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- Antigen structure
- References [44]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 17815-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17815-1-AP, RRID:AB_2255542
- Product name
- Syntaxin 17 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Syntaxin 17 antibody (Cat. #17815-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.
Inhibition of HDAC6 promotes microvascular endothelial cells to phagocytize myelin debris and reduces inflammatory response to accelerate the repair of spinal cord injury.
Key roles of autophagosome/endosome maturation mediated by Syntaxin17 in methamphetamine-induced neuronal damage in mice.
MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy.
Porphyromonas gingivalis, a periodontal pathogen, impairs post-infarcted myocardium by inhibiting autophagosome-lysosome fusion.
TRAF6 triggers Mycobacterium-infected host autophagy through Rab7 ubiquitination.
RNA m(6)A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis.
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.
Discovery of a potent inhibitor of chaperone-mediated autophagy that targets the HSC70-LAMP2A interaction in non-small cell lung cancer cells.
Deceiving the big eaters: Salmonella Typhimurium SopB subverts host cell xenophagy in macrophages via dual mechanisms.
Porcine Reproductive and Respiratory Syndrome Virus nsp5 Induces Incomplete Autophagy by Impairing the Interaction of STX17 and SNAP29.
Doxorubicin induces cardiomyocyte death owing to the accumulation of dysfunctional mitochondria by inhibiting the autophagy fusion process.
Decreased syntaxin17 expression contributes to the pathogenesis of acute pancreatitis in murine models by impairing autophagic degradation.
Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to promote liver fibrosis.
Low syntaxin 17 expression in donor liver is associated with poor graft prognosis in recipients of living donor liver transplantation.
TFEB ameliorates autophagy flux disturbance induced by PBDE-47 via up-regulating autophagy-lysosome fusion.
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.
Methamphetamine-mediated dissemination of β-amyloid: Disturbances in endocytosis, transport and clearance of β-amyloid in microglial BV2 cells.
Weakened interaction of ATG14 and the SNARE complex blocks autophagosome-lysosome fusion contributes to fluoride-induced developmental neurotoxicity.
Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins.
Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization.
Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media.
Mystery of methamphetamine-induced autophagosome accumulation in hippocampal neurons: loss of syntaxin 17 in defects of dynein-dynactin driving and autophagosome-late endosome/lysosome fusion.
Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation.
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis.
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.
Autophagy impairment as a key feature for acetaminophen-induced ototoxicity.
A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress.
Mild hypothermia pretreatment extenuates liver ischemia-reperfusion injury through Rab7-mediated autophagosomes-lysosomes fusion.
DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.
DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy.
Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.
Silencing DAPK3 blocks the autophagosome-lysosome fusion by mediating SNAP29 in trophoblast cells under high glucose treatment.
Hyperoxia reduces STX17 expression and inhibits the autophagic flux in alveolar type II epithelial cells in newborn rats.
SNARE proteins rescue impaired autophagic flux in Down syndrome.
Microtubule destabilization caused by silicate via HDAC6 activation contributes to autophagic dysfunction in bone mesenchymal stem cells.
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model.
Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells.
Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.
Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth.
Ren X, Wang J, Wei H, Li X, Tian Y, Wang Z, Yin Y, Guo Z, Qin Z, Wu M, Zeng X
International journal of biological sciences 2024;20(5):1905-1926
International journal of biological sciences 2024;20(5):1905-1926
Inhibition of HDAC6 promotes microvascular endothelial cells to phagocytize myelin debris and reduces inflammatory response to accelerate the repair of spinal cord injury.
Wu C, Pan Y, Wang L, Liu M, Tu P, Chen S, Shi L, Yan D, Ma Y, Guo Y
CNS neuroscience & therapeutics 2024 Mar;30(3):e14439
CNS neuroscience & therapeutics 2024 Mar;30(3):e14439
Key roles of autophagosome/endosome maturation mediated by Syntaxin17 in methamphetamine-induced neuronal damage in mice.
Wang X, Hu M, Chen J, Lou X, Zhang H, Li M, Cheng J, Ma T, Xiong J, Gao R, Chen X, Wang J
Molecular medicine (Cambridge, Mass.) 2024 Jan 3;30(1):4
Molecular medicine (Cambridge, Mass.) 2024 Jan 3;30(1):4
MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy.
Shi X, Wu W, Feng Z, Fan P, Shi R, Zhang X
Cell reports 2023 Sep 26;42(9):113045
Cell reports 2023 Sep 26;42(9):113045
Porphyromonas gingivalis, a periodontal pathogen, impairs post-infarcted myocardium by inhibiting autophagosome-lysosome fusion.
