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Learn11289-1-AP
antibody from Proteintech Group
Targeting: PARP3
ADPRT3, ADPRTL3, ARTD3, hPARP-3, IRT1, pADPRT-3
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 11289-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11289-1-AP, RRID:AB_2283392
- Product name
- PARP3 antibody
- Antibody type
- Polyclonal
- Description
- PARP3 antibody (Cat. #11289-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response.
Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease.
Yue W, Li X, Zhan X, Wang L, Ma J, Bi M, Wang Q, Gu X, Xie B, Liu T, Guo H, Zhu X, Song C, Qiao J, Li M
EBioMedicine 2024 May;103:105129
EBioMedicine 2024 May;103:105129
Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.
Arnold MR, Langelier MF, Gartrell J, Kirby IT, Sanderson DJ, Bejan DS, Šileikytė J, Sundalam SK, Nagarajan S, Marimuthu P, Duell AK, Shelat AA, Pascal JM, Cohen MS
Cell chemical biology 2022 Dec 15;29(12):1694-1708.e10
Cell chemical biology 2022 Dec 15;29(12):1694-1708.e10
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease.
Prokhorova E, Agnew T, Wondisford AR, Tellier M, Kaminski N, Beijer D, Holder J, Groslambert J, Suskiewicz MJ, Zhu K, Reber JM, Krassnig SC, Palazzo L, Murphy S, Nielsen ML, Mangerich A, Ahel D, Baets J, O'Sullivan RJ, Ahel I
Molecular cell 2021 Jun 17;81(12):2640-2655.e8
Molecular cell 2021 Jun 17;81(12):2640-2655.e8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human kidney tissue were subjected to SDS PAGE followed by western blot with 11289-1-AP(PARP3 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using PARP3 antibody 11289-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 11289-1-AP(PARP3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 11289-1-AP(PARP3 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
