12000-1-AP

antibody from Proteintech Group

Targeting: CCL5 D17S136E, MGC17164, RANTES, SCYA5, SISd, TCP228

Provider product page for 12000-1-AP

Western blot

ELISA

Antibody data

Antibody Data
Antigen structure
References [25]
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Product number: 12000-1-AP - Provider product page
Provider: Proteintech Group
Product name: RANTES antibody
Antibody type: Polyclonal
Description: RANTES antibody (Cat. #12000-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CCL5 protein structure - 12000-1-AP shown in red.

Submitted references A Novel FGF2-Targeted Inhibitor (N-trans-feruloyloctopamine) Suppresses UVB-Induced Skin Damage and Hyperpigmentation.

Li B, Jin W, Liu B, Yang J, Wu S, He M, Jiang Z, Wang Z, Huang L, Li X, Cao K, Duan L, Wang K, Lai C, Gao Y, Cai H
Advanced healthcare materials 2026 Mar;15(9):e02250

Folate promotes colorectal cancer progression by impairing CD8(+) T cell function and recruitment via SLC19A1/p-AKT/NOTCH1 axis and CCL5 downregulation.

Qing S, Ling Y, Lai Y, Hu Y, Zhong Y, Liu Y, Liu X, Fang Y, Qian J, Deng H, Peng Y, Wu D, Shen Z
Journal of translational medicine 2026 Mar 13;24(1)

Identification of novel protein biomarkers of macrophage polarization using comparative proteomic analyses of murine primary macrophages.

Liu B, Nguyen PL, Li P, Naldrett MJ, Alvarez S, Yu J
Journal of immunology (Baltimore, Md. : 1950) 2025 Oct 1;214(10):2730-2742

The combination of flaxseed lignans and PD-1/ PD-L1 inhibitor inhibits breast cancer growth via modulating gut microbiome and host immunity.

Wu H, Liu J, Zhang XH, Jin S, Li P, Liu H, Zhao L, Wang J, Zhao S, Tian HD, Lai JR, Hao Y, Liu GR, Hou K, Yan M, Liu SL, Pang D
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 May;80:101222

Tumor-derived exosomal CCT6A serves as a matchmaker introducing chemokines to tumor-associated macrophages in pancreatic ductal adenocarcinoma.

Ma T, Guo WW, Zhang M, He W, Dongzhi C, Gongye X, Xia P, Chai Y, Chen Z, Zhu Y, Qu C, Liu J, Yang Z, Ma W, Tian M, Yuan Y
Cell death & disease 2025 May 15;16(1):382

Egln3 expression in microglia enhances the neuroinflammatory responses in Alzheimer's disease.

Guan J, Wu P, Liu M, Jiang C, Meng X, Wu X, Lu M, Fan Y, Gan L
Brain, behavior, and immunity 2025 Mar;125:21-32

Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway.

Jin Z, Jin Z, Liu Z, Yin Y, Zhang Y, Zhang Y, Kang J, Fang Y, Jiang W, Ning B
Communications biology 2025 Jul 29;8(1):1127

Integration of transcriptomics and metabolomics reveals the mechanism of Glycyrrhizae Radix Et Rhizoma extract inhibiting CCL5 in the treatment of acute pharyngitis.

Han X, Sun C, Ding H, Deng S, Li M, Lou J, Song X, Kai G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156360

Mesangial angiogenesis and interstitial eosinophilic infiltration in diabetic nephropathy are associated with elevated CD248 expression.

Li X, Zhang J, Wang Y, Yu T, Jiang S, Gao Y, Zhang H, Li W
Renal failure 2025 Dec;47(1):2510552

Human cytomegalovirus UL23 inhibits immune cell migration and blocks antiviral immune cell responses by reducing the expression of chemokines CCL2 and CCL5.

Wang H, Zhang C, Li M, Zhao W, Wang J, Ran Y, Yang X, Deng Z, Chen J, Li H
Virulence 2025 Dec;16(1):2500493

The T-type voltage-gated Ca(2+) channel Ca(V)3.1 involves in the disruption of respiratory epithelial barrier induced by Pasteurella multocida toxin.

