12602-1-AP

antibody from Proteintech Group

Targeting: MAOB

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

12602-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#12602-1-AP, RRID:AB_2137273

Product name

MAOB antibody

Antibody type

Polyclonal

Description

MAOB antibody (Cat. #12602-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Neuroprotective Effects of Time-Restricted Feeding Combined With Different Protein Sources in MPTP-Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism.

Li T, Wu J, Zhou SY, Li MA, Zhao LP, Wang A, Song YZ, Huang WY, Tan LL, Qiao CM, Zhao WJ, Cui C, Shen YQ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e16502

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A skin-hypothalamus axis couples heat stress and metabolic dysfunction.

Zhou HY, Feng X, Wen J, Xiao Y, Wang LW, Chen LY, Xie GQ, Zhao JJ, Huang Y, Luo XH
Cell 2026 Apr 21;

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From network prediction to experimental validation: Multi-Target mechanisms of Artemisia absinthium L. Essential Oil (AAEO) against depression.

Liu Z, Wang Q, Li X, Zhao Y, Liu W, Guo Q, Yuan Y
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120308

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Indoleamine 2, 3-dioxygenase 1 inhibition mediates the therapeutic effects in Parkinson's disease mice by modulating inflammation and neurogenesis in a gut microbiota dependent manner.

Qiao CM, Ma XY, Tan LL, Xia YM, Li T, Wu J, Cui C, Zhao WJ, Shen YQ
Experimental neurology 2025 Mar;385:115142

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GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy.

Chen ZP, Zhao X, Wang S, Cai R, Liu Q, Ye H, Wang MJ, Peng SY, Xue WX, Zhang YX, Li W, Tang H, Huang T, Zhang Q, Li L, Gao L, Zhou H, Hang C, Zhu JN, Li X, Liu X, Cong Q, Yan C
Nature neuroscience 2025 Jul;28(7):1404-1417

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Nicotine and tar-multiple targets synergize to alter the immune micro-environment to induce prostate cancer.

Zeng L, He Y, Huang F, Jiang X, Li YA, Hu K
Discover oncology 2025 Jul 7;16(1):1277

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Fluorinated Coumarin Derivatives as Selective PET Tracer for MAO-B Imaging.

Wu N, Zhang X, Li Y, Zhang J, Cui M
Journal of medicinal chemistry 2025 Jan 9;68(1):324-337

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Antifibrotic effects of specific targeting of the 5-hydroxytryptamine 2B receptor (5-HT(2B)R) in murine models and ex vivo models of scleroderma skin.

Trinh-Minh T, Tran-Manh C, Györfi AH, Dickel N, Liebel C, Zhou X, Wang J, Kunz M, Arozenius H, Pettersson L, Lindgren S, Wenglén C, Distler JHW
Arthritis & rheumatology (Hoboken, N.J.) 2025 Aug;77(8):1063-1076

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Integrative Omics Analysis Reveals Metabolic Features of Ground-Glass Opacity-Associated Lung Cancer.

Shi S, Luo D, Yang Y, Wang X
Journal of Cancer 2024;15(7):1848-1862

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Citrobacter rodentium infection impairs dopamine metabolism and exacerbates the pathology of Parkinson's disease in mice.

He Y, Zhao J, Ma Y, Yan X, Duan Y, Zhang X, Dong H, Fang R, Zhang Y, Li Q, Yang P, Yu M, Fei J, Huang F
Journal of neuroinflammation 2024 Jun 7;21(1):153

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Shaoyao Decoction reduced T lymphocyte activation by regulating of intestinal flora and 5-hydroxytryptamine metabolism in ulcerative colitis.

Zhen J, Li Y, Zhang Y, Zhou Y, Zhao L, Huang G, Xu A
Chinese medicine 2024 Jun 15;19(1):87

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P7C3 suppresses astrocytic senescence to protect dopaminergic neurons: Implication in the mouse model of Parkinson's disease.

Chen Y, Zhu Z, Yan Y, Sun H, Wang G, Du X, Li F, Yuan S, Wang W, Wang M, Gu C
CNS neuroscience & therapeutics 2024 Jul;30(7):e14819

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Metabolic reprogramming and heterogeneity during the decidualization process of endometrial stromal cells.

Jia Z, Wei Y, Zhang Y, Song K, Yuan J
Cell communication and signaling : CCS 2024 Jul 30;22(1):385

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Identification and experimental validation of KMO as a critical immune-associated mitochondrial gene in unstable atherosclerotic plaque.

Liao FJ, Shen SL, Bao HL, Li H, Zhao QW, Chen L, Gong CW, Xiong CZ, Liu WP, Li W, Liu DN
Journal of translational medicine 2024 Jul 18;22(1):668

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Evaluation of the Neuroprotective Effect of Total Glycosides of Cistanche deserticola and Investigation of Novel Brain-Targeting Natural MAO-B Inhibitors.

Zhai X, Xie W, Yaqoob MD, Zhao F, Zhu HZ, Yang SS, Wang K, Wang X, Wang HC, Wang X
ACS chemical neuroscience 2024 Dec 18;15(24):4544-4558

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Monoamine oxidases activity maintains endometrial monoamine homeostasis and participates in embryo implantation and development.

