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- Antibody Data
- Antigen structure
- References [150]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 14787-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14787-1-AP, RRID:AB_2070970
- Product name
- CBS antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CBS antibody (Cat. #14787-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Clonal Stabilization Reveals a DAO/3MST-Expressing MDCK Subpopulation With Robust d-Cysteine-Mediated H(2)S Production.
Hydrogen sulfide ameliorates oxalate crystal-related renal injury via inhibiting the activation of NOD-like receptor thermal protein domain associated protein 3 inflammasome in mice.
Elevation of H(2)S Underlies Social Deficits in Environmental Factor Double-Hit Autism Model.
PGK1 Persulfidation Promotes the Proliferation and Metastasis of Breast Cancer.
Ca2 + influx channel inhibitor SARAF protects rats from severe acute pancreatitis induced colonitis.
Liver-Targeted AAV-DJ-hCBS Therapy Achieves Long-Term Correction of Metabolic Imbalance in CBS-Deficient Mice.
Effect of gentiopicroside on endogenous formaldehyde homocysteine-pathway related proteins in rats with non-alcoholic steatohepatitis.
Allicin ameliorates acute myocardial infarction in rats by modulating calcium homeostasis in cardiomyocytes through the induction of hydrogen sulfide production.
Analysis of novel therapeutic targets and construction of a prognostic model for hepatocellular carcinoma.
L-cysteine mitigates busulfan-induced testicular injury through modulation of CBS/H(2)S axis.
Translocation of SIRT6 promotes glycolysis reprogramming to exacerbate diabetic angiopathy.
A novel role of exostosin glycosyltransferase 2 (EXT2) in glioblastoma cell metabolism, radiosensitivity and ferroptosis.
Impaired xCT-mediated cystine uptake drives serine and proline metabolic reprogramming and mitochondrial fission in skeletal muscle cells.
Hydrogen Sulfide Ameliorates Heart Aging by Downregulating Matrix Metalloproteinase-9.
Hydrogen Sulfide Attenuates Cisplatin-Induced Acute Kidney Injury via Dual Inhibition of Apoptosis and Pyroptosis.
Folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism.
Altered Production and Cellular Levels of Hydrogen Sulfide (H(2)S) in Placental Trophoblasts from Pregnancies Affected by Pre-Eclampsia.
Cth/Mpst double ablation results in early onset fatty liver disease in lean mice.
A Slow Hydrogen Sulfide Donor GYY-4137 Partially Improves Vascular Function in Spontaneously Hypertensive Rats Fed a High-Fat Diet.
Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2.
CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B(1) cytotoxicity.
GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Attenuates Skeletal Muscle Abnormalities in a Murine Model of Duchenne Muscular Dystrophy.
The treatment of primary CoQ deficiency requires the targeting of multiple pathogenic mechanisms.
Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation.
The double face of licorice-kansui herb pair: Cure or curse, depending on the combining ratio and mediated by hydrogen sulfide.
Impaired Iron-Sulfur Cluster Synthesis Induces Mitochondrial PARthanatos in Diabetic Cardiomyopathy.
Impaired hydrogen sulfide biosynthesis underlies eccentric contraction-induced force loss in dystrophin-deficient skeletal muscle.
H(2)S Donor SPRC Ameliorates Ischemic Stroke by Upregulating CD24.
Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism.
Bio-nanocomplexes impair iron homeostasis to induce non-canonical ferroptosis in cancer cells.
Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells.
Vasoactive Effects of Chronic Treatment with ACE Inhibitor Zofenopril in Zucker Obese Diabetic Rats: The Role of Nitroso and Sul?de Signalization.
Key role of the CSE/transsulfuration pathway in macrophage phenotypic change under iron overload.
Epidermal growth factor increases cystathionine β-synthase expression in cultured embryonic spinal cord cells.
Shensu IV maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels.
Cancer-associated fibroblasts reprogram cysteine metabolism to increase tumor resistance to ferroptosis in pancreatic cancer.
Endogenous hydrogen sulfide accelerated trauma-induced heterotopic ossification through the Ca(2+)/ERK pathway-enhanced aberrant osteogenic activity.
Asynchronous changes of hydrogen sulfide and its generating enzymes in most tissues with the aging process.
Role of Sex and Early Life Stress Experience on Porcine Cardiac and Brain Tissue Expression of the Oxytocin and H(2)S Systems.
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer.
Oncogenic accumulation of cysteine promotes cancer cell proliferation by regulating the translation of D-type cyclins.
H(2)S alleviated sepsis-induced acute kidney injury by inhibiting PERK/Bax-Bcl2 pathway.
The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury.
Hydrogen sulfide dysfunction in metabolic syndrome-associated vascular complications involves cGMP regulation through soluble guanylyl cyclase persulfidation.
Exogenous hydrogen sulfide ameliorates diabetes-associated cognitive dysfunction by regulating the nrf-2/HO-1 axis and the NLRP3 inflammasome pathway in diabetic rats.
RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells.
The Effect of Targeted Hyperoxemia on Brain Immunohistochemistry after Long-Term, Resuscitated Porcine Acute Subdural Hematoma and Hemorrhagic Shock.
Integrative gene expression analysis and animal model reveal immune- and autophagy-related biomarkers in osteomyelitis.
Hydrogen sulfide ameliorated endothelial dysfunction in hyperhomocysteinemia rats: Mechanism of IRE1α/JNK pathway-mediated autophagy.
Identification and Validation of the miR/RAS/RUNX2 Autophagy Regulatory Network in AngII-Induced Hypertensive Nephropathy in MPC5 Cells Treated with Hydrogen Sulfide Donors.
Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT.
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.
PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.
CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway.
Cystathionine β-Synthase Suppresses NLRP3 Inflammasome Activation via Redox Regulation in Microglia.
Sodium hydrosulfide moderately alleviates the hallmark symptoms of Duchenne muscular dystrophy in mdx mice.
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760.
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Hydrogen sulfide inhibits the rupture of fetal membranes throngh anti-aging pathways.
Proteome Profiling of the Dystrophic mdx Mice Diaphragm.
A prognostic risk model, tumor immune environment modulation, and drug prediction of ferroptosis and amino acid metabolism-related genes in hepatocellular carcinoma.
B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis.
Cystine/Glutamate Xc(-) Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis.
Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice.
Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats.
Reduced Renal CSE/CBS/H2S Contributes to the Progress of Lupus Nephritis.
Hydrogen Sulfide Inhibited Sympathetic Activation in D-Galactose-Induced Aging Rats by Upregulating Klotho and Inhibiting Inflammation in the Paraventricular Nucleus.
PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors.
Hydrogen sulfide ameliorates senescence in vascular endothelial cells through ameliorating inflammation and activating PPARδ/SGLT2/STAT3 signaling pathway.
Hydrogen sulfide as an anti-calcification stratagem in human aortic valve: Altered biogenesis and mitochondrial metabolism of H(2)S lead to H(2)S deficiency in calcific aortic valve disease.
Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats.
Brain Histology and Immunohistochemistry After Resuscitation From Hemorrhagic Shock in Swine With Pre-Existing Atherosclerosis and Sodium Thiosulfate (Na(2)S(2)O(3)) Treatment.
A novel ferroptosis-related gene signature to predict overall survival in patients with osteosarcoma.
Deletion of cystathionine-γ-lyase in bone marrow-derived cells promotes colitis-associated carcinogenesis.
Molecular convergence between Down syndrome and fragile X syndrome identified using human pluripotent stem cell models.
MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT.
Endogenous H(2)S targets mitochondria to promote continual phagocytosis of erythrocytes by microglia after intracerebral hemorrhage.
SM22α-lineage niche cells regulate intramembranous bone regeneration via PDGFRβ-triggered hydrogen sulfide production.
Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation.
Endogenous and exogenous hydrogen sulfide modulates urothelial bladder carcinoma development in human cell lines.
MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity.
Altered transsulfuration pathway enzymes and redox homeostasis in inherited retinal degenerative diseases.
Cystathionine β-synthase is required for oocyte quality by ensuring proper meiotic spindle assembly.
Vasoactive Effects of Chronic Treatment with Fructose and Slow-Releasing H(2)S Donor GYY-4137 in Spontaneously Hypertensive Rats: The Role of Nitroso and Sulfide Signalization.
Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia.
