Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS6488 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IKBKE polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human IKBKE.
- Description
- The functional IKK complex contains three subunits, IKKÏ«, IKKÉÇ and IKKÎÛ (also designated NEMO), and each appear to make essential contributions to I°ÙB phosphorylation. IKK-i is a serine/threonine kinase that shares homology with IKKÏ« and IKKÉÇ. IKK-i is primarily expressed in immune cells and is induced by lipopolysaccharide and by proinflammatory cytokines including TNFÏ«, IL-1 and IL-6. Overexpression of IKK-i was shown to result in phosphorylation of I°ÙBÏ« on Ser32 and Ser36, and in NF°ÙB activation, suggesting that IKK-i may act as an I°ÙB kinase in the immune system.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of IKBKE pAb in extracts from HUVEC cells.