13393-1-AP

antibody from Proteintech Group

Targeting: PTGS1 COX1, PGHS-1, PTGHS

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

13393-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#13393-1-AP, RRID:AB_10644323

Product name

COX-1/Cyclooxygenase-1 antibody

Antibody type

Polyclonal

Description

COX-1/Cyclooxygenase-1 antibody (Cat. #13393-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

ACSL1 Contributes to Metabolic-Associated Fatty Liver Disease by Mediating Arachidonic Acid Metabolism.

Tan M, Zhou Z, Peng C, Ke X, Long Q, Huang K
Lipids 2026 Mar;61(2):175-185

---

FADS1 contributes to anesthesia/surgery-induced cognitive impairment by aggravating omega-6 fatty acid metabolic disruption in aged mice.

Chen Z, Wu Q, Ma J, Shi Y, Zhang Q, Wu H, Zhang Y, Li Z, Ruan X, Xiong L, Cong P, Tian L
Journal of neuroinflammation 2026 Feb 11;23(1)

---

Platelet-derived microvesicles modulate the bioenergetic and inflammatory phenotype of human polymorphonuclear leukocytes.

Soucy MN, Hébert MPA, Doiron JA, Barnett DA, Lamarre SG, Hebert-Chatelain E, Boudreau LH
Journal of leukocyte biology 2025 Sep 1;117(9)

---

Iron overload exaggerates renal ischemia-reperfusion injury by promoting tubular cuproptosis via interrupting function of LIAS.

Chen S, Chen T, Xu C, Yu X, Shi J, Yang C, Zhu T
Redox biology 2025 Oct;86:103795

---

The role of 12-lipoxygenase in regulating megakaryocyte maturation and platelet-like particles production.

Gauvin VL, Soucy MN, Richard JD, Graham KA, Matthew AJ, Hébert MPA, Doiron JA, Johnson M, Allain EP, Barnett DA, Turcotte S, Boudreau LH
Thrombosis research 2025 Oct;254:109445

---

Identification and verification of biomarkers associated with arachidonic acid metabolism in non-alcoholic fatty liver disease.

Li J, Su WW, Wang ZL, Ji XF, Wang JW, Wang K
Scientific reports 2025 Mar 12;15(1):8521

---

PINK1 affects mitochondrial oxidative phosphorylation by regulating MFN2 to alleviate diabetic kidney disease.

Pei X, Liu J, Wei Y, Zhu Y, Li Y, Wang Q, Zhuang L, Jin G
International immunopharmacology 2025 Jun 5;157:114786

---

KLF10 Induced by Hypothermic Machine Perfusion Alleviates Renal Inflammation Through BIRC2 /Noncanonical NF-κB Pathway.

Hu Q, Chen H, Lan J, Chen Y, Liu Z, Xiong Y, Zhou W, Zhong Z, Ye Q
Transplantation 2025 Jun 1;109(6):e273-e286

---

Qihuang Zhuyu formula modulates mitochondrial function to inhibit platelet activation via endocannabinoid signaling mediated by the SIRT1/PPARα pathway.

Shi R, Sun W, Yin S, Sun T, Yang N, Zhang H, Yao Y, Lai K, Chen X, Yu P
Journal of ethnopharmacology 2025 Feb 10;338(Pt 1):119006

---

Integrating Metabolomics and Network Analyses to Explore Mechanisms of Geum japonicum var. chinense Against Pulmonary Fibrosis: Involvement of Arachidonic Acid Metabolic Pathway.

Ran J, Wang Q, Lu T, Pang X, Liao S, He X
International journal of molecular sciences 2025 Feb 10;26(4)

---

Arachidonic acid enhances hepatocyte bile acid uptake and alleviates cholestatic liver disease by upregulating OATP1 expression.

Ma Y, Zou C, Yang Y, Fang M, Guan Y, Sun J, Gao Y, Shang Z, Zhang X
Food & function 2024 Sep 30;15(19):9916-9927

---

A splice-altering homozygous variant in COX18 causes severe sensory-motor neuropathy with oculofacial apraxia.

