Antibody data
- Antibody Data
- Antigen structure
- References [236]
- Comments [0]
- Validations
- Western blot [2]
- ELISA [1]
- Immunocytochemistry [2]
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Validation data
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- Product number
- H00008878-M01 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#H00008878-M01, RRID:AB_548364
- Product name
- Mouse Monoclonal p62/SQSTM1 Antibody
- Antibody type
- Monoclonal
- Description
- IgG purified.
- Reactivity
- Human, Mouse, Rat, Bovine, Hamster, Rabbit
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on β-amyloid clearance.
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study.
Simvastatin increases temozolomide-induced cell death by targeting the fusion of autophagosomes and lysosomes.
Beclin 1/Bcl-2 complex-dependent autophagy activity modulates renal susceptibility to ischemia-reperfusion injury and mediates renoprotection by Klotho.
Autophagy-dependent cancer cells circumvent loss of the upstream regulator RB1CC1/FIP200 and loss of LC3 conjugation by similar mechanisms.
SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent Autophagy.
Pathogenic implications of dysregulated miRNAs in propionic acidemia related cardiomyopathy.
HIV Tat-mediated induction of autophagy regulates the disruption of ZO-1 in brain endothelial cells.
Autophagy Pathway Mapping to Elucidate the Function of Novel Autophagy Regulators Identified by High-Throughput Screening.
Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson's Disease Research.
Determination of Autophagy in the Caco-2 Spontaneously Differentiating Model of Intestinal Epithelial Cells.
Syntaxin-17-Dependent Mitochondrial Dynamics is Essential for Protection Against Oxidative-Stress-Induced Apoptosis.
Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart.
Citalopram Reduces Aggregation of ATXN3 in a YAC Transgenic Mouse Model of Machado-Joseph Disease.
miR-181a/b downregulation exerts a protective action on mitochondrial disease models.
Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function.
Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
Autophagy inhibition enhances PD-L1 expression in gastric cancer.
Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy.
Co-localization of autophagy-related protein p62 with cancer stem cell marker dclk1 may hamper dclk1's elimination during colon cancer development and progression.
Human cytomegalovirus hijacks the autophagic machinery and LC3 homologs in order to optimize cytoplasmic envelopment of mature infectious particles.
Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice.
Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.
TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.
Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth.
Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
AMH prevents primordial ovarian follicle loss and fertility alteration in cyclophosphamide-treated mice.
Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.
Beclin1 decreases the RIPA-insoluble fraction of amyotrophic lateral sclerosis-linked SOD1 mutant via autophagy.
A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex.
The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy.
The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species.
Vincristine ablation of Sirt2 induces cell apoptosis and mitophagy via Hsp70 acetylation in MDA-MB-231 cells.
Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.
Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.
p300 Mediates Muscle Wasting in Lewis Lung Carcinoma.
Graphene oxide sensitizes cancer cells to chemotherapeutics by inducing early autophagy events, promoting nuclear trafficking and necrosis.
An Engineered DC-Targeting Lentivector Induces Robust T Cell Responses and Inhibits HBV Replication in HBV Transgenic Mice via Upregulating T Cell Autophagy.
Autophagy inhibition improves the cytotoxic effects of receptor tyrosine kinase inhibitors.
Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo.
Significant predictors of overall survival in patients with hepatocellular carcinoma after surgical resection.
GIMAP6 is required for T cell maintenance and efficient autophagy in mice.
Quantifying autophagy using novel LC3B and p62 TR-FRET assays.
LC3B is not recruited along with the autophagy elongation complex (ATG5-12/16L1) at HCV replication site and is dispensable for viral replication.
Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice.
Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins.
High-Fructose Consumption Impairs the Redox System and Protein Quality Control in the Brain of Syrian Hamsters: Therapeutic Effects of Melatonin.
SMER28 is a mTOR-independent small molecule enhancer of autophagy that protects mouse bone marrow and liver against radiotherapy.
Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy.
Parkin is a disease modifier in the mutant SOD1 mouse model of ALS.
ZZ-dependent regulation of p62/SQSTM1 in autophagy.
Probing aggrephagy using chemically-induced protein aggregates.
Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes.
Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis.
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.
Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk.
Neuroprotective Effects of Creatine in the CMVMJD135 Mouse Model of Spinocerebellar Ataxia Type 3.
LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.
Ventilator-induced diaphragmatic dysfunction in MDX mice.
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer.
Temporal partitioning of adaptive responses of the murine heart to fasting.
Identification of an IL-1-induced gene expression pattern in AR+ PCa cells that mimics the molecular phenotype of AR- PCa cells.
Inhibition of mTOR complexes protects cancer cells from glutamine starvation induced cell death by restoring Akt stability.
Blocking Autophagy in Oligodendrocytes Limits Functional Recovery after Spinal Cord Injury.
Autophagy alteration prevents primary cilium disassembly in RPE1 cells.
Increased O-GlcNAcylation of SNAP29 Drives Arsenic-Induced Autophagic Dysfunction.
Protective role of Parkin in skeletal muscle contractile and mitochondrial function.
Melatonin Prevents the Harmful Effects of Obesity on the Brain, Including at the Behavioral Level.
Amifostine Protects Mouse Liver Against Radiation-induced Autophagy Blockage.
Autophagic processes in Mytilus galloprovincialis hemocytes: Effects of Vibrio tapetis.
Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.
Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy.
Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-β Levels in Primary Neurons from an Alzheimer's Disease Transgenic Model.
Low-level arsenic causes proteotoxic stress and not oxidative stress.
Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation.
C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis.
Turnover of Lipidated LC3 and Autophagic Cargoes in Mammalian Cells.
Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart.
Bacteroides fragilis Enterotoxin Induces Formation of Autophagosomes in Endothelial Cells but Interferes with Fusion with Lysosomes for Complete Autophagic Flux through a Mitogen-Activated Protein Kinase-, AP-1-, and C/EBP Homologous Protein-Dependent Pathway.
N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson's disease.
The Role of Autophagy in Critical Illness-induced Liver Damage.
mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy.
Upregulated Autophagy in Sertoli Cells of Ethanol-Treated Rats Is Associated with Induction of Inducible Nitric Oxide Synthase (iNOS), Androgen Receptor Suppression and Germ Cell Apoptosis.
A Rab20-Dependent Membrane Trafficking Pathway Controls M. tuberculosis Replication by Regulating Phagosome Spaciousness and Integrity.
MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy.
Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.
Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration.
Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis.
Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy.
Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis.
Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells.
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line.
Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease.
Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration.
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.
Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response.
Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension.
Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons.
Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils.
Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy.
Measuring Autophagy in the Context of Cancer.
Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice.
Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins.
Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis.
Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a Protein-induced Autophagy in Pancreatic Intraepithelial Neoplasms.
Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small cell lung cancer cells.
A Preclinical Study Evaluating AAVrh10-Based Gene Therapy for Sanfilippo Syndrome.
Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.
Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors.
Biotinylation: a novel posttranslational modification linking cell autonomous circadian clocks with metabolism.
Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt.
Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer.
Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.
Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells.
Melatonin reduces endoplasmic reticulum stress and autophagy in liver of leptin-deficient mice.
A cell-based quantitative high-throughput image screening identified novel autophagy modulators.
Oncolytic Adenovirus Loaded with L-carnosine as Novel Strategy to Enhance the Antitumor Activity.
BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy.
Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.
Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth.
Streptococcus pneumoniae induces autophagy through the inhibition of the PI3K-I/Akt/mTOR pathway and ROS hypergeneration in A549 cells.
The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila.
Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling.
Caspase-2 protects against oxidative stress in vivo.
Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice.
Autophagy mediates degradation of nuclear lamina.
Pathogenic Ubqln2 gains toxic properties to induce neuron death.
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
Graphene oxide as a chemosensitizer: diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects.
Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling.
An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice.
FGF signalling regulates bone growth through autophagy.
Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation.
Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases.
Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.
3D bioprinting of biomimetic aortic vascular constructs with self-supporting cells.
Unsaturated fatty acids induce non-canonical autophagy.
Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice.
Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity.
Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy.
Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.
Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent.
The autophagy/lysosome pathway is impaired in SCA7 patients and SCA7 knock-in mice.
Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation.
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.
Melatonin administration decreases adipogenesis in the liver of ob/ob mice through autophagy modulation.
Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages.
Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy.
The non-receptor tyrosine kinase Ack1 regulates the fate of activated EGFR by inducing trafficking to the p62/NBR1 pre-autophagosome.
Defective autophagy impairs ATF3 activity and worsens lung injury during endotoxemia.
The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells.
Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability.
Dual role for CHOP in the crosstalk between autophagy and apoptosis to determine cell fate in response to amino acid deprivation.
Imaging autophagy.
Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.
Reactive oxygen species regulation of autophagy in skeletal muscles.
Excitotoxic glutamate insults block autophagic flux in hippocampal neurons.
p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines.
Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation.
New autophagy reporter mice reveal dynamics of proximal tubular autophagy.
Suppression of autophagic flux by bile acids in hepatocytes.
scyllo-Inositol promotes robust mutant Huntingtin protein degradation.
Phosphorylated AKT inhibits the apoptosis induced by DRAM-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of DRAM to mitochondria.
Clinicopathologic report of ocular involvement in ALS patients with C9orf72 mutation.
IL-1β induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells.
Chloroquine promotes the anticancer effect of TACE in a rabbit VX2 liver tumor model.
Atg4b-dependent autophagic flux alleviates Huntington's disease progression.
p62/SQSTM1 enhances NOD2-mediated signaling and cytokine production through stabilizing NOD2 oligomerization.
MIR376A is a regulator of starvation-induced autophagy.
Impairment of autophagic flux promotes glucose reperfusion-induced neuro2A cell death after glucose deprivation.
Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.
Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.
The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression.
The ubiquitin ligase parkin mediates resistance to intracellular pathogens.
Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts.
T-type calcium channel blockers inhibit autophagy and promote apoptosis of malignant melanoma cells.
PINK1 is degraded through the N-end rule pathway.
Site-specific Mtm1 mutagenesis by an AAV-Cre vector reveals that myotubularin is essential in adult muscle.
Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration.
RalGDS-dependent cardiomyocyte autophagy is required for load-induced ventricular hypertrophy.
Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway.
Impairment of autophagy decreases ventilator-induced lung injury by blockade of the NF-κB pathway.
Autophagy facilitates organelle clearance during differentiation of human erythroblasts: evidence for a role for ATG4 paralogs during autophagosome maturation.
Recombinant protein rVP1 upregulates BECN1-independent autophagy, MAPK1/3 phosphorylation and MMP9 activity via WIPI1/WIPI2 to promote macrophage migration.
Defective autophagy and mTORC1 signaling in myotubularin null mice.
Host cell autophagy modulates early stages of adenovirus infections in airway epithelial cells.
Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis.
Autophagic-lysosomal pathway is the main proteolytic system modified in the skeletal muscle of esophageal cancer patients.
Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells.
Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity.
C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis.
