18243-1-AP

antibody from Proteintech Group

Targeting: TXNIP ARRDC6, EST01027, HHCPA78, THIF, VDUP1

Provider product page for 18243-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [38]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 18243-1-AP - Provider product page
Provider: Proteintech Group
Product name: TXNIP antibody
Antibody type: Polyclonal
Description: KD/KO validated TXNIP antibody (Cat. #18243-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TXNIP protein structure - 18243-1-AP shown in red.

Submitted references Bletilla striata Polysaccharide Promotes Diabetic Wound Healing Through Inhibition of the NLRP3 Inflammasome.

Zhao Y, Wang Q, Yan S, Zhou J, Huang L, Zhu H, Ye F, Zhang Y, Chen L, Chen L, Zheng T
Frontiers in pharmacology 2021;12:659215

Downregulation of miR-135b-5p Suppresses Progression of Esophageal Cancer and Contributes to the Effect of Cisplatin.

Di Y, Jiang Y, Shen X, Liu J, Gao Y, Cai H, Sun X, Ning D, Liu B, Lei J, Jin S
Frontiers in oncology 2021;11:679348

Upregulation of thioredoxin contributes to inhibiting diabetic hearing impairment.

Ren X, Lv J, Fu Y, Zhang N, Zhang C, Dong Z, Chudhary M, Zhong S, Kong L, Kong H
Diabetes research and clinical practice 2021 Sep;179:109025

Ceramide induces the apoptosis of non‑small cell lung cancer cells through the Txnip/Trx1 complex.

Shi Y, Jin Y, Liu F, Jiang J, Cao J, Lu Y, Yang J
International journal of molecular medicine 2021 May;47(5)

MondoA Is Required for Normal Myogenesis and Regulation of the Skeletal Muscle Glycogen Content in Mice.

Ran H, Lu Y, Zhang Q, Hu Q, Zhao J, Wang K, Tong X, Su Q
Diabetes & metabolism journal 2021 May;45(3):439-451

Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.

Han M, Li S, Li L
Journal of cellular and molecular medicine 2021 May 24;25(13):5963-75

Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration.

Yi W, Zhang Y, Liu B, Zhou Y, Liao D, Qiao X, Gao D, Xie T, Yao Q, Zhang Y, Qiu Y, Huang G, Chen Z, Chen C, Ju Z
Cell reports 2021 Mar 30;34(13):108922

Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells.

Yang M, Zhang W, Yu X, Wang F, Li Y, Zhang Y, Yang Y
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 14;27:e930083

The piperine derivative HJ105 inhibits Aβ_1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.

Yang X, Zhi J, Leng H, Chen Y, Gao H, Ma J, Ji J, Hu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jul;87:153571

Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes.

Collins JA, Kapustina M, Bolduc JA, Pike JFW, Diekman BO, Mix K, Chubinskaya S, Eroglu E, Michel T, Poole LB, Furdui CM, Loeser RF
Free radical biology & medicine 2021 Apr;166:90-103

Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis.

Zheng T, Wang Q, Bian F, Zhao Y, Ma W, Zhang Y, Lu W, Lei P, Zhang L, Hao X, Chen L
Toxicology and applied pharmacology 2021 Apr 1;416:115468

Rosmarinic acid alleviates di-2-ethylhexyl phthalate (DEHP) -induced thyroid dysfunction via multiple inflammasomes activation.

Wu H, Ma K, Na X
The Journal of toxicological sciences 2020;45(7):373-390

Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats.

Yu J, Wang WN, Matei N, Li X, Pang JW, Mo J, Chen SP, Tang JP, Yan M, Zhang JH
Oxidative medicine and cellular longevity 2020;2020:4717258

Epigenetic repression of miR-17 contributed to di(2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal muscle.

Wei J, Hao Q, Chen C, Li J, Han X, Lei Z, Wang T, Wang Y, You X, Chen X, Li H, Ding Y, Huang W, Hu Y, Lin S, Shen H, Lin Y
Theranostics 2020;10(20):9230-9248

HPV 16 E6/E7 Promote the Glucose Uptake of GLUT1 in Lung Cancer Through Downregulation of TXNIP Due to Inhibition of PTEN Phosphorylation.

Tang JY, Li DY, He L, Qiu XS, Wang EH, Wu GP
Frontiers in oncology 2020;10:559543

Thioredoxin interacting protein (TXNIP) acts as a tumor suppressor in human prostate cancer.

Xie M, Xie R, Xie S, Wu Y, Wang W, Li X, Xu Y, Liu B, Zhou Y, Wang T, Gao L, Pan T
Cell biology international 2020 Oct;44(10):2094-2106

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway.

Jia Y, Cui R, Wang C, Feng Y, Li Z, Tong Y, Qu K, Liu C, Zhang J
Redox biology 2020 May;32:101534

Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.

Zhu Y, Zhu C, Yang H, Deng J, Fan D
Pharmacological research 2020 May;155:104746

PSMD12 promotes breast cancer growth via inhibiting the expression of pro-apoptotic genes.

