Antibody data
- Antibody Data
- Antigen structure
- References [53]
- Comments [0]
- Validations [0]
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- Product number
- 67373-1-Ig - Provider product page

- Provider
- Proteintech Group
- Product name
- ACC1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated ACC1 antibody (Cat. #67373-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse, Rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1A11G10
- Vial size
- 20ul, 150ul
Submitted references NUDT7 Modulates the UBA52-SREBF1 Signaling Axis to Promote PRRSV Replication via Lipid Synthesis.
Flavonoid GL-V9 as a novel and potent acetyl-coa carboxylase 1 inhibitor confers cisplatin hypersensitivity in ovarian cancer.
Dendrobium officinale polysaccharide ameliorate hyperlipidemia through LKB1/AMPK and CD36/PGC-1α/UCP1 activation and gut microbiota modulation.
The Porcine Colitis Model Recapitulates the Visceral Adipose Metabolic Reprogramming of Human Ulcerative Colitis.
KCNK3 coordinates adipocyte lipid storage and thermogenic shifts via AMPK, modulating a ferroptosis-permissive state.
Network toxicology and machine learning revealed the association between non-alcoholic fatty liver disease induced by polystyrene nanoplastics.
Knockdown of ACC1 promotes migration and invasion of U251 glioma cells by epigenetically suppressing SDH.
Inhibition of Aberrant Activated Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism.
SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis.
MTFR2-Mediated Fission Drives Fatty Acid and Mitochondrial Co-Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis.
Ultrasound-Guided Functionalized Extracellular Vesicles for Visualized, Controlled, and Efficient Renal Delivery for Enhanced Kidney Repair.
BRD4 Inhibitor Alleviates Recurrent Spontaneous Abortion via Regulating BRD4/STAT3/IL-17A Axis to Decrease the Th17 Cell Differentiation.
miRNA-novel-216 regulated fatty acid composition and progesterone synthesis in goat granulosa cells by targeting the TPD52.
Riboflavin-PLGA nanoparticles enhance the effectiveness of the pyruvate carboxylase inhibitor ZY-444 in targeting lipogenesis in colon and breast cancer.
Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells.
miR-125b-5p regulates FFA-induced hepatic steatosis in L02 cells by targeting estrogen-related receptor alpha.
Spatial isotope deep tracing deciphers inter-tissue metabolic crosstalk.
HKDC1 promotes ovarian cancer progression through boosting lipid metabolism and immune escape by stabilizing G6PC/G6PC2.
Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation.
Ursolic Acid Ameliorates Alcoholic Liver Injury through Attenuating Oxidative Stress-Mediated Ferroptosis and Modulating Gut Microbiota.
Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages.
Dramatic Suppression of Lipogenesis and No Increase in Beta-Oxidation Gene Expression Are among the Key Effects of Bergamot Flavonoids in Fatty Liver Disease.
Endothelial Drp1 Couples VEGF-induced Redox Signaling with Glycolysis Through Cysteine Oxidation to Drive Angiogenesis.
Time-restricted feeding ameliorates non-alcoholic fatty liver disease through modulating hepatic nicotinamide metabolism via gut microbiota remodeling.
PEDV inhibits HNRNPA3 expression by miR-218-5p to enhance cellular lipid accumulation and promote viral replication.
Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes.
Ganoderma lucidum Spore Powder Alleviates Metabolic-Associated Fatty Liver Disease by Improving Lipid Accumulation and Oxidative Stress via Autophagy.
mTORC2 knockdown mediates lipid metabolism to alleviate hyperlipidemic pancreatitis through PPARα.
C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport.
Fatty acid synthesis and oxidation regulate human endoderm differentiation by mediating SMAD3 nuclear localization via acetylation.
The Different Mechanisms of Lipid Accumulation in Hepatocytes Induced by Oleic Acid/Palmitic Acid and High-Fat Diet.
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
Discovery of a natural small-molecule AMP-activated kinase activator that alleviates nonalcoholic steatohepatitis.