West Nile virus (WNV) replication is independent of autophagy in mammalian cells.
Tissue specific induction of p62/Sqstm1 by farnesoid X receptor.
Genetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survival.
(-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilization.
MAP1B Interaction with the FW Domain of the Autophagic Receptor Nbr1 Facilitates Its Association to the Microtubule Network.
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease.
Sorafenib has potent antitumor activity against multiple myeloma in vitro, ex vivo, and in vivo in the 5T33MM mouse model.
Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease.
Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence.
Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice.
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
A centronuclear myopathy--dynamin 2 mutation impairs autophagy in mice.
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
Age-related oxidative stress compromises endosomal proteostasis.
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.
Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery.
Modulation of pediatric brain tumor autophagy and chemosensitivity.
Targeting of distinct signaling cascades and cancer-associated fibroblasts define the efficacy of Sorafenib against prostate cancer cells.
Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function.
Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model.
Rotenone inhibits autophagic flux prior to inducing cell death.
Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.
"Autophagic flux" in normal mouse tissues: focus on endogenous LC3A processing.
Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.
Lung autophagic response following exposure of mice to whole body irradiation, with and without amifostine.
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Pancreatic cancers require autophagy for tumor growth.
Glucocorticoids downregulate Fyn and inhibit IP(3)-mediated calcium signaling to promote autophagy in T lymphocytes.
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity.
In vivo requirement for Atg5 in antigen presentation by dendritic cells.
14-3-3Tau regulates Beclin 1 and is required for autophagy.
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase.
Monitoring autophagic degradation of p62/SQSTM1.
Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling.
Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.
Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia.
Benito-Cuesta I, Ordóñez-Gutiérrez L, Wandosell F
Autophagy 2021 Mar;17(3):656-671
Autophagy 2021 Mar;17(3):656-671
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Hossain MI, Marcus JM, Lee JH, Garcia PL, Singh V, Shacka JJ, Zhang J, Gropen TI, Falany CN, Andrabi SA
Autophagy 2021 Jun;17(6):1330-1348
Autophagy 2021 Jun;17(6):1330-1348
Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study.
Van Dyck L, Vanhorebeek I, Wilmer A, Schrijvers A, Derese I, Mebis L, Wouters PJ, Van den Berghe G, Gunst J, Casaer MP
Critical care (London, England) 2020 May 24;24(1):249
Critical care (London, England) 2020 May 24;24(1):249
Simvastatin increases temozolomide-induced cell death by targeting the fusion of autophagosomes and lysosomes.
Shojaei S, Koleini N, Samiei E, Aghaei M, Cole LK, Alizadeh J, Islam MI, Vosoughi AR, Albokashy M, Butterfield Y, Marzban H, Xu F, Thliveris J, Kardami E, Hatch GM, Eftekharpour E, Akbari M, Hombach-Klonisch S, Klonisch T, Ghavami S
The FEBS journal 2020 Mar;287(5):1005-1034
The FEBS journal 2020 Mar;287(5):1005-1034
Beclin 1/Bcl-2 complex-dependent autophagy activity modulates renal susceptibility to ischemia-reperfusion injury and mediates renoprotection by Klotho.
Li P, Shi M, Maique J, Shaffer J, Yan S, Moe OW, Hu MC
American journal of physiology. Renal physiology 2020 Mar 1;318(3):F772-F792
American journal of physiology. Renal physiology 2020 Mar 1;318(3):F772-F792
Autophagy-dependent cancer cells circumvent loss of the upstream regulator RB1CC1/FIP200 and loss of LC3 conjugation by similar mechanisms.
Towers CG, Wodetzki D, Thorburn A
Autophagy 2020 Jul;16(7):1332-1340
Autophagy 2020 Jul;16(7):1332-1340
SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent Autophagy.
Pires Da Silva J, Monceaux K, Guilbert A, Gressette M, Piquereau J, Novotova M, Ventura-Clapier R, Garnier A, Lemaire C
Cells 2020 Feb 12;9(2)
Cells 2020 Feb 12;9(2)
Pathogenic implications of dysregulated miRNAs in propionic acidemia related cardiomyopathy.
Fulgencio-Covián A, Alonso-Barroso E, Guenzel AJ, Rivera-Barahona A, Ugarte M, Pérez B, Barry MA, Pérez-Cerdá C, Richard E, Desviat LR
Translational research : the journal of laboratory and clinical medicine 2020 Apr;218:43-56
Translational research : the journal of laboratory and clinical medicine 2020 Apr;218:43-56
HIV Tat-mediated induction of autophagy regulates the disruption of ZO-1 in brain endothelial cells.
Liao K, Niu F, Hu G, Guo ML, Sil S, Buch S
Tissue barriers 2020 Apr 2;8(2):1748983
Tissue barriers 2020 Apr 2;8(2):1748983
Autophagy Pathway Mapping to Elucidate the Function of Novel Autophagy Regulators Identified by High-Throughput Screening.
Wirth M, Tooze SA
Methods in molecular biology (Clifton, N.J.) 2019;1880:375-387
Methods in molecular biology (Clifton, N.J.) 2019;1880:375-387
Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson's Disease Research.
Stathakos P, Jimenez-Moreno N, Crompton L, Nistor P, Caldwell MA, Lane JD
Methods in molecular biology (Clifton, N.J.) 2019;1880:257-280
Methods in molecular biology (Clifton, N.J.) 2019;1880:257-280
Determination of Autophagy in the Caco-2 Spontaneously Differentiating Model of Intestinal Epithelial Cells.
Tunçer S, Banerjee S
Methods in molecular biology (Clifton, N.J.) 2019;1854:55-70
Methods in molecular biology (Clifton, N.J.) 2019;1854:55-70
Syntaxin-17-Dependent Mitochondrial Dynamics is Essential for Protection Against Oxidative-Stress-Induced Apoptosis.
Wang B, Xiao X, Huang F, Liu R
Antioxidants (Basel, Switzerland) 2019 Oct 30;8(11)
Antioxidants (Basel, Switzerland) 2019 Oct 30;8(11)
Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart.
Vidal R, Wagner JUG, Braeuning C, Fischer C, Patrick R, Tombor L, Muhly-Reinholz M, John D, Kliem M, Conrad T, Guimarães-Camboa N, Harvey R, Dimmeler S, Sauer S
JCI insight 2019 Nov 14;4(22)
JCI insight 2019 Nov 14;4(22)
Citalopram Reduces Aggregation of ATXN3 in a YAC Transgenic Mouse Model of Machado-Joseph Disease.
Ashraf NS, Duarte-Silva S, Shaw ED, Maciel P, Paulson HL, Teixeira-Castro A, Costa MDC
Molecular neurobiology 2019 May;56(5):3690-3701
Molecular neurobiology 2019 May;56(5):3690-3701
miR-181a/b downregulation exerts a protective action on mitochondrial disease models.
Indrieri A, Carrella S, Romano A, Spaziano A, Marrocco E, Fernandez-Vizarra E, Barbato S, Pizzo M, Ezhova Y, Golia FM, Ciampi L, Tammaro R, Henao-Mejia J, Williams A, Flavell RA, De Leonibus E, Zeviani M, Surace EM, Banfi S, Franco B
EMBO molecular medicine 2019 May;11(5)
EMBO molecular medicine 2019 May;11(5)
Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function.
Zhao L, Pascual F, Bacudio L, Suchanek AL, Young PA, Li LO, Martin SA, Camporez JP, Perry RJ, Shulman GI, Klett EL, Coleman RA
The Journal of biological chemistry 2019 May 31;294(22):8819-8833
The Journal of biological chemistry 2019 May 31;294(22):8819-8833
Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Wirth M, Zhang W, Razi M, Nyoni L, Joshi D, O'Reilly N, Johansen T, Tooze SA, Mouilleron S
Nature communications 2019 May 3;10(1):2055
Nature communications 2019 May 3;10(1):2055
ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
Wang B, Maxwell BA, Joo JH, Gwon Y, Messing J, Mishra A, Shaw TI, Ward AL, Quan H, Sakurada SM, Pruett-Miller SM, Bertorini T, Vogel P, Kim HJ, Peng J, Taylor JP, Kundu M
Molecular cell 2019 May 16;74(4):742-757.e8
Molecular cell 2019 May 16;74(4):742-757.e8
Autophagy inhibition enhances PD-L1 expression in gastric cancer.
Wang X, Wu WKK, Gao J, Li Z, Dong B, Lin X, Li Y, Li Y, Gong J, Qi C, Peng Z, Yu J, Shen L
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):140
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):140
Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy.
Eid N, Ito Y, Horibe A, Otsuki Y, Kondo Y
Cells 2019 Mar 25;8(3)
Cells 2019 Mar 25;8(3)
Co-localization of autophagy-related protein p62 with cancer stem cell marker dclk1 may hamper dclk1's elimination during colon cancer development and progression.
Roy BC, Ahmed I, Ramalingam S, Jala V, Haribabu B, Ramamoorthy P, Ashcraft J, Valentino J, Anant S, Sampath V, Umar S
Oncotarget 2019 Mar 22;10(24):2340-2354
Oncotarget 2019 Mar 22;10(24):2340-2354
Human cytomegalovirus hijacks the autophagic machinery and LC3 homologs in order to optimize cytoplasmic envelopment of mature infectious particles.
Taisne C, Lussignol M, Hernandez E, Moris A, Mouna L, Esclatine A
Scientific reports 2019 Mar 14;9(1):4560
Scientific reports 2019 Mar 14;9(1):4560
Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice.
Koike K, Beatman EL, Schweitzer KS, Justice MJ, Mikosz AM, Ni K, Clauss MA, Petrache I
American journal of physiology. Lung cellular and molecular physiology 2019 Mar 1;316(3):L558-L566
American journal of physiology. Lung cellular and molecular physiology 2019 Mar 1;316(3):L558-L566
Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.
Park JS, Lee YS, Lee DH, Bae SH
Free radical biology & medicine 2019 Jun;137:143-157
Free radical biology & medicine 2019 Jun;137:143-157
TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.
An H, Ordureau A, Paulo JA, Shoemaker CJ, Denic V, Harper JW
Molecular cell 2019 Jun 6;74(5):891-908.e10
Molecular cell 2019 Jun 6;74(5):891-908.e10
Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth.
Feng X, Jia Y, Zhang Y, Ma F, Zhu Y, Hong X, Zhou Q, He R, Zhang H, Jin J, Piao D, Huang H, Li Q, Qiu X, Zhang Z
Autophagy 2019 Jul;15(7):1130-1149
Autophagy 2019 Jul;15(7):1130-1149
Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
Schweitzer GG, Collier SL, Chen Z, McCommis KS, Pittman SK, Yoshino J, Matkovich SJ, Hsu FF, Chrast R, Eaton JM, Harris TE, Weihl CC, Finck BN
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):652-667
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):652-667
AMH prevents primordial ovarian follicle loss and fertility alteration in cyclophosphamide-treated mice.
Sonigo C, Beau I, Grynberg M, Binart N
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):1278-1287
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):1278-1287
Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.
Rashid T, Nemazanyy I, Paolini C, Tatsuta T, Crespin P, de Villeneuve D, Brodesser S, Benit P, Rustin P, Baraibar MA, Agbulut O, Olivier A, Protasi F, Langer T, Chrast R, de Lonlay P, de Foucauld H, Blaauw B, Pende M
The EMBO journal 2019 Jan 3;38(1)
The EMBO journal 2019 Jan 3;38(1)
Beclin1 decreases the RIPA-insoluble fraction of amyotrophic lateral sclerosis-linked SOD1 mutant via autophagy.
Wei YM, Han B
Neuroscience letters 2019 Jan 18;690:106-111
Neuroscience letters 2019 Jan 18;690:106-111
A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex.
Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M, Settembre C
The EMBO journal 2019 Jan 15;38(2)
The EMBO journal 2019 Jan 15;38(2)
The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy.
Horos R, Büscher M, Kleinendorst R, Alleaume AM, Tarafder AK, Schwarzl T, Dziuba D, Tischer C, Zielonka EM, Adak A, Castello A, Huber W, Sachse C, Hentze MW
Cell 2019 Feb 21;176(5):1054-1067.e12
Cell 2019 Feb 21;176(5):1054-1067.e12
The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species.
Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F
Nature communications 2019 Feb 19;10(1):651
Nature communications 2019 Feb 19;10(1):651
Vincristine ablation of Sirt2 induces cell apoptosis and mitophagy via Hsp70 acetylation in MDA-MB-231 cells.
Sun F, Jiang X, Wang X, Bao Y, Feng G, Liu H, Kou X, Zhu Q, Jiang L, Yang Y
Biochemical pharmacology 2019 Apr;162:142-153
Biochemical pharmacology 2019 Apr;162:142-153
Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.
Vargas JNS, Wang C, Bunker E, Hao L, Maric D, Schiavo G, Randow F, Youle RJ
Molecular cell 2019 Apr 18;74(2):347-362.e6
Molecular cell 2019 Apr 18;74(2):347-362.e6
Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.
Sica V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S, Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N, Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC, Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC
Cell reports 2019 Apr 16;27(3):820-834.e9
Cell reports 2019 Apr 16;27(3):820-834.e9
p300 Mediates Muscle Wasting in Lewis Lung Carcinoma.
Sin TK, Zhu JZ, Zhang G, Li YP
Cancer research 2019 Apr 1;79(7):1331-1342
Cancer research 2019 Apr 1;79(7):1331-1342
Graphene oxide sensitizes cancer cells to chemotherapeutics by inducing early autophagy events, promoting nuclear trafficking and necrosis.
Lin KC, Lin MW, Hsu MN, Yu-Chen G, Chao YC, Tuan HY, Chiang CS, Hu YC
Theranostics 2018;8(9):2477-2487
Theranostics 2018;8(9):2477-2487
An Engineered DC-Targeting Lentivector Induces Robust T Cell Responses and Inhibits HBV Replication in HBV Transgenic Mice via Upregulating T Cell Autophagy.
Ma S, Chen X, Tan Q, Dai S, Li D, Wu S, Yu Y, Zang G, Tang Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1041-1059
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1041-1059
Autophagy inhibition improves the cytotoxic effects of receptor tyrosine kinase inhibitors.
Aveic S, Pantile M, Polo P, Sidarovich V, De Mariano M, Quattrone A, Longo L, Tonini GP
Cancer cell international 2018;18:63
Cancer cell international 2018;18:63
Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo.
Liu ZQ, Lee JN, Son M, Lim JY, Dutta RK, Maharjan Y, Kwak S, Oh GT, Byun K, Choe SK, Park R
Autophagy 2018;14(6):1011-1027
Autophagy 2018;14(6):1011-1027
Significant predictors of overall survival in patients with hepatocellular carcinoma after surgical resection.
Lin CW, Chen YS, Lin CC, Lee PH, Lo GH, Hsu CC, Hsieh PM, Koh KW, Bair MJ, Dai CY, Huang JF, Chuang WL, Chen YL, Yu ML
PloS one 2018;13(9):e0202650
PloS one 2018;13(9):e0202650
GIMAP6 is required for T cell maintenance and efficient autophagy in mice.
Pascall JC, Webb LMC, Eskelinen EL, Innocentin S, Attaf-Bouabdallah N, Butcher GW
PloS one 2018;13(5):e0196504
PloS one 2018;13(5):e0196504
Quantifying autophagy using novel LC3B and p62 TR-FRET assays.
Bresciani A, Spiezia MC, Boggio R, Cariulo C, Nordheim A, Altobelli R, Kuhlbrodt K, Dominguez C, Munoz-Sanjuan I, Wityak J, Fodale V, Marchionini DM, Weiss A
PloS one 2018;13(3):e0194423
PloS one 2018;13(3):e0194423
LC3B is not recruited along with the autophagy elongation complex (ATG5-12/16L1) at HCV replication site and is dispensable for viral replication.
Fahmy AM, Khabir M, Blanchet M, Labonté P
PloS one 2018;13(10):e0205189
PloS one 2018;13(10):e0205189
Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice.
Chao X, Wang S, Zhao K, Li Y, Williams JA, Li T, Chavan H, Krishnamurthy P, He XC, Li L, Ballabio A, Ni HM, Ding WX
Gastroenterology 2018 Sep;155(3):865-879.e12
Gastroenterology 2018 Sep;155(3):865-879.e12
Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins.
Winer H, Fraiberg M, Abada A, Dadosh T, Tamim-Yecheskel BC, Elazar Z
Nature communications 2018 Sep 14;9(1):3744
Nature communications 2018 Sep 14;9(1):3744
High-Fructose Consumption Impairs the Redox System and Protein Quality Control in the Brain of Syrian Hamsters: Therapeutic Effects of Melatonin.
Bermejo-Millo JC, Guimarães MRM, de Luxán-Delgado B, Potes Y, Pérez-Martínez Z, Díaz-Luis A, Caballero B, Solano JJ, Vega-Naredo I, Coto-Montes A
Molecular neurobiology 2018 Oct;55(10):7973-7986
Molecular neurobiology 2018 Oct;55(10):7973-7986
SMER28 is a mTOR-independent small molecule enhancer of autophagy that protects mouse bone marrow and liver against radiotherapy.
Koukourakis MI, Giatromanolaki A, Fylaktakidou K, Sivridis E, Zois CE, Kalamida D, Mitrakas A, Pouliliou S, Karagounis IV, Simopoulos K, Ferguson DJP, Harris AL
Investigational new drugs 2018 Oct;36(5):773-781
Investigational new drugs 2018 Oct;36(5):773-781
Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy.
Manzella N, Santin Y, Maggiorani D, Martini H, Douin-Echinard V, Passos JF, Lezoualc'h F, Binda C, Parini A, Mialet-Perez J
Aging cell 2018 Oct;17(5):e12811
Aging cell 2018 Oct;17(5):e12811
Parkin is a disease modifier in the mutant SOD1 mouse model of ALS.
Palomo GM, Granatiero V, Kawamata H, Konrad C, Kim M, Arreguin AJ, Zhao D, Milner TA, Manfredi G
EMBO molecular medicine 2018 Oct;10(10)
EMBO molecular medicine 2018 Oct;10(10)
ZZ-dependent regulation of p62/SQSTM1 in autophagy.
Zhang Y, Mun SR, Linares JF, Ahn J, Towers CG, Ji CH, Fitzwalter BE, Holden MR, Mi W, Shi X, Moscat J, Thorburn A, Diaz-Meco MT, Kwon YT, Kutateladze TG
Nature communications 2018 Oct 22;9(1):4373
Nature communications 2018 Oct 22;9(1):4373
Probing aggrephagy using chemically-induced protein aggregates.
Janssen AFJ, Katrukha EA, van Straaten W, Verlhac P, Reggiori F, Kapitein LC
Nature communications 2018 Oct 12;9(1):4245
Nature communications 2018 Oct 12;9(1):4245
Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes.
Mattar P, Bravo-Sagua R, Tobar N, Fuentes C, Troncoso R, Breitwieser G, Lavandero S, Cifuentes M
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3585-3594
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3585-3594
Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis.
Civiletto G, Dogan SA, Cerutti R, Fagiolari G, Moggio M, Lamperti C, Benincá C, Viscomi C, Zeviani M
EMBO molecular medicine 2018 Nov;10(11)
EMBO molecular medicine 2018 Nov;10(11)
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.
Dogan SA, Cerutti R, Benincá C, Brea-Calvo G, Jacobs HT, Zeviani M, Szibor M, Viscomi C
Cell metabolism 2018 Nov 6;28(5):764-775.e5
Cell metabolism 2018 Nov 6;28(5):764-775.e5
Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk.
Cai J, Pires KM, Ferhat M, Chaurasia B, Buffolo MA, Smalling R, Sargsyan A, Atkinson DL, Summers SA, Graham TE, Boudina S
Cell reports 2018 Nov 13;25(7):1708-1717.e5
Cell reports 2018 Nov 13;25(7):1708-1717.e5
Neuroprotective Effects of Creatine in the CMVMJD135 Mouse Model of Spinocerebellar Ataxia Type 3.
Duarte-Silva S, Neves-Carvalho A, Soares-Cunha C, Silva JM, Teixeira-Castro A, Vieira R, Silva-Fernandes A, Maciel P
Movement disorders : official journal of the Movement Disorder Society 2018 May;33(5):815-826
Movement disorders : official journal of the Movement Disorder Society 2018 May;33(5):815-826
LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.
Henderson MX, Peng C, Trojanowski JQ, Lee VMY
Acta neuropathologica communications 2018 May 31;6(1):45
Acta neuropathologica communications 2018 May 31;6(1):45
Ventilator-induced diaphragmatic dysfunction in MDX mice.
Liang F, Li T, Azuelos I, Giordano C, Liang H, Hussain SN, Matecki S, Petrof BJ
Muscle & nerve 2018 Mar;57(3):442-448
Muscle & nerve 2018 Mar;57(3):442-448
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer.
Cevatemre B, Erkısa M, Aztopal N, Karakas D, Alper P, Tsimplouli C, Sereti E, Dimas K, Armutak EII, Gurevin EG, Uvez A, Mori M, Berardozzi S, Ingallina C, D'Acquarica I, Botta B, Ozpolat B, Ulukaya E
Pharmacological research 2018 Mar;129:500-514
Pharmacological research 2018 Mar;129:500-514
Temporal partitioning of adaptive responses of the murine heart to fasting.
Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado BA, Peliciari-Garcia RA, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, Darley-Usmar V, Zhang J, Frank SJ, Chatham JC, Young ME
Life sciences 2018 Mar 15;197:30-39
Life sciences 2018 Mar 15;197:30-39
Identification of an IL-1-induced gene expression pattern in AR+ PCa cells that mimics the molecular phenotype of AR- PCa cells.
