DPAB-DC1273

SENP6 antibody from Creative Diagnostics
KIAA0797, SUSP1
Western blot
Recommended by provider
ELISA
Recommended by provider

Antibody data

Product number
DPAB-DC1273
Provider
Creative Diagnostics
Proper citation
Creative Diagnostics Cat#DPAB-DC1273, RRID:AB_2498612
Product name
Anti-SENP6 (aa 1-110) polyclonal antibody
Provider product page
Creative Diagnostics - DPAB-DC1273
Antibody type
Polyclonal
Description
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Vial size
50  ml
Storage
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Handling
The antibody solution should be gently mixed before use.
Provider Type Product Number
- No reagents -