Differential effects of subchronic acrylonitrile exposure on hydrogen sulfide levels in rat blood, brain, and liver.
Hydrogen Sulfide Attenuated Sepsis-Induced Myocardial Dysfunction Through TLR4 Pathway and Endoplasmic Reticulum Stress.
Exogenous H(2) S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
Glucose-induced decrease of cystathionine β-synthase mediates renal injuries.
mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis.
ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes.
Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling.
Polyphenol-Rich Extract from Litchi chinensis Seeds Alleviates Hypertension-Induced Renal Damage in Rats.
Vascular Effects of Low-Dose ACE2 Inhibitor MLN-4760-Benefit or Detriment in Essential Hypertension?
Cystathionine γ-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis.
Age-related differences in responses to hydrogen sulfide in the bladder of spontaneously hypertensive rats.
Fructose Intake Impairs the Synergistic Vasomotor Manifestation of Nitric Oxide and Hydrogen Sulfide in Rat Aorta.
Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia.
Cerebral Immunohistochemical Characterization of the H(2)S and the Oxytocin Systems in a Porcine Model of Acute Subdural Hematoma.
Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation.
Atorvastatin protects against contrast-induced acute kidney injury via upregulation of endogenous hydrogen sulfide.
Coenzyme Q10 modulates sulfide metabolism and links the mitochondrial respiratory chain to pathways associated to one carbon metabolism.
Inhibition of endogenous hydrogen sulfide biosynthesis enhances the anti-cancer effect of 3,3'-diindolylmethane in human gastric cancer cells.
Chronopharmacological targeting of Rev-erbα by puerarin alleviates hyperhomocysteinemia in mice.
Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p.
Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.
Arterial Hypertension and Plasma Glucose Modulate the Vasoactive Effects of Nitroso-Sulfide Coupled Signaling in Human Intrarenal Arteries.
Hydrogen sulfide-mediated resistance against water avoidance stress-induced gastritis by maintenance of gastric microbial homeostasis.
Modulation of the functions of myeloid-derived suppressor cells : a new strategy of hydrogen sulfide anti-cancer effects.
3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics.
Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease.
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.
Trophoblast H2S Maintains Early Pregnancy via Regulating Maternal-Fetal Interface Immune Hemostasis.
ZYZ-803 Mitigates Endoplasmic Reticulum Stress-Related Necroptosis after Acute Myocardial Infarction through Downregulating the RIP3-CaMKII Signaling Pathway.
Hydrogen sulfide-induced relaxation of the bladder is attenuated in spontaneously hypertensive rats.
Cystathionine-γ-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis.
[Exogenous hydrogen sulfide improves erectile dysfunction by inhibiting apoptosis of corpus cavernosum smooth muscle cells in rats with cavernous nerve injury].
Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes.
Inhibition of hydrogen sulfide synthesis reverses acquired resistance to 5-FU through miR-215-5p-EREG/TYMS axis in colon cancer cells.
Decreased Expression of Cystathionine β-Synthase Exacerbates Intestinal Barrier Injury in Ulcerative Colitis.
Exogenous H(2)S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD(+)-SIRT3 pathway in cardiac tissues of db/db mice.
Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina.
Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.
Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways.
Hydrogen Sulfide Attenuates LPS-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress.
Comparative analysis of molecular signatures suggests the use of gabapentin for the management of endometriosis-associated pain.
Possible role of hydrogen sulfide as an endogenous relaxation factor in the rat bladder and prostate.
The protective effect of polyunsaturated fatty acid intake during pregnancy against embryotoxicity of sodium valproate in mice.
Drug resistance induces the upregulation of H(2)S-producing enzymes in HCT116 colon cancer cells.
Reduced adipose tissue H(2)S in obesity.
Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation.
Exogenous Hydrogen Sulfide Ameliorates Diabetes-Associated Cognitive Decline by Regulating the Mitochondria-Mediated Apoptotic Pathway and IL-23/IL-17 Expression in db/db Mice.
Ligustrazine modulates renal cysteine biosynthesis in rats exposed to cadmium.
The effect of hydrogen sulfide-releasing naproxen (ATB-346) versus naproxen on formation of stress-induced gastric lesions, the regulation of systemic inflammation, hypoxia and alterations in gastric microcirculation.
Inhibition of RhoA/Rho kinase pathway and smooth muscle contraction by hydrogen sulfide.
Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H(2)S system: Role of oxidative stress and endoplasmic reticulum stress.
Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis.
H(2)S-induced S-sulfhydration of lactate dehydrogenase a (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells.
Cystathionine-gamma-lyase deficient mice are protected against the development of multiorgan failure and exhibit reduced inflammatory response during burn.
Decreased Endogenous Hydrogen Sulfide Generation in Penile Tissues of Diabetic Rats with Erectile Dysfunction.
Endogenous CBS-H2S Pathway Contributes to the Development of CCI-Induced Neuropathic Pain.
Interaction between endogenous carbon monoxide and hydrogen sulfide in the mechanism of gastroprotection against acute aspirin-induced gastric damage.
Beetroot juice reduces infarct size and improves cardiac function following ischemia-reperfusion injury: Possible involvement of endogenous H2S.
Inhibition of RhoA-dependent pathway and contraction by endogenous hydrogen sulfide in rabbit gastric smooth muscle cells.
Neuronal regulation of expression of hydrogen sulfide-producing enzyme cystathionine β-synthase in rat spinal cord astrocytes.
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate.
The cysteine dioxgenase knockout mouse: altered cysteine metabolism in nonhepatic tissues leads to excess H2S/HS(-) production and evidence of pancreatic and lung toxicity.
The inhibitory role of hydrogen sulfide in airway hyperresponsiveness and inflammation in a mouse model of asthma.
Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur.
Miyamoto A, Ueno H, Kimura H, Nakagawa T, Shibuya N
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71699
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71699
Hydrogen sulfide ameliorates oxalate crystal-related renal injury via inhibiting the activation of NOD-like receptor thermal protein domain associated protein 3 inflammasome in mice.
Shi Y, Chen L, Li M, Wang J, Yin P, Zhou X, Cong Q, Song K
Urolithiasis 2026 Mar 24;54(1)
Urolithiasis 2026 Mar 24;54(1)
Elevation of H(2)S Underlies Social Deficits in Environmental Factor Double-Hit Autism Model.
Ma H, Xu Q, Dong S, Guo M, Liu H, Wang T, Wang M, Wang Y, Wu S
Neuroscience bulletin 2026 Mar 23;
Neuroscience bulletin 2026 Mar 23;
PGK1 Persulfidation Promotes the Proliferation and Metastasis of Breast Cancer.
Luo C, Zhao M, Wang Y, Xu Y, Chen S, Liang W, Yang K, Hu J
Antioxidants & redox signaling 2026 Feb;44(4-6):164-181
Antioxidants & redox signaling 2026 Feb;44(4-6):164-181
Ca2 + influx channel inhibitor SARAF protects rats from severe acute pancreatitis induced colonitis.
Liu Y, Cao J, Liu H
3 Biotech 2026 Apr;16(4):130
3 Biotech 2026 Apr;16(4):130
Liver-Targeted AAV-DJ-hCBS Therapy Achieves Long-Term Correction of Metabolic Imbalance in CBS-Deficient Mice.
Joschko CP, Wang CC, van Buiten A, Goris M, Hoogstra-Berends F, Wang J, Bacurio JH, Chen Y, Jia N, Deng J, Hu S, Nacht M, Chiocco MJ, Henning RH, Deelman LE
International journal of molecular sciences 2026 Apr 7;27(7)
International journal of molecular sciences 2026 Apr 7;27(7)
Effect of gentiopicroside on endogenous formaldehyde homocysteine-pathway related proteins in rats with non-alcoholic steatohepatitis.
Chen J, Zuo H, Jiao Y, Zhao H, Ma X, Xiao Y, Li X, Zhao W, Shi A, Chen W
Frontiers in pharmacology 2025;16:1700101
Frontiers in pharmacology 2025;16:1700101
Allicin ameliorates acute myocardial infarction in rats by modulating calcium homeostasis in cardiomyocytes through the induction of hydrogen sulfide production.
Liu W, Xu S, Wang J, Li X, Liu R, Zhao L, Li Y, Shi R, Zhang J
Frontiers in pharmacology 2025;16:1557685
Frontiers in pharmacology 2025;16:1557685
Analysis of novel therapeutic targets and construction of a prognostic model for hepatocellular carcinoma.