Uncarboxylated Osteocalcin Decreases SCD1 by Activating AMPK to Alleviate Hepatocyte Lipid Accumulation.
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function.
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.
Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
Garlic-derived exosomes regulate PFKFB3 expression to relieve liver dysfunction in high-fat diet-fed mice via macrophage-hepatocyte crosstalk.
CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor.
Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats.
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
Hawk tea prevents high-fat diet-induced obesity in mice by activating the AMPK/ACC/SREBP1c signaling pathways and regulating the gut microbiota.
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Polyphyllin I improves myocardial damage in coronary artery disease via modulating lipid metabolism and myocardial apoptosis.
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARα Pathway.
High-Salt Attenuates the Efficacy of Dapagliflozin in Tubular Protection by Impairing Fatty Acid Metabolism in Diabetic Kidney Disease.
CARS senses cysteine deprivation to activate AMPK for cell survival.
The Histone Demethylase JMJD1C Regulates CAMKK2-AMPK Signaling to Participate in Cardiac Hypertrophy.
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Lipid-lowering and antioxidative effects of Apium graveolens L. root flavonoid extracts.
Yan Y, Li C, Zhang J, Li R, Yin B, Zhang S, Zhang Y, Zhang X, Han J, Huang J
International journal of biological sciences 2026;22(3):1590-1610
International journal of biological sciences 2026;22(3):1590-1610
Flavonoid GL-V9 as a novel and potent acetyl-coa carboxylase 1 inhibitor confers cisplatin hypersensitivity in ovarian cancer.
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Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158021
Dendrobium officinale polysaccharide ameliorate hyperlipidemia through LKB1/AMPK and CD36/PGC-1α/UCP1 activation and gut microbiota modulation.
Gong Y, Fang H, Wu L, Zhang J, Wen Y, Rao Y, Zhao Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar 4;
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The Porcine Colitis Model Recapitulates the Visceral Adipose Metabolic Reprogramming of Human Ulcerative Colitis.
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Network toxicology and machine learning revealed the association between non-alcoholic fatty liver disease induced by polystyrene nanoplastics.
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Ecotoxicology and environmental safety 2026 Apr 1;314:120058
Knockdown of ACC1 promotes migration and invasion of U251 glioma cells by epigenetically suppressing SDH.
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International journal of oncology 2025 Sep;67(3)
Inhibition of Aberrant Activated Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism.
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SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis.
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MTFR2-Mediated Fission Drives Fatty Acid and Mitochondrial Co-Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis.
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miRNA-novel-216 regulated fatty acid composition and progesterone synthesis in goat granulosa cells by targeting the TPD52.
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Riboflavin-PLGA nanoparticles enhance the effectiveness of the pyruvate carboxylase inhibitor ZY-444 in targeting lipogenesis in colon and breast cancer.
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Scientific reports 2025 Dec 30;16(1):125
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Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells.
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miR-125b-5p regulates FFA-induced hepatic steatosis in L02 cells by targeting estrogen-related receptor alpha.
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Nature communications 2025 Aug 26;16(1):7934
HKDC1 promotes ovarian cancer progression through boosting lipid metabolism and immune escape by stabilizing G6PC/G6PC2.
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Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation.
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Frontiers in pharmacology 2024;15:1414856
Ursolic Acid Ameliorates Alcoholic Liver Injury through Attenuating Oxidative Stress-Mediated Ferroptosis and Modulating Gut Microbiota.
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Journal of agricultural and food chemistry 2024 Sep 25;72(38):21181-21192
Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages.
Wei X, Wu D, Li J, Wu M, Li Q, Che Z, Cheng X, Cheng Q, Yin F, Zhang H, Wang X, Abtahi S, Zuo L, Hang L, Ma L, Kuo WT, Liu X, Turner JR, Wang H, Xiao J, Wang F
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Dramatic Suppression of Lipogenesis and No Increase in Beta-Oxidation Gene Expression Are among the Key Effects of Bergamot Flavonoids in Fatty Liver Disease.
