Ab102061

antibody from Aladdin Scientific
Targeting: ERBB2 CD340, HER-2, HER2, NEU, NGL
Provider product page for Ab102061

Antibody data

Product number
Ab102061 - Provider product page
Provider
Aladdin Scientific
Product name
ErbB2/Her2 Mouse mAb
Antibody type
Monoclonal
Description
Mouse anti Human ErbB 2 Antibody, Monoclonal(1C4-1H3-1H3), could be used for WB, IHC and so on .Application:WB: 1/500-1/1000IHC: 1/50-1/100Protein FunctionProtein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Reactivity
Human, Mouse, Rat
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
AA 1094-1111
Antibody clone number
1C4-1H3-1H3
Vial size
100_l,10_l,1ml,50_l
Concentration
1 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
ERBB2 protein structure - Ab102061 shown in red.