Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 12998-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12998-1-AP, RRID:AB_10597388
- Product name
- NF-L antibody
- Antibody type
- Polyclonal
- Description
- NF-L antibody (Cat. #12998-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Bisphenol S impairs mitochondrial function by targeting Myo19/oxidative phosphorylation pathway contributing to axonal and dendritic injury.
C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress.
Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam.
Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelination.
<Editors' Choice> Supernatant from activated omentum accelerates wound healing in diabetic mice wound model.
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy.
LncRNA Gm16638-201 Inhibits the 14-3-3Ɛ Pathway in the Murine Prefrontal Cortex to Induce Depressive Behaviors.
A comprehensive mouse brain acetylome-the cellular-specific distribution of acetylated brain proteins.
Hypoxia-pretreated mesenchymal stem cell-derived exosomes-loaded low-temperature extrusion 3D-printed implants for neural regeneration after traumatic brain injury in canines.
Injectable and reactive oxygen species-scavenging gelatin hydrogel promotes neural repair in experimental traumatic brain injury.
In situ forming and biocompatible hyaluronic acid hydrogel with reactive oxygen species-scavenging activity to improve traumatic brain injury repair by suppressing oxidative stress and neuroinflammation.
Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment.
Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons.
Serum Protein Biomarker Findings Reflective of Oxidative Stress and Vascular Abnormalities in Male, but Not Female, Collision Sport Athletes.
Control the fate of human umbilical cord mesenchymal stem cells with dual-enzymatically cross-linked gelatin hydrogels for potential applications in nerve regeneration.
Perinatal exposure to nonylphenol delayed myelination in offspring cerebellum.
Inhibiting endogenous tissue plasminogen activator enhanced neuronal apoptosis and axonal injury after traumatic brain injury.
Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury.
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Achaete-Scute Homolog 1 Expression Controls Cellular Differentiation of Neuroblastoma.
Bone marrow mesenchymal stem cells repair spinal cord ischemia/reperfusion injury by promoting axonal growth and anti-autophagy.
Zhang X, Gong H, Zhao Y, Wu Y, Cheng J, Song Y, Wang B, Qin Y, Sun M
Environment international 2024 Apr;186:108643
Environment international 2024 Apr;186:108643
C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress.
Cicardi ME, Hallgren JH, Mawrie D, Krishnamurthy K, Markandaiah SS, Nelson AT, Kankate V, Anderson EN, Pasinelli P, Pandey UB, Eischen CM, Trotti D
iScience 2023 Sep 15;26(9):107505
iScience 2023 Sep 15;26(9):107505
Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam.
Saletti PG, Mowrey WB, Liu W, Li Q, McCullough J, Aniceto R, Lin IH, Eklund M, Casillas-Espinosa PM, Ali I, Santana-Gomez C, Coles L, Shultz SR, Jones N, Staba R, O'Brien TJ, Moshé SL, Agoston DV, Galanopoulou AS, EpiBioS4Rx Study Group
Epilepsia open 2023 Jun;8(2):586-608
Epilepsia open 2023 Jun;8(2):586-608
Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelination.
Wang Y, Sadike D, Huang B, Li P, Wu Q, Jiang N, Fang Y, Song G, Xu L, Wang W, Xie M
Journal of neuroinflammation 2023 Feb 18;20(1):41
Journal of neuroinflammation 2023 Feb 18;20(1):41
<Editors' Choice> Supernatant from activated omentum accelerates wound healing in diabetic mice wound model.
Li Y, Hashikawa K, Ebisawa K, Kambe M, Higuchi S, Kamei Y
Nagoya journal of medical science 2023 Aug;85(3):528-541
Nagoya journal of medical science 2023 Aug;85(3):528-541
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy.
Chen ZP, Wang S, Zhao X, Fang W, Wang Z, Ye H, Wang MJ, Ke L, Huang T, Lv P, Jiang X, Zhang Q, Li L, Xie ST, Zhu JN, Hang C, Chen D, Liu X, Yan C
Nature neuroscience 2023 Apr;26(4):542-554
Nature neuroscience 2023 Apr;26(4):542-554
LncRNA Gm16638-201 Inhibits the 14-3-3Ɛ Pathway in the Murine Prefrontal Cortex to Induce Depressive Behaviors.
Zhang T, Wang WL, Liu TJ, Lu S, Bian YC, Xiao R, Zhang CL
Biological & pharmaceutical bulletin 2022;45(11):1616-1626
Biological & pharmaceutical bulletin 2022;45(11):1616-1626
A comprehensive mouse brain acetylome-the cellular-specific distribution of acetylated brain proteins.