Bi H, Wang F, Lin L, Zhang D, Chen M, Shang Y, Hua L, Chen H, Wu B, Peng Z
Virulence 2025 Dec;16(1):2466482

Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency.

Yang S, Sun Y, Luo W, Zhou X, Gu X, Zhang W, Zhu H, Wu W, Wu X, Yu M, Wang S
Materials today. Bio 2025 Aug;33:101930

Targeting S100A8/A9-NCF1 axis in tumor microenvironment to prevent tumor metastasis by self-assembled peptide nanofibers.

Guo Y, Zhang Z, Huang H, Wu Y, Yin L, Zhou Y, Ding F, Hong S, Steinmetz NF, Cai H
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Apr 2;33(4):1502-1518

Identification and knockout of a herbivore susceptibility gene enhances planthopper resistance and increases rice yield.

Kuai P, Lin N, Ye M, Ye M, Chen L, Chen S, Zu H, Hu L, Gatehouse AMR, Lou Y
Nature food 2024 Oct;5(10):846-859

Vimentin, inversely correlating with infiltration of CD8 + T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma.

Liang Y, He S, Liu Q, Liu T, Tan Y, Peng T, Huang C, Lu X, Zheng S
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119781

NME4 suppresses NFκB2-CCL5 axis, restricting CD8+ T cell tumour infiltration in oesophageal squamous cell carcinoma.

Zheng S, He S, Liang Y, Liu Q, Liu T, Tan Y, Peng T, Huang C, Gao H, Lu X
Immunology 2024 Oct;173(2):408-421

Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis.

Xiong Z, Yu SL, Xie ZX, Zhuang RL, Peng SR, Wang Q, Gao Z, Li BH, Xie JJ, Huang H, Li KW
iScience 2024 May 17;27(5):109674

LARP7 Contributes to Glucose-Induced Cardiac Dysfunction, Apoptosis and Fibrosis by Inhibiting the Degradation of STING.

Sun J, Wang Z, Duan Y, Liu C, Zhao S, Deng J
Frontiers in bioscience (Landmark edition) 2024 Jul 26;29(7):274

miR-450a-2-3p targets ERK(1/2) to ameliorate ISO-induced cardiac fibrosis in mice.

Liu L, Luo F
Genes & nutrition 2024 Aug 19;19(1):16

PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma Progression.

Tang J, He J, Guo H, Lin H, Li M, Yang T, Wang HY, Li D, Liu J, Li L, Xia H, Zhuo Z, Miao L
Research (Washington, D.C.) 2023;6:0033

Identification and Preliminary Clinical Validation of Key Extracellular Proteins as the Potential Biomarkers in Hashimoto's Thyroiditis by Comprehensive Analysis.

Xi Z, Yang T, Huang T, Zhou J, Yang P
Biomedicines 2023 Nov 24;11(12)

Targeted Deletion of Rictor in BMSCs Reduces the Biological Activity of K7M2 Cells and Mitigates OS-Induced Bone Destruction.

Lu J, Dai D, Zhang J, Wang R, Miao D, Sun W
Stem cells (Dayton, Ohio) 2023 Jun 15;41(6):672-683

Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression.

Xu J, Shi Q, Lou J, Wang B, Wang W, Niu J, Guo L, Chen C, Yu Y, Huang Y, Guo W, Lan J, Zhu Y, Ren T, Tang X
Journal for immunotherapy of cancer 2023 Apr;11(4)

Upregulation of STAT1-CCL5 axis is a biomarker of colon cancer and promotes the proliferation of colon cancer cells.

Niu M, Yi M, Dong B, Luo S, Wu K
Annals of translational medicine 2020 Aug;8(15):951

Effects of CCL5 on the biological behavior of breast cancer and the mechanisms of its interaction with tumor‑associated macrophages.

An G, Wu F, Huang S, Feng L, Bai J, Gu S, Zhao X
Oncology reports 2019 Dec;42(6):2499-2511

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