BS2205

antibody from Bioworld Technology, Inc

Targeting: ACTN3

Immunocytochemistry

Antibody data

Submit

Validation data

Product number: BS2205 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS2205, RRID:AB_1662691
Product name: Actinin Ï«3 (E25) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to the N-terminus of Human Actinin-Ï«3.
Description: The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and Ï«-actinins. There are four tissue-specific Ï«-actinins, namely Ï«-actinin-1, Ï«-actinin-2, Ï«-actinin-3 and Ï«-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each Ï«-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding Ï«-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

ACTN3 protein structure - BS2205 shown in red.