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Endothelial Drp1 Couples VEGF-induced Redox Signaling with Glycolysis Through Cysteine Oxidation to Drive Angiogenesis.
Nagarkoti S, Kim YM, Das A, Ash D, A Vitriol E, Read TA, Sudhahar V, Hossain MS, Yadav S, McMenamin M, Kelley S, Lucas R, Stepp D, Belin de Chantemele EJ, Caldwell RB, Fulton DJ, Fukai T, Ushio-Fukai M
bioRxiv : the preprint server for biology 2024 Jun 16;
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Time-restricted feeding ameliorates non-alcoholic fatty liver disease through modulating hepatic nicotinamide metabolism via gut microbiota remodeling.
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PEDV inhibits HNRNPA3 expression by miR-218-5p to enhance cellular lipid accumulation and promote viral replication.
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mBio 2024 Feb 14;15(2):e0319723
Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes.
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The EMBO journal 2024 Dec;43(24):6383-6409
Ganoderma lucidum Spore Powder Alleviates Metabolic-Associated Fatty Liver Disease by Improving Lipid Accumulation and Oxidative Stress via Autophagy.
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Antioxidants (Basel, Switzerland) 2024 Dec 9;13(12)
mTORC2 knockdown mediates lipid metabolism to alleviate hyperlipidemic pancreatitis through PPARα.
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Journal of biochemical and molecular toxicology 2024 Aug;38(8):e23802
Journal of biochemical and molecular toxicology 2024 Aug;38(8):e23802
C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport.
Wu Y, Zheng W, Xu G, Zhu L, Li Z, Chen J, Wang L, Chen S
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Cell death and differentiation 2024 Aug;31(8):1070-1084
Fatty acid synthesis and oxidation regulate human endoderm differentiation by mediating SMAD3 nuclear localization via acetylation.
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Developmental cell 2023 Sep 25;58(18):1670-1687.e4
The Different Mechanisms of Lipid Accumulation in Hepatocytes Induced by Oleic Acid/Palmitic Acid and High-Fat Diet.
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Molecules (Basel, Switzerland) 2023 Sep 20;28(18)
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
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iScience 2023 Nov 17;26(11):108226
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Chen J, Xu L, Zhang XQ, Liu X, Zhang ZX, Zhu QM, Liu JY, Iqbal MO, Ding N, Shao CL, Wei MY, Gu YC
Marine life science & technology 2023 May;5(2):196-210
Marine life science & technology 2023 May;5(2):196-210
Uncarboxylated Osteocalcin Decreases SCD1 by Activating AMPK to Alleviate Hepatocyte Lipid Accumulation.
Wang D, Zhang M, Xu J, Yang J
Molecules (Basel, Switzerland) 2023 Mar 31;28(7)
Molecules (Basel, Switzerland) 2023 Mar 31;28(7)
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function.
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Acta pharmacologica Sinica 2023 Feb;44(2):356-366
Acta pharmacologica Sinica 2023 Feb;44(2):356-366
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.
Wang K, Fu S, Dong L, Zhang D, Wang M, Wu X, Shen E, Luo L, Li C, Nice EC, Huang C, Zou B
Autophagy 2023 Dec;19(12):3132-3150
Autophagy 2023 Dec;19(12):3132-3150
Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
Chen M, Zhu JY, Mu WJ, Luo HY, Li Y, Li S, Yan LJ, Li RY, Guo L
Nature communications 2023 Dec 18;14(1):8391
Nature communications 2023 Dec 18;14(1):8391
Garlic-derived exosomes regulate PFKFB3 expression to relieve liver dysfunction in high-fat diet-fed mice via macrophage-hepatocyte crosstalk.
Liu J, Li W, Bian Y, Jiang X, Zhu F, Yin F, Yin L, Song X, Guo H, Liu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Apr;112:154679
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Apr;112:154679
CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor.
Ngamkham J, Siritutsoontorn S, Saisomboon S, Vaeteewoottacharn K, Jitrapakdee S
Frontiers in oncology 2022;12:966089
Frontiers in oncology 2022;12:966089
Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats.