Ji Y, Chen Z, Cen Z, Ye Y, Li S, Lu X, Shao Q, Wang D, Ji J, Ji Q
Frontiers in cellular neuroscience 2022;16:980815
Frontiers in cellular neuroscience 2022;16:980815
Hypoxia-pretreated mesenchymal stem cell-derived exosomes-loaded low-temperature extrusion 3D-printed implants for neural regeneration after traumatic brain injury in canines.
Liu X, Wang J, Wang P, Zhong L, Wang S, Feng Q, Wei X, Zhou L
Frontiers in bioengineering and biotechnology 2022;10:1025138
Frontiers in bioengineering and biotechnology 2022;10:1025138
Injectable and reactive oxygen species-scavenging gelatin hydrogel promotes neural repair in experimental traumatic brain injury.
Zhang D, Chang R, Ren Y, He Y, Guo S, Guan F, Yao M
International journal of biological macromolecules 2022 Oct 31;219:844-863
International journal of biological macromolecules 2022 Oct 31;219:844-863
In situ forming and biocompatible hyaluronic acid hydrogel with reactive oxygen species-scavenging activity to improve traumatic brain injury repair by suppressing oxidative stress and neuroinflammation.
Zhang D, Ren Y, He Y, Chang R, Guo S, Ma S, Guan F, Yao M
Materials today. Bio 2022 Jun;15:100278
Materials today. Bio 2022 Jun;15:100278
Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment.
Wang L, Zhang D, Ren Y, Guo S, Li J, Ma S, Yao M, Guan F
Materials today. Bio 2022 Jan;13:100201
Materials today. Bio 2022 Jan;13:100201
Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons.
Zhu PP, Hung HF, Batchenkova N, Nixon-Abell J, Henderson J, Zheng P, Renvoisé B, Pang S, Xu CS, Saalfeld S, Funke J, Xie Y, Svara F, Hess HF, Blackstone C
Human molecular genetics 2022 Aug 23;31(16):2779-2795
Human molecular genetics 2022 Aug 23;31(16):2779-2795
Serum Protein Biomarker Findings Reflective of Oxidative Stress and Vascular Abnormalities in Male, but Not Female, Collision Sport Athletes.
Major BP, McDonald SJ, O'Brien WT, Symons GF, Clough M, Costello D, Sun M, Brady RD, Mccullough J, Aniceto R, Lin IH, Law M, Mychasiuk R, O'Brien TJ, Agoston DV, Shultz SR
Frontiers in neurology 2020;11:549624
Frontiers in neurology 2020;11:549624
Control the fate of human umbilical cord mesenchymal stem cells with dual-enzymatically cross-linked gelatin hydrogels for potential applications in nerve regeneration.
Li J, Gao F, Ma S, Zhang Y, Zhang J, Guan F, Yao M
Journal of tissue engineering and regenerative medicine 2020 Sep;14(9):1261-1271
Journal of tissue engineering and regenerative medicine 2020 Sep;14(9):1261-1271
Perinatal exposure to nonylphenol delayed myelination in offspring cerebellum.
Jiang Y, You M, Li S, Xu Y, Wang Y
Biochemical pharmacology 2020 Aug;178:114120
Biochemical pharmacology 2020 Aug;178:114120
Inhibiting endogenous tissue plasminogen activator enhanced neuronal apoptosis and axonal injury after traumatic brain injury.
Zhao JJ, Liu ZW, Wang B, Huang TQ, Guo D, Zhao YL, Song JN
Neural regeneration research 2020 Apr;15(4):667-675
Neural regeneration research 2020 Apr;15(4):667-675
Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury.
Ying Z, Pan C, Shao T, Liu L, Li L, Guo D, Zhang S, Yuan T, Cao R, Jiang Z, Chen S, Wang F, Wang X
Molecular cell 2018 Nov 1;72(3):457-468.e5
Molecular cell 2018 Nov 1;72(3):457-468.e5
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Liu J, Wang L, Du Y, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Achaete-Scute Homolog 1 Expression Controls Cellular Differentiation of Neuroblastoma.
Kasim M, Heß V, Scholz H, Persson PB, Fähling M
Frontiers in molecular neuroscience 2016;9:156
Frontiers in molecular neuroscience 2016;9:156
Bone marrow mesenchymal stem cells repair spinal cord ischemia/reperfusion injury by promoting axonal growth and anti-autophagy.
Yin F, Meng C, Lu R, Li L, Zhang Y, Chen H, Qin Y, Guo L
Neural regeneration research 2014 Sep 15;9(18):1665-71
Neural regeneration research 2014 Sep 15;9(18):1665-71
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 12998-1-AP(NEFL antibody) at dilution of 1:4000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of NIH3T3 cells, using NEFL antibody 12998-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 12998-1-AP(NEFL antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 12998-1-AP(NEFL antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue