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- Antibody Data
- Antigen structure
- References [333]
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- Western blot [1]
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- Immunohistochemistry [2]
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- Product number
- 12375-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12375-1-AP, RRID:AB_2085127
- Product name
- COX2/ Cyclooxygenase 2/ PTGS2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated COX2/ Cyclooxygenase 2/ PTGS2 antibody (Cat. #12375-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Echinatin attenuates acute lung injury and inflammatory responses via TAK1-MAPK/NF-κB and Keap1-Nrf2-HO-1 signaling pathways in macrophages.
Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin's neuroprotective action against diabetes-induced cognitive impairment.
Epigallocatechin-3-gallate confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis, apoptosis, and autophagy via modulation of 14-3-3η.
YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes.
3D Printing of a Vascularized Mini-Liver Based on the Size-Dependent Functional Enhancements of Cell Spheroids for Rescue of Liver Failure.
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3.
Chondroprotective effects of Apolipoprotein D in knee osteoarthritis mice through the PI3K/AKT/mTOR signaling pathway.
Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer.
Resveratrol-loaded sulfated Hericium erinaceus β-glucan-chitosan nanoparticles: Preparation, characterization and synergistic anti-inflammatory effects.
Glycyrrhizin regulates antioxidation through Nrf2 signaling pathway in rat temporomandibular joint osteoarthritis.
Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.
Quercetin-3-O-β-D-glucuronide attenuates osteoarthritis by inhibiting cartilage extracellular matrix degradation and inflammation.
Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway.
Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora.
COX-2/sEH-Mediated Macrophage Activation Is a Target for Pulmonary Protection in Mouse Models of Chronic Obstructive Pulmonary Disease.
Potential Impact of Hypoxic Astrocytes on the Aggravation of Depressive Symptoms in Parkinson's Disease.
Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury.
Gut microbiota regulates the ALK5/NOX1 axis by altering glutamine metabolism to inhibit ferroptosis of intrahepatic cholangiocarcinoma cells.
Addition of α-synuclein aggregates to the intestinal environment recapitulates Parkinsonian symptoms in model systems.
Ultrasound Nanobubble Coupling Agent for Effective Noninvasive Deep-Layer Drug Delivery.
PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway.
Danggui-Shaoyao-San (DSS) ameliorates the progression of osteoarthritis via suppressing the NF-κB signaling pathway: an in vitro and in vivo study combined with bioinformatics analysis.
Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities.
Gypenoside XLIX attenuates sepsis-induced splenic injury through inhibiting inflammation and oxidative stress.
Penicimides A and B, two novel diels-alder [4 + 2] cycloaddition ergosteroids from Penicillium herquei.
Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.
Calcitriol promotes M2 polarization of tumor-associated macrophages in 4T1 mouse mammary gland cancer via the induction of proinflammatory cytokines.
Inhibition of LSD1 via SP2509 attenuated the progression of rheumatoid arthritis.
Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells.
Single‐cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitis.
Asiaticoside ameliorates DSS-induced colitis in mice by inhibiting inflammatory response, protecting intestinal barrier and regulating intestinal microecology.
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene.
Quercetin alleviates hyperoxia-induced bronchopulmonary dysplasia by inhibiting ferroptosis through the MAPK/PTGS2 pathway: Insights from network pharmacology, molecular docking, and experimental evaluations.
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Transgenic human C-reactive protein affects oxidative stress but not inflammation biomarkers in the aorta of spontaneously hypertensive rats.
Network Pharmacology Analysis and Machine-Learning Models Confirmed the Ability of YiShen HuoXue Decoction to Alleviate Renal Fibrosis by Inhibiting Pyroptosis.
The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.
Exploring Dysregulated Ferroptosis-Related Genes in Septic Myocardial Injury Based on Human Heart Transcriptomes: Evidence and New Insights.
Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling.
Selenomethionine against titanium particle-induced osteolysis by regulating the ROS-dependent NLRP3 inflammasome activation via the β-catenin signaling pathway.
rhFGF-21 accelerates corneal epithelial wound healing through the attenuation of oxidative stress and inflammatory mediators in diabetic mice.
Liensinine pretreatment reduces inflammation, oxidative stress, apoptosis, and autophagy to alleviate sepsis acute kidney injury.
PPM1K mediates metabolic disorder of branched-chain amino acid and regulates cerebral ischemia-reperfusion injury by activating ferroptosis in neurons.
Novel molecule BBC0901 inhibits BRD4 and acts as a catabolic regulator in the pathogenesis of osteoarthritis.
Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1.
Baicalein Attenuates Neuroinflammation in LPS-Treated BV-2 Cells by Inhibiting Glycolysis via STAT3/c-Myc Pathway.
Role of dysregulated ferroptosis‑related genes in cardiomyocyte ischemia‑reperfusion injury: Experimental verification and bioinformatics analysis.
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-κB pathway and activation Nrf2 pathway in macrophages.
Pachymic acid suppresses the inflammatory response of chondrocytes and alleviates the progression of osteoarthritis via regulating the Sirtuin 6/NF-κB signal axis.