Shiheido-Watanabe Y, Maejima Y, Nakagama S, Fan Q, Tamura N, Sasano T
International journal of oral science 2023 Sep 18;15(1):42
International journal of oral science 2023 Sep 18;15(1):42
TRAF6 triggers Mycobacterium-infected host autophagy through Rab7 ubiquitination.
Ma Q, Yu J, Liu L, Ma X, Zhang J, Zhang J, Wang X, Deng G, Wu X
Cell death discovery 2023 Nov 28;9(1):427
Cell death discovery 2023 Nov 28;9(1):427
RNA m(6)A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis.
Han X, Liu L, Huang S, Xiao W, Gao Y, Zhou W, Zhang C, Zheng H, Yang L, Xie X, Liang Q, Tu Z, Yu H, Fu J, Wang L, Zhang X, Qian L, Zhou Y
Nature communications 2023 Nov 13;14(1):7328
Nature communications 2023 Nov 13;14(1):7328
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.
Zheng W, Chen Q, Liu H, Zeng L, Zhou Y, Liu X, Bai Y, Zhang J, Pan Y, Shao C
Autophagy 2023 Mar;19(3):839-857
Autophagy 2023 Mar;19(3):839-857
Discovery of a potent inhibitor of chaperone-mediated autophagy that targets the HSC70-LAMP2A interaction in non-small cell lung cancer cells.
Dong RF, Qin CJ, Yin Y, Han LL, Xiao CM, Wang KD, Wei RY, Xia YZ, Kong LY
British journal of pharmacology 2023 Jun 13;
British journal of pharmacology 2023 Jun 13;
Deceiving the big eaters: Salmonella Typhimurium SopB subverts host cell xenophagy in macrophages via dual mechanisms.
Chatterjee R, Chaudhuri D, Setty SRG, Chakravortty D
Microbes and infection 2023 Jul-Aug;25(6):105128
Microbes and infection 2023 Jul-Aug;25(6):105128
Porcine Reproductive and Respiratory Syndrome Virus nsp5 Induces Incomplete Autophagy by Impairing the Interaction of STX17 and SNAP29.
Zhou Y, Li Y, Tao R, Li J, Fang L, Xiao S
Microbiology spectrum 2023 Feb 23;11(2):e0438622
Microbiology spectrum 2023 Feb 23;11(2):e0438622
Doxorubicin induces cardiomyocyte death owing to the accumulation of dysfunctional mitochondria by inhibiting the autophagy fusion process.
Toda N, Sato T, Muraoka M, Lin D, Saito M, Li G, Song QC, Yanagisawa T, Yamauchi M
Free radical biology & medicine 2023 Feb 1;195:47-57
Free radical biology & medicine 2023 Feb 1;195:47-57
Decreased syntaxin17 expression contributes to the pathogenesis of acute pancreatitis in murine models by impairing autophagic degradation.
Wang TT, Zhang LC, Qin Z, Chen SJ, Zeng JM, Li JY, An L, Wang CY, Gao Y, Wang LM, Zhao ZX, Liu ZQ, Wang SG
Acta pharmacologica Sinica 2023 Dec;44(12):2445-2454
Acta pharmacologica Sinica 2023 Dec;44(12):2445-2454
Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to promote liver fibrosis.
Liu X, Tan S, Liu H, Jiang J, Wang X, Li L, Wu B
Hepatology (Baltimore, Md.) 2023 Apr 1;77(4):1181-1197
Hepatology (Baltimore, Md.) 2023 Apr 1;77(4):1181-1197
Low syntaxin 17 expression in donor liver is associated with poor graft prognosis in recipients of living donor liver transplantation.
Tomiyama T, Shimokawa M, Harada N, Toshida K, Morinaga A, Kosai-Fujimoto Y, Tomino T, Kurihara T, Nagao Y, Toshima T, Morita K, Itoh S, Yoshizumi T
Hepatology research : the official journal of the Japan Society of Hepatology 2022 Oct;52(10):872-881
Hepatology research : the official journal of the Japan Society of Hepatology 2022 Oct;52(10):872-881
TFEB ameliorates autophagy flux disturbance induced by PBDE-47 via up-regulating autophagy-lysosome fusion.
Tang H, Huang H, Wang D, Li P, Tian Z, Li D, Wang S, Ma R, Xia T, Wang A
Journal of hazardous materials 2022 May 15;430:128483
Journal of hazardous materials 2022 May 15;430:128483
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.