Thomas-Jardin SE, Kanchwala MS, Jacob J, Merchant S, Meade RK, Gahnim NM, Nawas AF, Xing C, Delk NA
The Prostate 2018 Jun;78(8):595-606
The Prostate 2018 Jun;78(8):595-606
Inhibition of mTOR complexes protects cancer cells from glutamine starvation induced cell death by restoring Akt stability.
Khan MW, Layden BT, Chakrabarti P
Biochimica et biophysica acta. Molecular basis of disease 2018 Jun;1864(6 Pt A):2040-2052
Biochimica et biophysica acta. Molecular basis of disease 2018 Jun;1864(6 Pt A):2040-2052
Blocking Autophagy in Oligodendrocytes Limits Functional Recovery after Spinal Cord Injury.
Saraswat Ohri S, Bankston AN, Mullins SA, Liu Y, Andres KR, Beare JE, Howard RM, Burke DA, Riegler AS, Smith AE, Hetman M, Whittemore SR
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jun 27;38(26):5900-5912
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jun 27;38(26):5900-5912
Autophagy alteration prevents primary cilium disassembly in RPE1 cells.
Maharjan Y, Lee JN, Kwak S, Lim H, Dutta RK, Liu ZQ, So HS, Park R
Biochemical and biophysical research communications 2018 Jun 2;500(2):242-248
Biochemical and biophysical research communications 2018 Jun 2;500(2):242-248
Increased O-GlcNAcylation of SNAP29 Drives Arsenic-Induced Autophagic Dysfunction.
Dodson M, Liu P, Jiang T, Ambrose AJ, Luo G, Rojo de la Vega M, Cholanians AB, Wong PK, Chapman E, Zhang DD
Molecular and cellular biology 2018 Jun 1;38(11)
Molecular and cellular biology 2018 Jun 1;38(11)
Protective role of Parkin in skeletal muscle contractile and mitochondrial function.
Gouspillou G, Godin R, Piquereau J, Picard M, Mofarrahi M, Mathew J, Purves-Smith FM, Sgarioto N, Hepple RT, Burelle Y, Hussain SNA
The Journal of physiology 2018 Jul;596(13):2565-2579
The Journal of physiology 2018 Jul;596(13):2565-2579
Melatonin Prevents the Harmful Effects of Obesity on the Brain, Including at the Behavioral Level.
Rubio-González A, Bermejo-Millo JC, de Luxán-Delgado B, Potes Y, Pérez-Martínez Z, Boga JA, Vega-Naredo I, Caballero B, Solano JJ, Coto-Montes A, Members of Research Team cROS (cellular Response to Oxidative Stress).
Molecular neurobiology 2018 Jul;55(7):5830-5846
Molecular neurobiology 2018 Jul;55(7):5830-5846
Amifostine Protects Mouse Liver Against Radiation-induced Autophagy Blockage.
Koukourakis MI, Giatromanolaki A, Fylaktakidou K, Kouroupi M, Sivridis E, Zois CE, Kalamida D, Mitrakas A, Pouliliou S, Karagounis IV, Simopoulos K, Ferguson DJP, Harris AL
Anticancer research 2018 Jan;38(1):227-238
Anticancer research 2018 Jan;38(1):227-238
Autophagic processes in Mytilus galloprovincialis hemocytes: Effects of Vibrio tapetis.
Balbi T, Cortese K, Ciacci C, Bellese G, Vezzulli L, Pruzzo C, Canesi L
Fish & shellfish immunology 2018 Feb;73:66-74
Fish & shellfish immunology 2018 Feb;73:66-74
Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.
Gstrein T, Edwards A, Přistoupilová A, Leca I, Breuss M, Pilat-Carotta S, Hansen AH, Tripathy R, Traunbauer AK, Hochstoeger T, Rosoklija G, Repic M, Landler L, Stránecký V, Dürnberger G, Keane TM, Zuber J, Adams DJ, Flint J, Honzik T, Gut M, Beltran S, Mechtler K, Sherr E, Kmoch S, Gut I, Keays DA
Nature neuroscience 2018 Feb;21(2):207-217
Nature neuroscience 2018 Feb;21(2):207-217
Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy.
An H, Harper JW
Nature cell biology 2018 Feb;20(2):135-143
Nature cell biology 2018 Feb;20(2):135-143
Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-β Levels in Primary Neurons from an Alzheimer's Disease Transgenic Model.
Ordóñez-Gutiérrez L, Benito-Cuesta I, Abad JL, Casas J, Fábrias G, Wandosell F
Pharmaceutical research 2018 Feb 6;35(3):49
Pharmaceutical research 2018 Feb 6;35(3):49
Low-level arsenic causes proteotoxic stress and not oxidative stress.
Dodson M, de la Vega MR, Harder B, Castro-Portuguez R, Rodrigues SD, Wong PK, Chapman E, Zhang DD
Toxicology and applied pharmacology 2018 Feb 15;341:106-113
Toxicology and applied pharmacology 2018 Feb 15;341:106-113
Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation.
Li Y, Chao X, Yang L, Lu Q, Li T, Ding WX, Ni HM
The American journal of pathology 2018 Aug;188(8):1833-1846
The American journal of pathology 2018 Aug;188(8):1833-1846
C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis.
Zhang X, Wu WK, Xu W, Man K, Wang X, Han J, Leung WY, Wu R, Liu K, Yu J
Theranostics 2017;7(11):2822-2836
Theranostics 2017;7(11):2822-2836
Turnover of Lipidated LC3 and Autophagic Cargoes in Mammalian Cells.
Rodríguez-Arribas M, Yakhine-Diop SM, González-Polo RA, Niso-Santano M, Fuentes JM
Methods in enzymology 2017;587:55-70
Methods in enzymology 2017;587:55-70
Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart.
McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME
Journal of molecular and cellular cardiology 2017 Sep;110:80-95
Journal of molecular and cellular cardiology 2017 Sep;110:80-95
Bacteroides fragilis Enterotoxin Induces Formation of Autophagosomes in Endothelial Cells but Interferes with Fusion with Lysosomes for Complete Autophagic Flux through a Mitogen-Activated Protein Kinase-, AP-1-, and C/EBP Homologous Protein-Dependent Pathway.
Ko SH, Jeon JI, Myung HS, Kim YJ, Kim JM
Infection and immunity 2017 Oct;85(10)
Infection and immunity 2017 Oct;85(10)
N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson's disease.
García-Sanz P, Orgaz L, Bueno-Gil G, Espadas I, Rodríguez-Traver E, Kulisevsky J, Gutierrez A, Dávila JC, González-Polo RA, Fuentes JM, Mir P, Vicario C, Moratalla R
Movement disorders : official journal of the Movement Disorder Society 2017 Oct;32(10):1409-1422
Movement disorders : official journal of the Movement Disorder Society 2017 Oct;32(10):1409-1422
The Role of Autophagy in Critical Illness-induced Liver Damage.
Thiessen SE, Derese I, Derde S, Dufour T, Pauwels L, Bekhuis Y, Pintelon I, Martinet W, Van den Berghe G, Vanhorebeek I
Scientific reports 2017 Oct 26;7(1):14150
Scientific reports 2017 Oct 26;7(1):14150
mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy.
Bartolomeo R, Cinque L, De Leonibus C, Forrester A, Salzano AC, Monfregola J, De Gennaro E, Nusco E, Azario I, Lanzara C, Serafini M, Levine B, Ballabio A, Settembre C
The Journal of clinical investigation 2017 Oct 2;127(10):3717-3729
The Journal of clinical investigation 2017 Oct 2;127(10):3717-3729
Upregulated Autophagy in Sertoli Cells of Ethanol-Treated Rats Is Associated with Induction of Inducible Nitric Oxide Synthase (iNOS), Androgen Receptor Suppression and Germ Cell Apoptosis.
Horibe A, Eid N, Ito Y, Hamaoka H, Tanaka Y, Kondo Y
International journal of molecular sciences 2017 May 15;18(5)
International journal of molecular sciences 2017 May 15;18(5)
A Rab20-Dependent Membrane Trafficking Pathway Controls M. tuberculosis Replication by Regulating Phagosome Spaciousness and Integrity.
Schnettger L, Rodgers A, Repnik U, Lai RP, Pei G, Verdoes M, Wilkinson RJ, Young DB, Gutierrez MG
Cell host & microbe 2017 May 10;21(5):619-628.e5
Cell host & microbe 2017 May 10;21(5):619-628.e5
MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy.
Ma X, Zhang S, He L, Rong Y, Brier LW, Sun Q, Liu R, Fan W, Chen S, Yue Z, Kim J, Guan KL, Li D, Zhong Q
Autophagy 2017 Mar 4;13(3):592-607
Autophagy 2017 Mar 4;13(3):592-607
Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.
Henderson MX, Chung CH, Riddle DM, Zhang B, Gathagan RJ, Seeholzer SH, Trojanowski JQ, Lee VMY
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Jun 14;37(24):5870-5884
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Jun 14;37(24):5870-5884
Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration.
Lee EB, Porta S, Michael Baer G, Xu Y, Suh E, Kwong LK, Elman L, Grossman M, Lee VM, Irwin DJ, Van Deerlin VM, Trojanowski JQ
Acta neuropathologica 2017 Jul;134(1):65-78
Acta neuropathologica 2017 Jul;134(1):65-78
Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis.
Benitez BA, Sands MS
Scientific reports 2017 Jul 24;7(1):6332
Scientific reports 2017 Jul 24;7(1):6332
Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy.
Joachim J, Razi M, Judith D, Wirth M, Calamita E, Encheva V, Dynlacht BD, Snijders AP, O'Reilly N, Jefferies HBJ, Tooze SA
Current biology : CB 2017 Jul 24;27(14):2123-2136.e7
Current biology : CB 2017 Jul 24;27(14):2123-2136.e7
Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis.
Santarino IB, Viegas MS, Domingues NS, Ribeiro AM, Soares MP, Vieira OV
Scientific reports 2017 Jul 19;7(1):5812
Scientific reports 2017 Jul 19;7(1):5812
Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells.
Panayotopoulou EG, Müller AK, Börries M, Busch H, Hu G, Lev S
Oncotarget 2017 Jul 11;8(28):45088-45104
Oncotarget 2017 Jul 11;8(28):45088-45104
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A
EMBO molecular medicine 2017 Jan;9(1):112-132
EMBO molecular medicine 2017 Jan;9(1):112-132
Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line.
Aydinlik S, Erkisa M, Cevatemre B, Sarimahmut M, Dere E, Ari F, Ulukaya E
Biochimica et biophysica acta. General subjects 2017 Feb;1861(2):49-57
Biochimica et biophysica acta. General subjects 2017 Feb;1861(2):49-57
Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease.
Covell DJ, Robinson JL, Akhtar RS, Grossman M, Weintraub D, Bucklin HM, Pitkin RM, Riddle D, Yousef A, Trojanowski JQ, Lee VM
Neuropathology and applied neurobiology 2017 Dec;43(7):604-620
Neuropathology and applied neurobiology 2017 Dec;43(7):604-620
Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration.