B7H3 increases ferroptosis resistance by inhibiting cholesterol metabolism in colorectal cancer.
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.
Kaempferol Improves Breast Cancer-Related Depression through the COX-2/PGE2 Pathway.
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells.
Elsholtzia bodinieri Vaniot ameliorated acute lung injury in mice by regulating pyroptosis, inflammation, oxidative stress and macrophage polarization.
PPAR-γ Agonist GW1929 Targeted to Macrophages with Dendrimer-Graphene Nanostars Reduces Liver Fibrosis and Inflammation.
Lnc-17Rik promotes the immunosuppressive function of Myeloid-Derived suppressive cells in esophageal cancer.
Consumption of Nutritionally Enriched Hen Eggs Enhances Endothelium-Dependent Vasodilation via Cyclooxygenase Metabolites in Healthy Young People-A Randomized Study.
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment.
Ent-kauranes and ent-atisanes from Euphorbia wallichii and their anti-inflammatory activity.
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway.
Network Pharmacology Prediction and Experimental Verification for Anti-Ferroptosis of Edaravone After Experimental Intracerebral Hemorrhage.
Long non-coding RNA PVT1 regulates atherosclerosis progression via the microRNA-106b-5p/ACSL4 axis.
Pien Tze Huang attenuated acetaminophen-induced liver injury by autophagy mediated-NLRP3 inflammasome inhibition.
Low-Dose Sodium Salicylate Promotes Ovulation by Regulating Steroids via CYP17A1.
Antidepression of Xingpijieyu formula targets gut microbiota derived from depressive disorder.
Iso-seco-tanapartholide induces p62 covalent oligomerization to activate KEAP1-NRF2 redox pathway in rheumatoid arthritis.
Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury.
The Possibility of IPC to Prevent Ischemic-Reperfusion Injury in Skeletal Muscle in a Rat.
Bisphenol A induced neuronal apoptosis and enhanced autophagy in vitro through Nrf2/HO-1 and Akt/mTOR pathways.
Ginsenoside Rb1 protects hippocampal neurons in depressed rats based on mitophagy-regulated astrocytic pyroptosis.
The ethanol extract of Scutellaria baicalensis Georgi attenuates complete Freund's adjuvant (CFA)-induced inflammatory pain by suppression of P2X3 receptor.
Anti-inflammatory iridoid glycosides from Paederia scandens (Lour.) Merrill.
Role of omentin-1 in susceptibility to anxiety and depression like behaviors.
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Altered trafficking of miRNAs at mitochondria modulates mitochondrial functions and cell death in brain ischemia.
Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma.
Inhibition effect of 1-acetoxy-6α-(2-methylbutyryl)eriolanolide toward soluble epoxide hydrolase: Multispectral analysis, molecular dynamics simulation, biochemical, and in vitro cell-based studies.
Synergistic effect of constituent drugs of Baibutang on improving Yin-deficiency pulmonary fibrosis in rats.
Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer.
1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model.
Experimental Periodontitis Deteriorates Cognitive Function and Impairs Insulin Signaling in a Streptozotocin-Induced Alzheimer's Disease Rat Model.
Betaine Inhibits NLRP3 Inflammasome Hyperactivation and Regulates Microglial M1/M2 Phenotypic Differentiation, Thereby Attenuating Lipopolysaccharide-Induced Depression-Like Behavior.
LXR agonist inhibits inflammation through regulating MyD88 mRNA alternative splicing.
Mechanism of Tripterygium wilfordii Hook.F.- Trichosanthes kirilowii Maxim decoction in treatment of diabetic kidney disease based on network pharmacology and molecular docking.
Inhibition of fucosylation by 2-fluorofucose attenuated acetaminophen-induced liver injury via its anti-inflammation and anti-oxidative stress effects.
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Dehydrocostus Lactone Suppresses Dextran Sulfate Sodium-Induced Colitis by Targeting the IKKα/β-NF-κB and Keap1-Nrf2 Signalling Pathways.
Naoluo Xintong Decoction in the Treatment of Ischemic Stroke: A Network Analysis of the Mechanism of Action.
PLA2G6 Silencing Suppresses Melanoma Progression and Affects Ferroptosis Revealed by Quantitative Proteomics.
Serum-derived exosomes from SD rats induce inflammation in macrophages through the mTOR pathway.
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.
Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control.
Quercetin in Tonglong Qibi decoction ameliorates testosterone-induced benign prostatic hyperplasia in rats by regulating Nrf2 signalling pathways and oxidative stress.
BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency.
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes.
Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling.
Orally Administered Ginkgolide C Attenuates DSS-Induced Colitis by Maintaining Gut Barrier Integrity, Inhibiting Inflammatory Responses, and Regulating Intestinal Flora.
Recombinant porcine beta defensin 2 alleviates inflammatory responses induced by Escherichia coli in IPEC-J2 cells.
Preconception exposure to dibutyl phthalate (DBP) impairs spermatogenesis by activating NF-κB/COX-2/RANKL signaling in Sertoli cells.
