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- References [20]
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- Product number
- 11372-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11372-1-AP, RRID:AB_2203743
- Product name
- TLE3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TLE3 antibody (Cat. #11372-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis.
TLE3 and TLE4-coordinated colonic macrophage-CD4(+) T cell crosstalk maintains intestinal immune homeostasis.
Zeb1 and Tle3 are trans-factors that differentially regulate the expression of myosin heavy chain-embryonic and skeletal muscle differentiation.
HHEX suppresses advanced thyroid cancer by interacting with TLE3.
TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis.
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination.
Pharmacological modulation of RORα controls fat browning, adaptive thermogenesis, and body weight in mice.
Defining the proteolytic landscape during enterovirus infection.
Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.
RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination.
Small molecule JQ1 promotes prostate cancer invasion via BET-independent inactivation of FOXA1.
Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer.
Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism.
Transducin-like enhancer of split 3 regulates proliferation of melanoma cells via histone deacetylase activity.
Tle corepressors are differentially partitioned to instruct CD8(+) T cell lineage choice and identity.
The transcriptional co-repressor TLE3 regulates myogenic differentiation by repressing the activity of the MyoD transcription factor.
Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs.
Cross-regulation between FOXA1 and ErbB2 signaling in estrogen receptor-negative breast cancer.
TLE3 is a dual-function transcriptional coregulator of adipogenesis.
Xu P, Xi Y, Kim JW, Zhu J, Zhang M, Xu M, Ren S, Yang D, Ma X, Xie W
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1241-1256
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1241-1256
TLE3 and TLE4-coordinated colonic macrophage-CD4(+) T cell crosstalk maintains intestinal immune homeostasis.
Li X, Zhang B, Zhang X, Yu S, Xue HH, Hu X
Mucosal immunology 2023 Feb;16(1):50-60
Mucosal immunology 2023 Feb;16(1):50-60
Zeb1 and Tle3 are trans-factors that differentially regulate the expression of myosin heavy chain-embryonic and skeletal muscle differentiation.
Kumar P, Zehra A, Saini M, Mathew SJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23074
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23074
HHEX suppresses advanced thyroid cancer by interacting with TLE3.
Xu Z, Feng Y, Yan Y, Jin H, Chen Y, Han Y, Huang S, Feng F, Fu H, Yin Y, Huang Y, Wang H, Cheng W
Molecular and cellular endocrinology 2023 Aug 20;574:111988
Molecular and cellular endocrinology 2023 Aug 20;574:111988
TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis.
Anstine LJ, Majmudar PR, Aponte A, Singh S, Zhao R, Weber-Bonk KL, Abdul-Karim FW, Valentine M, Seachrist DD, Grennel-Nickelson KE, Cuellar-Vite L, Sizemore GM, Sizemore ST, Webb BM, Thompson CL, Keri RA
Cancer research 2023 Apr 4;83(7):997-1015
Cancer research 2023 Apr 4;83(7):997-1015
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination.
Wang Y, Zhang Y, Zhang S, Kim B, Hull VL, Xu J, Prabhu P, Gregory M, Martinez-Cerdeno V, Zhan X, Deng W, Guo F
Cell reports 2021 Oct 5;37(1):109695
Cell reports 2021 Oct 5;37(1):109695
Pharmacological modulation of RORα controls fat browning, adaptive thermogenesis, and body weight in mice.
Auclair M, Roblot N, Capel E, Fève B, Antoine B
American journal of physiology. Endocrinology and metabolism 2021 Feb 1;320(2):E219-E233
American journal of physiology. Endocrinology and metabolism 2021 Feb 1;320(2):E219-E233
Defining the proteolytic landscape during enterovirus infection.
Saeed M, Kapell S, Hertz NT, Wu X, Bell K, Ashbrook AW, Mark MT, Zebroski HA, Neal ML, Flodström-Tullberg M, MacDonald MR, Aitchison JD, Molina H, Rice CM
PLoS pathogens 2020 Sep;16(9):e1008927
PLoS pathogens 2020 Sep;16(9):e1008927
Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.
Li Q, Sun Y, Jarugumilli GK, Liu S, Dang K, Cotton JL, Xiol J, Chan PY, DeRan M, Ma L, Li R, Zhu LJ, Li JH, Leiter AB, Ip YT, Camargo FD, Luo X, Johnson RL, Wu X, Mao J
Cell stem cell 2020 May 7;26(5):675-692.e8
Cell stem cell 2020 May 7;26(5):675-692.e8
RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination.
