CABT-RM135

antibody from Creative Diagnostics

Targeting: TAF15 hTAFII68, Npl3, RBP56, TAF2N

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

CABT-RM135

Provider

Creative Diagnostics

Product name

Rat Anti-TAF15 monoclonal antibody, clone 23G22

Antibody type

Monoclonal

Description

TATA-binding protein-associated factor 2N is encoded by the TAF15 gene in human. TAF15 is a ubiquitously distributed protein that is found in all fetal and adult tissues. It is a RNA and ssDNA-binding protein that plays specific roles during transcription initiation at distinct promoters and can enter the preinitiation complex together with the RNA polymerase II (Pol II). TAF15 shuttles between the nucleus and the cytoplasm. It can be dimethylated by protein arginine N-methyltransferase 1 (PRMT1) at Arg206 to asymmetric dimethylarginine. This methylation favors its nuclear localization and it also considered to be essential for its gene regulatory function. TAF15 contains an N-terminal activation domain, an RNA recognition motif (RRM) and many Arg-Gly-Gly (RGG) repeats at its C-terminal end. Its N-terminus serves as an essential transforming domain in the fusion oncoprotein created by chromosomal translocation in certain human chondrosarcomas. Depletion of TAF15 has a growth-inhibitory effect and results in increased apoptosis.

Reactivity

Human

Host

Rat

Conjugate

Unconjugated

Isotype

IgG