Baron O, Boudi A, Dias C, Schilling M, Nölle A, Vizcay-Barrena G, Rattray I, Jungbluth H, Scheper W, Fleck RA, Bates GP, Fanto M
Current biology : CB 2017 Dec 4;27(23):3626-3642.e6
Current biology : CB 2017 Dec 4;27(23):3626-3642.e6
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.
Rocchi A, Yamamoto S, Ting T, Fan Y, Sadleir K, Wang Y, Zhang W, Huang S, Levine B, Vassar R, He C
PLoS genetics 2017 Aug;13(8):e1006962
PLoS genetics 2017 Aug;13(8):e1006962
Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response.
Willy JA, Young SK, Mosley AL, Gawrieh S, Stevens JL, Masuoka HC, Wek RC
The Journal of biological chemistry 2017 Aug 25;292(34):14050-14065
The Journal of biological chemistry 2017 Aug 25;292(34):14050-14065
Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension.
Orcholski ME, Khurshudyan A, Shamskhou EA, Yuan K, Chen IY, Kodani SD, Morisseau C, Hammock BD, Hong EM, Alexandrova L, Alastalo TP, Berry G, Zamanian RT, de Jesus Perez VA
American journal of physiology. Lung cellular and molecular physiology 2017 Aug 1;313(2):L252-L266
American journal of physiology. Lung cellular and molecular physiology 2017 Aug 1;313(2):L252-L266
Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons.
Redmann M, Benavides GA, Berryhill TF, Wani WY, Ouyang X, Johnson MS, Ravi S, Barnes S, Darley-Usmar VM, Zhang J
Redox biology 2017 Apr;11:73-81
Redox biology 2017 Apr;11:73-81
Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils.
Redmann M, Wani WY, Volpicelli-Daley L, Darley-Usmar V, Zhang J
Redox biology 2017 Apr;11:429-437
Redox biology 2017 Apr;11:429-437
Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy.
Zhang Y, Nguyen DT, Olzomer EM, Poon GP, Cole NJ, Puvanendran A, Phillips BR, Hesselson D
Cell chemical biology 2017 Apr 20;24(4):471-480.e4
Cell chemical biology 2017 Apr 20;24(4):471-480.e4
Measuring Autophagy in the Context of Cancer.
Morgan MJ, Thorburn A
Advances in experimental medicine and biology 2016;899:121-43
Advances in experimental medicine and biology 2016;899:121-43
Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice.
Wilson CH, Nikolic A, Kentish SJ, Shalini S, Hatzinikolas G, Page AJ, Dorstyn L, Kumar S
Cell death discovery 2016;2:16009
Cell death discovery 2016;2:16009
Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins.
Mouna L, Hernandez E, Bonte D, Brost R, Amazit L, Delgui LR, Brune W, Geballe AP, Beau I, Esclatine A
Autophagy 2016;12(2):327-42
Autophagy 2016;12(2):327-42
Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis.
Conlon DM, Thomas T, Fedotova T, Hernandez-Ono A, Di Paolo G, Chan RB, Ruggles K, Gibeley S, Liu J, Ginsberg HN
The Journal of clinical investigation 2016 Oct 3;126(10):3852-3867
The Journal of clinical investigation 2016 Oct 3;126(10):3852-3867
Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a Protein-induced Autophagy in Pancreatic Intraepithelial Neoplasms.
Gong J, Belinsky G, Sagheer U, Zhang X, Grippo PJ, Chung C
The Journal of biological chemistry 2016 Oct 14;291(42):22074-22085
The Journal of biological chemistry 2016 Oct 14;291(42):22074-22085
Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small cell lung cancer cells.
Zhou Y, Li Y, Ni HM, Ding WX, Zhong H
Toxicology and applied pharmacology 2016 Nov 1;310:140-149
Toxicology and applied pharmacology 2016 Nov 1;310:140-149
A Preclinical Study Evaluating AAVrh10-Based Gene Therapy for Sanfilippo Syndrome.
Winner LK, Beard H, Hassiotis S, Lau AA, Luck AJ, Hopwood JJ, Hemsley KM
Human gene therapy 2016 May;27(5):363-75
Human gene therapy 2016 May;27(5):363-75
Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.
Yeo SY, Itahana Y, Guo AK, Han R, Iwamoto K, Nguyen HT, Bao Y, Kleiber K, Wu YJ, Bay BH, Voorhoeve M, Itahana K
eLife 2016 Mar 9;5:e07101
eLife 2016 Mar 9;5:e07101
Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors.
Jin HO, Hong SE, Park JA, Chang YH, Hong YJ, Park IC, Lee JK
Scientific reports 2016 Jun 30;6:28945
Scientific reports 2016 Jun 30;6:28945
Biotinylation: a novel posttranslational modification linking cell autonomous circadian clocks with metabolism.
He L, Hamm JA, Reddy A, Sams D, Peliciari-Garcia RA, McGinnis GR, Bailey SM, Chow CW, Rowe GC, Chatham JC, Young ME
American journal of physiology. Heart and circulatory physiology 2016 Jun 1;310(11):H1520-32
American journal of physiology. Heart and circulatory physiology 2016 Jun 1;310(11):H1520-32
Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt.
Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, König T, Kukat A, Trifunovic A
EMBO reports 2016 Jul;17(7):953-64
EMBO reports 2016 Jul;17(7):953-64
Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
Korwitz A, Merkwirth C, Richter-Dennerlein R, Tröder SE, Sprenger HG, Quirós PM, López-Otín C, Rugarli EI, Langer T
The Journal of cell biology 2016 Jan 18;212(2):157-66
The Journal of cell biology 2016 Jan 18;212(2):157-66
Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer.
Puvirajesinghe TM, Bertucci F, Jain A, Scerbo P, Belotti E, Audebert S, Sebbagh M, Lopez M, Brech A, Finetti P, Charafe-Jauffret E, Chaffanet M, Castellano R, Restouin A, Marchetto S, Collette Y, Gonçalvès A, Macara I, Birnbaum D, Kodjabachian L, Johansen T, Borg JP
Nature communications 2016 Jan 12;7:10318
Nature communications 2016 Jan 12;7:10318
Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.
Sydow A, Hochgräfe K, Könen S, Cadinu D, Matenia D, Petrova O, Joseph M, Dennissen FJ, Mandelkow EM
Acta neuropathologica communications 2016 Feb 25;4:17
Acta neuropathologica communications 2016 Feb 25;4:17
Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells.
Haldar AK, Piro AS, Finethy R, Espenschied ST, Brown HE, Giebel AM, Frickel EM, Nelson DE, Coers J
mBio 2016 Dec 13;7(6)
mBio 2016 Dec 13;7(6)
Melatonin reduces endoplasmic reticulum stress and autophagy in liver of leptin-deficient mice.
de Luxán-Delgado B, Potes Y, Rubio-González A, Caballero B, Solano JJ, Fernández-Fernández M, Bermúdez M, Rodrigues Moreira Guimarães M, Vega-Naredo I, Boga JA, Coto-Montes A
Journal of pineal research 2016 Aug;61(1):108-23
Journal of pineal research 2016 Aug;61(1):108-23
A cell-based quantitative high-throughput image screening identified novel autophagy modulators.
Li Y, McGreal S, Zhao J, Huang R, Zhou Y, Zhong H, Xia M, Ding WX
Pharmacological research 2016 Aug;110:35-49
Pharmacological research 2016 Aug;110:35-49
Oncolytic Adenovirus Loaded with L-carnosine as Novel Strategy to Enhance the Antitumor Activity.
Garofalo M, Iovine B, Kuryk L, Capasso C, Hirvinen M, Vitale A, Yliperttula M, Bevilacqua MA, Cerullo V
Molecular cancer therapeutics 2016 Apr;15(4):651-60
Molecular cancer therapeutics 2016 Apr;15(4):651-60
BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy.
Pedro JM, Wei Y, Sica V, Maiuri MC, Zou Z, Kroemer G, Levine B
Autophagy 2015;11(3):452-9
Autophagy 2015;11(3):452-9
Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.
LaPash Daniels CM, Paffenroth E, Austin EV, Glebov K, Lewis D, Walter J, Messing A
PloS one 2015;10(9):e0138132
PloS one 2015;10(9):e0138132
Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth.
Yang H, Peng YF, Ni HM, Li Y, Shi YH, Ding WX, Fan J
PloS one 2015;10(6):e0130953
PloS one 2015;10(6):e0130953
Streptococcus pneumoniae induces autophagy through the inhibition of the PI3K-I/Akt/mTOR pathway and ROS hypergeneration in A549 cells.
Li P, Shi J, He Q, Hu Q, Wang YY, Zhang LJ, Chan WT, Chen WX
PloS one 2015;10(3):e0122753
PloS one 2015;10(3):e0122753
The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila.
Jacomin AC, Bescond A, Soleilhac E, Gallet B, Schoehn G, Fauvarque MO, Taillebourg E
PloS one 2015;10(11):e0143078
PloS one 2015;10(11):e0143078
Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling.
Nemazanyy I, Montagnac G, Russell RC, Morzyglod L, Burnol AF, Guan KL, Pende M, Panasyuk G
Nature communications 2015 Sep 21;6:8283
Nature communications 2015 Sep 21;6:8283
Caspase-2 protects against oxidative stress in vivo.
Shalini S, Puccini J, Wilson CH, Finnie J, Dorstyn L, Kumar S
Oncogene 2015 Sep 17;34(38):4995-5002
Oncogene 2015 Sep 17;34(38):4995-5002
Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice.
Williams JA, Ni HM, Ding Y, Ding WX
American journal of physiology. Gastrointestinal and liver physiology 2015 Sep 1;309(5):G324-40
American journal of physiology. Gastrointestinal and liver physiology 2015 Sep 1;309(5):G324-40
Autophagy mediates degradation of nuclear lamina.
Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, Ricketts MD, Lamark T, Adam SA, Marmorstein R, Zong WX, Johansen T, Goldman RD, Adams PD, Berger SL
Nature 2015 Nov 5;527(7576):105-9
Nature 2015 Nov 5;527(7576):105-9
Pathogenic Ubqln2 gains toxic properties to induce neuron death.
Wu Q, Liu M, Huang C, Liu X, Huang B, Li N, Zhou H, Xia XG
Acta neuropathologica 2015 Mar;129(3):417-28
Acta neuropathologica 2015 Mar;129(3):417-28
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
Bakkar N, Kousari A, Kovalik T, Li Y, Bowser R
Molecular and cellular biology 2015 Jul;35(14):2385-99
Molecular and cellular biology 2015 Jul;35(14):2385-99
Graphene oxide as a chemosensitizer: diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects.
Chen GY, Meng CL, Lin KC, Tuan HY, Yang HJ, Chen CL, Li KC, Chiang CS, Hu YC
Biomaterials 2015 Feb;40:12-22
Biomaterials 2015 Feb;40:12-22
Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling.