Lei P, Li W, Xie D, Guan H, Huang X, Huang B
PeerJ 2025;13:e19899
PeerJ 2025;13:e19899
L-cysteine mitigates busulfan-induced testicular injury through modulation of CBS/H(2)S axis.
Liu S, Wei B, Wei H, Xu A, Sheng L, Sun X, Dong Y, Yang H
Frontiers in cell and developmental biology 2025;13:1679330
Frontiers in cell and developmental biology 2025;13:1679330
Translocation of SIRT6 promotes glycolysis reprogramming to exacerbate diabetic angiopathy.
Pang K, Huang J, Zhang S, Guan Y, Zou N, Kang J, Du H, Zhao D, Abramochkin DV, Chen H, Zhang N, Gu Y, Liu N, Niu Y, Xiong Z, Zhang X, Lu F, Fan H, Tian J, Yu B, Li S, Zhang W
Redox biology 2025 Sep;85:103736
Redox biology 2025 Sep;85:103736
A novel role of exostosin glycosyltransferase 2 (EXT2) in glioblastoma cell metabolism, radiosensitivity and ferroptosis.
Matesanz-Sánchez R, Peitzsch M, Lange I, Mircetic J, Seifert M, Cordes N, Vehlow A
Cell death and differentiation 2025 Sep;32(9):1664-1678
Cell death and differentiation 2025 Sep;32(9):1664-1678
Impaired xCT-mediated cystine uptake drives serine and proline metabolic reprogramming and mitochondrial fission in skeletal muscle cells.
Kanaan MN, Karam CY, Kennedy LS, Pileggi CA, Hamilton L, Cuperlovic-Culf M, Harper ME
Redox biology 2025 Oct;86:103839
Redox biology 2025 Oct;86:103839
Hydrogen Sulfide Ameliorates Heart Aging by Downregulating Matrix Metalloproteinase-9.
He K, Zhang H, Tan B, Song C, Liang Z, Zhang L, Tian D, Xiao L, Xue H, Guo Q, Teng X, Jin S, An C, Wu Y
Cardiovascular drugs and therapy 2025 Oct;39(5):967-981
Cardiovascular drugs and therapy 2025 Oct;39(5):967-981
Hydrogen Sulfide Attenuates Cisplatin-Induced Acute Kidney Injury via Dual Inhibition of Apoptosis and Pyroptosis.
Han Z, Jia Y, Yan D, Xue Y, Deng T, Wang P, Xiao L, Wang X
Biomedicines 2025 Nov 3;13(11)
Biomedicines 2025 Nov 3;13(11)
Folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism.
Huang J, Lu W, Zhao S, Cai Z, Li L, Hu Z, Jiang Y, Deng J, Tang Y, Shi C, Wang C, Liu G, Li S
Redox biology 2025 Mar;80:103501
Redox biology 2025 Mar;80:103501
Altered Production and Cellular Levels of Hydrogen Sulfide (H(2)S) in Placental Trophoblasts from Pregnancies Affected by Pre-Eclampsia.
Chu X, Xu J, Shen X, Sheng W, Sun J, Gu Y, Lewis DF, Cooper D, Zoorob D, Wang Y
Pathophysiology : the official journal of the International Society for Pathophysiology 2025 Mar 4;32(1)
Pathophysiology : the official journal of the International Society for Pathophysiology 2025 Mar 4;32(1)
Cth/Mpst double ablation results in early onset fatty liver disease in lean mice.
Katsouda A, Markou M, Valakos D, Theodorou I, Papapetropoulos A
Redox biology 2025 Jun;83:103641
Redox biology 2025 Jun;83:103641
A Slow Hydrogen Sulfide Donor GYY-4137 Partially Improves Vascular Function in Spontaneously Hypertensive Rats Fed a High-Fat Diet.
Aydemir BG, Berenyiova A, Cebova M, Henderson JD, Barta A, Cacanyiova S
Pathophysiology : the official journal of the International Society for Pathophysiology 2025 Jun 18;32(2)
Pathophysiology : the official journal of the International Society for Pathophysiology 2025 Jun 18;32(2)
Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2.
Jiang Z, Liu D, Li T, Gai C, Xin D, Zhao Y, Song Y, Cheng Y, Li T, Wang Z
Neural regeneration research 2025 Jun 1;20(6):1776-1788
Neural regeneration research 2025 Jun 1;20(6):1776-1788
CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B(1) cytotoxicity.
Yang H, Ji X, Zhong H, Yang X, Hu D, Cai G, Wu Z
Science China. Life sciences 2025 Jul;68(7):2121-2136
Science China. Life sciences 2025 Jul;68(7):2121-2136
GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Attenuates Skeletal Muscle Abnormalities in a Murine Model of Duchenne Muscular Dystrophy.
Myszka M, Jakubczak E, Mucha O, Hajok K, Waśniowska U, Nalepa A, Dulak J, Łoboda A
Antioxidants & redox signaling 2025 Jul;43(1-3):115-137
Antioxidants & redox signaling 2025 Jul;43(1-3):115-137
The treatment of primary CoQ deficiency requires the targeting of multiple pathogenic mechanisms.
González-García P, Jiménez-Sánchez L, Corral-Sarasa J, López-Herrador S, Torres-Rusillo S, Díaz-Casado ME, López LC
Communications medicine 2025 Jul 10;5(1):286
Communications medicine 2025 Jul 10;5(1):286
Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation.
Zampas P, Li Z, Katsouda A, Varela A, Psarras S, Davos CH, Lefer DJ, Papapetropoulos A
Pharmacological research 2025 Jan;211:107542
Pharmacological research 2025 Jan;211:107542
The double face of licorice-kansui herb pair: Cure or curse, depending on the combining ratio and mediated by hydrogen sulfide.
Li N, Xue W, Wang C, Fan X, Yu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:155692
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:155692
Impaired Iron-Sulfur Cluster Synthesis Induces Mitochondrial PARthanatos in Diabetic Cardiomyopathy.
Wang M, Zhang S, Tian J, Yang F, Chen H, Bai S, Kang J, Pang K, Huang J, Dong M, Dong S, Tian Z, Fang S, Fan H, Lu F, Yu B, Li S, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(1):e2406695
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(1):e2406695
Impaired hydrogen sulfide biosynthesis underlies eccentric contraction-induced force loss in dystrophin-deficient skeletal muscle.
Southern WM, Johnson EE, Fasbender EK, Fallon KS, Cavazos CL, Lowe DA, Rodney GG, Ervasti JM
The Journal of clinical investigation 2025 Jan 14;135(5)
The Journal of clinical investigation 2025 Jan 14;135(5)
H(2)S Donor SPRC Ameliorates Ischemic Stroke by Upregulating CD24.
Wang C, Li S, Li Q, Xi H, Li J, Zhu Q, Wu P, Zhu YZ, Mao Y
CNS neuroscience & therapeutics 2025 Feb;31(2):e70243
CNS neuroscience & therapeutics 2025 Feb;31(2):e70243
Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism.
Jiang H, Wang X, Liang Y, Hou Y, Yue X, Zhang Z, Chen D, Fan X, Du A
Brain research bulletin 2025 Feb;221:111203
Brain research bulletin 2025 Feb;221:111203
Bio-nanocomplexes impair iron homeostasis to induce non-canonical ferroptosis in cancer cells.
Wang X, Zhang T, Wang S, Shi H, Dong H, Huang Y, Lai W, Hu Y, Yue C
Journal of nanobiotechnology 2025 Feb 19;23(1):121
Journal of nanobiotechnology 2025 Feb 19;23(1):121
Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells.
Huang J, Fang K, Lu W, Wu R, Chen Y, Li L, Hu Z, Cai Z, Jiang Y, Fan X, Deng J, Liu G, Luo Z, Cui L, Li S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e07803
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e07803
Vasoactive Effects of Chronic Treatment with ACE Inhibitor Zofenopril in Zucker Obese Diabetic Rats: The Role of Nitroso and Sul?de Signalization.
Saman E, Cebova M, Majzunova M, Berenyiova A, Garaiova V, Cacanyiova S
Physiological research 2025 Dec 31;74(Suppl 2):S231-S244
Physiological research 2025 Dec 31;74(Suppl 2):S231-S244
Key role of the CSE/transsulfuration pathway in macrophage phenotypic change under iron overload.
