical sciences 2025 Jan;41(1):e12913
Single-cell RNA sequencing of the carotid artery and femoral artery of rats exposed to hindlimb unloading.
Li C, Pan Y, Wang Y, Li X, Tie Y, Li S, Wang R, Zhao X, Fan J, Yan X, Wang Y, Sun X
Cellular and molecular life sciences : CMLS 2025 Jan 21;82(1):50
Cellular and molecular life sciences : CMLS 2025 Jan 21;82(1):50
Puerarin reduces diabetic nephropathy-induced podocyte pyroptosis by modulating the SIRT1/NLRP3/caspase-1 pathway.
Wang L, Xie X, Chen Q, Chen Y, Xu X, Liang T
Molecular and cellular endocrinology 2025 Jan 1;595:112409
Molecular and cellular endocrinology 2025 Jan 1;595:112409
Bioinformatics analysis and validation of novel biomarkers and competitive endogenous RNA networks involved in pyroptosis in diabetic nephropathy.
Wu S, Yao L, Zhang W, Chen P, Jiang J, Ma Y
Scientific reports 2025 Feb 14;15(1):5530
Scientific reports 2025 Feb 14;15(1):5530
KLF5 drives granulosa cell apoptosis and inflammatory injury in polycystic ovary syndrome via transcriptional activation of TXNIP.
Wang Y, Liu J, Jiang Y, Liu Y, Kuang H, Feng X
In vitro cellular & developmental biology. Animal 2025 Dec;61(10):1300-1310
In vitro cellular & developmental biology. Animal 2025 Dec;61(10):1300-1310
Cadmium exposure upregulates TXNIP and aggravates calcium oxalate kidney stone formation by promoting cell-crystal adhesion, apoptosis and macrophage M1 polarization.
Xiang H, Yang Y, Chen L, He Z, Zhou Q, Dong C, Jiang Q, Chen Q, Su X, Yang S
Ecotoxicology and environmental safety 2025 Dec;308:119481
Ecotoxicology and environmental safety 2025 Dec;308:119481
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein m(6)A methylation.
Zhou P, Huang Y, Wang Z, Chen D, Long B, Qin P, Li Y, Yang C, Li Q
Molecular biomedicine 2025 Dec 29;6(1):150
Molecular biomedicine 2025 Dec 29;6(1):150
Metformin Nanodelivery System Alleviates Morphine-Induced Analgesic Tolerance via Inhibiting the TXNIP/NLRP3/GSDMD Axis.
Yao D, Zhao X, Wang Y, Xu X, Cao L, Sun T, Zhao A, Chen J
ACS applied bio materials 2025 Dec 15;8(12):11075-11088
ACS applied bio materials 2025 Dec 15;8(12):11075-11088
HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition.
Liu G, Zhao B, Chen Q, Li X, Zhu X, Duan M, Zhang M, Liu Z, Wen X, Guo J, Zheng M, Wang R, Luo M
Scientific reports 2025 Aug 19;15(1):30411
Scientific reports 2025 Aug 19;15(1):30411
Lipid metabolism analysis reveals that DGAT1 regulates Th17 survival by controlling lipid peroxidation in uveitis.
Wang T, Duan R, Li Z, Zhang B, Jiang Q, Jiang L, Lv J, Su W, Feng L
JCI insight 2025 Apr 8;10(7)
JCI insight 2025 Apr 8;10(7)
Swietenolide inhibits the TXNIP/NLRP3 pathways via Nrf2 activation to ameliorate cognitive dysfunction in diabetic mice.
Song X, Fan S, Gao Y, Ma A, Zhang X, Zhou Z, Zheng Y, Du L, Zhu X
Neuropharmacology 2025 Apr 1;267:110312
Neuropharmacology 2025 Apr 1;267:110312
Identification of immune-related endoplasmic reticulum stress genes in proliferative diabetic retinopathy using bioinformatics analysis.
Chen H, Chen E, Liu M, Wang J, Yin J, Zhao P, Xu Y
Frontiers in endocrinology 2024;15:1341206
Frontiers in endocrinology 2024;15:1341206
piR112710 attenuates diabetic cardiomyopathy through inhibiting Txnip/NLRP3-mediated pyroptosis in db/db mice.
