ADGRB1

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]

Description

Adhesion G protein-coupled receptor B1

Tissue specificity

Tissue enriched (brain)

Predicted location

Membrane, Secreted in brain

Protein family

Cancer-related genes
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

8 (142449430 - 142545009)

Ensembl ID

ENSG00000181790  (ver. 103.38)

Orthologs

Mouse Adgrb1: ENSMUSG00000034730

UniProt

O14514

neXtProt

NX_O14514

Human splice variants
Mouse splice variants

Protein structure