Yuan Z, Chen Y, Xin Y, Zhang Y, Dong Z, Wang J, Wang X, Yang G, Li S
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2025 Apr;88:127611
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2025 Apr;88:127611
Epidermal growth factor increases cystathionine β-synthase expression in cultured embryonic spinal cord cells.
Eguchi R, Higashida Y, Oouchi M, Yamaguchi S, Otsuguro KI
In vitro cellular & developmental biology. Animal 2025 Apr;61(4):416-424
In vitro cellular & developmental biology. Animal 2025 Apr;61(4):416-424
Shensu IV maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels.
Zhou S, Zheng L, Zheng T, Zhan H, Lin Q, Wei J, Huang Y
Frontiers in pharmacology 2024;15:1447249
Frontiers in pharmacology 2024;15:1447249
Cancer-associated fibroblasts reprogram cysteine metabolism to increase tumor resistance to ferroptosis in pancreatic cancer.
Zhu Y, Fang S, Fan B, Xu K, Xu L, Wang L, Zhu L, Chen C, Wu R, Ni J, Wang J
Theranostics 2024;14(4):1683-1700
Theranostics 2024;14(4):1683-1700
Endogenous hydrogen sulfide accelerated trauma-induced heterotopic ossification through the Ca(2+)/ERK pathway-enhanced aberrant osteogenic activity.
Yuan Z, Li J, He K, Sun Z, Luo G, Liu H, Dong J, Zhou C, Cui H, Fan C
Redox biology 2024 Sep;75:103265
Redox biology 2024 Sep;75:103265
Asynchronous changes of hydrogen sulfide and its generating enzymes in most tissues with the aging process.
He K, Tan B, Lu A, Bai L, Song C, Miao Y, Liu B, Chen Q, Teng X, Dai J, Wu Y
Bioscience reports 2024 Oct 30;44(10)
Bioscience reports 2024 Oct 30;44(10)
Role of Sex and Early Life Stress Experience on Porcine Cardiac and Brain Tissue Expression of the Oxytocin and H(2)S Systems.
Münz F, Abele N, Zink F, Wolfschmitt EM, Hogg M, Barck C, Anetzberger J, Hoffmann A, Gröger M, Calzia E, Waller C, Radermacher P, Merz T
Biomolecules 2024 Oct 30;14(11)
Biomolecules 2024 Oct 30;14(11)
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer.
Zheng H, Chen H, Cai Y, Shen M, Li X, Han Y, Deng X, Cao H, Liu J, Li H, Liu B, Li G, Wang X, Chen H, Hou J, Lin SH, Zong L, Zhang Y
Molecular cell 2024 Oct 17;84(20):4016-4030.e6
Molecular cell 2024 Oct 17;84(20):4016-4030.e6
Oncogenic accumulation of cysteine promotes cancer cell proliferation by regulating the translation of D-type cyclins.
Okano Y, Yamauchi T, Fukuzaki R, Tsuruta A, Yoshida Y, Tsurudome Y, Ushijima K, Matsunaga N, Koyanagi S, Ohdo S
The Journal of biological chemistry 2024 Nov;300(11):107890
The Journal of biological chemistry 2024 Nov;300(11):107890
H(2)S alleviated sepsis-induced acute kidney injury by inhibiting PERK/Bax-Bcl2 pathway.
Song C, Chen Q, Xu J, He K, Guo Q, Teng X, Xue H, Xiao L, Tian D, Jin S, An C, Wu Y
Nitric oxide : biology and chemistry 2024 Nov 1;152:11-18
Nitric oxide : biology and chemistry 2024 Nov 1;152:11-18
The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury.
Zhao Y, Li T, Jiang Z, Gai C, Yu S, Xin D, Li T, Liu D, Wang Z
Neural regeneration research 2024 May;19(5):1084-1094
Neural regeneration research 2024 May;19(5):1084-1094
Hydrogen sulfide dysfunction in metabolic syndrome-associated vascular complications involves cGMP regulation through soluble guanylyl cyclase persulfidation.
Smimmo M, Casale V, Casillo GM, Mitidieri E, d'Emmanuele di Villa Bianca R, Bello I, Schettino A, Montanaro R, Brancaleone V, Indolfi C, Cirino G, Di Lorenzo A, Bucci M, Panza E, Vellecco V
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116466
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116466
Exogenous hydrogen sulfide ameliorates diabetes-associated cognitive dysfunction by regulating the nrf-2/HO-1 axis and the NLRP3 inflammasome pathway in diabetic rats.
Chen H, Sun H, Hua W, Chang H, Chen W, Ma S
European journal of pharmacology 2024 Mar 5;966:176344
European journal of pharmacology 2024 Mar 5;966:176344
RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells.
Li A, Xie J, Lv L, Zheng Z, Yang W, Zhuo W, Yang S, Cai D, Duan J, Liu P, Min J, Wei J
International journal of oncology 2024 Jun;64(6)
International journal of oncology 2024 Jun;64(6)
The Effect of Targeted Hyperoxemia on Brain Immunohistochemistry after Long-Term, Resuscitated Porcine Acute Subdural Hematoma and Hemorrhagic Shock.
Münz F, Datzmann T, Hoffmann A, Gröger M, Mathieu R, Mayer S, Zink F, Gässler H, Wolfschmitt EM, Hogg M, Calzia E, Asfar P, Radermacher P, Kapapa T, Merz T
International journal of molecular sciences 2024 Jun 14;25(12)
International journal of molecular sciences 2024 Jun 14;25(12)
Integrative gene expression analysis and animal model reveal immune- and autophagy-related biomarkers in osteomyelitis.
Shi X, Li M, Ni H, Wu Y, Li Y, Chen X, Xu Y
Immunity, inflammation and disease 2024 Jul;12(7):e1339
Immunity, inflammation and disease 2024 Jul;12(7):e1339
Hydrogen sulfide ameliorated endothelial dysfunction in hyperhomocysteinemia rats: Mechanism of IRE1α/JNK pathway-mediated autophagy.
Gao Y, Xu J, He K, Guo Q, Xiao L, Jin S, Tian D, Teng X, An C, Xue H, Wu Y
Nitric oxide : biology and chemistry 2024 Dec 1;153:72-81
Nitric oxide : biology and chemistry 2024 Dec 1;153:72-81
Identification and Validation of the miR/RAS/RUNX2 Autophagy Regulatory Network in AngII-Induced Hypertensive Nephropathy in MPC5 Cells Treated with Hydrogen Sulfide Donors.
Ye Q, Ren M, Fan D, Mao Y, Zhu YZ
Antioxidants (Basel, Switzerland) 2024 Aug 7;13(8)
Antioxidants (Basel, Switzerland) 2024 Aug 7;13(8)
Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT.
Yamauchi T, Okano Y, Terada D, Yasukochi S, Tsuruta A, Tsurudome Y, Ushijima K, Matsunaga N, Koyanagi S, Ohdo S
Cancer & metabolism 2024 Aug 7;12(1):23
Cancer & metabolism 2024 Aug 7;12(1):23
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.
Li Q, Kang J, Liu N, Huang J, Zhang X, Pang K, Zhang S, Wang M, Zhao Y, Dong S, Li H, Zhao D, Lu F, Zhang W
Free radical biology & medicine 2024 Apr;216:118-138
Free radical biology & medicine 2024 Apr;216:118-138
PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.
Yamamoto T, Hayashida T, Masugi Y, Oshikawa K, Hayakawa N, Itoh M, Nishime C, Suzuki M, Nagayama A, Kawai Y, Hishiki T, Matsuura T, Naito Y, Kubo A, Yamamoto A, Yoshioka Y, Kurahori T, Nagasaka M, Takizawa M, Takano N, Kawakami K, Sakamoto M, Wakui M, Yamamoto T, Kitagawa Y, Kabe Y, Horisawa K, Suzuki A, Matsumoto M, Suematsu M
Cancer research 2024 Apr 1;84(7):1065-1083
Cancer research 2024 Apr 1;84(7):1065-1083
CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway.
Katsouda A, Markou M, Zampas P, Varela A, Davos CH, Vellecco V, Cirino G, Bucci M, Papapetropoulos A
Frontiers in pharmacology 2023;14:1090654
Frontiers in pharmacology 2023;14:1090654
Cystathionine β-Synthase Suppresses NLRP3 Inflammasome Activation via Redox Regulation in Microglia.