Lin PH, Duann P, Komazaki S, Park KH, Li H, Sun M, Sermersheim M, Gumpper K, Parrington J, Galione A, Evans AM, Zhu MX, Ma J
The Journal of biological chemistry 2015 Feb 6;290(6):3377-89
The Journal of biological chemistry 2015 Feb 6;290(6):3377-89
An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice.
Walker AK, Tripathy K, Restrepo CR, Ge G, Xu Y, Kwong LK, Trojanowski JQ, Lee VM
Human molecular genetics 2015 Dec 20;24(25):7241-54
Human molecular genetics 2015 Dec 20;24(25):7241-54
FGF signalling regulates bone growth through autophagy.
Cinque L, Forrester A, Bartolomeo R, Svelto M, Venditti R, Montefusco S, Polishchuk E, Nusco E, Rossi A, Medina DL, Polishchuk R, De Matteis MA, Settembre C
Nature 2015 Dec 10;528(7581):272-5
Nature 2015 Dec 10;528(7581):272-5
Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation.
Jurkuvenaite A, Benavides GA, Komarova S, Doran SF, Johnson M, Aggarwal S, Zhang J, Darley-Usmar VM, Matalon S
Free radical biology & medicine 2015 Aug;85:83-94
Free radical biology & medicine 2015 Aug;85:83-94
Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases.
Porta S, Kwong LK, Trojanowski JQ, Lee VM
Journal of neuropathology and experimental neurology 2015 Apr;74(4):380-7
Journal of neuropathology and experimental neurology 2015 Apr;74(4):380-7
Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.
Cheong JK, Zhang F, Chua PJ, Bay BH, Thorburn A, Virshup DM
The Journal of clinical investigation 2015 Apr;125(4):1401-18
The Journal of clinical investigation 2015 Apr;125(4):1401-18
3D bioprinting of biomimetic aortic vascular constructs with self-supporting cells.
Kucukgul C, Ozler SB, Inci I, Karakas E, Irmak S, Gozuacik D, Taralp A, Koc B
Biotechnology and bioengineering 2015 Apr;112(4):811-21
Biotechnology and bioengineering 2015 Apr;112(4):811-21
Unsaturated fatty acids induce non-canonical autophagy.
Niso-Santano M, Malik SA, Pietrocola F, Bravo-San Pedro JM, Mariño G, Cianfanelli V, Ben-Younès A, Troncoso R, Markaki M, Sica V, Izzo V, Chaba K, Bauvy C, Dupont N, Kepp O, Rockenfeller P, Wolinski H, Madeo F, Lavandero S, Codogno P, Harper F, Pierron G, Tavernarakis N, Cecconi F, Maiuri MC, Galluzzi L, Kroemer G
The EMBO journal 2015 Apr 15;34(8):1025-41
The EMBO journal 2015 Apr 15;34(8):1025-41
Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice.
Ni HM, Bhakta A, Wang S, Li Z, Manley S, Huang H, Copple B, Ding WX
PloS one 2014;9(12):e115849
PloS one 2014;9(12):e115849
Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity.
Manley S, Ni HM, Williams JA, Kong B, DiTacchio L, Guo G, Ding WX
Redox biology 2014;2:991-1002
Redox biology 2014;2:991-1002
Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy.
Park S, Choi SG, Yoo SM, Son JH, Jung YK
Autophagy 2014;10(11):1906-20
Autophagy 2014;10(11):1906-20
Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.
Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, Gallazzini M, Olson EN, Lam H, Henske EP, Dong Z, Apte U, Pallet N, Johnson RL, Terzi F, Kwiatkowski DJ, Scoazec JY, Martignoni G, Pende M
The Journal of experimental medicine 2014 Oct 20;211(11):2249-63
The Journal of experimental medicine 2014 Oct 20;211(11):2249-63
Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent.
Morgan MJ, Gamez G, Menke C, Hernandez A, Thorburn J, Gidan F, Staskiewicz L, Morgan S, Cummings C, Maycotte P, Thorburn A
Autophagy 2014 Oct 1;10(10):1814-26
Autophagy 2014 Oct 1;10(10):1814-26
The autophagy/lysosome pathway is impaired in SCA7 patients and SCA7 knock-in mice.
Alves S, Cormier-Dequaire F, Marinello M, Marais T, Muriel MP, Beaumatin F, Charbonnier-Beaupel F, Tahiri K, Seilhean D, El Hachimi K, Ruberg M, Stevanin G, Barkats M, den Dunnen W, Priault M, Brice A, Durr A, Corvol JC, Sittler A
Acta neuropathologica 2014 Nov;128(5):705-22
Acta neuropathologica 2014 Nov;128(5):705-22
Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation.
MacVicar TD, Lane JD
Journal of cell science 2014 May 15;127(Pt 10):2313-25
Journal of cell science 2014 May 15;127(Pt 10):2313-25
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.
Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC
Nature 2014 May 1;509(7498):105-9
Nature 2014 May 1;509(7498):105-9
Melatonin administration decreases adipogenesis in the liver of ob/ob mice through autophagy modulation.
de Luxán-Delgado B, Caballero B, Potes Y, Rubio-González A, Rodríguez I, Gutiérrez-Rodríguez J, Solano JJ, Coto-Montes A
Journal of pineal research 2014 Mar;56(2):126-33
Journal of pineal research 2014 Mar;56(2):126-33
Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages.
Al-Khodor S, Marshall-Batty K, Nair V, Ding L, Greenberg DE, Fraser ID
Cellular microbiology 2014 Mar;16(3):378-95
Cellular microbiology 2014 Mar;16(3):378-95
Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy.
Chua JP, Reddy SL, Merry DE, Adachi H, Katsuno M, Sobue G, Robins DM, Lieberman AP
Human molecular genetics 2014 Mar 1;23(5):1376-86
Human molecular genetics 2014 Mar 1;23(5):1376-86
The non-receptor tyrosine kinase Ack1 regulates the fate of activated EGFR by inducing trafficking to the p62/NBR1 pre-autophagosome.
Jones S, Cunningham DL, Rappoport JZ, Heath JK
Journal of cell science 2014 Mar 1;127(Pt 5):994-1006
Journal of cell science 2014 Mar 1;127(Pt 5):994-1006
Defective autophagy impairs ATF3 activity and worsens lung injury during endotoxemia.
Aguirre A, López-Alonso I, González-López A, Amado-Rodríguez L, Batalla-Solís E, Astudillo A, Blázquez-Prieto J, Fernández AF, Galván JA, dos Santos CC, Albaiceta GM
Journal of molecular medicine (Berlin, Germany) 2014 Jun;92(6):665-76
Journal of molecular medicine (Berlin, Germany) 2014 Jun;92(6):665-76
The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells.
Boyer-Guittaut M, Poillet L, Liang Q, Bôle-Richard E, Ouyang X, Benavides GA, Chakrama FZ, Fraichard A, Darley-Usmar VM, Despouy G, Jouvenot M, Delage-Mourroux R, Zhang J
Autophagy 2014 Jun;10(6):986-1003
Autophagy 2014 Jun;10(6):986-1003
Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability.
Bharath LP, Mueller R, Li Y, Ruan T, Kunz D, Goodrich R, Mills T, Deeter L, Sargsyan A, Anandh Babu PV, Graham TE, Symons JD
Canadian journal of physiology and pharmacology 2014 Jul;92(7):605-12
Canadian journal of physiology and pharmacology 2014 Jul;92(7):605-12
Dual role for CHOP in the crosstalk between autophagy and apoptosis to determine cell fate in response to amino acid deprivation.
B'chir W, Chaveroux C, Carraro V, Averous J, Maurin AC, Jousse C, Muranishi Y, Parry L, Fafournoux P, Bruhat A
Cellular signalling 2014 Jul;26(7):1385-91
Cellular signalling 2014 Jul;26(7):1385-91
Imaging autophagy.
Karanasios E, Stapleton E, Manifava M, Ktistakis NT
Current protocols in cytometry 2014 Jul 1;69:12.34.1-12.34.16
Current protocols in cytometry 2014 Jul 1;69:12.34.1-12.34.16
Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.
Gump JM, Staskiewicz L, Morgan MJ, Bamberg A, Riches DW, Thorburn A
Nature cell biology 2014 Jan;16(1):47-54
Nature cell biology 2014 Jan;16(1):47-54
Reactive oxygen species regulation of autophagy in skeletal muscles.
Rahman M, Mofarrahi M, Kristof AS, Nkengfac B, Harel S, Hussain SN
Antioxidants & redox signaling 2014 Jan 20;20(3):443-59
Antioxidants & redox signaling 2014 Jan 20;20(3):443-59
Excitotoxic glutamate insults block autophagic flux in hippocampal neurons.
Kulbe JR, Mulcahy Levy JM, Coultrap SJ, Thorburn A, Bayer KU
Brain research 2014 Jan 13;1542:12-9
Brain research 2014 Jan 13;1542:12-9
p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines.
Chang MA, Morgado M, Warren CR, Hinton CV, Farach-Carson MC, Delk NA
The Prostate 2014 Feb;74(2):149-63
The Prostate 2014 Feb;74(2):149-63
Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation.
Tung YT, Wang BJ, Hsu WM, Hu MK, Her GM, Huang WP, Liao YF
Molecular neurobiology 2014 Feb;49(1):10-27
Molecular neurobiology 2014 Feb;49(1):10-27
New autophagy reporter mice reveal dynamics of proximal tubular autophagy.
Li L, Wang ZV, Hill JA, Lin F
Journal of the American Society of Nephrology : JASN 2014 Feb;25(2):305-15
Journal of the American Society of Nephrology : JASN 2014 Feb;25(2):305-15
Suppression of autophagic flux by bile acids in hepatocytes.
Manley S, Ni HM, Kong B, Apte U, Guo G, Ding WX
Toxicological sciences : an official journal of the Society of Toxicology 2014 Feb;137(2):478-90
Toxicological sciences : an official journal of the Society of Toxicology 2014 Feb;137(2):478-90
scyllo-Inositol promotes robust mutant Huntingtin protein degradation.
Lai AY, Lan CP, Hasan S, Brown ME, McLaurin J
The Journal of biological chemistry 2014 Feb 7;289(6):3666-76
The Journal of biological chemistry 2014 Feb 7;289(6):3666-76
Phosphorylated AKT inhibits the apoptosis induced by DRAM-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of DRAM to mitochondria.
Liu K, Shi Y, Guo XH, Ouyang YB, Wang SS, Liu DJ, Wang AN, Li N, Chen DX
Cell death & disease 2014 Feb 20;5:e1078
Cell death & disease 2014 Feb 20;5:e1078
Clinicopathologic report of ocular involvement in ALS patients with C9orf72 mutation.