Induction of COX-2 by feline calicivirus via activation of the MEK1-ERK1/2 pathway, and attenuation of feline lung inflammation and injury by MEK1 inhibitor AZD6244 (selumetinib).
Neutrophil membrane-mimicking nanodecoys with intrinsic anti-inflammatory properties alleviate sepsis-induced acute liver injury and lethality in a mouse endotoxemia model.
Lipoxin A(4) and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.
Zuojin Pill attenuates Helicobacter pylori-induced chronic atrophic gastritis in rats and improves gastric epithelial cells function in GES-1 cells.
Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization.
Methionine strengthens anti-inflammation of rice protein via depressing NF-κB activation and stimulating Msr expression in rats fed cholesterol-enriched diets.
DEHP induces ferroptosis in testes via p38α-lipid ROS circulation and destroys the BTB integrity.
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2.
Effects of black tea and black brick tea with fungal growth on lowering uric acid levels in hyperuricemic mice.
Construction and comprehensive analysis of a lncRNA-mRNA interactive network to reveal a potential lncRNA for hepatic encephalopathy development.
Cortistatin attenuates titanium particle-induced osteolysis through regulation of TNFR1-ROS-caspase-3 signaling in osteoblasts.
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR.
Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrin α5.
Efficacy of auranofin as an inhibitor of desmoid progression.
Synthesis compound XCR-7a ameliorates LPS-induced inflammatory response by inhibiting the phosphorylation of c-Fos.
Effect of oridonin on oxylipins in the livers of mice with acute liver injury induced by D-galactosamine and lipopolysaccharide.
Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer.
Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells.
Evaluation of the therapeutic efficacy of human bone marrow mesenchymal stem cells with COX-2 silence and TGF-β3 overexpression in rabbits with antigen-induced arthritis.
Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice.
TNF signaling pathway-mediated microglial activation in the PFC underlies acute paradoxical sleep deprivation-induced anxiety-like behaviors in mice.
Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading.
Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury.
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.
METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice.
Multi-omics profiling reveals Chitinase-3-like protein 1 as a key mediator in the crosstalk between sarcopenia and liver cancer.
L-Methionine inhibits 4-hydroxy-2-nonenal accumulation and suppresses inflammation in growing rats.
Elsholtzia bodinieri Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses.
Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis.
Contribution of cyclooxygenase-2 overexpression to enhancement in tonically active glutamatergic inputs to the rostral ventrolateral medulla in hypertension.
The effects of Jiawei Duhuo Jisheng mixture on Wnt/β-catenin signaling pathway in the synovium inflamed by knee osteoarthritis: An in vitro and in vivo experiment.
Rice protein suppresses 4-hydroxy-2-nonenal-induced inflammation owing to methionine availability.
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Mechanism exploration of ancient pharmaceutic processing (Paozhi) improving the gastroprotective efficacy of Aucklandiae Radix.
Ferroptosis is involved in PGPS-induced otitis media in C57BL/6 mice.
Harmine Alleviated Sepsis-Induced Cardiac Dysfunction by Modulating Macrophage Polarization via the STAT/MAPK/NF-κB Pathway.
Tributyltin Oxide Exposure During in vitro Maturation Disrupts Oocyte Maturation and Subsequent Embryonic Developmental Competence in Pigs.
Periodontitis Deteriorates Cognitive Function and Impairs Neurons and Glia in a Mouse Model of Alzheimer's Disease.
Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD.
Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.
GPX4-Regulated Ferroptosis Mediates S100-Induced Experimental Autoimmune Hepatitis Associated with the Nrf2/HO-1 Signaling Pathway.
A Novel Hydrogen Sulfide Donor Reduces Pilocarpine-Induced Status Epilepticus and Regulates Microglial Inflammatory Profile.
Active-Ingredient Screening and Synergistic Action Mechanism of Shegan Mixture for Anti-Asthma Effects Based on Network Pharmacology in a Mouse Model of Asthma.
Activation of α7nAChR Protects Against Gastric Inflammation and Dysmotility in Parkinson's Disease Rats.
Berberine Improves Irinotecan-Induced Intestinal Mucositis Without Impairing the Anti-colorectal Cancer Efficacy of Irinotecan by Inhibiting Bacterial β-glucuronidase.
Pseudomonas aeruginosa PcrV Enhances the Nitric Oxide-Mediated Tumoricidal Activity of Tumor-Associated Macrophages via a TLR4/PI3K/AKT/mTOR-Glycolysis-Nitric Oxide Circuit.
Targeting cancer cell plasticity by HDAC inhibition to reverse EBV-induced dedifferentiation in nasopharyngeal carcinoma.
Circulating prostaglandin E(2): a novel potential prognostic biomarker in patients with hepatocellular carcinoma.
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
PARP-1 involves in UVB-induced inflammatory response in keratinocytes and skin injury via regulation of ROS-dependent EGFR transactivation and p38 signaling.
Micro-RNA miR-542-3p suppresses decidualization by targeting ILK pathways in human endometrial stromal cells.