Mou YJ, Ma YT, Yuan X, Wang M, Liu Y, Pei CS, Liu CF, Hou XO, Hu LF
Antioxidants & redox signaling 2023 Sep 5;
Antioxidants & redox signaling 2023 Sep 5;
Sodium hydrosulfide moderately alleviates the hallmark symptoms of Duchenne muscular dystrophy in mdx mice.
Myszka M, Mucha O, Podkalicka P, Waśniowska U, Dulak J, Łoboda A
European journal of pharmacology 2023 Sep 15;955:175928
European journal of pharmacology 2023 Sep 15;955:175928
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760.
Cacanyiova S, Cebova M, Simko F, Baka T, Bernatova I, Kluknavsky M, Zorad S, Krskova K, Shaman E, Zemancikova A, Barta A, Aydemir BG, Berenyiova A
Biological research 2023 Oct 25;56(1):55
Biological research 2023 Oct 25;56(1):55
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Wang M, Tang J, Zhang S, Pang K, Zhao Y, Liu N, Huang J, Kang J, Dong S, Li H, Tian Z, Duan B, Lu F, Zhang W
Cell death discovery 2023 Oct 24;9(1):394
Cell death discovery 2023 Oct 24;9(1):394
Hydrogen sulfide inhibits the rupture of fetal membranes throngh anti-aging pathways.
Wang J, Xu J, Chao B, Liu H, Xie L, Qi H, Luo X
Placenta 2023 Nov;143:22-33
Placenta 2023 Nov;143:22-33
Proteome Profiling of the Dystrophic mdx Mice Diaphragm.
Mucha O, Myszka M, Podkalicka P, Świderska B, Malinowska A, Dulak J, Łoboda A
Biomolecules 2023 Nov 13;13(11)
Biomolecules 2023 Nov 13;13(11)
A prognostic risk model, tumor immune environment modulation, and drug prediction of ferroptosis and amino acid metabolism-related genes in hepatocellular carcinoma.
Ji L, Zhang Q, Cao Y, Liu L
Human cell 2023 May;36(3):1173-1189
Human cell 2023 May;36(3):1173-1189
B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis.
Du X, Ma X, Tan Y, Shao F, Li C, Zhao Y, Miao Y, Han L, Dang G, Song Y, Yang D, Deng Z, Wang Y, Jiang C, Kong W, Feng J, Wang X
Signal transduction and targeted therapy 2023 Mar 13;8(1):103
Signal transduction and targeted therapy 2023 Mar 13;8(1):103
Cystine/Glutamate Xc(-) Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis.
Orlowska K, Fling RR, Nault R, Schilmiller AL, Zacharewski TR
Chemical research in toxicology 2023 Jun 19;36(6):900-915
Chemical research in toxicology 2023 Jun 19;36(6):900-915
Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice.
Li W, Jia Y, Gong Z, Dong Z, Yu F, Fu Y, Jiang C, Kong W
NPJ science of food 2023 Jul 17;7(1):36
NPJ science of food 2023 Jul 17;7(1):36
Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats.
Tanaka Y, Kawano M, Nakashima S, Yamaguchi C, Asahina M, Sakamoto M, Shirouchi B, Tashiro K, Imaizumi K, Sato M
Scientific reports 2023 Feb 21;13(1):3053
Scientific reports 2023 Feb 21;13(1):3053
Reduced Renal CSE/CBS/H2S Contributes to the Progress of Lupus Nephritis.
Wang X, Lin T, He Y, Zhou Y, Peng Y, Zhang W, Ni X
Biology 2023 Feb 16;12(2)
Biology 2023 Feb 16;12(2)
Hydrogen Sulfide Inhibited Sympathetic Activation in D-Galactose-Induced Aging Rats by Upregulating Klotho and Inhibiting Inflammation in the Paraventricular Nucleus.
Yu H, Yu Q, Mi Y, Wang P, Jin S, Xiao L, Guo Q, Wu Y
Biomedicines 2023 Feb 15;11(2)
Biomedicines 2023 Feb 15;11(2)
PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors.
Stokes ME, Calvo V, Fujisawa S, Dudgeon C, Huang S, Ballal N, Shen L, Gasparek J, Betzenhauser M, Taylor SJ, Staschke KA, Rigby AC, Mulvihill MJ, Bose N, Lightcap ES, Surguladze D
Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Dec 1;29(23):4870-4882
Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Dec 1;29(23):4870-4882
Hydrogen sulfide ameliorates senescence in vascular endothelial cells through ameliorating inflammation and activating PPARδ/SGLT2/STAT3 signaling pathway.
Tian D, Meng J, Li L, Xue H, Geng Q, Miao Y, Xu M, Wang R, Zhang X, Wu Y
Acta biochimica et biophysica Sinica 2023 Aug 16;55(9):1358-1369
Acta biochimica et biophysica Sinica 2023 Aug 16;55(9):1358-1369
Hydrogen sulfide as an anti-calcification stratagem in human aortic valve: Altered biogenesis and mitochondrial metabolism of H(2)S lead to H(2)S deficiency in calcific aortic valve disease.
Combi Z, Potor L, Nagy P, Sikura KÉ, Ditrói T, Jurányi EP, Galambos K, Szerafin T, Gergely P, Whiteman M, Torregrossa R, Ding Y, Beke L, Hendrik Z, Méhes G, Balla G, Balla J
Redox biology 2023 Apr;60:102629
Redox biology 2023 Apr;60:102629
Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats.
Liang Z, Miao Y, Teng X, Xiao L, Guo Q, Xue H, Tian D, Jin S, Wu Y
Frontiers in molecular biosciences 2022;9:947778
Frontiers in molecular biosciences 2022;9:947778
Brain Histology and Immunohistochemistry After Resuscitation From Hemorrhagic Shock in Swine With Pre-Existing Atherosclerosis and Sodium Thiosulfate (Na(2)S(2)O(3)) Treatment.
Denoix N, McCook O, Scheuerle A, Kapapa T, Hoffmann A, Gündel H, Waller C, Szabo C, Radermacher P, Merz T
Frontiers in medicine 2022;9:925433
Frontiers in medicine 2022;9:925433
A novel ferroptosis-related gene signature to predict overall survival in patients with osteosarcoma.
Li J, Wu F, Xiao X, Su L, Guo X, Yao J, Zhu H
American journal of translational research 2022;14(9):6082-6094
American journal of translational research 2022;14(9):6082-6094
Deletion of cystathionine-γ-lyase in bone marrow-derived cells promotes colitis-associated carcinogenesis.
Thanki KK, Johnson P, Higgins EJ, Maskey M, Phillips C, Dash S, Almenas FA, Govar AA, Tian B, Villéger R, Beswick E, Wang R, Szabo C, Chao C, Pinchuk IV, Hellmich MR, Módis K
Redox biology 2022 Sep;55:102417
Redox biology 2022 Sep;55:102417
Molecular convergence between Down syndrome and fragile X syndrome identified using human pluripotent stem cell models.
Susco SG, Ghosh S, Mazzucato P, Angelini G, Beccard A, Barrera V, Berryer MH, Messana A, Lam D, Hazelbaker DZ, Barrett LE
Cell reports 2022 Sep 6;40(10):111312
Cell reports 2022 Sep 6;40(10):111312
MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT.
Zhang J, Cen L, Zhang X, Tang C, Chen Y, Zhang Y, Yu M, Lu C, Li M, Li S, Lin B, Zhang T, Song X, Yu C, Wu H, Shen Z
Redox biology 2022 Oct;56:102469
Redox biology 2022 Oct;56:102469
Endogenous H(2)S targets mitochondria to promote continual phagocytosis of erythrocytes by microglia after intracerebral hemorrhage.
Yan X, He M, Huang H, Wang Q, Hu Y, Wang X, Jin M, Wang Y, Xia Y, Li Y, Chen G, Cheng J, Jia J
Redox biology 2022 Oct;56:102442
Redox biology 2022 Oct;56:102442
SM22α-lineage niche cells regulate intramembranous bone regeneration via PDGFRβ-triggered hydrogen sulfide production.