Jiao A, Liu H, Wang H, Yu J, Gong L, Zhang H, Fu L
Cellular signalling 2024 Oct;122:111333
Cellular signalling 2024 Oct;122:111333
Sesamol Alleviated Lipotoxicity-Induced Dysfunction in MIN6 Cells via Facilitating Cellular Senescence Caused by Endoplasmic Reticulum Stress.
Xie Y, Tang Y, Yang J, Atta M, Wang N, Qin H
Journal of biochemical and molecular toxicology 2024 Nov;38(11):e70038
Journal of biochemical and molecular toxicology 2024 Nov;38(11):e70038
BAP1 inactivation promotes lactate production by leveraging the subcellular localization of LDHA in melanoma.
Zheng G, Shi J, Li Q, Jin X, Fang Y, Zhang Z, Cao Q, Zhu L, Shen J
Cell death discovery 2024 Nov 26;10(1):483
Cell death discovery 2024 Nov 26;10(1):483
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, Wang Y, Li YT, Wang TC, Kan TY, Wang J, Tao HR
Military Medical Research 2024 May 6;11(1):28
Military Medical Research 2024 May 6;11(1):28
Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis.
Jia L, Gong Y, Jiang X, Fan X, Ji Z, Ma T, Li R, Liu F
Journal of ethnopharmacology 2024 May 10;325:117887
Journal of ethnopharmacology 2024 May 10;325:117887
Molecular Regulation of Transforming Growth Factor-β1-induced Thioredoxin-interacting Protein Ubiquitination and Proteasomal Degradation in Lung Fibroblasts: Implication in Pulmonary Fibrosis.
Taleb SJ, Ye Q, Baoyinna B, Dedad M, Pisini D, Parinandi NL, Cantley LC, Zhao J, Zhao Y
Journal of respiratory biology and translational medicine 2024 Mar;1(1)
Journal of respiratory biology and translational medicine 2024 Mar;1(1)
Shexiang Tongxin dropping pills protect against ischemic stroke-induced cerebral microvascular dysfunction via suppressing TXNIP/NLRP3 signaling pathway.
Zhu L, Yang YM, Huang Y, Xie HK, Luo Y, Li C, Wang W, Chen Y
Journal of ethnopharmacology 2024 Mar 25;322:117567
Journal of ethnopharmacology 2024 Mar 25;322:117567
Punicalagin Ameliorates Diabetic Liver Injury by Inhibiting Pyroptosis and Promoting Autophagy via Modulation of the FoxO1/TXNIP Signaling Pathway.
Tan X, Long Y, Zhang R, Zhang Y, You Z, Yang L
Molecular nutrition & food research 2024 Jun;68(12):e2300912
Molecular nutrition & food research 2024 Jun;68(12):e2300912
O-GlcNAc Modification Is a Promising Therapeutic Target for Diabetic Retinopathy.
Dong W, Imdad L, Xu S, Wang Y, Liu C, Song S, Li Z, Kong Y, Kong L, Ren X
International journal of molecular sciences 2024 Jun 6;25(11)
International journal of molecular sciences 2024 Jun 6;25(11)
Circ6834 suppresses non-small cell lung cancer progression by destabilizing ANHAK and regulating miR-873-5p/TXNIP axis.
Wang M, Ding X, Fang X, Xu J, Chen Y, Qian Y, Zhang J, Yu D, Zhang X, Ma X, Zhu T, Gu J, Zhang X
Molecular cancer 2024 Jun 18;23(1):128
Molecular cancer 2024 Jun 18;23(1):128
Diagnostic and predictive significance of the ferroptosis-related gene TXNIP in lung adenocarcinoma stem cells based on multi-omics.
Zheng Y, Yang W, Wu W, Jin F, Lu D, Gao J, Wang S
Translational oncology 2024 Jul;45:101926
Translational oncology 2024 Jul;45:101926
TXNIP knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis.
Zhao Y, Chen Y, Liu Z, Zhou L, Huang J, Luo X, Luo Y, Li J, Lin Y, Lai J, Liu J
Free radical biology & medicine 2024 Jul;219:1-16
Free radical biology & medicine 2024 Jul;219:1-16
The downregulation of SCGN induced by lipotoxicity promotes NLRP3-mediated β-cell pyroptosis.
