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- Antibody Data
- Antigen structure
- References [44]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 10056-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10056-1-AP, RRID:AB_513447
- Product name
- MEF2C antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MEF2C antibody (Cat. #10056-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Developmental disruption of Mef2c in Medial Ganglionic Eminence-derived cortical inhibitory interneurons impairs cellular and circuit function.
NAP-seq reveals multiple classes of structured noncoding RNAs with regulatory functions.
CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice.
METTL3 promotes microglial inflammation via MEF2C in spinal cord injury.
METTL3 Promotes the Differentiation of Goat Skeletal Muscle Satellite Cells by Regulating MEF2C mRNA Stability in a m(6)A-Dependent Manner.
The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2.
Dietary leucine and fish oil cooperatively regulate skeletal myofiber type transformation via the CaMKII signaling pathway of pigs.
lncRNA GPRC5D-AS1 as a ceRNA inhibits skeletal muscle aging by regulating miR-520d-5p.
LncRNA TCONS_00323213 Promotes Myogenic Differentiation by Interacting with PKNOX2 to Upregulate MyoG in Porcine Satellite Cells.
MEF2C Expression Is Regulated by the Post-transcriptional Activation of the METTL3-m(6)A-YTHDF1 Axis in Myoblast Differentiation.
Molecular subtypes of osteosarcoma classified by cancer stem cell related genes define immunological cell infiltration and patient survival.
Molecular targeting of vulnerable RNA sequences in SARS CoV-2: identifying clinical feasibility.
MEF2C promotes M1 macrophage polarization and Th1 responses.
PERK Signaling Controls Myoblast Differentiation by Regulating MicroRNA Networks.
Type I interferon response-related microglial Mef2c deregulation at the onset of Alzheimer's pathology in 5×FAD mice.
Integrated analysis of long non-coding RNAs (lncRNAs) and mRNA expression profiles identifies lncRNA PRKG1-AS1 playing important roles in skeletal muscle aging.
Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans.
Appropriate timing for hypothermic machine perfusion to preserve livers donated after circulatory death.
Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation.
Placental P-glycoprotein inhibition enhances susceptibility to Di-(2-ethylhexyl)-phthalate induced cardiac malformations in mice: A possibly promising target for congenital heart defects prevention.
Administration of SB239063 Ameliorates Ovariectomy-Induced Bone Loss via Suppressing Osteoclastogenesis in Mice.
Interhemispheric Connectivity Potentiates the Basolateral Amygdalae and Regulates Social Interaction and Memory.
Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway.
Novel formononetin-7-sal ester ameliorates pulmonary fibrosis via MEF2c signaling pathway.
The effect of maternal exposure to di-(2-ethylhexyl)-phthalate on fetal cardiac development in mice.
Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes.
NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.
Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2.
Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions.
Stimulus-specific combinatorial functionality of neuronal c-fos enhancers.
Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.
The zinc finger gene Fezf2 is required for the development of excitatory neurons in the basolateral complex of the amygdala.
Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone.
Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue.
MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease.
COUP-TFII controls amygdala patterning by regulating neuropilin expression.
Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.
Retinoic acid receptor α mediates all-trans-retinoic acid-induced Klf4 gene expression by regulating Klf4 promoter activity in vascular smooth muscle cells.
Tangentially migrating transient glutamatergic neurons control neurogenesis and maintenance of cerebral cortical progenitor pools.
Pax6 is required at the telencephalic pallial-subpallial boundary for the generation of neuronal diversity in the postnatal limbic system.
Developmental origin of the neuronal subtypes that comprise the amygdalar fear circuit in the mouse.
Cutting edge: human latency-associated peptide+ T cells: a novel regulatory T cell subset.
c-MYC independent nuclear reprogramming favors cardiogenic potential of induced pluripotent stem cells.
iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism.
Ward C, Nasrallah K, Tran D, Sabri E, Vazquez A, Sjulson L, Castillo PE, Batista-Brito R
bioRxiv : the preprint server for biology 2024 May 1;
bioRxiv : the preprint server for biology 2024 May 1;
NAP-seq reveals multiple classes of structured noncoding RNAs with regulatory functions.
Liu S, Huang J, Zhou J, Chen S, Zheng W, Liu C, Lin Q, Zhang P, Wu D, He S, Ye J, Liu S, Zhou K, Li B, Qu L, Yang J
Nature communications 2024 Mar 18;15(1):2425
Nature communications 2024 Mar 18;15(1):2425
CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice.