Zhong Y, Li Z, Jin R, Yao Y, He S, Lei M, Wang X, Shi C, Gao L, Peng X
Nutrients 2022 Nov 24;14(23)
Nutrients 2022 Nov 24;14(23)
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
Zhang W, Ho CT, Lu M
International journal of molecular sciences 2022 May 17;23(10)
International journal of molecular sciences 2022 May 17;23(10)
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
Cheng L, Shi L, He C, Wang C, Lv Y, Li H, An Y, Dai H, Duan Y, Zhang H, Huang Y, Fu W, Meng Y, Zhao B
Phytotherapy research : PTR 2022 Jun;36(6):2495-2510
Phytotherapy research : PTR 2022 Jun;36(6):2495-2510
Hawk tea prevents high-fat diet-induced obesity in mice by activating the AMPK/ACC/SREBP1c signaling pathways and regulating the gut microbiota.
Tao W, Cao W, Yu B, Chen H, Gong R, Luorong Q, Luo J, Yao L, Zhang D
Food & function 2022 Jun 6;13(11):6056-6071
Food & function 2022 Jun 6;13(11):6056-6071
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Li R, Xiao J, Cao Y, Huang Q, Ho CT, Lu M
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Polyphyllin I improves myocardial damage in coronary artery disease via modulating lipid metabolism and myocardial apoptosis.
Yang Z, Yang X, An M
Journal of biochemical and molecular toxicology 2022 Dec;36(12):e23219
Journal of biochemical and molecular toxicology 2022 Dec;36(12):e23219
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
Wang JQ, Li LL, Hu A, Deng G, Wei J, Li YF, Liu YB, Lu XY, Qiu ZP, Shi XJ, Zhao X, Luo J, Song BL
Nature 2022 Aug;608(7922):413-420
Nature 2022 Aug;608(7922):413-420
FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARα Pathway.
Zhuang L, Mao Y, Liu Z, Li C, Jin Q, Lu L, Tao R, Yan X, Chen K
Frontiers in cardiovascular medicine 2021;8:722908
Frontiers in cardiovascular medicine 2021;8:722908
High-Salt Attenuates the Efficacy of Dapagliflozin in Tubular Protection by Impairing Fatty Acid Metabolism in Diabetic Kidney Disease.
Zou M, Chen Y, Zheng Z, Sheng S, Jia Y, Wang X, Ren S, Yang Y, Li X, Dong W, Guan M, Zhang Q, Xue Y
Frontiers in pharmacology 2021;12:741087
Frontiers in pharmacology 2021;12:741087
CARS senses cysteine deprivation to activate AMPK for cell survival.
Yuan M, Yan R, Zhang Y, Qiu Y, Jiang Z, Liu H, Wang Y, Sun L, Zhang H, Gao P
The EMBO journal 2021 Nov 2;40(21):e108028
The EMBO journal 2021 Nov 2;40(21):e108028
The Histone Demethylase JMJD1C Regulates CAMKK2-AMPK Signaling to Participate in Cardiac Hypertrophy.
Yu S, Li Y, Zhao H, Wang Q, Chen P
Frontiers in physiology 2020;11:539
Frontiers in physiology 2020;11:539
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
Zou G, Zhang X, Wang L, Li X, Xie T, Zhao J, Yan J, Wang L, Ye H, Jiao S, Xiang R, Shi Y
Theranostics 2020;10(15):6839-6853
Theranostics 2020;10(15):6839-6853
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Lu XY, Shi XJ, Hu A, Wang JQ, Ding Y, Jiang W, Sun M, Zhao X, Luo J, Qi W, Song BL
Nature 2020 Dec;588(7838):479-484
Nature 2020 Dec;588(7838):479-484
Lipid-lowering and antioxidative effects of Apium graveolens L. root flavonoid extracts.
He Y, Shi Y, Zhang A, Zhang X, Sun J, Tian L
RSC advances 2019 Aug 23;9(46):26757-26767
RSC advances 2019 Aug 23;9(46):26757-26767
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