Zhou X, Liu J, Zheng Y, Zhang Z, Wu Y, Yang W, Liu J, Huang Y, Yi Y, Zhao Z, Xiao H, Mo X, Wang J
Cell reports 2022 May 3;39(5):110750
Cell reports 2022 May 3;39(5):110750
Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation.
Zhu H, Chan KT, Huang X, Cerra C, Blake S, Trigos AS, Anderson D, Creek DJ, De Souza DP, Wang X, Fu C, Jana M, Sanij E, Pearson RB, Kang J
eLife 2022 Jun 27;11
eLife 2022 Jun 27;11
Endogenous and exogenous hydrogen sulfide modulates urothelial bladder carcinoma development in human cell lines.
Panza E, Bello I, Smimmo M, Brancaleone V, Mitidieri E, Bucci M, Cirino G, Sorrentino R, D Emmanuele di Villa Bianca R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113137
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113137
MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity.
Katsouda A, Valakos D, Dionellis VS, Bibli SI, Akoumianakis I, Karaliota S, Zuhra K, Fleming I, Nagahara N, Havaki S, Gorgoulis VG, Thanos D, Antoniades C, Szabo C, Papapetropoulos A
The Journal of experimental medicine 2022 Jul 4;219(7)
The Journal of experimental medicine 2022 Jul 4;219(7)
Altered transsulfuration pathway enzymes and redox homeostasis in inherited retinal degenerative diseases.
Badiei A, Beltran WA, Aguirre GD
Experimental eye research 2022 Feb;215:108902
Experimental eye research 2022 Feb;215:108902
Cystathionine β-synthase is required for oocyte quality by ensuring proper meiotic spindle assembly.
Cao Y, Zhu X, Zhen P, Tian Y, Ji D, Xue K, Yan W, Chai J, Liu H, Wang W
Cell proliferation 2022 Dec;55(12):e13322
Cell proliferation 2022 Dec;55(12):e13322
Vasoactive Effects of Chronic Treatment with Fructose and Slow-Releasing H(2)S Donor GYY-4137 in Spontaneously Hypertensive Rats: The Role of Nitroso and Sulfide Signalization.
Berenyiova A, Cebova M, Aydemir BG, Golas S, Majzunova M, Cacanyiova S
International journal of molecular sciences 2022 Aug 16;23(16)
International journal of molecular sciences 2022 Aug 16;23(16)
Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia.
Nakladal D, Lambooy SPH, Mišúth S, Čepcová D, Joschko CP, van Buiten A, Goris M, Hoogstra-Berends F, Kloosterhuis NJ, Huijkman N, van de Sluis B, Diercks GF, Buikema JH, Henning RH, Deelman LE
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Apr;36(4):e22260
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Apr;36(4):e22260
Differential effects of subchronic acrylonitrile exposure on hydrogen sulfide levels in rat blood, brain, and liver.
Yang B, Yin C, Zhang Y, Xing G, Wang S, Li F, Aschner M, Lu R
Toxicology research 2022 Apr;11(2):374-384
Toxicology research 2022 Apr;11(2):374-384
Hydrogen Sulfide Attenuated Sepsis-Induced Myocardial Dysfunction Through TLR4 Pathway and Endoplasmic Reticulum Stress.
Chen YH, Teng X, Hu ZJ, Tian DY, Jin S, Wu YM
Frontiers in physiology 2021;12:653601
Frontiers in physiology 2021;12:653601
Exogenous H(2) S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
Zhang L, Jiang X, Liu N, Li M, Kang J, Chen L, Tang J, Dong S, Lu F, Zhang W
Journal of cellular and molecular medicine 2021 Sep;25(17):8201-8214
Journal of cellular and molecular medicine 2021 Sep;25(17):8201-8214
Glucose-induced decrease of cystathionine β-synthase mediates renal injuries.
Yu Y, Xiao L, Ren Z, Zhu G, Wang W, Jia Y, Peng A, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21576
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21576
mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis.
Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I
Molecular cell 2021 May 20;81(10):2076-2093.e9
Molecular cell 2021 May 20;81(10):2076-2093.e9
ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes.
Lai X, Wang M, Zhu Y, Feng X, Liang H, Wu J, Nie L, Li L, Shao L
Journal of hazardous materials 2021 May 15;410:124566
Journal of hazardous materials 2021 May 15;410:124566
Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling.
Tian D, Teng X, Jin S, Chen Y, Xue H, Xiao L, Wu Y
Journal of advanced research 2021 Jan;27:115-125
Journal of advanced research 2021 Jan;27:115-125
Polyphenol-Rich Extract from Litchi chinensis Seeds Alleviates Hypertension-Induced Renal Damage in Rats.
Yao Y, Liu T, Yin L, Man S, Ye S, Ma L
Journal of agricultural and food chemistry 2021 Feb 24;69(7):2138-2148
Journal of agricultural and food chemistry 2021 Feb 24;69(7):2138-2148
Vascular Effects of Low-Dose ACE2 Inhibitor MLN-4760-Benefit or Detriment in Essential Hypertension?
Berenyiova A, Bernatova I, Zemancikova A, Drobna M, Cebova M, Golas S, Balis P, Liskova S, Valaskova Z, Krskova K, Zorad S, Dayar E, Cacanyiova S
Biomedicines 2021 Dec 24;10(1)
Biomedicines 2021 Dec 24;10(1)
Cystathionine γ-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis.
Bok R, Guerra DD, Lorca RA, Wennersten SA, Harris PS, Rauniyar AK, Stabler SP, MacLean KN, Roede JR, Brown LD, Hurt KJ
Redox biology 2021 Apr;40:101827
Redox biology 2021 Apr;40:101827
Age-related differences in responses to hydrogen sulfide in the bladder of spontaneously hypertensive rats.
Zou S, Shimizu T, Yamamoto M, Shimizu S, Higashi Y, Karashima T, Saito M
International journal of urology : official journal of the Japanese Urological Association 2021 Apr;28(4):459-465
International journal of urology : official journal of the Japanese Urological Association 2021 Apr;28(4):459-465
Fructose Intake Impairs the Synergistic Vasomotor Manifestation of Nitric Oxide and Hydrogen Sulfide in Rat Aorta.
Berenyiova A, Golas S, Drobna M, Cebova M, Cacanyiova S
International journal of molecular sciences 2021 Apr 30;22(9)
International journal of molecular sciences 2021 Apr 30;22(9)
Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia.
Zhong L, Ding W, Zeng Q, He B, Zhang H, Wang L, Fan J, He S, Zhang Y, Wei A
Oxidative medicine and cellular longevity 2020;2020:7286958
Oxidative medicine and cellular longevity 2020;2020:7286958
Cerebral Immunohistochemical Characterization of the H(2)S and the Oxytocin Systems in a Porcine Model of Acute Subdural Hematoma.
Denoix N, Merz T, Unmuth S, Hoffmann A, Nespoli E, Scheuerle A, Huber-Lang M, Gündel H, Waller C, Radermacher P, McCook O
Frontiers in neurology 2020;11:649
Frontiers in neurology 2020;11:649
Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation.
Koike Y, Li B, Ganji N, Zhu H, Miyake H, Chen Y, Lee C, Janssen Lok M, Zozaya C, Lau E, Lee D, Chusilp S, Zhang Z, Yamoto M, Wu RY, Inoue M, Uchida K, Kusunoki M, Delgado-Olguin P, Mertens L, Daneman A, Eaton S, Sherman PM, Pierro A
Nature communications 2020 Oct 2;11(1):4950
Nature communications 2020 Oct 2;11(1):4950
Atorvastatin protects against contrast-induced acute kidney injury via upregulation of endogenous hydrogen sulfide.
Yan L, Jiaqiong L, Yue G, Xiaoyong L, Xuexian T, Ming L, Yinglan L, Xinxue L, Zena H
Renal failure 2020 Nov;42(1):270-281
Renal failure 2020 Nov;42(1):270-281
Coenzyme Q10 modulates sulfide metabolism and links the mitochondrial respiratory chain to pathways associated to one carbon metabolism.
González-García P, Hidalgo-Gutiérrez A, Mascaraque C, Barriocanal-Casado E, Bakkali M, Ziosi M, Abdihankyzy UB, Sánchez-Hernández S, Escames G, Prokisch H, Martín F, Quinzii CM, López LC
Human molecular genetics 2020 Nov 25;29(19):3296-3311
Human molecular genetics 2020 Nov 25;29(19):3296-3311
Inhibition of endogenous hydrogen sulfide biosynthesis enhances the anti-cancer effect of 3,3'-diindolylmethane in human gastric cancer cells.
