Antibody data
- Antibody Data
- Antigen structure
- References [23]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 17815-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17815-1-AP, RRID:AB_2255542
- Product name
- Syntaxin 17 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Syntaxin 17 antibody (Cat. #17815-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mystery of methamphetamine-induced autophagosome accumulation in hippocampal neurons: loss of syntaxin 17 in defects of dynein-dynactin driving and autophagosome-late endosome/lysosome fusion.
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.
Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation.
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis.
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.
Autophagy impairment as a key feature for acetaminophen-induced ototoxicity.
A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress.
Mild hypothermia pretreatment extenuates liver ischemia-reperfusion injury through Rab7-mediated autophagosomes-lysosomes fusion.
DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.
DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy.
Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.
Silencing DAPK3 blocks the autophagosome-lysosome fusion by mediating SNAP29 in trophoblast cells under high glucose treatment.
Hyperoxia reduces STX17 expression and inhibits the autophagic flux in alveolar type II epithelial cells in newborn rats.
SNARE proteins rescue impaired autophagic flux in Down syndrome.
Microtubule destabilization caused by silicate via HDAC6 activation contributes to autophagic dysfunction in bone mesenchymal stem cells.
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model.
Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells.
Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.
Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth.
Xu H, Zhu Y, Chen X, Yang T, Wang X, Song X, Xie X, Hu M, Jiang L, Cheng J, Gao R, Wang J
Archives of toxicology 2021 Oct;95(10):3263-3284
Archives of toxicology 2021 Oct;95(10):3263-3284
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.
Yan JM, Zhang WK, Yan LN, Jiao YJ, Zhou CM, Yu XJ
Autophagy 2021 Nov 6;:1-14
Autophagy 2021 Nov 6;:1-14
Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation.
Wu S, Lu H, Wang W, Song L, Liu M, Cao Y, Qi X, Sun J, Gong L
Cell death & disease 2021 May 13;12(5):480
Cell death & disease 2021 May 13;12(5):480
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis.
Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, Antonucci L, Todoric J, Liu Y, Hu Y, Diaz-Meco MT, Moscat J, Metallo CM, Lowy AM, Sun B, Karin M
Cancer cell 2021 May 10;39(5):678-693.e11
Cancer cell 2021 May 10;39(5):678-693.e11
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.
Zheng ZG, Zhu ST, Cheng HM, Zhang X, Cheng G, Thu PM, Wang SP, Li HJ, Ding M, Qiang L, Chen XW, Zhong Q, Li P, Xu X
Autophagy 2021 Jul;17(7):1592-1613
Autophagy 2021 Jul;17(7):1592-1613
Autophagy impairment as a key feature for acetaminophen-induced ototoxicity.
Zhao T, Zheng T, Yu H, Hu BH, Hu B, Ma P, Yang Y, Yang N, Hu J, Cao T, Chen G, Yan B, Peshoff M, Hatzoglou M, Geng R, Li B, Zheng QY
Cell death & disease 2021 Jan 4;12(1):3
Cell death & disease 2021 Jan 4;12(1):3
A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress.
Arora K, Liyanage P, Zhong Q, Naren AP
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21185
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21185
Mild hypothermia pretreatment extenuates liver ischemia-reperfusion injury through Rab7-mediated autophagosomes-lysosomes fusion.
Liu A, Wang W, Lu Z, Liu Z, Zhou W, Zhong Z, Ye Q
Biochemical and biophysical research communications 2021 Apr 23;550:15-21
Biochemical and biophysical research communications 2021 Apr 23;550:15-21
DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.
Cao Y, Li R, Shen M, Li C, Zou Y, Jiang Q, Liu S, Lu C, Li H, Liu H, Cai Y
Cell death & disease 2021 Apr 20;12(5):416
Cell death & disease 2021 Apr 20;12(5):416
DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
Tian X, Zheng P, Zhou C, Wang X, Ma H, Ma W, Zhou X, Teng J, Chen J
Autophagy 2020 May;16(5):797-810
Autophagy 2020 May;16(5):797-810
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy.