Wang X, Tang X, Zhu P, Hua D, Xie Z, Guo M, Que M, Yan J, Li X, Xia Q, Luo X, Bi J, Zhao Y, Zhou Z, Li S, Luo A
Cellular and molecular life sciences : CMLS 2024 Mar 13;81(1):138
Cellular and molecular life sciences : CMLS 2024 Mar 13;81(1):138
METTL3 promotes microglial inflammation via MEF2C in spinal cord injury.
Wang D, Qian W, Wu D, Wu Y, Lu K, Zou G
Cell and tissue research 2024 Feb;395(2):189-197
Cell and tissue research 2024 Feb;395(2):189-197
METTL3 Promotes the Differentiation of Goat Skeletal Muscle Satellite Cells by Regulating MEF2C mRNA Stability in a m(6)A-Dependent Manner.
Zhao S, Cao J, Sun Y, Zhou H, Zhu Q, Dai D, Zhan S, Guo J, Zhong T, Wang L, Li L, Zhang H
International journal of molecular sciences 2023 Sep 14;24(18)
International journal of molecular sciences 2023 Sep 14;24(18)
The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2.
Zheng X, Su F, Lei M, Li J, Zhang C, Zhang Y, Wei M, Li W, Chen S, Liu Y, Gao Q, Hao L
European journal of pharmacology 2023 Oct 15;957:175969
European journal of pharmacology 2023 Oct 15;957:175969
Dietary leucine and fish oil cooperatively regulate skeletal myofiber type transformation via the CaMKII signaling pathway of pigs.
Gong S, Yin Y, Han M, Guo L, Duan Y, Guo Q, Yin J, Li F
Food & function 2023 Jan 3;14(1):133-147
Food & function 2023 Jan 3;14(1):133-147
lncRNA GPRC5D-AS1 as a ceRNA inhibits skeletal muscle aging by regulating miR-520d-5p.
Yu M, He X, Liu T, Li J
Aging 2023 Dec 9;15(23):13980-13997
Aging 2023 Dec 9;15(23):13980-13997
LncRNA TCONS_00323213 Promotes Myogenic Differentiation by Interacting with PKNOX2 to Upregulate MyoG in Porcine Satellite Cells.
Li M, Liu Q, Xie S, Fu C, Li J, Tian C, Li X, Li C
International journal of molecular sciences 2023 Apr 5;24(7)
International journal of molecular sciences 2023 Apr 5;24(7)
MEF2C Expression Is Regulated by the Post-transcriptional Activation of the METTL3-m(6)A-YTHDF1 Axis in Myoblast Differentiation.
Yang X, Ning Y, Abbas Raza SH, Mei C, Zan L
Frontiers in veterinary science 2022;9:900924
Frontiers in veterinary science 2022;9:900924
Molecular subtypes of osteosarcoma classified by cancer stem cell related genes define immunological cell infiltration and patient survival.
Guo L, Yan T, Guo W, Niu J, Wang W, Ren T, Huang Y, Xu J, Wang B
Frontiers in immunology 2022;13:986785
Frontiers in immunology 2022;13:986785
Molecular targeting of vulnerable RNA sequences in SARS CoV-2: identifying clinical feasibility.
Gallicano GI, Casey JL, Fu J, Mahapatra S
Gene therapy 2022 May;29(5):304-311
Gene therapy 2022 May;29(5):304-311
MEF2C promotes M1 macrophage polarization and Th1 responses.
Zhao X, Di Q, Liu H, Quan J, Ling J, Zhao Z, Xiao Y, Wu H, Wu Z, Song W, An H, Chen W
Cellular & molecular immunology 2022 Apr;19(4):540-553
Cellular & molecular immunology 2022 Apr;19(4):540-553
PERK Signaling Controls Myoblast Differentiation by Regulating MicroRNA Networks.
Tan YY, Zhang Y, Li B, Ou YW, Xie SJ, Chen PP, Mei SQ, Huang QJ, Zheng LL, Qu LH
Frontiers in cell and developmental biology 2021;9:670435
Frontiers in cell and developmental biology 2021;9:670435
Type I interferon response-related microglial Mef2c deregulation at the onset of Alzheimer's pathology in 5×FAD mice.
Xue F, Tian J, Yu C, Du H, Guo L
Neurobiology of disease 2021 May;152:105272
Neurobiology of disease 2021 May;152:105272
Integrated analysis of long non-coding RNAs (lncRNAs) and mRNA expression profiles identifies lncRNA PRKG1-AS1 playing important roles in skeletal muscle aging.