Ren Y, Xu X, Mao CY, Han KK, Xu YJ, Cao BY, Zhang ZB, Sethi G, Tang XW, Mao XL
Acta pharmacologica Sinica 2020 Mar;41(3):394-403
Acta pharmacologica Sinica 2020 Mar;41(3):394-403
Small molecule JQ1 promotes prostate cancer invasion via BET-independent inactivation of FOXA1.
Wang L, Xu M, Kao CY, Tsai SY, Tsai MJ
The Journal of clinical investigation 2020 Apr 1;130(4):1782-1792
The Journal of clinical investigation 2020 Apr 1;130(4):1782-1792
Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer.
Parolia A, Cieslik M, Chu SC, Xiao L, Ouchi T, Zhang Y, Wang X, Vats P, Cao X, Pitchiaya S, Su F, Wang R, Feng FY, Wu YM, Lonigro RJ, Robinson DR, Chinnaiyan AM
Nature 2019 Jul;571(7765):413-418
Nature 2019 Jul;571(7765):413-418
Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism.
Pearson S, Loft A, Rajbhandari P, Simcox J, Lee S, Tontonoz P, Mandrup S, Villanueva CJ
Genes & development 2019 Jul 1;33(13-14):747-762
Genes & development 2019 Jul 1;33(13-14):747-762
Transducin-like enhancer of split 3 regulates proliferation of melanoma cells via histone deacetylase activity.
Ogawa M, Yaginuma T, Nakatomi C, Nakajima T, Tada-Shigeyama Y, Addison WN, Urata M, Matsubara T, Watanabe K, Matsuo K, Sato T, Honda H, Hikiji H, Watanabe S, Kokabu S
Oncotarget 2019 Jan 8;10(3):404-414
Oncotarget 2019 Jan 8;10(3):404-414
Tle corepressors are differentially partitioned to instruct CD8(+) T cell lineage choice and identity.
Xing S, Shao P, Li F, Zhao X, Seo W, Wheat JC, Ramasamy S, Wang J, Li X, Peng W, Yu S, Liu C, Taniuchi I, Sweetser DA, Xue HH
The Journal of experimental medicine 2018 Aug 6;215(8):2211-2226
The Journal of experimental medicine 2018 Aug 6;215(8):2211-2226
The transcriptional co-repressor TLE3 regulates myogenic differentiation by repressing the activity of the MyoD transcription factor.
Kokabu S, Nakatomi C, Matsubara T, Ono Y, Addison WN, Lowery JW, Urata M, Hudnall AM, Hitomi S, Nakatomi M, Sato T, Osawa K, Yoda T, Rosen V, Jimi E
The Journal of biological chemistry 2017 Aug 4;292(31):12885-12894
The Journal of biological chemistry 2017 Aug 4;292(31):12885-12894
Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.
Ortega FJ, Serrano M, Rodriguez-Cuenca S, Moreno-Navarrete JM, Gómez-Serrano M, Sabater M, Rodriguez-Hermosa JI, Xifra G, Ricart W, Peral B, Vidal-Puig A, Fernández-Real JM
Journal of molecular medicine (Berlin, Germany) 2015 Jan;93(1):83-92
Journal of molecular medicine (Berlin, Germany) 2015 Jan;93(1):83-92
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs.
Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P
Cell metabolism 2013 Mar 5;17(3):423-35
Cell metabolism 2013 Mar 5;17(3):423-35
Cross-regulation between FOXA1 and ErbB2 signaling in estrogen receptor-negative breast cancer.
Naderi A, Meyer M, Dowhan DH
Neoplasia (New York, N.Y.) 2012 Apr;14(4):283-96
Neoplasia (New York, N.Y.) 2012 Apr;14(4):283-96
TLE3 is a dual-function transcriptional coregulator of adipogenesis.
Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, Wroblewski K, Schmedt C, Chao LC, Boyadjian R, Mandrup S, Hevener A, Saez E, Tontonoz P
Cell metabolism 2011 Apr 6;13(4):413-427
Cell metabolism 2011 Apr 6;13(4):413-427
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 11372-1-AP(TLE3 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TLE3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TLE3. This antibody recognizes human,mouse,rat antigen. The TLE3 antibody has been validated for the following applications: ELISA, WB, IHC, IF, IP analysis.