Inhibition of chikusetsusaponin IVa on inflammatory responses in RAW264.7 cell line via MAPK pathway.
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway.
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury.
Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.
Effects of medicine food Fructus Gardeniae on liver and kidney functions after oral administration to rats for 12 weeks.
α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice.
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Echinacea polysaccharide attenuates lipopolysaccharide‑induced acute kidney injury via inhibiting inflammation, oxidative stress and the MAPK signaling pathway.
Myricetin ameliorates sepsis-associated acute lung injury in a murine sepsis model.
Maltol prevents the progression of osteoarthritis by targeting PI3K/Akt/NF-κB pathway: In vitro and in vivo studies.
Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation.
miR-34a-5p up-regulates the IL-1β/COX2/PGE2 inflammation pathway and induces the release of CGRP via inhibition of SIRT1 in rat trigeminal ganglion neurons.
Pro-Inflammatory Effects of Indoxyl Sulfate in Mice: Impairment of Intestinal Homeostasis and Immune Response.
BML-111, the lipoxin A(4) agonist, modulates VEGF or CoCl(2)-induced migration, angiogenesis and permeability in tumor-derived endothelial cells.
Annexin A1 Attenuates Neutrophil Migration and IL-6 Expression through Fpr2 in a Mouse Model of Streptococcus suis-Induced Meningitis.
Compound Kushen Injection intervenes metabolic reprogramming and epithelial-mesenchymal transition of HCC via regulating β-catenin/c-Myc signaling.
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells.
The expression profile and bioinformatics analysis of microRNAs in human bronchial epithelial cells treated by beryllium sulfate.
Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis.
Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues.
Angiotensin II type 1 receptor is involved in flow-induced vasomotor responses of isolated middle cerebral arteries: role of oxidative stress.
Chronic intermittent hypoxia vs chronic continuous hypoxia: Effects on vascular endothelial function and myocardial contractility.
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-κB Pathway.
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
Phenylethanol Glycosides Protect Myocardial Hypertrophy Induced by Abdominal Aortic Constriction via ECE-1 Demethylation Inhibition and PI3K/PKB/eNOS Pathway Enhancement.
miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition.
Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo.
A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation.
Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies.
Arachidonic Acid Metabolites of CYP450 Enzymes and HIF-1α Modulate Endothelium-Dependent Vasorelaxation in Sprague-Dawley Rats under Acute and Intermittent Hyperbaric Oxygenation.
Simvastatin Improves Behavioral Disorders and Hippocampal Inflammatory Reaction by NMDA-Mediated Anti-inflammatory Function in MPTP-Treated Mice.
TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice.
Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.
The TGF-β1/COX-2-dependant pathway serves a key role in the generation of OKC-induced M2-polarized macrophage-like cells and angiogenesis.
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
(-)-Hydroxycitric Acid Alleviates Oleic Acid-Induced Steatosis, Oxidative Stress, and Inflammation in Primary Chicken Hepatocytes by Regulating AMP-Activated Protein Kinase-Mediated Reactive Oxygen Species Levels.
OPA1 and MICOS Regulate mitochondrial crista dynamics and formation.
Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
Inhibitory Effects of Bound Polyphenol from Foxtail Millet Bran on Colitis-Associated Carcinogenesis by the Restoration of Gut Microbiota in a Mice Model.
Hispidulin Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia and Attenuates the Activation of Akt, NF-κB, and STAT3 Pathway.
The Activation of Heat-Shock Protein After Copper(II) and/or Arsenic(III)-Induced Imbalance of Homeostasis, Inflammatory Response in Chicken Rectum.
MGP Promotes Colon Cancer Proliferation by Activating the NF-κB Pathway through Upregulation of the Calcium Signaling Pathway.
10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells.
miR-211-5p alleviates focal cerebral ischemia-reperfusion injury in rats by down-regulating the expression of COX2.
Resveratrol slows the tumourigenesis of pancreatic cancer by inhibiting NFκB activation.
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload.
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Karyopherin α 2 promotes proliferation, migration and invasion through activating NF-κB/p65 signaling pathways in melanoma cells.
Baicalein attenuates the neuroinflammation in LPS-activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2/NF-κB expressions and regulation of metabolic abnormality.
Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1/2 in polycystic ovary syndrome.
Elevated levels of arachidonic acid metabolites in follicular fluid of PCOS patients.
MiRNA-192-5p attenuates airway remodeling and autophagy in asthma by targeting MMP-16 and ATG7.
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Autotaxin stimulates LPA2 receptor in macrophages and exacerbates dextran sulfate sodium-induced acute colitis.
Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.
Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer.
Protective effect of hydroxysafflor yellow A on dopaminergic neurons against 6-hydroxydopamine, activating anti-apoptotic and anti-neuroinflammatory pathways.
Analysis of Cyclooxygenase 2, Programmed Cell Death Ligand 1, and Arginase 1 Expression in Human Pituitary Adenoma.
Arsenic nano complex induced degradation of YAP sensitized ESCC cancer cells to radiation and chemotherapy.
Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice.