Ouyang S, Xiang S, Wang X, Yang X, Liu X, Zhang M, Zhou Y, Xiao Y, Zhou L, Fan G, Yang J
Cell death discovery 2024 Jul 27;10(1):340
Cell death discovery 2024 Jul 27;10(1):340
Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering.
Zhang WY, Wei QQ, Zhang T, Wang CS, Chen J, Wang JH, Xie X, Jiang P
Journal of neuroinflammation 2024 Jul 20;21(1):177
Journal of neuroinflammation 2024 Jul 20;21(1):177
KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling.
Chen Y, Sun L, Liu H, Li J, Guo L, Wang Z
Immunity, inflammation and disease 2024 Feb;12(2):e1199
Immunity, inflammation and disease 2024 Feb;12(2):e1199
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease.
Du Y, Wu M, Song S, Bian Y, Shi Y
Renal failure 2024 Dec;46(1):2338933
Renal failure 2024 Dec;46(1):2338933
Aminoadipic acid aggravates atherosclerotic vascular inflammation through ROS/TXNIP/NLRP3 pathway, a harmful microbial metabolite reduced by paeonol.
Wang T, Wu H, Shi X, Dai M, Liu Y
The international journal of biochemistry & cell biology 2024 Dec;177:106678
The international journal of biochemistry & cell biology 2024 Dec;177:106678
Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation.
Zhang Y, Li B, Fu Y, Cai H, Zheng Y
Cellular signalling 2024 Dec;124:111469
Cellular signalling 2024 Dec;124:111469
Atorvastatin inhibits glioma glycolysis and immune escape by modulating the miR-125a-5p/TXLNA axis.
Gao K, Zhou T, Yin Y, Sun X, Jiang H, Li T
Hereditas 2024 Dec 26;161(1):54
Hereditas 2024 Dec 26;161(1):54
Betaine improves METH-induced depressive-like behavior and cognitive impairment by alleviating neuroinflammation via NLRP3 inflammasome inhibition.
Hui R, Xu J, Zhou M, Xie B, Zhou M, Zhang L, Cong B, Ma C, Wen D
Progress in neuro-psychopharmacology & biological psychiatry 2024 Dec 20;135:111093
Progress in neuro-psychopharmacology & biological psychiatry 2024 Dec 20;135:111093
Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy.
Hu Z, Zhou Y, Gao C, Liu J, Pan C, Guo J
Diabetology & metabolic syndrome 2024 Dec 18;16(1):296
Diabetology & metabolic syndrome 2024 Dec 18;16(1):296
Comparison of Endoplasmic Reticulum Stress and Pyroptosis Induced by Pathogenic Calcium Oxalate Monohydrate and Physiologic Calcium Oxalate Dihydrate Crystals in HK-2 Cells: Insights into Kidney Stone Formation.
Nong WJ, Tong XY, Ouyang JM
Cells 2024 Dec 15;13(24)
Cells 2024 Dec 15;13(24)
Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury.
Zhang S, Zhao N, Song S, Wang Y, Wang Y, Sun C, Dong M, Huo M, Xu N, Liu W, Li G
Toxicology and applied pharmacology 2024 Apr;485:116890
Toxicology and applied pharmacology 2024 Apr;485:116890
Upregulation of UHRF1 Promotes PINK1-mediated Mitophagy to Alleviates Ferroptosis in Diabetic Nephropathy.
Ji H, Zhao Y, Ma X, Wu L, Guo F, Huang F, Song Y, Wang J, Qin G
Inflammation 2024 Apr;47(2):718-732
Inflammation 2024 Apr;47(2):718-732
Exosome-based WTAP siRNA delivery ameliorates myocardial ischemia-reperfusion injury.
Yin T, Wang N, Jia F, Wu Y, Gao L, Zhang J, Hou R
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2024 Apr;197:114218
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2024 Apr;197:114218
A novel cuproptosis pattern and tumor immune microenvironment characterization in urothelial carcinoma of the bladder.
Feng H, Deng Z, Huang Y, Liu Z, Ruan Y, Wang T, Liu J
Frontiers in immunology 2023;14:1219209
Frontiers in immunology 2023;14:1219209
BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2.
Chen Y, Jin L, Ma Y, Liu Y, Zhu Q, Huang Y, Feng W
Cancer science 2023 Sep;114(9):3568-3582
Cancer science 2023 Sep;114(9):3568-3582
Tremella fuciformis polysaccharides alleviates UV-provoked skin cell damage via regulation of thioredoxin interacting protein and thioredoxin reductase 2.
Lin M, Bao C, Chen L, Geng S, Wang H, Xiao Z, Gong T, Ji C, Cheng B
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2023 Oct;22(10):2285-2296
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2023 Oct;22(10):2285-2296
PIAS3 promotes ferroptosis by regulating TXNIP via TGF-β signaling pathway in hepatocellular carcinoma.
Bao W, Wang J, Fan K, Gao Y, Chen J
Pharmacological research 2023 Oct;196:106915
Pharmacological research 2023 Oct;196:106915
Glycosides of Buyang Huanwu decoction inhibits pyroptosis associated with cerebral ischemia-reperfusion through Nrf2-mediated antioxidant signaling pathway both in vivo and in vitro.
She Y, Shao L, Jiao K, Sun R, Lang T, Long H, Tang Y, Zhang W, Ding C, Deng C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155001
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155001
Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis.
Li T, Yang J, Tan A, Chen H
Diabetology & metabolic syndrome 2023 Nov 22;15(1):239
Diabetology & metabolic syndrome 2023 Nov 22;15(1):239
The PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells.
Qu Y, Zong S, Wang Z, Du P, Wen Y, Li H, Wu N, Xiao H
Drug and chemical toxicology 2023 Mar;46(2):369-379
Drug and chemical toxicology 2023 Mar;46(2):369-379
SIRT1 Inhibits High Glucose-Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation.
Lian L, Le Z, Wang Z, Chen YA, Jiao X, Qi H, Hejtmancik JF, Ma X, Zheng Q, Ren Y
Investigative ophthalmology & visual science 2023 Mar 1;64(3):16
Investigative ophthalmology & visual science 2023 Mar 1;64(3):16
Synergistic effects of combined treatment of 1,2-dichloroethane and high-dose ethanol on liver damage in mice and the related mechanisms.
Yang J, Zhang L, Wang T, Zhang J, Li M, Jin X, Tan X, Wang G, Zhao F, Jin Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113812
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113812
Dihydrotanshinone Triggers Porimin-Dependent Oncosis by ROS-Mediated Mitochondrial Dysfunction in Non-Small-Cell Lung Cancer.
Zhang D, Yuan R, Pan J, Fan Q, Sun K, Xu Z, Gao X, Wang Q, He J, Ye Y, Mu Z, Leng J, Gao H
International journal of molecular sciences 2023 Jul 26;24(15)
International journal of molecular sciences 2023 Jul 26;24(15)
Salidroside protects pancreatic β-cells against pyroptosis by regulating the NLRP3/GSDMD pathway in diabetic conditions.
Zhou J, Yan S, Guo X, Gao Y, Chen S, Li X, Zhang Y, Wang Q, Zheng T, Chen L
International immunopharmacology 2023 Jan;114:109543
International immunopharmacology 2023 Jan;114:109543
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Tian Y, Feng X, Zhou Z, Qin S, Chen S, Zhao J, Hou J, Liu D
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein.
Shi S, Pan X, Chen M, Zhang L, Zhang S, Wang X, Shi S, Chen Z, Lin W, Jiang Y
Hepatology communications 2023 Aug 1;7(8)
Hepatology communications 2023 Aug 1;7(8)
ChREBP-β/TXNIP aggravates frucose-induced renal injury through triggering ferroptosis of renal tubular epithelial cells.
Guo H, Fang T, Cheng Y, Li T, Qu JR, Xu CF, Deng XQ, Sun B, Chen LM
Free radical biology & medicine 2023 Apr;199:154-165
Free radical biology & medicine 2023 Apr;199:154-165
Attenuation of ROS/Chloride Efflux-Mediated NLRP3 Inflammasome Activation Contributes to Alleviation of Diabetic Cardiomyopathy in Rats after Sleeve Gastrectomy.
