PFBW-152

antibody from Creative Biolabs

Targeting: PDPN aggrus, Gp38, GP40, PA2.26, T1A-2

No application information provided.

Antibody Data

Product number

PFBW-152

Provider

Creative Biolabs

Product name

Recombinant Mouse Anti-Mouse Pdpn Antibody Fab Fragment (mAb237)

Antibody type

Monoclonal

Description

Recombinant Mouse Antibody (mAb237) Fab Fragment is specific to mouse Pdpn, expressed in Chinese Hamster Ovary cells (CHO). 237mAb has an absolute specificity for a Tn antigen carrying glycopeptide derived from the tumor-associated protein podoplanin. The high affinity syngeneic monoclonal antibody (mAb) 237mAb (IgG2a) is specific for Ag104A, an aggressive fibrosarcoma that arose spontaneously in an aging mouse. 237mAb was found to be unreactive with another spontaneous tumor, Ag104B isolated from the same mouse, and was not reactive with any other tumor line tested. 237mAb was shown to recognize a glycopeptide within the extracellular domain of the tumor-associated glycoprotein podoplanin (also known as aggrus, T1alpha, and OTS8) formed as a result of a tumor-specific mutation in the chaperone gene Cosmc that had abolished the functionality of the enzyme core 1 beta3-galactosyltransferase. This disruption of O-glycan core 1 synthesis yielded a tumor-specific glycopeptide antigen with a single Thr O-linked GalNAc (i.e., the Tn antigen) as part of the epitope. Unlike the other reported antibody complex structure, 237mAb has little, if any, affinity for the normally glycosylated podoplanin, which makes it an attractive target for immunotherapeutic investigation.

Reactivity

Mouse

Host

Mouse

Storage

Store the antibody (in aliquots) at -20¡ãC. Avoid repeated freezing and thawing of samples.