Inhibitory Effects of Peroxidase from Foxtail Millet Bran on Colitis-Associated Colorectal Carcinogenesis by the Blockage of Glycerophospholipid Metabolism.
Anti-inflammatory effect of Ganluyin, a Chinese classic prescription, in chronic pharyngitis rat model.
Berberine combined with cyclosporine A alleviates acute graft-versus-host disease in murine models.
Wogonoside inhibits inflammatory cytokine production in lipopolysaccharide-stimulated macrophage by suppressing the activation of the JNK/c-Jun signaling pathway.
4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease.
Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease.
C-Phycocyanin Alleviates Bladder Inflammation and Dysfunction in Cyclophosphamide-Induced Cystitis in a Mouse Model by Inhibiting COX-2 and EP4.
Role of Antioxidants in the Protection from Aging-Related Diseases.
Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression.
Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice.
Neferine Attenuates Acute Kidney Injury by Inhibiting NF-κB Signaling and Upregulating Klotho Expression.
TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats.
Melatonin inhibits lung metastasis of gastric cancer in vivo.
Pentamidine protects mice from cecal ligation and puncture-induced brain damage via inhibiting S100B/RAGE/NF-κB.
Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways.
Dioscin attenuates Bleomycin-Induced acute lung injury via inhibiting the inflammatory response in mice.
Therapeutic effect of yttrium oxide nanoparticles for the treatment of fulminant hepatic failure.
Dehydroepiandrosterone alleviates E. Coli O157:H7-induced inflammation by preventing the activation of p38 MAPK and NF-κB pathways in mice peritoneal macrophages.
Polysaccharides isolated from Nostoc commune Vaucher inhibit colitis-associated colon tumorigenesis in mice and modulate gut microbiota.
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic agent-damaged mitosis.
SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia.
β-arrestin 2 negatively regulates NOD2 signalling pathway through association with TRAF6 in microglia after cerebral ischaemia/reperfusion injury.
Nano hydroxyapatite induces glioma cell apoptosis by suppressing NF-κB signaling pathway.
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways.
Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis.
Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb.
BG-4 from Bitter Gourd (Momordica charantia) Differentially Affects Inflammation In Vitro and In Vivo.
Clearance of apoptotic cells by mesenchymal stem cells contributes to immunosuppression via PGE2.
Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway.
The profiling of bioactives in Akebia trifoliata pericarp and metabolites, bioavailability and in vivo anti-inflammatory activities in DSS-induced colitis mice.
Melatonin therapy protects against renal injury before and after release of bilateral ureteral obstruction in rats.
Endothelial cell transient receptor potential channel C5 (TRPC5) is essential for endothelium-dependent contraction in mouse carotid arteries.
Semaphoring 4D is required for the induction of antioxidant stress and anti-inflammatory effects of dihydromyricetin in colon cancer.
MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4.
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Trans-10-hydroxy-2-decenoic acid alleviates LPS-induced blood-brain barrier dysfunction by activating the AMPK/PI3K/AKT pathway.
Total flavonoids from sea buckthorn ameliorates lipopolysaccharide/cigarette smoke-induced airway inflammation.
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
MicroRNA-204-5p suppresses IL6-mediated inflammatory response and chemokine generation in HK-2 renal tubular epithelial cells by targeting IL6R.
ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS.
High Concentration of Aspirin Induces Apoptosis in Rat Tendon Stem Cells via Inhibition of the Wnt/β-Catenin Pathway.
Flavonoid-Rich Ethanol Extract from the Leaves of Diospyros kaki Attenuates D-Galactose-Induced Oxidative Stress and Neuroinflammation-Mediated Brain Aging in Mice.
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
Anti-Inflammatory and Antioxidant Effects of Kelong-Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats.
Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and Autophagy.
Combination Treatment of Icariin and L-DOPA Against 6-OHDA-Lesioned Dopamine Neurotoxicity.
GABAB receptor mediate hippocampal neuroinflammation in adolescent male and female mice after cold expose.
Impacts of simultaneous exposure to arsenic (III) and copper (II) on inflammatory response, immune homeostasis, and heat shock response in chicken thymus.
HMGB1 knock-down promoting tumor cells viability and arrest pro-apoptotic proteins via Stat3/NFκB in HepG2 cells.
Enhancement of glyoxalase 1, a polyfunctional defense enzyme, by quercetin in the brain in streptozotocin-induced diabetic rats.
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity.
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Alterations of antioxidant indexes and inflammatory cytokine expression aggravated hepatocellular apoptosis through mitochondrial and death receptor-dependent pathways in Gallus gallus exposed to arsenic and copper.
Copper and arsenic-induced oxidative stress and immune imbalance are associated with activation of heat shock proteins in chicken intestines.
HPV16 E7 increases COX-2 expression and promotes the proliferation of breast cancer.
Peroxisome Proliferator-Activated Receptor (PPARγ) Plays a Protective Role in Cigarette Smoking-Induced Inflammation via AMP-Activated Protein Kinase (AMPK) Signaling.