Fawzi AA, Simonett JM, Purta P, Moss HE, Lowry JL, Deng HX, Siddique N, Sufit R, Bigio EH, Volpe NJ, Siddique T
Amyotrophic lateral sclerosis & frontotemporal degeneration 2014 Dec;15(7-8):569-80
Amyotrophic lateral sclerosis & frontotemporal degeneration 2014 Dec;15(7-8):569-80
IL-1β induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells.
Chang MA, Patel V, Gwede M, Morgado M, Tomasevich K, Fong EL, Farach-Carson MC, Delk NA
Journal of cellular biochemistry 2014 Dec;115(12):2188-97
Journal of cellular biochemistry 2014 Dec;115(12):2188-97
Chloroquine promotes the anticancer effect of TACE in a rabbit VX2 liver tumor model.
Gao L, Song JR, Zhang JW, Zhao X, Zhao QD, Sun K, Deng WJ, Li R, Lv G, Cheng HY, Wei LX
International journal of biological sciences 2013;9(4):322-30
International journal of biological sciences 2013;9(4):322-30
Atg4b-dependent autophagic flux alleviates Huntington's disease progression.
Proenca CC, Stoehr N, Bernhard M, Seger S, Genoud C, Roscic A, Paganetti P, Liu S, Murphy LO, Kuhn R, Bouwmeester T, Galimberti I
PloS one 2013;8(7):e68357
PloS one 2013;8(7):e68357
p62/SQSTM1 enhances NOD2-mediated signaling and cytokine production through stabilizing NOD2 oligomerization.
Park S, Ha SD, Coleman M, Meshkibaf S, Kim SO
PloS one 2013;8(2):e57138
PloS one 2013;8(2):e57138
MIR376A is a regulator of starvation-induced autophagy.
Korkmaz G, Tekirdag KA, Ozturk DG, Kosar A, Sezerman OU, Gozuacik D
PloS one 2013;8(12):e82556
PloS one 2013;8(12):e82556
Impairment of autophagic flux promotes glucose reperfusion-induced neuro2A cell death after glucose deprivation.
Jang BG, Choi BY, Kim JH, Kim MJ, Sohn M, Suh SW
PloS one 2013;8(10):e76466
PloS one 2013;8(10):e76466
Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.
Devereaux K, Dall'Armi C, Alcazar-Roman A, Ogasawara Y, Zhou X, Wang F, Yamamoto A, De Camilli P, Di Paolo G
PloS one 2013;8(10):e76405
PloS one 2013;8(10):e76405
Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.
MacCallum SF, Groves MJ, James J, Murray K, Appleyard V, Prescott AR, Drbal AA, Nicolaou A, Cunningham J, Haydock S, Ganley IG, Westwood NJ, Coates PJ, Lain S, Tauro S
Scientific reports 2013;3:1275
Scientific reports 2013;3:1275
The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression.
B'chir W, Maurin AC, Carraro V, Averous J, Jousse C, Muranishi Y, Parry L, Stepien G, Fafournoux P, Bruhat A
Nucleic acids research 2013 Sep;41(16):7683-99
Nucleic acids research 2013 Sep;41(16):7683-99
The ubiquitin ligase parkin mediates resistance to intracellular pathogens.
Manzanillo PS, Ayres JS, Watson RO, Collins AC, Souza G, Rae CS, Schneider DS, Nakamura K, Shiloh MU, Cox JS
Nature 2013 Sep 26;501(7468):512-6
Nature 2013 Sep 26;501(7468):512-6
Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts.
Liang Q, Benavides GA, Vassilopoulos A, Gius D, Darley-Usmar V, Zhang J
The Biochemical journal 2013 Sep 1;454(2):249-57
The Biochemical journal 2013 Sep 1;454(2):249-57
T-type calcium channel blockers inhibit autophagy and promote apoptosis of malignant melanoma cells.
Das A, Pushparaj C, Herreros J, Nager M, Vilella R, Portero M, Pamplona R, Matias-Guiu X, Martí RM, Cantí C
Pigment cell & melanoma research 2013 Nov;26(6):874-85
Pigment cell & melanoma research 2013 Nov;26(6):874-85
PINK1 is degraded through the N-end rule pathway.
Yamano K, Youle RJ
Autophagy 2013 Nov 1;9(11):1758-69
Autophagy 2013 Nov 1;9(11):1758-69
Site-specific Mtm1 mutagenesis by an AAV-Cre vector reveals that myotubularin is essential in adult muscle.
Joubert R, Vignaud A, Le M, Moal C, Messaddeq N, Buj-Bello A
Human molecular genetics 2013 May 1;22(9):1856-66
Human molecular genetics 2013 May 1;22(9):1856-66
Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration.
Crabtree D, Boyer-Guittaut M, Ouyang X, Fineberg N, Zhang J
Neuroscience letters 2013 Mar 22;538:3-8
Neuroscience letters 2013 Mar 22;538:3-8
RalGDS-dependent cardiomyocyte autophagy is required for load-induced ventricular hypertrophy.
Rifki OF, Bodemann BO, Battiprolu PK, White MA, Hill JA
Journal of molecular and cellular cardiology 2013 Jun;59:128-38
Journal of molecular and cellular cardiology 2013 Jun;59:128-38
Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway.
Sandri M, Barberi L, Bijlsma AY, Blaauw B, Dyar KA, Milan G, Mammucari C, Meskers CG, Pallafacchina G, Paoli A, Pion D, Roceri M, Romanello V, Serrano AL, Toniolo L, Larsson L, Maier AB, Muñoz-Cánoves P, Musarò A, Pende M, Reggiani C, Rizzuto R, Schiaffino S
Biogerontology 2013 Jun;14(3):303-23
Biogerontology 2013 Jun;14(3):303-23
Impairment of autophagy decreases ventilator-induced lung injury by blockade of the NF-κB pathway.
López-Alonso I, Aguirre A, González-López A, Fernández ÁF, Amado-Rodríguez L, Astudillo A, Batalla-Solís E, Albaiceta GM
American journal of physiology. Lung cellular and molecular physiology 2013 Jun 15;304(12):L844-52
American journal of physiology. Lung cellular and molecular physiology 2013 Jun 15;304(12):L844-52
Autophagy facilitates organelle clearance during differentiation of human erythroblasts: evidence for a role for ATG4 paralogs during autophagosome maturation.
Betin VM, Singleton BK, Parsons SF, Anstee DJ, Lane JD
Autophagy 2013 Jun 1;9(6):881-93
Autophagy 2013 Jun 1;9(6):881-93
Recombinant protein rVP1 upregulates BECN1-independent autophagy, MAPK1/3 phosphorylation and MMP9 activity via WIPI1/WIPI2 to promote macrophage migration.
Liao CC, Ho MY, Liang SM, Liang CM
Autophagy 2013 Jan;9(1):5-19
Autophagy 2013 Jan;9(1):5-19
Defective autophagy and mTORC1 signaling in myotubularin null mice.
Fetalvero KM, Yu Y, Goetschkes M, Liang G, Valdez RA, Gould T, Triantafellow E, Bergling S, Loureiro J, Eash J, Lin V, Porter JA, Finan PM, Walsh K, Yang Y, Mao X, Murphy LO
Molecular and cellular biology 2013 Jan;33(1):98-110
Molecular and cellular biology 2013 Jan;33(1):98-110
Host cell autophagy modulates early stages of adenovirus infections in airway epithelial cells.
Zeng X, Carlin CR
Journal of virology 2013 Feb;87(4):2307-19
Journal of virology 2013 Feb;87(4):2307-19
Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis.
Pan JA, Fan Y, Gandhirajan RK, Madesh M, Zong WX
The Journal of biological chemistry 2013 Feb 1;288(5):2952-63
The Journal of biological chemistry 2013 Feb 1;288(5):2952-63
Autophagic-lysosomal pathway is the main proteolytic system modified in the skeletal muscle of esophageal cancer patients.
Tardif N, Klaude M, Lundell L, Thorell A, Rooyackers O
The American journal of clinical nutrition 2013 Dec;98(6):1485-92
The American journal of clinical nutrition 2013 Dec;98(6):1485-92
Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells.
Dodson M, Liang Q, Johnson MS, Redmann M, Fineberg N, Darley-Usmar VM, Zhang J
Autophagy 2013 Dec;9(12):1996-2008
Autophagy 2013 Dec;9(12):1996-2008
Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity.
Ni HM, Du K, You M, Ding WX
The American journal of pathology 2013 Dec;183(6):1815-1825
The American journal of pathology 2013 Dec;183(6):1815-1825
C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.
Mizielinska S, Lashley T, Norona FE, Clayton EL, Ridler CE, Fratta P, Isaacs AM
Acta neuropathologica 2013 Dec;126(6):845-57
Acta neuropathologica 2013 Dec;126(6):845-57
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
Liu Y, Shoji-Kawata S, Sumpter RM Jr, Wei Y, Ginet V, Zhang L, Posner B, Tran KA, Green DR, Xavier RJ, Shaw SY, Clarke PG, Puyal J, Levine B
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 17;110(51):20364-71
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 17;110(51):20364-71
ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis.
Cabrera S, Fernández AF, Mariño G, Aguirre A, Suárez MF, Español Y, Vega JA, Laurà R, Fueyo A, Fernández-García MS, Freije JM, Kroemer G, López-Otín C
Autophagy 2013 Aug;9(8):1188-200
Autophagy 2013 Aug;9(8):1188-200
West Nile virus (WNV) replication is independent of autophagy in mammalian cells.
Vandergaast R, Fredericksen BL
PloS one 2012;7(9):e45800
PloS one 2012;7(9):e45800
Tissue specific induction of p62/Sqstm1 by farnesoid X receptor.
Williams JA, Thomas AM, Li G, Kong B, Zhan L, Inaba Y, Xie W, Ding WX, Guo GL
PloS one 2012;7(8):e43961
PloS one 2012;7(8):e43961
Genetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survival.
Hagemann TL, Jobe EM, Messing A
PloS one 2012;7(5):e37304
PloS one 2012;7(5):e37304
(-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilization.
Zhang Y, Yang ND, Zhou F, Shen T, Duan T, Zhou J, Shi Y, Zhu XQ, Shen HM
PloS one 2012;7(10):e46749
PloS one 2012;7(10):e46749
MAP1B Interaction with the FW Domain of the Autophagic Receptor Nbr1 Facilitates Its Association to the Microtubule Network.
Marchbank K, Waters S, Roberts RG, Solomon E, Whitehouse CA
International journal of cell biology 2012;2012:208014
International journal of cell biology 2012;2012:208014
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
Krüger U, Wang Y, Kumar S, Mandelkow EM
Neurobiology of aging 2012 Oct;33(10):2291-305
Neurobiology of aging 2012 Oct;33(10):2291-305
Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease.
Lai AY, McLaurin J
Biochimica et biophysica acta 2012 Oct;1822(10):1629-37
Biochimica et biophysica acta 2012 Oct;1822(10):1629-37
Sorafenib has potent antitumor activity against multiple myeloma in vitro, ex vivo, and in vivo in the 5T33MM mouse model.