Mavillard F, Guerra-Castellano A, Guerrero-Gómez D, Rivas E, Cantero G, Servian-Morilla E, Folland C, Ravenscroft G, Martín MA, Miranda-Vizuete A, Cabrera-Serrano M, Diaz-Moreno I, Paradas C
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167330

---

m(6)A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1.

Xiao L, De Jesus DF, Ju CW, Wei JB, Hu J, DiStefano-Forti A, Tsuji T, Cero C, Männistö V, Manninen SM, Wei S, Ijaduola O, Blüher M, Cypess AM, Pihlajamäki J, Tseng YH, He C, Kulkarni RN
Cell metabolism 2024 Oct 1;36(10):2207-2227.e9

---

Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways.

Ni L, Zhu X, Zhao Q, Shen Y, Tao L, Zhang J, Lin H, Zhuge W, Cho YC, Cui R, Zhu W
Neoplasia (New York, N.Y.) 2024 May;51:100991

---

FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.

Kodavati M, Wang H, Guo W, Mitra J, Hegde PM, Provasek V, Rao VHM, Vedula I, Zhang A, Mitra S, Tomkinson AE, Hamilton DJ, Van Den Bosch L, Hegde ML
Nature communications 2024 Mar 9;15(1):2156

---

Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.

Li XQ, Cai MP, Wang MY, Shi BW, Yang GY, Wang J, Chu BB, Ming SL
Virologica Sinica 2024 Jun;39(3):403-413

---

Exposure to nicotine regulates prostaglandin E2 secretion and autophagy of granulosa cells to retard follicular maturation in mammals.

Zhou X, He Y, Quan H, Yang J, Li S, Jiang Y, Li J, Yuan X
Ecotoxicology and environmental safety 2024 Jun 1;277:116358

---

Aspirin modulates production of pro-inflammatory and pro-resolving mediators in endothelial cells.

Rood KM, Patel N, DeVengencie IM, Quinn JP, Gowdy KM, Costantine MM, Kniss DA
PloS one 2023;18(4):e0283163

---

Oryza sativa L. Indica Seed Coat Ameliorated Concanavalin A-Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways.

Zhao Z, Li Y, Guo S, Chen Y, Yin H, Li Y, Cheng G, Tian L
International journal of molecular sciences 2023 Sep 25;24(19)

---

Canine Gallbladder Erosion/Ulcer and Hemocholecyst: Clinicopathological Characteristics of 14 Cases.

Mitsui I, Uchida K
Animals : an open access journal from MDPI 2023 Oct 26;13(21)

---

Consumption of Nutritionally Enriched Hen Eggs Enhances Endothelium-Dependent Vasodilation via Cyclooxygenase Metabolites in Healthy Young People-A Randomized Study.

Šušnjara P, Mihaljević Z, Stupin A, Kolobarić N, Matić A, Jukić I, Kralik Z, Kralik G, Miloloža A, Pavošević T, Šerić V, Lončarić Z, Kerovec D, Galović O, Drenjančević I
Nutrients 2023 Mar 25;15(7)

---

Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.

Zheng M, Hu Z, Wang Y, Wang C, Zhong C, Cui W, You J, Gao B, Sun X, La L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154495

---

M2 Macrophage Membrane-Mediated Biomimetic-Nanoparticle Carrying COX-siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation.

Sun J, Ju F, Jin J, Wang HL, Li ZJ, Sun YC, Chen QZ, Yang QQ, Tan J, Zhou YL
Small (Weinheim an der Bergstrasse, Germany) 2023 Aug;19(33):e2300326

---

PET117 assembly factor stabilizes translation activator TACO1 thereby upregulates mitochondria-encoded cytochrome C oxidase 1 synthesis.

Sun Q, Shi L, Li S, Li J, Zhang R, Huang X, Shao Y, Feng Z, Peng Y, Yang Z, Liu J, Liu H, Long J
Free radical biology & medicine 2023 Aug 20;205:13-24

---

Glucose Starvation Inhibits Ferroptosis by Activating the LKB1/AMPK Signaling Pathway and Promotes the High Speed Linear Motility of Dairy Goat Sperm.

