M00286-1

antibody from Boster Biological Technology

Targeting: MMP2 CLG4, CLG4A, TBE-1

Provider product page for M00286-1

Western blot

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [46]
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Validations
Western blot [1]

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Product number: M00286-1 - Provider product page
Provider: Boster Biological Technology
Product name: Anti-MMP2 Rabbit Monoclonal Antibody
Antibody type: Monoclonal
Description: Monoclonal antibody for MMP 2/MMP2 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC, WB. Reactive species: Human, Mouse, Rat MMP 2/MMP2 information: Molecular Weight: 73882 MW; Subcellular Localization: Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes; Tissue Specificity: Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Antibody clone number: BBA-13
Vial size: 100ug/vial
Concentration: 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: At -20°C for one year. Avoid repeated freezing and thawing.

MMP2 protein structure - M00286-1 shown in red.

Submitted references Comprehensive Analysis of Sideroflexin 4 in Hepatocellular Carcinoma by Bioinformatics and Experiments.

Du Z, Zhang Z, Han X, Xie H, Yan W, Tian D, Liu M, Rao C
International journal of medical sciences 2023;20(10):1300-1315

Enterolactone and trabectedin suppress epithelial ovarian cancer synergistically via upregulating THBS1.

Zeng Z, Lin C, Zhang MC, Kossinna P, Wang P, Cao D, Wang J, Xu M, Wang X, Li Q, Xu X, Yang H, Zhu S, Liu GR, Xie K, Yang J, Luo Y, Wang Y, Zhang XH, Lin J, Chen H, Liu SL, Liu H
Phytotherapy research : PTR 2023 Oct;37(10):4722-4739

Single and Combined Effects of Short-Term Selenium Deficiency and T-2 Toxin-Induced Kidney Pathological Injury Through the MMPs/TIMPs System.

Guo Z, Chilufya MM, Deng H, Qiao L, Liu J, Xiao X, Zhao Y, Lin X, Liu H, Xiang R, Han J
Biological trace element research 2023 Oct;201(10):4850-4860

Trophoblast cellular adhesion molecule expression regulated by different genes and their correlation with pregnancy-induced hypertension.

Chen Y, Fan Y, Pan X, Liao Y, Xiang G
Cellular and molecular biology (Noisy-le-Grand, France) 2023 Nov 30;69(12):26-32

Licoflavone A Suppresses Gastric Cancer Growth and Metastasis by Blocking the VEGFR-2 Signaling Pathway.

Hongxia G, Xiaojie J, Guangxian L, Min Z, Shiwei N, Wangjie C, Han Z, Yuanding Z, Chenghao L, Yaling L, Yun S, Yongqi L
Journal of oncology 2022;2022:5497991

MiR-31 improves spinal cord injury in mice by promoting the migration of bone marrow mesenchymal stem cells.

Zhang Y, Cao L, Du R, Tian F, Li X, Yuan Y, Wang C
PloS one 2022;17(9):e0272499

Licoricidin combats gastric cancer by targeting the ICMT/Ras pathway in vitro and in vivo.

Ma H, Wu F, Bai Y, Wang T, Ma S, Guo L, Liu G, Leng G, Kong Y, Zhang Y
Frontiers in pharmacology 2022;13:972825

Chronic exposure to microcystin-leucine-arginine induces epithelial hyperplasia and inflammation in the mouse bladder.

Zhang S, Wu W, Peng Y, Liu L, Zhang Y, Wang R, Chen Z, Chu L, Zhang X, Bu Q, Jiang D, Wang J, Wang Y, Wang L
Ecotoxicology and environmental safety 2022 Oct 1;244:114033

Low expression of RECK in oral squamous cell carcinoma patients induces a shorter survival rate through an imbalance of RECK/MMPs.

Yuan J, Li W, Zhu J, Deng S, Tao X
International journal of clinical and experimental pathology 2020;13(3):501-508

Decoy receptor 2 mediation of the senescent phenotype of tubular cells by interacting with peroxiredoxin 1 presents a novel mechanism of renal fibrosis in diabetic nephropathy.

Jia C, Ke-Hong C, Fei X, Huan-Zi D, Jie Y, Li-Ming W, Xiao-Yue W, Jian-Guo Z, Ya-Ni H
Kidney international 2020 Sep;98(3):645-662

The overexpression of uPA promotes the proliferation and fibrinolytic activity of human umbilical vein endothelial cells.

Song T, Meng S, Xu ST, Jin SJ, Zeng QZ, Gu GJ
International journal of clinical and experimental pathology 2019;12(8):2959-2966

Untangling the response of bone tumor cells and bone forming cells to matrix stiffness and adhesion ligand density by means of hydrogels.