Investigation of constituents from Cinnamomum camphora (L.) J. Presl and evaluation of their anti-inflammatory properties in lipopolysaccharide-stimulated RAW 264.7 macrophages.
Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis.
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.
Arachidonic acid induces macrophage cell cycle arrest through the JNK signaling pathway.
Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
Loganin prevents BV-2 microglia cells from Aβ(1-42) -induced inflammation via regulating TLR4/TRAF6/NF-κB axis.
Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress.
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.
Proteomic profiling of human decidual immune proteins during Toxoplasma gondii infection.
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.
Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.
Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity.
Localized delivery of miRNAs targets cyclooxygenases and reduces flexor tendon adhesions.
HPV16 E6 Promotes Breast Cancer Proliferation via Upregulation of COX-2 Expression.
Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra.
Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice.
Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice.
Copper or/and arsenic induce oxidative stress-cascaded, nuclear factor kappa B-dependent inflammation and immune imbalance, trigging heat shock response in the kidney of chicken.
Effect of ART1 on the proliferation and migration of mouse colon carcinoma CT26 cells in vivo.
EpCAM and COX‑2 expression are positively correlated in human breast cancer.
High soluble endoglin levels do not induce changes in structural parameters of mouse heart.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model.
Gx-50 reduces β-amyloid-induced TNF-α, IL-1β, NO, and PGE2 expression and inhibits NF-κB signaling in a mouse model of Alzheimer's disease.
Ibuprofen attenuates nephropathy in streptozotocin‑induced diabetic rats.
A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways.
The modulatory effect of anandamide on nitroglycerin-induced sensitization in the trigeminal system of the rat.
Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice.
Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth.
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study.
Cerebral ischemia increases bone marrow CD4+CD25+FoxP3+ regulatory T cells in mice via signals from sympathetic nervous system.
MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.
Potent effects of dioscin against obesity in mice.
Mangiferin attenuates renal fibrosis through down-regulation of osteopontin in diabetic rats.
Potent effects of the total saponins from Dioscorea nipponica Makino against streptozotocin-induced type 2 diabetes mellitus in rats.
Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice.
Anti-inflammation Effects of Oxysophoridine on Cerebral Ischemia-Reperfusion Injury in Mice.
Potent effects of dioscin against liver fibrosis.
Celecoxib ameliorates non-alcoholic steatohepatitis in type 2 diabetic rats via suppression of the non-canonical Wnt signaling pathway expression.
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells.
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats.
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation.
Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation.
Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.
Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
Akebia Saponin D attenuates amyloid β-induced cognitive deficits and inflammatory response in rats: involvement of Akt/NF-κB pathway.
Luo L, Wang H, Xiong J, Chen X, Shen X, Zhang H
PloS one 2024;19(5):e0303556
PloS one 2024;19(5):e0303556
Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin's neuroprotective action against diabetes-induced cognitive impairment.
Zheng Y, Wang C, Liu W, Chen J, Sun Y, Chang D, Wang H, Xu W, Lu JJ, Zhou X, Huang M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116579
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116579
Epigallocatechin-3-gallate confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis, apoptosis, and autophagy via modulation of 14-3-3η.
Hu T, Hu FJ, Huang H, Zhang ZY, Qiao YM, Huang WX, Wang YC, Tang XY, Lai SQ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116542
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116542
YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes.
Huang J, Wang X, Li N, Fan W, Li X, Zhou Q, Liu J, Li W, Zhang Z, Liu X, Zeng S, Yang H, Tian M, Yang P, Hou S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(19):e2308031
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(19):e2308031
3D Printing of a Vascularized Mini-Liver Based on the Size-Dependent Functional Enhancements of Cell Spheroids for Rescue of Liver Failure.
Zhang J, Chen X, Chai Y, Zhuo C, Xu Y, Xue T, Shao D, Tao Y, Li M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(17):e2309899
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(17):e2309899
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3.
Kundu A, Ghosh P, Bishayi B
International immunopharmacology 2024 May 30;133:112153
International immunopharmacology 2024 May 30;133:112153
Chondroprotective effects of Apolipoprotein D in knee osteoarthritis mice through the PI3K/AKT/mTOR signaling pathway.
Zhang G, Huang C, Wang R, Guo J, Qin Y, Lv S
International immunopharmacology 2024 May 30;133:112005
International immunopharmacology 2024 May 30;133:112005
Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer.
Hsieh MS, Ling HH, Setiawan SA, Hardianti MS, Fong IH, Yeh CT, Chen JH
Chemico-biological interactions 2024 May 25;395:111004
Chemico-biological interactions 2024 May 25;395:111004
Resveratrol-loaded sulfated Hericium erinaceus β-glucan-chitosan nanoparticles: Preparation, characterization and synergistic anti-inflammatory effects.
Zhang Z, Ge M, Wu D, Li W, Chen W, Liu P, Zhang H, Yang Y
Carbohydrate polymers 2024 May 15;332:121916
Carbohydrate polymers 2024 May 15;332:121916
Glycyrrhizin regulates antioxidation through Nrf2 signaling pathway in rat temporomandibular joint osteoarthritis.