Martello A, Lauriola A, Mellis D, Parish E, Dawson JC, Imrie L, Vidmar M, Gammoh N, Mitić T, Brittan M, Mills NL, Carragher NO, D'Arca D, Caporali A
EMBO reports 2020 Jul 3;21(7):e48192
EMBO reports 2020 Jul 3;21(7):e48192
Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.
Zheng Z, Zhou Y, Ye L, Lu Q, Zhang K, Zhang J, Xie L, Wu Y, Xu K, Zhang H, Xiao J
Experimental neurology 2020 Feb;324:113138
Experimental neurology 2020 Feb;324:113138
Silencing DAPK3 blocks the autophagosome-lysosome fusion by mediating SNAP29 in trophoblast cells under high glucose treatment.
Wang Y, Ji L, Peng Z, Lai R, Zhang X, Xu Y, Chen Z, Liu R, Zhong Y, Hu H, Wang L
Molecular and cellular endocrinology 2020 Feb 15;502:110674
Molecular and cellular endocrinology 2020 Feb 15;502:110674
Hyperoxia reduces STX17 expression and inhibits the autophagic flux in alveolar type II epithelial cells in newborn rats.
Zhang D, Zhao X, Zhang D, Gao S, Xue X, Fu J
International journal of molecular medicine 2020 Aug;46(2):773-781
International journal of molecular medicine 2020 Aug;46(2):773-781
SNARE proteins rescue impaired autophagic flux in Down syndrome.
Aivazidis S, Jain A, Rauniyar AK, Anderson CC, Marentette JO, Orlicky DJ, Fritz KS, Harris PS, Siegel D, Maclean KN, Roede JR
PloS one 2019;14(11):e0223254
PloS one 2019;14(11):e0223254
Microtubule destabilization caused by silicate via HDAC6 activation contributes to autophagic dysfunction in bone mesenchymal stem cells.
Li Z, Liu S, Fu T, Peng Y, Zhang J
Stem cell research & therapy 2019 Nov 27;10(1):351
Stem cell research & therapy 2019 Nov 27;10(1):351
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Wang K, Ma H, Liu H, Ye W, Li Z, Cheng L, Zhang L, Lei Y, Shen L, Zhang F
Cell reports 2019 May 14;27(7):2075-2091.e5
Cell reports 2019 May 14;27(7):2075-2091.e5
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, Chen S, Shi A, Chan DC, Song Z
Cell reports 2018 Jun 5;23(10):2989-3005
Cell reports 2018 Jun 5;23(10):2989-3005
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
McLelland GL, Goiran T, Yi W, Dorval G, Chen CX, Lauinger ND, Krahn AI, Valimehr S, Rakovic A, Rouiller I, Durcan TM, Trempe JF, Fon EA
eLife 2018 Apr 20;7
eLife 2018 Apr 20;7
Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model.
Morales I, Sanchez A, Rodriguez-Sabate C, Rodriguez M
PloS one 2017;12(10):e0185989
PloS one 2017;12(10):e0185989
Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells.
Li X, Zhu F, Jiang J, Sun C, Zhong Q, Shen M, Wang X, Tian R, Shi C, Xu M, Peng F, Guo X, Hu J, Ye D, Wang M, Qin R
Autophagy 2016 Sep;12(9):1521-37
Autophagy 2016 Sep;12(9):1521-37
Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.
McLelland GL, Lee SA, McBride HM, Fon EA
The Journal of cell biology 2016 Aug 1;214(3):275-91
The Journal of cell biology 2016 Aug 1;214(3):275-91
Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth.
Yang H, Peng YF, Ni HM, Li Y, Shi YH, Ding WX, Fan J
PloS one 2015;10(6):e0130953
PloS one 2015;10(6):e0130953
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- L02 cells were subjected to SDS PAGE followed by western blot with 17815-1-AP( STX17 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 17815-1-AP(STX17 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Syntaxin 17 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Syntaxin 17. This antibody recognizes human,mouse,rat antigen. The Syntaxin 17 antibody has been validated for the following applications: ELISA, IHC, WB analysis.