Ye F, Li X, Sun K, Xu W, Shi H, Bian J, Lu R, Ye Y
Life sciences 2020 Nov 15;261:118348
Life sciences 2020 Nov 15;261:118348
Chronopharmacological targeting of Rev-erbα by puerarin alleviates hyperhomocysteinemia in mice.
Chen M, Zhou C, Xu H, Zhang T, Wu B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109936
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109936
Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p.
Xue WL, Chen RQ, Zhang QQ, Li XH, Cao L, Li MY, Li Y, Lin G, Chen Y, Wang MJ, Zhu YC
American journal of physiology. Cell physiology 2020 May 1;318(5):C857-C869
American journal of physiology. Cell physiology 2020 May 1;318(5):C857-C869
Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.
Peleli M, Bibli SI, Li Z, Chatzianastasiou A, Varela A, Katsouda A, Zukunft S, Bucci M, Vellecco V, Davos CH, Nagahara N, Cirino G, Fleming I, Lefer DJ, Papapetropoulos A
Biochemical pharmacology 2020 Jun;176:113833
Biochemical pharmacology 2020 Jun;176:113833
Arterial Hypertension and Plasma Glucose Modulate the Vasoactive Effects of Nitroso-Sulfide Coupled Signaling in Human Intrarenal Arteries.
Cacanyiova S, Krskova K, Zorad S, Frimmel K, Drobna M, Valaskova Z, Misak A, Golas S, Breza J, Breza J Jr, Berenyiova A
Molecules (Basel, Switzerland) 2020 Jun 23;25(12)
Molecules (Basel, Switzerland) 2020 Jun 23;25(12)
Hydrogen sulfide-mediated resistance against water avoidance stress-induced gastritis by maintenance of gastric microbial homeostasis.
Han Y, Li Y, Hu Z, Wang X, Liu J, Ren X, Yu Y, Li Y, Li W, Sun Y
MicrobiologyOpen 2020 Jan;9(1):e00951
MicrobiologyOpen 2020 Jan;9(1):e00951
Modulation of the functions of myeloid-derived suppressor cells : a new strategy of hydrogen sulfide anti-cancer effects.
De Cicco P, Ercolano G, Rubino V, Terrazzano G, Ruggiero G, Cirino G, Ianaro A
British journal of pharmacology 2020 Feb;177(4):884-897
British journal of pharmacology 2020 Feb;177(4):884-897
3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics.
Abdollahi Govar A, Törő G, Szaniszlo P, Pavlidou A, Bibli SI, Thanki K, Resto VA, Chao C, Hellmich MR, Szabo C, Papapetropoulos A, Módis K
British journal of pharmacology 2020 Feb;177(4):866-883
British journal of pharmacology 2020 Feb;177(4):866-883
Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease.
Sikura KÉ, Potor L, Szerafin T, Oros M, Nagy P, Méhes G, Hendrik Z, Zarjou A, Agarwal A, Posta N, Torregrossa R, Whiteman M, Fürtös I, Balla G, Balla J
British journal of pharmacology 2020 Feb;177(4):793-809
British journal of pharmacology 2020 Feb;177(4):793-809
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.
Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E
Molecular cell 2020 Dec 3;80(5):876-891.e6
Molecular cell 2020 Dec 3;80(5):876-891.e6
Trophoblast H2S Maintains Early Pregnancy via Regulating Maternal-Fetal Interface Immune Hemostasis.
Wang B, Xu T, Li Y, Wang W, Lyu C, Luo D, Yang Q, Ning N, Chen ZJ, Yan J, Chen DB, Li J
The Journal of clinical endocrinology and metabolism 2020 Dec 1;105(12):e4275-89
The Journal of clinical endocrinology and metabolism 2020 Dec 1;105(12):e4275-89
ZYZ-803 Mitigates Endoplasmic Reticulum Stress-Related Necroptosis after Acute Myocardial Infarction through Downregulating the RIP3-CaMKII Signaling Pathway.
Chang L, Wang Z, Ma F, Tran B, Zhong R, Xiong Y, Dai T, Wu J, Xin X, Guo W, Xie Y, Mao Y, Zhu YZ
Oxidative medicine and cellular longevity 2019;2019:6173685
Oxidative medicine and cellular longevity 2019;2019:6173685
Hydrogen sulfide-induced relaxation of the bladder is attenuated in spontaneously hypertensive rats.
Zou S, Shimizu T, Yamamoto M, Shimizu S, Higashi Y, Saito M
International urology and nephrology 2019 Sep;51(9):1507-1515
International urology and nephrology 2019 Sep;51(9):1507-1515
Cystathionine-γ-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis.
Módis K, Ramanujam VS, Govar AA, Lopez E, Anderson KE, Wang R, Szabo C
Biochemical pharmacology 2019 Nov;169:113604
Biochemical pharmacology 2019 Nov;169:113604
[Exogenous hydrogen sulfide improves erectile dysfunction by inhibiting apoptosis of corpus cavernosum smooth muscle cells in rats with cavernous nerve injury].
Zeng Q, He S, Zhong L, Wang L, Cheng F, Zhang H, Hui J, Wei A
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019 Nov 30;39(11):1329-1336
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019 Nov 30;39(11):1329-1336
Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes.
Goren I, Köhler Y, Aglan A, Pfeilschifter J, Beck KF, Frank S
Nitric oxide : biology and chemistry 2019 Jun 1;87:31-42
Nitric oxide : biology and chemistry 2019 Jun 1;87:31-42
Inhibition of hydrogen sulfide synthesis reverses acquired resistance to 5-FU through miR-215-5p-EREG/TYMS axis in colon cancer cells.
Chen S, Yue T, Huang Z, Zhu J, Bu D, Wang X, Pan Y, Liu Y, Wang P
Cancer letters 2019 Dec 1;466:49-60
Cancer letters 2019 Dec 1;466:49-60
Decreased Expression of Cystathionine β-Synthase Exacerbates Intestinal Barrier Injury in Ulcerative Colitis.
Chen S, Zuo S, Zhu J, Yue T, Bu D, Wang X, Wang P, Pan Y, Liu Y
Journal of Crohn's & colitis 2019 Aug 14;13(8):1067-1080
Journal of Crohn's & colitis 2019 Aug 14;13(8):1067-1080
Exogenous H(2)S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD(+)-SIRT3 pathway in cardiac tissues of db/db mice.
Sun Y, Teng Z, Sun X, Zhang L, Chen J, Wang B, Lu F, Liu N, Yu M, Peng S, Wang Y, Zhao D, Zhao Y, Ren H, Cheng Z, Dong S, Lu F, Zhang W
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E284-E297
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E284-E297
Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina.
Badiei A, Sudharsan R, Santana E, Dunaief JL, Aguirre GD
Experimental eye research 2019 Apr;181:72-84
Experimental eye research 2019 Apr;181:72-84
Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.
Pang HQ, Yue SJ, Tang YP, Chen YY, Tan YJ, Cao YJ, Shi XQ, Zhou GS, Kang A, Huang SL, Shi YJ, Sun J, Tang ZS, Duan JA
Frontiers in pharmacology 2018;9:165
Frontiers in pharmacology 2018;9:165
Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways.
Zhang GY, Lu D, Duan SF, Gao YR, Liu SY, Hong Y, Dong PZ, Chen YG, Li T, Wang DY, Cheng XS, He F, Wei JS, Li GY, Zhang QY, Wu DD, Ji XY
Oxidative medicine and cellular longevity 2018;2018:9647809
Oxidative medicine and cellular longevity 2018;2018:9647809
Hydrogen Sulfide Attenuates LPS-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress.
Chen Y, Jin S, Teng X, Hu Z, Zhang Z, Qiu X, Tian D, Wu Y
Oxidative medicine and cellular longevity 2018;2018:6717212
Oxidative medicine and cellular longevity 2018;2018:6717212
Comparative analysis of molecular signatures suggests the use of gabapentin for the management of endometriosis-associated pain.
Bellessort B, Bachelot A, Grouthier V, De Lombares C, Narboux-Neme N, Garagnani P, Pirazzini C, Astigiano S, Mastracci L, Fontaine A, Alfama G, Duvernois-Berthet E, Levi G
Journal of pain research 2018;11:715-725
Journal of pain research 2018;11:715-725
Possible role of hydrogen sulfide as an endogenous relaxation factor in the rat bladder and prostate.