Du X, Shen X, Dai L, Bi F, Zhang H, Lu C
Biochemical and biophysical research communications 2020 May 28;526(2):368-374

HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.

Yang X, Ji J, Liu C, Zhou M, Li H, Ye S, Hu Q
International immunopharmacology 2020 Jun;83:106383

Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model.

Chen H, Peng Y, Wang L, Wang X
Archives of physiology and biochemistry 2020 Jun 13;:1-8

High Glucose-Aggravated Hepatic Insulin Resistance: Role of the NLRP3 Inflammasome in Kupffer Cells.

Zheng T, Wang Q, Dong Y, Ma W, Zhang Y, Zhao Y, Bian F, Chen L
Obesity (Silver Spring, Md.) 2020 Jul;28(7):1270-1282

Endoplasmic reticulum stress and oxidative stress contribute to neuronal pyroptosis caused by cerebral venous sinus thrombosis in rats: Involvement of TXNIP/peroxynitrite-NLRP3 inflammasome activation.

Ding R, Ou W, Chen C, Liu Y, Li H, Zhang X, Chai H, Ding X, Wang Q
Neurochemistry international 2020 Dec;141:104856

NecroX-5 alleviate lipopolysaccharide-induced acute respiratory distress syndrome by inhibiting TXNIP/NLRP3 and NF-κB.

Fang XZ, Ge YL, Chen ZY, Shu HQ, Yang YY, Yu Y, Zhou XJ, Chen L, Cui SN, Wang YX, Yao SL, Shang Y
International immunopharmacology 2020 Apr;81:106257

Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes.

Shen F, Xiong Z, Kong J, Wang L, Cheng Y, Jin J, Huang Z
Toxicology letters 2019 Jan;300:105-115

Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.

Zhou F, Zhang Y, Chen J, Hu Y, Xu Y
Frontiers in endocrinology 2018;9:640

Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.

He W, Ye S, Zeng C, Xue S, Hu X, Zhang X, Gao S, Xiong Y, He X, Vivalda S, Li L, Wang Y, Ye Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury.

Hou Y, Wang Y, He Q, Li L, Xie H, Zhao Y, Zhao J
Behavioural brain research 2018 Jan 15;336:32-39

Effects of Hypobaric Hypoxia on Rat Retina and Protective Response of Resveratrol to the Stress.

Xin X, Dang H, Zhao X, Wang H
International journal of medical sciences 2017;14(10):943-950

Thioredoxin plays a key role in retinal neuropathy prior to endothelial damage in diabetic mice.

Ren X, Li C, Liu J, Zhang C, Fu Y, Wang N, Ma H, Lu H, Kong H, Kong L
Oncotarget 2017 Sep 22;8(37):61350-61364

Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease.

Zhang Y, Huang J, Yang X, Sun X, Xu Q, Wang B, Zhong P, Wei Z
Medicine 2017 Dec;96(49):e9108

Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas.

Cai Z, Zhang C, Zou Y, Lu C, Hu H, Qian J, Jiang L, Hu G
International journal of clinical oncology 2017 Aug;22(4):660-666

Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes.

Ratneswaran A, Sun MM, Dupuis H, Sawyez C, Borradaile N, Beier F
Journal of molecular medicine (Berlin, Germany) 2017 Apr;95(4):431-444

Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.

He K, Hu Y, Ma H, Zou Z, Xiao Y, Yang Y, Feng M, Li X, Ye X
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709

New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.

Ding C, Zhao Y, Shi X, Zhang N, Zu G, Li Z, Zhou J, Gao D, Lv L, Tian X, Yao J
Scientific reports 2016 Jun 27;6:28734

ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways.

Zeng H, Gu H, Chen C, Li M, Xia F, Xie L, Liu X, Zhang F, Tong X, Wang J, Yu Z, Zheng J
Oncotarget 2016 Jun 21;7(25):38347-38358

Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.

He K, Li X, Xiao Y, Yong Y, Zhang Z, Li S, Zhou T, Yang D, Gao P, Xin X
Food & function 2016 Aug 10;7(8):3505-15

FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer.

Ji S, Qin Y, Liang C, Huang R, Shi S, Liu J, Jin K, Liang D, Xu W, Zhang B, Liu L, Liu C, Xu J, Ni Q, Chiao PJ, Li M, Yu X
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Aug 1;22(15):3950-60

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human stomach tissue were subjected to SDS PAGE followed by western blot with 18243-1-AP(TXNIP antibody) at dilution of 1:300
Other comments: WB
Appendix: 18243-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HeLa cells using 18243-1-AP( TXNIP Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Other comments: IF
Appendix: 18243-1-AP.pdf

: Show more

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemistry of paraffin-embedded human lung tissue slide using 18243-1-AP( TXNIP Antibody) at dilution of 1:50 (under 40x lens)
Other comments: IHC
Appendix: 18243-1-AP.pdf

: Show more