orb385969

antibody from Biorbyt
Targeting: SERPINA3 AACT, ACT
Provider product page for orb385969
Immunohistochemistry

Antibody data

Product number
orb385969 - Provider product page
Provider
Biorbyt
Product name
Alpha-1-Antichymotrypsin Antibody / AACT / SERPINA3
Antibody type
Monoclonal
Description
Alpha 1-antichymotrypsin, or AACT, is a plasma protease inhibitor synthesized in the liver as a single glycopeptide chain. In human, the normal serum level of AACT is about one-tenth that of alpha 1-antitrypsin (AAT), with which it shares nucleic acid and protein sequence homology. Both are major acute phase reactants; their concentrations in plasma increase in response to trauma, surgery and infection. Elevated levels of AACT are widely, but not universally, reported in the cerebrospinal fluid and plasma of AD patients. Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the diagnosis of prostate cancer. AACT deficiency may also be a possible cause of chronic liver disease. AACT antibody reacts with histiocytes and histiocytic neoplasms. It is widely used to identify histiocytes and tumors derived from them. Acinar tumors of the pancreas and salivary gland may also exhibit AACT positivity.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
AACT/1451
Vial size
20 ug
Storage
Store the Alpha-1-Antichymotrypsin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
SERPINA3 protein structure - orb385969 shown in red.