Zheng Y, Liu T, Li Q, Li J
Aging 2021 May 29;13(11):15044-15060
Aging 2021 May 29;13(11):15044-15060
Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans.
Yu XX, Qiu WL, Yang L, Wang YC, He MY, Wang D, Zhang Y, Li LC, Zhang J, Wang Y, Xu CR
Cell research 2021 Aug;31(8):886-903
Cell research 2021 Aug;31(8):886-903
Appropriate timing for hypothermic machine perfusion to preserve livers donated after circulatory death.
Hu X, Wang W, Zeng C, He W, Zhong Z, Liu Z, Wang Y, Ye Q
Molecular medicine reports 2020 Sep;22(3):2003-2011
Molecular medicine reports 2020 Sep;22(3):2003-2011
Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation.
Pai EL, Chen J, Fazel Darbandi S, Cho FS, Chen J, Lindtner S, Chu JS, Paz JT, Vogt D, Paredes MF, Rubenstein JL
eLife 2020 May 26;9
eLife 2020 May 26;9
Placental P-glycoprotein inhibition enhances susceptibility to Di-(2-ethylhexyl)-phthalate induced cardiac malformations in mice: A possibly promising target for congenital heart defects prevention.
Tang C, Luo C, Hua Y, Zhou K, Duan H, Ma F, Zhang Y, Li Y, Qiu D, Wang C
PloS one 2019;14(5):e0214873
PloS one 2019;14(5):e0214873
Administration of SB239063 Ameliorates Ovariectomy-Induced Bone Loss via Suppressing Osteoclastogenesis in Mice.
Huang B, Wang J, Zhang X, Xie Z, Wu H, Liu J, Jie Z, Zhao X, Qin A, Fan S, Chen J, Zhao F
Frontiers in pharmacology 2019;10:900
Frontiers in pharmacology 2019;10:900
Interhemispheric Connectivity Potentiates the Basolateral Amygdalae and Regulates Social Interaction and Memory.
Huang TN, Hsu TT, Lin MH, Chuang HC, Hu HT, Sun CP, Tao MH, Lin JY, Hsueh YP
Cell reports 2019 Oct 1;29(1):34-48.e4
Cell reports 2019 Oct 1;29(1):34-48.e4
Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway.
Yin M, Shen Z, Yang L, Zheng W, Song H
International journal of molecular medicine 2019 May;43(5):2086-2102
International journal of molecular medicine 2019 May;43(5):2086-2102
Novel formononetin-7-sal ester ameliorates pulmonary fibrosis via MEF2c signaling pathway.
Zhao X, Qu G, Song C, Li R, Liu W, Lv C, Song X, Zhang J, Li M
Toxicology and applied pharmacology 2018 Oct 1;356:15-24
Toxicology and applied pharmacology 2018 Oct 1;356:15-24
The effect of maternal exposure to di-(2-ethylhexyl)-phthalate on fetal cardiac development in mice.
Tang C, Deng Y, Duan H, Zhang Y, Li Y, Qiu D, Zhou K, Hua Y, Wang C
Journal of applied toxicology : JAT 2018 Jun;38(6):834-842
Journal of applied toxicology : JAT 2018 Jun;38(6):834-842
Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes.
Kuerbitz J, Arnett M, Ehrman S, Williams MT, Vorhees CV, Fisher SE, Garratt AN, Muglia LJ, Waclaw RR, Campbell K
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jan 31;38(5):1160-1177
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jan 31;38(5):1160-1177
NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.
Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, Huang X, Sultan A, McKercher SR, Ambasudhan R, Xu H, Wang Y, Geschwind DH, Roberts AJ, Terskikh AV, Rissman RA, Masliah E, Lipton SA, Nakanishi N
Nature communications 2017 Nov 14;8(1):1488
Nature communications 2017 Nov 14;8(1):1488
Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2.
Qin S, Ware SM, Waclaw RR, Campbell K
Neural development 2017 Aug 16;12(1):13
Neural development 2017 Aug 16;12(1):13
Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions.
Fischer A, Warscheid B, Weber W, Radziwill G
Scientific reports 2016 Nov 30;6:38155
Scientific reports 2016 Nov 30;6:38155
Stimulus-specific combinatorial functionality of neuronal c-fos enhancers.
Joo JY, Schaukowitch K, Farbiak L, Kilaru G, Kim TK
Nature neuroscience 2016 Jan;19(1):75-83
Nature neuroscience 2016 Jan;19(1):75-83
Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.