Li S, Dong S, Shi B, Xu Q, Li L, Wang S, Zhang W, Zhong M, Zhu J, Cheng Y, Zhang G, Hu S
Oxidative medicine and cellular longevity 2022;2022:4608914
Oxidative medicine and cellular longevity 2022;2022:4608914
Downregulation of Inflammatory Response via Nrf2/Trx1/TXNIP Axis in Oxidative Stress-Induced ARPE-19 Cells and Mouse Model of AMD.
Yang Q, Cai W, Jin H, Shen T, Yu J
Oxidative medicine and cellular longevity 2022;2022:1497813
Oxidative medicine and cellular longevity 2022;2022:1497813
PPARγ Alleviates Sepsis-Induced Liver Injury by Inhibiting Hepatocyte Pyroptosis via Inhibition of the ROS/TXNIP/NLRP3 Signaling Pathway.
Li Z, Liu T, Feng Y, Tong Y, Jia Y, Wang C, Cui R, Qu K, Liu C, Zhang J
Oxidative medicine and cellular longevity 2022;2022:1269747
Oxidative medicine and cellular longevity 2022;2022:1269747
Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model.
Chen H, Peng Y, Wang L, Wang X
Archives of physiology and biochemistry 2022 Oct;128(5):1413-1420
Archives of physiology and biochemistry 2022 Oct;128(5):1413-1420
MicroRNA-25-5p negatively regulates TXNIP expression and relieves inflammatory responses of brain induced by lipopolysaccharide.
Wang J, Ye Z, Chen Y, Qiao X, Jin Y
Scientific reports 2022 Oct 26;12(1):17915
Scientific reports 2022 Oct 26;12(1):17915
Embryonic Deletion of TXNIP in GABAergic Neurons Enhanced Oxidative Stress in PV+ Interneurons in Primary Somatosensory Cortex of Aging Mice: Relevance to Schizophrenia.
Xue T, Wang X, Hu Y, Cheng Y, Li H, Shi Y, Wang L, Yin D, Cui D
Brain sciences 2022 Oct 15;12(10)
Brain sciences 2022 Oct 15;12(10)
Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension.
Wang R, Guo Y, Li L, Luo M, Peng L, Lv D, Cheng Z, Xue Q, Wang L, Huang J
Genes & diseases 2022 May;9(3):753-765
Genes & diseases 2022 May;9(3):753-765
Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways.
Miyahara H, Hasegawa K, Yashiro M, Ohara T, Fujisawa M, Yoshimura T, Matsukawa A, Tsukahara H
Scientific reports 2022 Mar 21;12(1):4819
Scientific reports 2022 Mar 21;12(1):4819
Localization of Thioredoxin-Interacting Protein in Aging and Alzheimer's Disease Brains.
Tsubaki H, Mendsaikhan A, Buyandelger U, Tooyama I, Walker DG
NeuroSci 2022 Jun;3(2):166-185
NeuroSci 2022 Jun;3(2):166-185
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats.
Zheng J, Liao Y, Xu Y, Mo Z
Clinical and experimental pharmacology & physiology 2022 Jul;49(7):719-730
Clinical and experimental pharmacology & physiology 2022 Jul;49(7):719-730
A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker.
Guo X, Huang M, Zhang H, Chen Q, Hu Y, Meng Y, Wu C, Tu C, Liu Y, Li A, Li Q, Zhou P, Liu S
Cancer cell international 2022 Jul 17;22(1):230
Cancer cell international 2022 Jul 17;22(1):230
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication.
Wang Q, Chen W, Zhang B, Gao Z, Zhang Q, Deng H, Han L, Shen XL
Chemico-biological interactions 2022 Feb 25;354:109844
Chemico-biological interactions 2022 Feb 25;354:109844
Artificial Intelligence-Assisted Bioinformatics, Microneedle, and Diabetic Wound Healing: A "New Deal" of an Old Drug.