Jiang T, Zhao J, Yu S, Mao Z, Gao C, Zhu Y, Mao C, Zheng L
Biomaterials 2019 Jan;188:130-143

Blockage of High-Affinity Choline Transporter Increases Visceral Hypersensitivity in Rats with Chronic Stress.

Zhao C, Lin M, Pan Y, Yu B
Gastroenterology research and practice 2018;2018:9252984

Silencing of lncRNA ZFAS1 inhibits malignancies by blocking Wnt/β-catenin signaling in gastric cancer cells.

Xu W, He L, Li Y, Tan Y, Zhang F, Xu H
Bioscience, biotechnology, and biochemistry 2018 Mar;82(3):456-465

The Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Anterior Segment.

Wang M, Li M, Yan P, Luo Q, Zhang Y, Du Z
Journal of ophthalmology 2017;2017:6067890

Inhibitory effects of doxycycline on the onset and progression of abdominal aortic aneurysm and its related mechanisms.

Yu M, Chen C, Cao Y, Qi R
European journal of pharmacology 2017 Sep 15;811:101-109

Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1α and autophagy in human osteosarcoma.

Zhang Y, Liu Y, Zou J, Yan L, Du W, Zhang Y, Sun H, Lu P, Geng S, Gu R, Zhang H, Bi Z
Oncotarget 2017 Oct 31;8(53):91134-91149

Enhancing E-cadherin expression via promoter-targeted miR-373 suppresses bladder cancer cells growth and metastasis.

Zhang Q, Wang C, Miao S, Li C, Chen Z, Li F
Oncotarget 2017 Nov 7;8(55):93969-93983

DEK promoted EMT and angiogenesis through regulating PI3K/AKT/mTOR pathway in triple-negative breast cancer.

Yang Y, Gao M, Lin Z, Chen L, Jin Y, Zhu G, Wang Y, Jin T
Oncotarget 2017 Nov 17;8(58):98708-98722

miR-320a functions as a suppressor for gliomas by targeting SND1 and β-catenin, and predicts the prognosis of patients.

Li H, Yu L, Liu J, Bian X, Shi C, Sun C, Zhou X, Wen Y, Hua D, Zhao S, Ren L, An T, Luo W, Wang Q, Yu S
Oncotarget 2017 Mar 21;8(12):19723-19737

In vivo inhibitory activity of andrographolide derivative ADN-9 against liver cancer and its mechanisms involved in inhibition of tumor angiogenesis.

Yang W, Zhao J, Wang Y, Xu H, Wu Z, Hu Y, Jiang K, Shen P, Ma C, Guan Z, Zhang Y, Ma J, Shang N, Yan G, Wang Z, Dai G
Toxicology and applied pharmacology 2017 Jul 15;327:1-12

AG1296 enhances plaque stability via inhibiting inflammatory responses and decreasing MMP-2 and MMP-9 expression in ApoE-/- mice.

Dong M, Zhou C, Ji L, Pan B, Zheng L
Biochemical and biophysical research communications 2017 Aug 5;489(4):426-431

Ezrin contributes to cervical cancer progression through induction of epithelial-mesenchymal transition.

Kong J, Di C, Piao J, Sun J, Han L, Chen L, Yan G, Lin Z
Oncotarget 2016 Apr 12;7(15):19631-42

Norcantharidin enhances TIMP‑2 anti‑vasculogenic mimicry activity for human gallbladder cancers through downregulating MMP‑2 and MT1‑MMP.

Zhu W, Sun W, Zhang JT, Liu ZY, Li XP, Fan YZ
International journal of oncology 2015 Feb;46(2):627-40

Intermittent cold stress enhances features of atherosclerotic plaque instability in apolipoprotein E‑deficient mice.

Zheng X, Wang Q, Zhang Y, Yang D, Li D, Tang B, Li X, Yang Y, Ma S
Molecular medicine reports 2014 Oct;10(4):1679-84

Kallistatin, a novel anti-angiogenesis agent, inhibits angiogenesis via inhibition of the NF-κB signaling pathway.

Huang KF, Huang XP, Xiao GQ, Yang HY, Lin JS, Diao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2014 May;68(4):455-61

Expression of the tissue inhibitor of metalloproteinase-3 by transplanted VSMCs modifies heart structure and function after myocardial infarction.

Jia ZB, Tian H, Kang K, Miao HZ, Liu KY, Jiang SL, Wang LP
Transplant immunology 2014 May;30(4):149-58

Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K/MMPs/Ln-5γ2 signaling pathway.

Zhang JT, Sun W, Zhang WZ, Ge CY, Liu ZY, Zhao ZM, Lu XS, Fan YZ
BMC cancer 2014 Mar 15;14:193

Genistein reinforces the inhibitory effect of Cisplatin on liver cancer recurrence and metastasis after curative hepatectomy.