Yan JM, Zhang WK, Yan LN, Jiao YJ, Zhou CM, Yu XJ
Autophagy 2022 Jul;18(7):1599-1612
Autophagy 2022 Jul;18(7):1599-1612
Methamphetamine-mediated dissemination of β-amyloid: Disturbances in endocytosis, transport and clearance of β-amyloid in microglial BV2 cells.
Tao L, Hu M, Zhang X, Wang X, Zhang Y, Chen X, Tang J, Wang J
Toxicology and applied pharmacology 2022 Jul 15;447:116090
Toxicology and applied pharmacology 2022 Jul 15;447:116090
Weakened interaction of ATG14 and the SNARE complex blocks autophagosome-lysosome fusion contributes to fluoride-induced developmental neurotoxicity.
Zhang Y, Han X, Tang Y, Zhang J, Hu Z, Xu W, Yao P, Niu Q
Ecotoxicology and environmental safety 2022 Jan 15;230:113108
Ecotoxicology and environmental safety 2022 Jan 15;230:113108
Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins.
Fote GM, Geller NR, Efstathiou NE, Hendricks N, Vavvas DG, Reidling JC, Thompson LM, Steffan JS
Journal of cell science 2022 Jan 15;135(2)
Journal of cell science 2022 Jan 15;135(2)
Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization.
Li Z, Fu WJ, Chen XQ, Wang S, Deng RS, Tang XP, Yang KD, Niu Q, Zhou H, Li QR, Lin Y, Liang M, Li SS, Ping YF, Liu XD, Bian XW, Yao XH
Journal of experimental & clinical cancer research : CR 2022 Feb 22;41(1):74
Journal of experimental & clinical cancer research : CR 2022 Feb 22;41(1):74
Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media.
Xie D, Zhao T, Zhang X, Kui L, Wang Q, Wu Y, Zheng T, Ma P, Zhang Y, Molteni H, Geng R, Yang Y, Li B, Zheng QY
Frontiers in cellular neuroscience 2021;15:753369
Frontiers in cellular neuroscience 2021;15:753369
Mystery of methamphetamine-induced autophagosome accumulation in hippocampal neurons: loss of syntaxin 17 in defects of dynein-dynactin driving and autophagosome-late endosome/lysosome fusion.
Xu H, Zhu Y, Chen X, Yang T, Wang X, Song X, Xie X, Hu M, Jiang L, Cheng J, Gao R, Wang J
Archives of toxicology 2021 Oct;95(10):3263-3284
Archives of toxicology 2021 Oct;95(10):3263-3284
Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation.
Wu S, Lu H, Wang W, Song L, Liu M, Cao Y, Qi X, Sun J, Gong L
Cell death & disease 2021 May 13;12(5):480
Cell death & disease 2021 May 13;12(5):480
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis.
Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, Antonucci L, Todoric J, Liu Y, Hu Y, Diaz-Meco MT, Moscat J, Metallo CM, Lowy AM, Sun B, Karin M
Cancer cell 2021 May 10;39(5):678-693.e11
Cancer cell 2021 May 10;39(5):678-693.e11
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.
Zheng ZG, Zhu ST, Cheng HM, Zhang X, Cheng G, Thu PM, Wang SP, Li HJ, Ding M, Qiang L, Chen XW, Zhong Q, Li P, Xu X
Autophagy 2021 Jul;17(7):1592-1613
Autophagy 2021 Jul;17(7):1592-1613
Autophagy impairment as a key feature for acetaminophen-induced ototoxicity.
Zhao T, Zheng T, Yu H, Hu BH, Hu B, Ma P, Yang Y, Yang N, Hu J, Cao T, Chen G, Yan B, Peshoff M, Hatzoglou M, Geng R, Li B, Zheng QY
Cell death & disease 2021 Jan 4;12(1):3
Cell death & disease 2021 Jan 4;12(1):3
A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress.
Arora K, Liyanage P, Zhong Q, Naren AP
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21185
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21185
Mild hypothermia pretreatment extenuates liver ischemia-reperfusion injury through Rab7-mediated autophagosomes-lysosomes fusion.
Liu A, Wang W, Lu Z, Liu Z, Zhou W, Zhong Z, Ye Q
Biochemical and biophysical research communications 2021 Apr 23;550:15-21
Biochemical and biophysical research communications 2021 Apr 23;550:15-21
DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.