Hu Z, Zhao J, Liu X, Li Y, Jiang H, Fang W, Long X
Journal of oral rehabilitation 2024 Mar;51(3):611-622
Journal of oral rehabilitation 2024 Mar;51(3):611-622
Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.
Yuan Q, Fang Y, Guo J, Zhang Z, Liao J, Kuang J
Toxicology and applied pharmacology 2024 Mar;484:116845
Toxicology and applied pharmacology 2024 Mar;484:116845
Quercetin-3-O-β-D-glucuronide attenuates osteoarthritis by inhibiting cartilage extracellular matrix degradation and inflammation.
Mao H, Feng Y, Feng J, Yusufu Y, Sun M, Yang L, Jiang Q
Journal of orthopaedic translation 2024 Mar;45:236-246
Journal of orthopaedic translation 2024 Mar;45:236-246
Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway.
Che J, Wang H, Dong J, Wu Y, Zhang H, Fu L, Zhang J
CNS neuroscience & therapeutics 2024 Mar;30(3):e14454
CNS neuroscience & therapeutics 2024 Mar;30(3):e14454
Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora.
Yang P, Huang S, Luo Z, Zhou S, Zhang C, Zhu Y, Yang J, Li L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116267
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116267
COX-2/sEH-Mediated Macrophage Activation Is a Target for Pulmonary Protection in Mouse Models of Chronic Obstructive Pulmonary Disease.
Duan JX, Guan XX, Cheng W, Deng DD, Chen P, Liu C, Zhou Y, Hammock BD, Yang HH
Laboratory investigation; a journal of technical methods and pathology 2024 Mar;104(3):100319
Laboratory investigation; a journal of technical methods and pathology 2024 Mar;104(3):100319
Potential Impact of Hypoxic Astrocytes on the Aggravation of Depressive Symptoms in Parkinson's Disease.
Peng Y, He J, Xiang H, Xie L, She J, Cheng D, Liu B, Hu J, Qian H
Journal of molecular neuroscience : MN 2024 Mar 5;74(1):28
Journal of molecular neuroscience : MN 2024 Mar 5;74(1):28
Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury.
Mohr ME, Li S, Trouten AM, Stairley RA, Roddy PL, Liu C, Zhang M, Sucov HM, Tao G
iScience 2024 Mar 15;27(3):109219
iScience 2024 Mar 15;27(3):109219
Gut microbiota regulates the ALK5/NOX1 axis by altering glutamine metabolism to inhibit ferroptosis of intrahepatic cholangiocarcinoma cells.
Zhang Q, Zhou J, Zhai D, Jiang Q, Yang M, Zhou M
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167152
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167152
Addition of α-synuclein aggregates to the intestinal environment recapitulates Parkinsonian symptoms in model systems.
Yang ZX, Zhang Y, Wang Q, Zhang L, Liu YF, Zhang Y, Ren Y, Zhou C, Gao HW, Zhang NX, Feng LY
Acta pharmacologica Sinica 2024 Jan;45(1):36-51
Acta pharmacologica Sinica 2024 Jan;45(1):36-51
Ultrasound Nanobubble Coupling Agent for Effective Noninvasive Deep-Layer Drug Delivery.
Han X, Wang F, Shen J, Chen S, Xiao P, Zhu Y, Yi W, Zhao Z, Cai Z, Cui W, Bai D
Advanced materials (Deerfield Beach, Fla.) 2024 Jan;36(3):e2306993
Advanced materials (Deerfield Beach, Fla.) 2024 Jan;36(3):e2306993
PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway.
Lv C, Zhou L, Meng Y, Yuan H, Geng J
Cellular signalling 2024 Jan;113:110974
Cellular signalling 2024 Jan;113:110974
Danggui-Shaoyao-San (DSS) ameliorates the progression of osteoarthritis via suppressing the NF-κB signaling pathway: an in vitro and in vivo study combined with bioinformatics analysis.
Chen S, Kang P, Zhao Z, Zhang H, Li J, Xu K, Gong D, Jiao F, Wang H, Zhang M
Aging 2024 Jan 8;16(1):648-664
Aging 2024 Jan 8;16(1):648-664
Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities.
Wang R, Zeng J, Chen L, Sun L, Wang Y, Xu J, He X
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117265
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117265
Gypenoside XLIX attenuates sepsis-induced splenic injury through inhibiting inflammation and oxidative stress.
Xu B, Yang R, Qiang J, Xu X, Zhou M, Ji X, Lu Y, Dong Z
International immunopharmacology 2024 Jan 25;127:111420
International immunopharmacology 2024 Jan 25;127:111420
Penicimides A and B, two novel diels-alder [4 + 2] cycloaddition ergosteroids from Penicillium herquei.
Deng M, Xiao Y, Wang S, Zhang M, Qiao Y, Huang S, Xie J, Zhou X
Bioorganic chemistry 2024 Feb;143:107025
Bioorganic chemistry 2024 Feb;143:107025
Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.