Yu Z, Huang P, Wang L, Meng F, Shi Q, Huang X, Qiu L, Wang H, Kong S, Wu J
BMC biology 2024 Aug 7;22(1):166

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Fasting-mimicking diet alleviates inflammatory pain by inhibiting neutrophil extracellular traps formation and neuroinflammation in the spinal cord.

Li T, Yue Y, Ma Y, Zhong Z, Guo M, Zhang J, Wang Z, Miao C
Cell communication and signaling : CCS 2023 Sep 21;21(1):250

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MAOA suppresses the growth of gastric cancer by interacting with NDRG1 and regulating the Warburg effect through the PI3K/AKT/mTOR pathway.

Wang YY, Zhou YQ, Xie JX, Zhang X, Wang SC, Li Q, Hu LP, Jiang SH, Yi SQ, Xu J, Cao H, Zhao EH, Li J
Cellular oncology (Dordrecht, Netherlands) 2023 Oct;46(5):1429-1444

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Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation.

Liu LL, Han Y, Zhang ZJ, Wang YQ, Hu YW, Kaznacheyeva E, Ding JQ, Guo DK, Wang GH, Li B, Ren HG
Acta pharmacologica Sinica 2023 Oct;44(10):1948-1961

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Components of the sympathetic nervous system as targets to modulate inflammation - rheumatoid arthritis synovial fibroblasts as neuron-like cells?

Cheng X, Lowin T, Honke N, Pongratz G
Journal of inflammation (London, England) 2023 Mar 14;20(1):9

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Vancomycin Pretreatment on MPTP-Induced Parkinson's Disease Mice Exerts Neuroprotection by Suppressing Inflammation Both in Brain and Gut.

Cui C, Hong H, Shi Y, Zhou Y, Qiao CM, Zhao WJ, Zhao LP, Wu J, Quan W, Niu GY, Wu YB, Li CS, Cheng L, Hong Y, Shen YQ
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2023 Jun;18(1-2):72-89

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Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation.

Sardar D, Cheng YT, Woo J, Choi DJ, Lee ZF, Kwon W, Chen HC, Lozzi B, Cervantes A, Rajendran K, Huang TW, Jain A, Arenkiel BR, Maze I, Deneen B
Science (New York, N.Y.) 2023 Jun 16;380(6650):eade0027

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Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth.

Liu D, Liang CH, Huang B, Zhuang X, Cui W, Yang L, Yang Y, Zhang Y, Fu X, Zhang X, Du L, Gu W, Wang X, Yin C, Chai R, Chu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(6):e2204006

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Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits.

Cheng YT, Woo J, Luna-Figueroa E, Maleki E, Harmanci AS, Deneen B
Neuron 2023 Apr 19;111(8):1301-1315.e5

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Norepinephrine Enhances Aerobic Glycolysis and May Act as a Predictive Factor for Immunotherapy in Gastric Cancer.

Wang Y, Wang S, Yang Q, Li J, Yu F, Zhao E
Journal of immunology research 2021;2021:5580672

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A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota.

Guo Y, Zhu X, Zeng M, Qi L, Tang X, Wang D, Zhang M, Xie Y, Li H, Yang X, Chen D
Translational psychiatry 2021 May 27;11(1):328

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Maternal high sugar and fat diet benefits offspring brain function via targeting on the gut-brain axis.

Wang D, Zhang H, Zeng M, Tang X, Zhu X, Guo Y, Qi L, Xie Y, Zhang M, Chen D
Aging 2021 Mar 26;13(7):10240-10274

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A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients.

Wu X, Sheng H, Wang L, Xia P, Wang Y, Yu L, Lv W, Hu J
Aging 2021 Mar 26;13(7):10034-10057

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Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function.

Jo J, Woo J, Cristobal CD, Choi JM, Wang CY, Ye Q, Smith JA, Ung K, Liu G, Cortes D, Jung SY, Arenkiel BR, Lee HK
EMBO reports 2021 Dec 6;22(12):e53200

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Andrographolide alleviates Parkinsonism in MPTP-PD mice via targeting mitochondrial fission mediated by dynamin-related protein 1.

Geng J, Liu W, Gao J, Jiang C, Fan T, Sun Y, Qin ZH, Xu Q, Guo W, Gao J
British journal of pharmacology 2019 Dec;176(23):4574-4591

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Involvement of monoamine oxidase-B in the acute neurotoxicity of MPTP in embryonic and newborn mice.

Sai T, Uchida K, Nakayama H
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 2013 May;65(4):365-73

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Changes of MAO-A and MAO-B Expressions in the Placenta of MPTP or MPP(+) Treated Mice.

Sai T, Uchida K, Nakayama H
Journal of toxicologic pathology 2013 Mar;26(1):73-7

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human liver tissue were subjected to SDS PAGE followed by western blot with 12602-1-AP(MAOB antibody) at dilution of 1:300

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The MAOB antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MAOB. This antibody recognizes human,mouse,rat antigen. The MAOB antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

12602-1-AP.pdf

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