Xue Y, Chen C, Tan R, Zhang J, Fang Q, Jin R, Mi X, Sun D, Xue Y, Wang Y, Xiong R, Lu H, Tan W
ACS applied materials & interfaces 2022 Aug 24;14(33):37396-37409
ACS applied materials & interfaces 2022 Aug 24;14(33):37396-37409
Identification of a novel mechanism for reversal of doxorubicin-induced chemotherapy resistance by TXNIP in triple-negative breast cancer via promoting reactive oxygen-mediated DNA damage.
Chen Y, Feng X, Yuan Y, Jiang J, Zhang P, Zhang B
Cell death & disease 2022 Apr 12;13(4):338
Cell death & disease 2022 Apr 12;13(4):338
Bletilla striata Polysaccharide Promotes Diabetic Wound Healing Through Inhibition of the NLRP3 Inflammasome.
Zhao Y, Wang Q, Yan S, Zhou J, Huang L, Zhu H, Ye F, Zhang Y, Chen L, Chen L, Zheng T
Frontiers in pharmacology 2021;12:659215
Frontiers in pharmacology 2021;12:659215
Downregulation of miR-135b-5p Suppresses Progression of Esophageal Cancer and Contributes to the Effect of Cisplatin.
Di Y, Jiang Y, Shen X, Liu J, Gao Y, Cai H, Sun X, Ning D, Liu B, Lei J, Jin S
Frontiers in oncology 2021;11:679348
Frontiers in oncology 2021;11:679348
Upregulation of thioredoxin contributes to inhibiting diabetic hearing impairment.
Ren X, Lv J, Fu Y, Zhang N, Zhang C, Dong Z, Chudhary M, Zhong S, Kong L, Kong H
Diabetes research and clinical practice 2021 Sep;179:109025
Diabetes research and clinical practice 2021 Sep;179:109025
Ceramide induces the apoptosis of non‑small cell lung cancer cells through the Txnip/Trx1 complex.
Shi Y, Jin Y, Liu F, Jiang J, Cao J, Lu Y, Yang J
International journal of molecular medicine 2021 May;47(5)
International journal of molecular medicine 2021 May;47(5)
MondoA Is Required for Normal Myogenesis and Regulation of the Skeletal Muscle Glycogen Content in Mice.
Ran H, Lu Y, Zhang Q, Hu Q, Zhao J, Wang K, Tong X, Su Q
Diabetes & metabolism journal 2021 May;45(3):439-451
Diabetes & metabolism journal 2021 May;45(3):439-451
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.
Han M, Li S, Li L
Journal of cellular and molecular medicine 2021 May 24;25(13):5963-75
Journal of cellular and molecular medicine 2021 May 24;25(13):5963-75
Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration.
Yi W, Zhang Y, Liu B, Zhou Y, Liao D, Qiao X, Gao D, Xie T, Yao Q, Zhang Y, Qiu Y, Huang G, Chen Z, Chen C, Ju Z
Cell reports 2021 Mar 30;34(13):108922
Cell reports 2021 Mar 30;34(13):108922
Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells.
Yang M, Zhang W, Yu X, Wang F, Li Y, Zhang Y, Yang Y
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 14;27:e930083
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 14;27:e930083
The piperine derivative HJ105 inhibits Aβ(1-42)-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.
Yang X, Zhi J, Leng H, Chen Y, Gao H, Ma J, Ji J, Hu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jul;87:153571
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jul;87:153571
MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment.
Lu Y, Li Y, Liu Q, Tian N, Du P, Zhu F, Han Y, Liu X, Liu X, Peng X, Wang X, Wu Y, Tong L, Li Y, Zhu Y, Wu L, Zhang P, Xu Y, Chen H, Li B, Tong X
Gastroenterology 2021 Aug;161(2):575-591.e16
Gastroenterology 2021 Aug;161(2):575-591.e16
Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes.
Collins JA, Kapustina M, Bolduc JA, Pike JFW, Diekman BO, Mix K, Chubinskaya S, Eroglu E, Michel T, Poole LB, Furdui CM, Loeser RF
Free radical biology & medicine 2021 Apr;166:90-103
Free radical biology & medicine 2021 Apr;166:90-103
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis.
