Antibody data

Product number
Ab115657 - Provider product page
Provider
Aladdin Scientific
Product name
MMP2 Mouse mAb
Antibody type
Monoclonal
Description
Mouse anti Human MMP2 Antibody, Monoclonal (C1), could be used for WB, IHC and so on. Application: WB: 0.5-2µg/mL IHC: 5-20µg/mL Protein Function Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly--Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.
Reactivity
Human, Mouse, Rat
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
AA 110-660
Antibody clone number
C1
Vial size
100_l,10_l,1ml,20_l,50_l
Concentration
Lot by Lot
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (12 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
MMP2 protein structure - Ab115657 shown in red.