Kharaziha P, De Raeve H, Fristedt C, Li Q, Gruber A, Johnsson P, Kokaraki G, Panzar M, Laane E, Osterborg A, Zhivotovsky B, Jernberg-Wiklund H, Grandér D, Celsing F, Björkholm M, Vanderkerken K, Panaretakis T
Cancer research 2012 Oct 15;72(20):5348-62
Cancer research 2012 Oct 15;72(20):5348-62
Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease.
Elrick MJ, Yu T, Chung C, Lieberman AP
Human molecular genetics 2012 Nov 15;21(22):4876-87
Human molecular genetics 2012 Nov 15;21(22):4876-87
Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence.
Chen J, Xavier S, Moskowitz-Kassai E, Chen R, Lu CY, Sanduski K, Špes A, Turk B, Goligorsky MS
The American journal of pathology 2012 Mar;180(3):973-983
The American journal of pathology 2012 Mar;180(3):973-983
Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice.
Ghazi-Noori S, Froud KE, Mizielinska S, Powell C, Smidak M, Fernandez de Marco M, O'Malley C, Farmer M, Parkinson N, Fisher EM, Asante EA, Brandner S, Collinge J, Isaacs AM
Brain : a journal of neurology 2012 Mar;135(Pt 3):819-32
Brain : a journal of neurology 2012 Mar;135(Pt 3):819-32
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD
Science signaling 2012 Mar 27;5(217):ra24
Science signaling 2012 Mar 27;5(217):ra24
A centronuclear myopathy--dynamin 2 mutation impairs autophagy in mice.
Durieux AC, Vassilopoulos S, Lainé J, Fraysse B, Briñas L, Prudhon B, Castells J, Freyssenet D, Bonne G, Guicheney P, Bitoun M
Traffic (Copenhagen, Denmark) 2012 Jun;13(6):869-79
Traffic (Copenhagen, Denmark) 2012 Jun;13(6):869-79
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
Ni HM, Boggess N, McGill MR, Lebofsky M, Borude P, Apte U, Jaeschke H, Ding WX
Toxicological sciences : an official journal of the Society of Toxicology 2012 Jun;127(2):438-50
Toxicological sciences : an official journal of the Society of Toxicology 2012 Jun;127(2):438-50
Age-related oxidative stress compromises endosomal proteostasis.
Cannizzo ES, Clement CC, Morozova K, Valdor R, Kaushik S, Almeida LN, Follo C, Sahu R, Cuervo AM, Macian F, Santambrogio L
Cell reports 2012 Jul 26;2(1):136-49
Cell reports 2012 Jul 26;2(1):136-49
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.
Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK
Science translational medicine 2012 Jul 25;4(144):144ra103
Science translational medicine 2012 Jul 25;4(144):144ra103
Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery.
Kovacs JR, Li C, Yang Q, Li G, Garcia IG, Ju S, Roodman DG, Windle JJ, Zhang X, Lu B
Cell death and differentiation 2012 Jan;19(1):144-52
Cell death and differentiation 2012 Jan;19(1):144-52
Modulation of pediatric brain tumor autophagy and chemosensitivity.
Levy JM, Thorburn A
Journal of neuro-oncology 2012 Jan;106(2):281-90
Journal of neuro-oncology 2012 Jan;106(2):281-90
Targeting of distinct signaling cascades and cancer-associated fibroblasts define the efficacy of Sorafenib against prostate cancer cells.
Kharaziha P, Rodriguez P, Li Q, Rundqvist H, Björklund AC, Augsten M, Ullén A, Egevad L, Wiklund P, Nilsson S, Kroemer G, Grander D, Panaretakis T
Cell death & disease 2012 Jan 26;3:e262
Cell death & disease 2012 Jan 26;3:e262
Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function.
Jaber N, Dou Z, Chen JS, Catanzaro J, Jiang YP, Ballou LM, Selinger E, Ouyang X, Lin RZ, Zhang J, Zong WX
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 7;109(6):2003-8
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 7;109(6):2003-8
Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model.
Gan L, Vargas MR, Johnson DA, Johnson JA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Dec 5;32(49):17775-87
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Dec 5;32(49):17775-87
Rotenone inhibits autophagic flux prior to inducing cell death.
Mader BJ, Pivtoraiko VN, Flippo HM, Klocke BJ, Roth KA, Mangieri LR, Shacka JJ
ACS chemical neuroscience 2012 Dec 19;3(12):1063-72
ACS chemical neuroscience 2012 Dec 19;3(12):1063-72
Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.
Ohmi K, Zhao HZ, Neufeld EF
PloS one 2011;6(11):e27461
PloS one 2011;6(11):e27461
"Autophagic flux" in normal mouse tissues: focus on endogenous LC3A processing.
Zois CE, Giatromanolaki A, Sivridis E, Papaiakovou M, Kainulainen H, Koukourakis MI
Autophagy 2011 Nov;7(11):1371-8
Autophagy 2011 Nov;7(11):1371-8
Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.
Li H, Wang P, Sun Q, Ding WX, Yin XM, Sobol RW, Stolz DB, Yu J, Zhang L
Cancer research 2011 May 15;71(10):3625-34
Cancer research 2011 May 15;71(10):3625-34
Lung autophagic response following exposure of mice to whole body irradiation, with and without amifostine.
Zois CE, Giatromanolaki A, Kainulainen H, Botaitis S, Torvinen S, Simopoulos C, Kortsaris A, Sivridis E, Koukourakis MI
Biochemical and biophysical research communications 2011 Jan 7;404(1):552-8
Biochemical and biophysical research communications 2011 Jan 7;404(1):552-8
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Deng HX, Chen W, Hong ST, Boycott KM, Gorrie GH, Siddique N, Yang Y, Fecto F, Shi Y, Zhai H, Jiang H, Hirano M, Rampersaud E, Jansen GH, Donkervoort S, Bigio EH, Brooks BR, Ajroud K, Sufit RL, Haines JL, Mugnaini E, Pericak-Vance MA, Siddique T
Nature 2011 Aug 21;477(7363):211-5
Nature 2011 Aug 21;477(7363):211-5
Pancreatic cancers require autophagy for tumor growth.
Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC
Genes & development 2011 Apr 1;25(7):717-29
Genes & development 2011 Apr 1;25(7):717-29
Glucocorticoids downregulate Fyn and inhibit IP(3)-mediated calcium signaling to promote autophagy in T lymphocytes.
Harr MW, McColl KS, Zhong F, Molitoris JK, Distelhorst CW
Autophagy 2010 Oct;6(7):912-21
Autophagy 2010 Oct;6(7):912-21
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Deng HX, Zhai H, Bigio EH, Yan J, Fecto F, Ajroud K, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T
Annals of neurology 2010 Jun;67(6):739-48
Annals of neurology 2010 Jun;67(6):739-48
Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity.
Whitehouse CA, Waters S, Marchbank K, Horner A, McGowan NW, Jovanovic JV, Xavier GM, Kashima TG, Cobourne MT, Richards GO, Sharpe PT, Skerry TM, Grigoriadis AE, Solomon E
Proceedings of the National Academy of Sciences of the United States of America 2010 Jul 20;107(29):12913-8
Proceedings of the National Academy of Sciences of the United States of America 2010 Jul 20;107(29):12913-8
In vivo requirement for Atg5 in antigen presentation by dendritic cells.
Lee HK, Mattei LM, Steinberg BE, Alberts P, Lee YH, Chervonsky A, Mizushima N, Grinstein S, Iwasaki A
Immunity 2010 Feb 26;32(2):227-39
Immunity 2010 Feb 26;32(2):227-39
14-3-3Tau regulates Beclin 1 and is required for autophagy.
Wang B, Ling S, Lin WC
PloS one 2010 Apr 29;5(4):e10409
PloS one 2010 Apr 29;5(4):e10409
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase.
Wu YT, Tan HL, Shui G, Bauvy C, Huang Q, Wenk MR, Ong CN, Codogno P, Shen HM
The Journal of biological chemistry 2010 Apr 2;285(14):10850-61
The Journal of biological chemistry 2010 Apr 2;285(14):10850-61
Monitoring autophagic degradation of p62/SQSTM1.
Bjørkøy G, Lamark T, Pankiv S, Øvervatn A, Brech A, Johansen T
Methods in enzymology 2009;452:181-97
Methods in enzymology 2009;452:181-97
Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling.
Mardakheh FK, Yekezare M, Machesky LM, Heath JK
The Journal of cell biology 2009 Oct 19;187(2):265-77
The Journal of cell biology 2009 Oct 19;187(2):265-77
Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.
Gal J, Ström AL, Kwinter DM, Kilty R, Zhang J, Shi P, Fu W, Wooten MW, Zhu H
Journal of neurochemistry 2009 Nov;111(4):1062-73
Journal of neurochemistry 2009 Nov;111(4):1062-73
Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.
Ferguson CJ, Lenk GM, Meisler MH
Human molecular genetics 2009 Dec 15;18(24):4868-78
Human molecular genetics 2009 Dec 15;18(24):4868-78
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia.
Jung HS, Chung KW, Won Kim J, Kim J, Komatsu M, Tanaka K, Nguyen YH, Kang TM, Yoon KH, Kim JW, Jeong YT, Han MS, Lee MK, Kim KW, Shin J, Lee MS
Cell metabolism 2008 Oct;8(4):318-24
Cell metabolism 2008 Oct;8(4):318-24
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Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: p62/SQSTM1 Antibody (2C11) [H00008878-M01] - WB analysis of p62 in p62 WT and KO mouse hepatocytes and HepG2 cell lysate using anti-p62/SQSTM1 antibody clone 2C11. Sample lane1: p62 +/- mouse hepatocytes, lane 2: p62 -/- mouse hepatocytes, lane3: Wt mouse hepatocytes, lane 4: HepG2 cells. This image is from a verified customer product review.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: p62/SQSTM1 Antibody (2C11) [H00008878-M01] - WB analysis of recombinant p62 protein (immunogen, 74.51 KDa) using SQSTM1/p62 antibody (clone 2C11).
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- ELISA: p62/SQSTM1 Antibody (2C11) [H00008878-M01] - Detection limit for recombinant GST tagged SQSTM1 is approximately 0.03ng/ml as a capture antibody.
Supportive validation
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- Novus Biologicals (provider)
- Main image
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- Immunocytochemistry/Immunofluorescence: p62/SQSTM1 Antibody (2C11) [H00008878-M01] - ICC-IF analysis of SQSTM1 protein in HeLa cell using SQSTM1/p62 antibody (clone 2C11) at 10 ug/ml concentration.
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunocytochemistry/Immunofluorescence: p62/SQSTM1 Antibody (2C11) [H00008878-M01] - Analysis of p62 in SH-SY5Y cells using anti-p62/SQSTM1 antibody. Red - p62 puncta; Blue - nuclear DAPI; Green - Cytoskeleton. Image from verified customer review.