Zheng T, Wang Q, Bian F, Zhao Y, Ma W, Zhang Y, Lu W, Lei P, Zhang L, Hao X, Chen L
Toxicology and applied pharmacology 2021 Apr 1;416:115468
Toxicology and applied pharmacology 2021 Apr 1;416:115468
Rosmarinic acid alleviates di-2-ethylhexyl phthalate (DEHP) -induced thyroid dysfunction via multiple inflammasomes activation.
Wu H, Ma K, Na X
The Journal of toxicological sciences 2020;45(7):373-390
The Journal of toxicological sciences 2020;45(7):373-390
Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats.
Yu J, Wang WN, Matei N, Li X, Pang JW, Mo J, Chen SP, Tang JP, Yan M, Zhang JH
Oxidative medicine and cellular longevity 2020;2020:4717258
Oxidative medicine and cellular longevity 2020;2020:4717258
Epigenetic repression of miR-17 contributed to di(2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal muscle.
Wei J, Hao Q, Chen C, Li J, Han X, Lei Z, Wang T, Wang Y, You X, Chen X, Li H, Ding Y, Huang W, Hu Y, Lin S, Shen H, Lin Y
Theranostics 2020;10(20):9230-9248
Theranostics 2020;10(20):9230-9248
HPV 16 E6/E7 Promote the Glucose Uptake of GLUT1 in Lung Cancer Through Downregulation of TXNIP Due to Inhibition of PTEN Phosphorylation.
Tang JY, Li DY, He L, Qiu XS, Wang EH, Wu GP
Frontiers in oncology 2020;10:559543
Frontiers in oncology 2020;10:559543
Thioredoxin interacting protein (TXNIP) acts as a tumor suppressor in human prostate cancer.
Xie M, Xie R, Xie S, Wu Y, Wang W, Li X, Xu Y, Liu B, Zhou Y, Wang T, Gao L, Pan T
Cell biology international 2020 Oct;44(10):2094-2106
Cell biology international 2020 Oct;44(10):2094-2106
Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway.
Jia Y, Cui R, Wang C, Feng Y, Li Z, Tong Y, Qu K, Liu C, Zhang J
Redox biology 2020 May;32:101534
Redox biology 2020 May;32:101534
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
Zhu Y, Zhu C, Yang H, Deng J, Fan D
Pharmacological research 2020 May;155:104746
Pharmacological research 2020 May;155:104746
PSMD12 promotes breast cancer growth via inhibiting the expression of pro-apoptotic genes.
Du X, Shen X, Dai L, Bi F, Zhang H, Lu C
Biochemical and biophysical research communications 2020 May 28;526(2):368-374
Biochemical and biophysical research communications 2020 May 28;526(2):368-374
HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.
Yang X, Ji J, Liu C, Zhou M, Li H, Ye S, Hu Q
International immunopharmacology 2020 Jun;83:106383
International immunopharmacology 2020 Jun;83:106383
High Glucose-Aggravated Hepatic Insulin Resistance: Role of the NLRP3 Inflammasome in Kupffer Cells.
Zheng T, Wang Q, Dong Y, Ma W, Zhang Y, Zhao Y, Bian F, Chen L
Obesity (Silver Spring, Md.) 2020 Jul;28(7):1270-1282
Obesity (Silver Spring, Md.) 2020 Jul;28(7):1270-1282
Endoplasmic reticulum stress and oxidative stress contribute to neuronal pyroptosis caused by cerebral venous sinus thrombosis in rats: Involvement of TXNIP/peroxynitrite-NLRP3 inflammasome activation.
Ding R, Ou W, Chen C, Liu Y, Li H, Zhang X, Chai H, Ding X, Wang Q
Neurochemistry international 2020 Dec;141:104856
Neurochemistry international 2020 Dec;141:104856
NecroX-5 alleviate lipopolysaccharide-induced acute respiratory distress syndrome by inhibiting TXNIP/NLRP3 and NF-κB.
Fang XZ, Ge YL, Chen ZY, Shu HQ, Yang YY, Yu Y, Zhou XJ, Chen L, Cui SN, Wang YX, Yao SL, Shang Y
International immunopharmacology 2020 Apr;81:106257
International immunopharmacology 2020 Apr;81:106257
Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes.