Chen P, Hu MD, Deng XF, Li B
Asian Pacific journal of cancer prevention : APJCP 2013;14(2):759-64

Clinical study of tumor angiogenesis and perfusion imaging using multi-slice spiral computed tomography for breast cancer.

Xu N, Lei Z, Li XL, Zhang J, Li C, Feng GQ, Li DN, Liu JY, Wei Q, Bian TT, Zou TY
Asian Pacific journal of cancer prevention : APJCP 2013;14(1):429-33

Molecular mechanism of inhibitory effects of CD59 gene on atherosclerosis in ApoE (-/-) mice.

Li B, Xu YJ, Chu XM, Gao MH, Wang XH, Nie SM, Yang F, Lv CY
Immunology letters 2013 Nov-Dec;156(1-2):68-81

Nodal promotes aggressive phenotype via Snail-mediated epithelial-mesenchymal transition in murine melanoma.

Fang R, Zhang G, Guo Q, Ning F, Wang H, Cai S, Du J
Cancer letters 2013 Jun 1;333(1):66-75

Establishment of a new representative model of human ovarian cancer in mice.

Zhang J, Chen X, Shi G, Xie X, Liu H, Zhang X, Lai Y, Zuo Y, Chen Z, Liu S, Wang H
Journal of ovarian research 2013 Feb 6;6(1):9

Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet.

Jin F, Jiang S, Yang D, Zhang X, Yang Y, Zhang Y, Li K, Yang Y, Ma S
Biochemical and biophysical research communications 2012 Nov 9;428(1):86-92

Efficacy of intravitreal captopril on oxygen-induced retinopathy in mice.

Di Y, Zhang YO, Yang Y, Wang AY, Lu Y, Chen XL
International journal of ophthalmology 2011;4(4):361-4

Knockdown of ribonuclease inhibitor expression with siRNA in non-invasive bladder cancer cell line BIU-87 promotes growth and metastasis potentials.

Chen J, Ou-Yang X, Gao J, Zhu J, He X, Rong J
Molecular and cellular biochemistry 2011 Mar;349(1-2):83-95

Downregulation of Id1 by small interfering RNA in prostate cancer PC3 cells in vivo and in vitro.

Ling YX, Tao J, Fang SF, Hui Z, Fang QR
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2011 Jan;20(1):9-17

Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model.

Chen LX, He YJ, Zhao SZ, Wu JG, Wang JT, Zhu LM, Lin TT, Sun BC, Li XR
Cancer biology & therapy 2011 Jan 15;11(2):229-35

Expression of MMP, HPSE, and FAP in stroma promoted corneal neovascularization induced by different etiological factors.

Shi W, Liu J, Li M, Gao H, Wang T
Current eye research 2010 Nov;35(11):967-77

19-peptide, a fragment of tumstatin, inhibits the growth of poorly differentiated gastric carcinoma cells in vitro and in vivo.

He Y, Jiang Y, Li YJ, Liu XH, Zhang L, Liu LJ, Shi H, Li HN, Ma YC, Jin XM
Journal of gastroenterology and hepatology 2010 May;25(5):935-41

Antitumor and antimetastatic activities of Rhizoma Paridis saponins.

Man S, Gao W, Zhang Y, Yan L, Ma C, Liu C, Huang L
Steroids 2009 Nov-Dec;74(13-14):1051-6

Cyclophosphamide promotes pulmonary metastasis on mouse lung adenocarcinoma.

Man S, Zhang Y, Gao W, Yan L, Ma C
Clinical & experimental metastasis 2008;25(8):855-64

Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma.

Zhang S, Li M, Gu Y, Liu Z, Xu S, Cui Y, Sun B
Journal of experimental & clinical cancer research : CR 2008 Nov 4;27(1):60

Tanshinone IIA inhibits atherosclerotic plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet.

Fang ZY, Lin R, Yuan BX, Liu Y, Zhang H
Life sciences 2007 Oct 13;81(17-18):1339-45

HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma.

Xu J, Xu HY, Zhang Q, Song F, Jiang JL, Yang XM, Mi L, Wen N, Tian R, Wang L, Yao H, Feng Q, Zhang Y, Xing JL, Zhu P, Chen ZN
Molecular cancer research : MCR 2007 Jun;5(6):605-14

Total saponins of Panax notoginseng protected rabbit iliac artery against balloon endothelial denudation injury.

Chen SW, Li XH, Ye KH, Jiang ZF, Ren XD
Acta pharmacologica Sinica 2004 Sep;25(9):1151-6

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Submitted by: Boster Biological Technology (provider)
Main image
Experimental details: Western blot analysis of MMP2 expression in (1)L6 cell lysate;(2)HeLa cell lysate.
Additional image