Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10-7563-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-c-erbB-2/Her2 Antibody
- Antibody type
- Monoclonal
- Description
- HER2, a known proto-oncogene, is located at the long arm of human chromosome 17 (17q12), encoding a type 1 tyrosine kinase growth factor receptor and the role of HER2 in the development of numerous types of human cancer. HER2 is a transmembrane receptor comprising an extracellular domain (ECD), a single transmembrane domain, and an intracellular domain (ICD) with tyrosine-kinase activity.The high-expression and amplification of C-erbB-2 and its protein products (P185) are found in a wide variety of tumors. HER2 is overexpressed in 10% to 35% of gastric and gastroesophageal junction (GEJ) adenocarcinomas.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
A partial length protein (amino aci
ds 301-522) was used as the immunog
en for this antibody (from extra ce
llular domain of c-erbB-2).- Isotype
- IgG
- Antibody clone number
- ABM45F5
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of c-erbB2 in human Breast cancer tissue using c-erbB2 antibody (Clone: ABM45F5) at 5 µg/ml.
- Protocol
- Protocol