Shen F, Xiong Z, Kong J, Wang L, Cheng Y, Jin J, Huang Z
Toxicology letters 2019 Jan;300:105-115
Toxicology letters 2019 Jan;300:105-115
Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.
Zhou F, Zhang Y, Chen J, Hu Y, Xu Y
Frontiers in endocrinology 2018;9:640
Frontiers in endocrinology 2018;9:640
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
He W, Ye S, Zeng C, Xue S, Hu X, Zhang X, Gao S, Xiong Y, He X, Vivalda S, Li L, Wang Y, Ye Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury.
Hou Y, Wang Y, He Q, Li L, Xie H, Zhao Y, Zhao J
Behavioural brain research 2018 Jan 15;336:32-39
Behavioural brain research 2018 Jan 15;336:32-39
Effects of Hypobaric Hypoxia on Rat Retina and Protective Response of Resveratrol to the Stress.
Xin X, Dang H, Zhao X, Wang H
International journal of medical sciences 2017;14(10):943-950
International journal of medical sciences 2017;14(10):943-950
Thioredoxin plays a key role in retinal neuropathy prior to endothelial damage in diabetic mice.
Ren X, Li C, Liu J, Zhang C, Fu Y, Wang N, Ma H, Lu H, Kong H, Kong L
Oncotarget 2017 Sep 22;8(37):61350-61364
Oncotarget 2017 Sep 22;8(37):61350-61364
Thioredoxin is implicated in the anti‑apoptotic effects of grape seed proanthocyanidin extract during hyperglycemia.
Ren X, Lu H, Wang N, Zhang C, Ji Y, Cui S, Dong Y, Yang K, Du M, Diao F, Kong L
Molecular medicine reports 2017 Nov;16(5):7731-7737
Molecular medicine reports 2017 Nov;16(5):7731-7737
Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease.
Zhang Y, Huang J, Yang X, Sun X, Xu Q, Wang B, Zhong P, Wei Z
Medicine 2017 Dec;96(49):e9108
Medicine 2017 Dec;96(49):e9108
Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas.
Cai Z, Zhang C, Zou Y, Lu C, Hu H, Qian J, Jiang L, Hu G
International journal of clinical oncology 2017 Aug;22(4):660-666
International journal of clinical oncology 2017 Aug;22(4):660-666
Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes.
Ratneswaran A, Sun MM, Dupuis H, Sawyez C, Borradaile N, Beier F
Journal of molecular medicine (Berlin, Germany) 2017 Apr;95(4):431-444
Journal of molecular medicine (Berlin, Germany) 2017 Apr;95(4):431-444
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
He K, Hu Y, Ma H, Zou Z, Xiao Y, Yang Y, Feng M, Li X, Ye X
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
Ding C, Zhao Y, Shi X, Zhang N, Zu G, Li Z, Zhou J, Gao D, Lv L, Tian X, Yao J
Scientific reports 2016 Jun 27;6:28734
Scientific reports 2016 Jun 27;6:28734
ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways.
Zeng H, Gu H, Chen C, Li M, Xia F, Xie L, Liu X, Zhang F, Tong X, Wang J, Yu Z, Zheng J
Oncotarget 2016 Jun 21;7(25):38347-38358
Oncotarget 2016 Jun 21;7(25):38347-38358
Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.
He K, Li X, Xiao Y, Yong Y, Zhang Z, Li S, Zhou T, Yang D, Gao P, Xin X
Food & function 2016 Aug 10;7(8):3505-15
Food & function 2016 Aug 10;7(8):3505-15
FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer.
Ji S, Qin Y, Liang C, Huang R, Shi S, Liu J, Jin K, Liang D, Xu W, Zhang B, Liu L, Liu C, Xu J, Ni Q, Chiao PJ, Li M, Yu X
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Aug 1;22(15):3950-60
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Aug 1;22(15):3950-60
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human stomach tissue were subjected to SDS PAGE followed by western blot with 18243-1-AP(TXNIP antibody) at dilution of 1:300
- Other comments
- WB
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HeLa cells using 18243-1-AP( TXNIP Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
- Other comments
- IF
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemistry of paraffin-embedded human lung tissue slide using 18243-1-AP( TXNIP Antibody) at dilution of 1:50 (under 40x lens)
- Other comments
- IHC
