GTX112888

Ho Y, Sh Yang YC, Chin YT, Chou SY, Chen YR, Shih YJ, Whang-Peng J, Changou CA, Liu HL, Lin SJ, Tang HY, Lin HY, Davis PJ
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Oct;120:346-355

Effects of carvacrol on human fibroblast (WS-1) and gastric adenocarcinoma (AGS) cells in vitro and on Wistar rats in vivo.

Günes-Bayir A, Kocyigit A, Güler EM, Bilgin MG, Ergün İS, Dadak A
Molecular and cellular biochemistry 2018 Nov;448(1-2):237-249

Pterostilbene modulates the suppression of multidrug resistance protein 1 and triggers autophagic and apoptotic mechanisms in cisplatin-resistant human oral cancer CAR cells via AKT signaling.

Chang HP, Lu CC, Chiang JH, Tsai FJ, Juan YN, Tsao JW, Chiu HY, Yang JS
International journal of oncology 2018 May;52(5):1504-1514

Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G₀/G₁ cell-cycle arrest.

Omer FAA, Hashim NBM, Ibrahim MY, Dehghan F, Yahayu M, Karimian H, Salim LZA, Mohan S
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Nov;39(11):1010428317731451

Panobinostat sensitizes KRAS-mutant non-small-cell lung cancer to gefitinib by targeting TAZ.

Lee WY, Chen PC, Wu WS, Wu HC, Lan CH, Huang YH, Cheng CH, Chen KC, Lin CW
International journal of cancer 2017 Nov 1;141(9):1921-1931

Extracellular signal-regulated kinase 8-mediated NF-κB activation increases sensitivity of human lung cancer cells to arsenic trioxide.

Wu DD, Lau ATY, Yu FY, Cai NL, Dai LJ, Ok Kim M, Jin DY, Xu YM
Oncotarget 2017 Jul 25;8(30):49144-49155

Pigment Epithelium-Derived Factor Mediates Autophagy and Apoptosis in Myocardial Hypoxia/Reoxygenation Injury.

Kuo HF, Liu PL, Chong IW, Liu YP, Chen YH, Ku PM, Li CY, Chen HH, Chiang HC, Wang CL, Chen HJ, Chen YC, Hsieh CC
PloS one 2016;11(5):e0156059

The aurora kinase inhibitor VX-680 shows anti-cancer effects in primary metastatic cells and the SW13 cell line.

Pezzani R, Rubin B, Bertazza L, Redaelli M, Barollo S, Monticelli H, Baldini E, Mian C, Mucignat C, Scaroni C, Mantero F, Ulisse S, Iacobone M, Boscaro M
Investigational new drugs 2016 Oct;34(5):531-40

The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death.

Chen PH, Chang CK, Shih CM, Cheng CH, Lin CW, Lee CC, Liu AJ, Ho KH, Chen KC
Neuropharmacology 2016 Nov;110(Pt A):362-375

Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells.

Xu YM, Wu DD, Zheng W, Yu FY, Yang F, Yao Y, Zhou Y, Ching YP, Lau AT
Oncotarget 2016 Feb 2;7(5):6146-58

Secretion of one adipokine Nampt/Visfatin suppresses the inflammatory stress-induced NF-κB activity and affects Nampt-dependent cell viability in Huh-7 cells.

Lin YC, Wu HC, Liao CC, Chou YC, Pan SF, Chiu CM
Mediators of inflammation 2015;2015:392471

Evaluation of the medicinal herb Graptopetalum paraguayense as a treatment for liver cancer.

Hsu WH, Chang CC, Huang KW, Chen YC, Hsu SL, Wu LC, Tsou AP, Lai JM, Huang CY
PloS one 2015;10(4):e0121298

MicroRNA-302b-inhibited E2F3 transcription factor is related to all trans retinoic acid-induced glioma cell apoptosis.

Chen PH, Shih CM, Chang WC, Cheng CH, Lin CW, Ho KH, Su PC, Chen KC
Journal of neurochemistry 2014 Dec;131(6):731-42

Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury.

Chen YW, Chou HC, Lin ST, Chen YH, Chang YJ, Chen L, Chan HL
Evidence-based complementary and alternative medicine : eCAM 2013;2013:364519

Acrylamide-induced mitochondria collapse and apoptosis in human astrocytoma cells.

Chen JH, Yang CH, Wang YS, Lee JG, Cheng CH, Chou CC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Jan;51:446-52

Quercetin-induced cardioprotection against doxorubicin cytotoxicity.

Chen JY, Hu RY, Chou HC
Journal of biomedical science 2013 Dec 20;20:95

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Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Sample (30 ug of whole cell lysate) A: 293T 10% SDS PAGE GTX112888 diluted at 1:1000
Validation comment: WB

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Untreated (¡V) and treated (+) HeLa whole cell extracts (30 ?g) were separated by 10% SDS-PAGE, and the membrane was blotted with Caspase 9 antibody [N2C3] (GTX112888) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Caspase 9 antibody [N2C3] detects Caspase 9 protein at cytoplasm and nucleus in human lung cancer by immunohistochemical analysis. Sample: Paraffin-embedded human lung cancer. Caspase 9 antibody [N2C3] (GTX112888) diluted at 1:400.