Huang TN, Chuang HC, Chou WH, Chen CY, Wang HF, Chou SJ, Hsueh YP
Nature neuroscience 2014 Feb;17(2):240-7
Nature neuroscience 2014 Feb;17(2):240-7
The zinc finger gene Fezf2 is required for the development of excitatory neurons in the basolateral complex of the amygdala.
Hirata-Fukae C, Hirata T
Developmental dynamics : an official publication of the American Association of Anatomists 2014 Aug;243(8):1030-6
Developmental dynamics : an official publication of the American Association of Anatomists 2014 Aug;243(8):1030-6
Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone.
López-Juárez A, Howard J, Ullom K, Howard L, Grande A, Pardo A, Waclaw R, Sun YY, Yang D, Kuan CY, Campbell K, Nakafuku M
Genes & development 2013 Jun 1;27(11):1272-87
Genes & development 2013 Jun 1;27(11):1272-87
Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue.
Ardehali R, Ali SR, Inlay MA, Abilez OJ, Chen MQ, Blauwkamp TA, Yazawa M, Gong Y, Nusse R, Drukker M, Weissman IL
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 26;110(9):3405-10
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 26;110(9):3405-10
MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease.
Elmer BM, Estes ML, Barrow SL, McAllister AK
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Aug 21;33(34):13791-804
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Aug 21;33(34):13791-804
COUP-TFII controls amygdala patterning by regulating neuropilin expression.
Tang K, Rubenstein JL, Tsai SY, Tsai MJ
Development (Cambridge, England) 2012 May;139(9):1630-9
Development (Cambridge, England) 2012 May;139(9):1630-9
Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.
Drukker M, Tang C, Ardehali R, Rinkevich Y, Seita J, Lee AS, Mosley AR, Weissman IL, Soen Y
Nature biotechnology 2012 May 27;30(6):531-42
Nature biotechnology 2012 May 27;30(6):531-42
Retinoic acid receptor α mediates all-trans-retinoic acid-induced Klf4 gene expression by regulating Klf4 promoter activity in vascular smooth muscle cells.
Shi JH, Zheng B, Chen S, Ma GY, Wen JK
The Journal of biological chemistry 2012 Mar 30;287(14):10799-811
The Journal of biological chemistry 2012 Mar 30;287(14):10799-811
Tangentially migrating transient glutamatergic neurons control neurogenesis and maintenance of cerebral cortical progenitor pools.
Teissier A, Waclaw RR, Griveau A, Campbell K, Pierani A
Cerebral cortex (New York, N.Y. : 1991) 2012 Feb;22(2):403-16
Cerebral cortex (New York, N.Y. : 1991) 2012 Feb;22(2):403-16
Pax6 is required at the telencephalic pallial-subpallial boundary for the generation of neuronal diversity in the postnatal limbic system.
Cocas LA, Georgala PA, Mangin JM, Clegg JM, Kessaris N, Haydar TF, Gallo V, Price DJ, Corbin JG
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Apr 6;31(14):5313-24
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Apr 6;31(14):5313-24
Developmental origin of the neuronal subtypes that comprise the amygdalar fear circuit in the mouse.
Waclaw RR, Ehrman LA, Pierani A, Campbell K
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 May 19;30(20):6944-53
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 May 19;30(20):6944-53
Cutting edge: human latency-associated peptide+ T cells: a novel regulatory T cell subset.
Gandhi R, Farez MF, Wang Y, Kozoriz D, Quintana FJ, Weiner HL
Journal of immunology (Baltimore, Md. : 1950) 2010 May 1;184(9):4620-4
Journal of immunology (Baltimore, Md. : 1950) 2010 May 1;184(9):4620-4
c-MYC independent nuclear reprogramming favors cardiogenic potential of induced pluripotent stem cells.
Martinez-Fernandez A, Nelson TJ, Ikeda Y, Terzic A
Journal of cardiovascular translational research 2010 Feb;3(1):13-23
Journal of cardiovascular translational research 2010 Feb;3(1):13-23
iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism.
Martinez-Fernandez A, Nelson TJ, Yamada S, Reyes S, Alekseev AE, Perez-Terzic C, Ikeda Y, Terzic A
Circulation research 2009 Sep 25;105(7):648-56
Circulation research 2009 Sep 25;105(7):648-56
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 10056-1-AP(MEF2C antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MEF2C antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MEF2C. This antibody recognizes human,mouse,rat antigen. The MEF2C antibody has been validated for the following applications: ELISA, WB, IHC, IP, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-MEF2C (IP:10056-1-AP, 3ug; Detection:10056-1-AP 1:500) with SH-SY5Y cells lysate 2000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 10056-1-AP(MEF2C antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