Zou S, Shimizu T, Shimizu S, Higashi Y, Nakamura K, Ono H, Aratake T, Saito M
Neurourology and urodynamics 2018 Nov;37(8):2519-2526
Neurourology and urodynamics 2018 Nov;37(8):2519-2526
The protective effect of polyunsaturated fatty acid intake during pregnancy against embryotoxicity of sodium valproate in mice.
Li K, Li J, Gu J, Guo X, Gao T, Li D
Food & function 2018 May 23;9(5):2634-2643
Food & function 2018 May 23;9(5):2634-2643
Drug resistance induces the upregulation of H(2)S-producing enzymes in HCT116 colon cancer cells.
Untereiner AA, Pavlidou A, Druzhyna N, Papapetropoulos A, Hellmich MR, Szabo C
Biochemical pharmacology 2018 Mar;149:174-185
Biochemical pharmacology 2018 Mar;149:174-185
Reduced adipose tissue H(2)S in obesity.
Katsouda A, Szabo C, Papapetropoulos A
Pharmacological research 2018 Feb;128:190-199
Pharmacological research 2018 Feb;128:190-199
Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation.
Brown-Borg HM, Rakoczy S, Wonderlich JA, Borg KE, Rojanathammanee L
Annals of the New York Academy of Sciences 2018 Apr;1418(1):118-136
Annals of the New York Academy of Sciences 2018 Apr;1418(1):118-136
Exogenous Hydrogen Sulfide Ameliorates Diabetes-Associated Cognitive Decline by Regulating the Mitochondria-Mediated Apoptotic Pathway and IL-23/IL-17 Expression in db/db Mice.
Ma S, Zhong D, Ma P, Li G, Hua W, Sun Y, Liu N, Zhang L, Zhang W
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(5):1838-1850
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(5):1838-1850
Ligustrazine modulates renal cysteine biosynthesis in rats exposed to cadmium.
Kuang W, Zhang X, Zhu W, Lan Z
Environmental toxicology and pharmacology 2017 Sep;54:125-132
Environmental toxicology and pharmacology 2017 Sep;54:125-132
The effect of hydrogen sulfide-releasing naproxen (ATB-346) versus naproxen on formation of stress-induced gastric lesions, the regulation of systemic inflammation, hypoxia and alterations in gastric microcirculation.
Magierowski M, Magierowska K, Surmiak M, Hubalewska-Mazgaj M, Kwiecien S, Wallace JL, Brzozowski T
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2017 Oct;68(5):749-756
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2017 Oct;68(5):749-756
Inhibition of RhoA/Rho kinase pathway and smooth muscle contraction by hydrogen sulfide.
Nalli AD, Wang H, Bhattacharya S, Blakeney BA, Murthy KS
Pharmacology research & perspectives 2017 Oct;5(5)
Pharmacology research & perspectives 2017 Oct;5(5)
Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H(2)S system: Role of oxidative stress and endoplasmic reticulum stress.
Liu S, Xin D, Wang L, Zhang T, Bai X, Li T, Xie Y, Xue H, Bo S, Liu D, Wang Z
Redox biology 2017 Oct;13:528-540
Redox biology 2017 Oct;13:528-540
Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis.
Phillips CM, Zatarain JR, Nicholls ME, Porter C, Widen SG, Thanki K, Johnson P, Jawad MU, Moyer MP, Randall JW, Hellmich JL, Maskey M, Qiu S, Wood TG, Druzhyna N, Szczesny B, Módis K, Szabo C, Chao C, Hellmich MR
Cancer research 2017 Nov 1;77(21):5741-5754
Cancer research 2017 Nov 1;77(21):5741-5754
H(2)S-induced S-sulfhydration of lactate dehydrogenase a (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells.
Untereiner AA, Oláh G, Módis K, Hellmich MR, Szabo C
Biochemical pharmacology 2017 Jul 15;136:86-98
Biochemical pharmacology 2017 Jul 15;136:86-98
Cystathionine-gamma-lyase deficient mice are protected against the development of multiorgan failure and exhibit reduced inflammatory response during burn.
Ahmad A, Druzhyna N, Szabo C
Burns : journal of the International Society for Burn Injuries 2017 Aug;43(5):1021-1033
Burns : journal of the International Society for Burn Injuries 2017 Aug;43(5):1021-1033
Decreased Endogenous Hydrogen Sulfide Generation in Penile Tissues of Diabetic Rats with Erectile Dysfunction.
Zhang Y, Yang J, Wang T, Wang SG, Liu JH, Yin CP, Ye ZQ
The journal of sexual medicine 2016 Mar;13(3):350-60
The journal of sexual medicine 2016 Mar;13(3):350-60
Endogenous CBS-H2S Pathway Contributes to the Development of CCI-Induced Neuropathic Pain.
Gui Y, Li A, Qiu B, Chen F, Chen L, Liu D, Chen S, Zhou W, Zhou H
Neurochemical research 2016 Jun;41(6):1381-9
Neurochemical research 2016 Jun;41(6):1381-9
Interaction between endogenous carbon monoxide and hydrogen sulfide in the mechanism of gastroprotection against acute aspirin-induced gastric damage.
Magierowski M, Magierowska K, Hubalewska-Mazgaj M, Adamski J, Bakalarz D, Sliwowski Z, Pajdo R, Kwiecien S, Brzozowski T
Pharmacological research 2016 Dec;114:235-250
Pharmacological research 2016 Dec;114:235-250
Beetroot juice reduces infarct size and improves cardiac function following ischemia-reperfusion injury: Possible involvement of endogenous H2S.
Salloum FN, Sturz GR, Yin C, Rehman S, Hoke NN, Kukreja RC, Xi L
Experimental biology and medicine (Maywood, N.J.) 2015 May;240(5):669-81
Experimental biology and medicine (Maywood, N.J.) 2015 May;240(5):669-81
Inhibition of RhoA-dependent pathway and contraction by endogenous hydrogen sulfide in rabbit gastric smooth muscle cells.
Nalli AD, Rajagopal S, Mahavadi S, Grider JR, Murthy KS
American journal of physiology. Cell physiology 2015 Mar 15;308(6):C485-95
American journal of physiology. Cell physiology 2015 Mar 15;308(6):C485-95
Neuronal regulation of expression of hydrogen sulfide-producing enzyme cystathionine β-synthase in rat spinal cord astrocytes.
Miyamoto R, Otsuguro K, Yamaguchi S, Ito S
Neuroscience research 2015 Aug;97:52-9
Neuroscience research 2015 Aug;97:52-9
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
Brown-Borg HM, Rakoczy S, Wonderlich JA, Armstrong V, Rojanathammanee L
Longevity & healthspan 2014;3(1):10
Longevity & healthspan 2014;3(1):10
Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate.
Jurkowska H, Roman HB, Hirschberger LL, Sasakura K, Nagano T, Hanaoka K, Krijt J, Stipanuk MH
Amino acids 2014 May;46(5):1353-65
Amino acids 2014 May;46(5):1353-65
The cysteine dioxgenase knockout mouse: altered cysteine metabolism in nonhepatic tissues leads to excess H2S/HS(-) production and evidence of pancreatic and lung toxicity.
Roman HB, Hirschberger LL, Krijt J, Valli A, Kožich V, Stipanuk MH
Antioxidants & redox signaling 2013 Oct 20;19(12):1321-36
Antioxidants & redox signaling 2013 Oct 20;19(12):1321-36
The inhibitory role of hydrogen sulfide in airway hyperresponsiveness and inflammation in a mouse model of asthma.
Zhang G, Wang P, Yang G, Cao Q, Wang R
The American journal of pathology 2013 Apr;182(4):1188-95
The American journal of pathology 2013 Apr;182(4):1188-95
Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur.
Stipanuk MH, Ueki I
Journal of inherited metabolic disease 2011 Feb;34(1):17-32
Journal of inherited metabolic disease 2011 Feb;34(1):17-32
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse kidney tissue were subjected to SDS PAGE followed by western blot with 14787-1-AP(CBS antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using CBS antibody 14787-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 14787-1-AP(CBS antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 14787-1-AP(CBS antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