Cao Y, Li R, Shen M, Li C, Zou Y, Jiang Q, Liu S, Lu C, Li H, Liu H, Cai Y
Cell death & disease 2021 Apr 20;12(5):416
Cell death & disease 2021 Apr 20;12(5):416
DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
Tian X, Zheng P, Zhou C, Wang X, Ma H, Ma W, Zhou X, Teng J, Chen J
Autophagy 2020 May;16(5):797-810
Autophagy 2020 May;16(5):797-810
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy.
Martello A, Lauriola A, Mellis D, Parish E, Dawson JC, Imrie L, Vidmar M, Gammoh N, Mitić T, Brittan M, Mills NL, Carragher NO, D'Arca D, Caporali A
EMBO reports 2020 Jul 3;21(7):e48192
EMBO reports 2020 Jul 3;21(7):e48192
Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.
Zheng Z, Zhou Y, Ye L, Lu Q, Zhang K, Zhang J, Xie L, Wu Y, Xu K, Zhang H, Xiao J
Experimental neurology 2020 Feb;324:113138
Experimental neurology 2020 Feb;324:113138
Silencing DAPK3 blocks the autophagosome-lysosome fusion by mediating SNAP29 in trophoblast cells under high glucose treatment.
Wang Y, Ji L, Peng Z, Lai R, Zhang X, Xu Y, Chen Z, Liu R, Zhong Y, Hu H, Wang L
Molecular and cellular endocrinology 2020 Feb 15;502:110674
Molecular and cellular endocrinology 2020 Feb 15;502:110674
Hyperoxia reduces STX17 expression and inhibits the autophagic flux in alveolar type II epithelial cells in newborn rats.
Zhang D, Zhao X, Zhang D, Gao S, Xue X, Fu J
International journal of molecular medicine 2020 Aug;46(2):773-781
International journal of molecular medicine 2020 Aug;46(2):773-781
SNARE proteins rescue impaired autophagic flux in Down syndrome.
Aivazidis S, Jain A, Rauniyar AK, Anderson CC, Marentette JO, Orlicky DJ, Fritz KS, Harris PS, Siegel D, Maclean KN, Roede JR
PloS one 2019;14(11):e0223254
PloS one 2019;14(11):e0223254
Microtubule destabilization caused by silicate via HDAC6 activation contributes to autophagic dysfunction in bone mesenchymal stem cells.
Li Z, Liu S, Fu T, Peng Y, Zhang J
Stem cell research & therapy 2019 Nov 27;10(1):351
Stem cell research & therapy 2019 Nov 27;10(1):351
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Wang K, Ma H, Liu H, Ye W, Li Z, Cheng L, Zhang L, Lei Y, Shen L, Zhang F
Cell reports 2019 May 14;27(7):2075-2091.e5
Cell reports 2019 May 14;27(7):2075-2091.e5
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, Chen S, Shi A, Chan DC, Song Z
Cell reports 2018 Jun 5;23(10):2989-3005
Cell reports 2018 Jun 5;23(10):2989-3005
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
McLelland GL, Goiran T, Yi W, Dorval G, Chen CX, Lauinger ND, Krahn AI, Valimehr S, Rakovic A, Rouiller I, Durcan TM, Trempe JF, Fon EA
eLife 2018 Apr 20;7
eLife 2018 Apr 20;7
Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model.
Morales I, Sanchez A, Rodriguez-Sabate C, Rodriguez M
PloS one 2017;12(10):e0185989
PloS one 2017;12(10):e0185989
Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells.
Li X, Zhu F, Jiang J, Sun C, Zhong Q, Shen M, Wang X, Tian R, Shi C, Xu M, Peng F, Guo X, Hu J, Ye D, Wang M, Qin R
Autophagy 2016 Sep;12(9):1521-37
Autophagy 2016 Sep;12(9):1521-37
Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.
McLelland GL, Lee SA, McBride HM, Fon EA
The Journal of cell biology 2016 Aug 1;214(3):275-91
The Journal of cell biology 2016 Aug 1;214(3):275-91
Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth.
Yang H, Peng YF, Ni HM, Li Y, Shi YH, Ding WX, Fan J
PloS one 2015;10(6):e0130953
PloS one 2015;10(6):e0130953
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- L02 cells were subjected to SDS PAGE followed by western blot with 17815-1-AP( STX17 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 17815-1-AP(STX17 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Syntaxin 17 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Syntaxin 17. This antibody recognizes human,mouse,rat antigen. The Syntaxin 17 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