Li Y, Zhang G, Wen F, Xian M, Guo S, Zhang X, Feng X, Hu Z, Hu J
Animals : an open access journal from MDPI 2023 Apr 23;13(9)

---

Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control.

Wu M, Zhao A, Yan X, Gao H, Zhang C, Liu X, Luo Q, Xie F, Liu S, Shi D
eLife 2022 Sep 26;11

---

Morphological changes of macrophages and their potential contribution to tendon healing.

Yang QQ, Zhang L, Zhou YL, Tang JB
Colloids and surfaces. B, Biointerfaces 2022 Jan;209(Pt 1):112145

---

Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage.

Bakalarz D, Surmiak M, Yang X, Wójcik D, Korbut E, Śliwowski Z, Ginter G, Buszewicz G, Brzozowski T, Cieszkowski J, Głowacka U, Magierowska K, Pan Z, Wang B, Magierowski M
Acta pharmaceutica Sinica. B 2021 Feb;11(2):456-475

---

Angiotensin II type 1 receptor is involved in flow-induced vasomotor responses of isolated middle cerebral arteries: role of oxidative stress.

Jukic I, Mihaljevic Z, Matic A, Mihalj M, Kozina N, Selthofer-Relatic K, Mihaljevic D, Koller A, Tartaro Bujak I, Drenjancevic I
American journal of physiology. Heart and circulatory physiology 2021 Apr 1;320(4):H1609-H1624

---

Arachidonic Acid Metabolites of CYP450 Enzymes and HIF-1α Modulate Endothelium-Dependent Vasorelaxation in Sprague-Dawley Rats under Acute and Intermittent Hyperbaric Oxygenation.

Mihaljević Z, Matić A, Stupin A, Frkanec R, Tavčar B, Kelava V, Tartaro Bujak I, Kolobarić N, Kibel A, Drenjančević I
International journal of molecular sciences 2020 Sep 1;21(17)

---

Evidence for Cytoprotective Effect of Carbon Monoxide Donor in the Development of Acute Esophagitis Leading to Acute Esophageal Epithelium Lesions.

Magierowska K, Bakalarz D, Wójcik D, Korbut E, Danielak A, Głowacka U, Pajdo R, Buszewicz G, Ginter G, Surmiak M, Kwiecień S, Chmura A, Magierowski M, Brzozowski T
Cells 2020 May 12;9(5)

---

COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria.

Pacheu-Grau D, Wasilewski M, Oeljeklaus S, Gibhardt CS, Aich A, Chudenkova M, Dennerlein S, Deckers M, Bogeski I, Warscheid B, Chacinska A, Rehling P
Journal of molecular biology 2020 Mar 27;432(7):2067-2079

---

Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease.

Zhao J, Gao W, Cai X, Xu J, Zou D, Li Z, Hu B, Zheng Y
Theranostics 2019;9(10):2843-2855

---

Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb.

Yu HH, Lin Y, Zeng R, Li X, Zhang T, Tasneem S, Chen C, Qiu YX, Li B, Liao J, Wang YH, Cai X, Wang W
Journal of ethnopharmacology 2019 Jun 28;238:111902

---

Ginsenoside metabolite compound K exerts anti-inflammatory and analgesic effects via downregulating COX2.

Chen J, Si M, Wang Y, Liu L, Zhang Y, Zhou A, Wei W
Inflammopharmacology 2019 Feb;27(1):157-166

---

Localized delivery of miRNAs targets cyclooxygenases and reduces flexor tendon adhesions.

Zhou YL, Yang QQ, Yan YY, Zhu C, Zhang L, Tang JB
Acta biomaterialia 2018 Apr 1;70:237-248

---

MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.

Aras S, Bai M, Lee I, Springett R, Hüttemann M, Grossman LI
Mitochondrion 2015 Jan;20:43-51

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse lung tissue were subjected to SDS PAGE followed by western blot with 13393-1-AP(PTGS1 antibody) at dilution of 1:200

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human stomach using 13393-1-AP(PTGS1 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The COX-1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human COX-1. This antibody recognizes human,mouse,rat antigen. The COX-1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

13393-1-AP.pdf

Show more