Brylka LJ, Alimy AR, Tschaffon-Müller MEA, Jiang S, Ballhause TM, Baranowsky A, von Kroge S, Delsmann J, Pawlus E, Eghbalian K, Püschel K, Schoppa A, Haffner-Luntzer M, Beech DJ, Beil FT, Amling M, Keller J, Ignatius A, Yorgan TA, Rolvien T, Schinke T
Bone research 2024 Feb 23;12(1):12
Bone research 2024 Feb 23;12(1):12
Calcitriol promotes M2 polarization of tumor-associated macrophages in 4T1 mouse mammary gland cancer via the induction of proinflammatory cytokines.
Stachowicz-Suhs M, Łabędź N, Anisiewicz A, Banach J, Kłopotowska D, Milczarek M, Piotrowska A, Dzięgiel P, Maciejczyk A, Matkowski R, Wietrzyk J
Scientific reports 2024 Feb 15;14(1):3778
Scientific reports 2024 Feb 15;14(1):3778
Inhibition of LSD1 via SP2509 attenuated the progression of rheumatoid arthritis.
Yu Z, Li P, Gao D, Hu Y, Xia F, Liu L, Liu J, Liu W, Zhang H
Immunologic research 2024 Aug;72(4):797-810
Immunologic research 2024 Aug;72(4):797-810
Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells.
Dai W, Xu B, Ding L, Zhang Z, Yang H, He T, Liu L, Pei X, Fu X
Free radical biology & medicine 2024 Aug 1;220:1-14
Free radical biology & medicine 2024 Aug 1;220:1-14
Single‐cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitis.
Liu J, Liao X, Li N, Xu Z, Yang W, Zhou H, Liu Y, Zhang Z, Wang G, Hou S
MedComm 2024 Apr;5(4):e534
MedComm 2024 Apr;5(4):e534
Asiaticoside ameliorates DSS-induced colitis in mice by inhibiting inflammatory response, protecting intestinal barrier and regulating intestinal microecology.
Liu K, Yin Y, Shi C, Yan C, Zhang Y, Qiu L, He S, Li G
Phytotherapy research : PTR 2024 Apr;38(4):2023-2040
Phytotherapy research : PTR 2024 Apr;38(4):2023-2040
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene.
Xu Y, Sun D, Xiong L, Zhang Z, Li Y, Liu K, Li H, Chen L
Bioorganic chemistry 2024 Apr;145:107190
Bioorganic chemistry 2024 Apr;145:107190
Quercetin alleviates hyperoxia-induced bronchopulmonary dysplasia by inhibiting ferroptosis through the MAPK/PTGS2 pathway: Insights from network pharmacology, molecular docking, and experimental evaluations.
Deng X, Chen D, Xie A, Li S, Chen A, Zhou Q, Yu R
Chemical biology & drug design 2024 Apr;103(4):e14520
Chemical biology & drug design 2024 Apr;103(4):e14520
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Cai Y, Zhu J, Zhu L, Hong L, Zhang J, Kong L, Chen C, Luo J
International immunopharmacology 2024 Apr 20;131:111789
International immunopharmacology 2024 Apr 20;131:111789
Transgenic human C-reactive protein affects oxidative stress but not inflammation biomarkers in the aorta of spontaneously hypertensive rats.
Nemeckova I, Eissazadeh S, Rathouska JU, Silhavy J, Malinska H, Pravenec M, Nachtigal P
BMC cardiovascular disorders 2024 Apr 16;24(1):211
BMC cardiovascular disorders 2024 Apr 16;24(1):211
Network Pharmacology Analysis and Machine-Learning Models Confirmed the Ability of YiShen HuoXue Decoction to Alleviate Renal Fibrosis by Inhibiting Pyroptosis.
Feng M, Luo F, Wu H, Chen Y, Zuo J, Weng X, Chen G, Zhong J
Drug design, development and therapy 2023;17:3169-3192
Drug design, development and therapy 2023;17:3169-3192
The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.
Li Y, Zhu S, Luo J, Tong Y, Zheng Y, Ji L, He Z, Jing Q, Huang J, Zhang Y, Bi Q
Drug design, development and therapy 2023;17:1515-1529
Drug design, development and therapy 2023;17:1515-1529
Exploring Dysregulated Ferroptosis-Related Genes in Septic Myocardial Injury Based on Human Heart Transcriptomes: Evidence and New Insights.
Zou HX, Hu T, Zhao JY, Qiu BQ, Zou CC, Xu QR, Liu JC, Lai SQ, Huang H
Journal of inflammation research 2023;16:995-1015
Journal of inflammation research 2023;16:995-1015
Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling.
Meng Q, Liu K, Liu Z, Liu J, Tian Z, Qin S, Wei J, Cheng L
Frontiers in immunology 2023;14:1251517
Frontiers in immunology 2023;14:1251517
Selenomethionine against titanium particle-induced osteolysis by regulating the ROS-dependent NLRP3 inflammasome activation via the β-catenin signaling pathway.
Yu R, Yuan Y, Liu Z, Liu L, Xu Z, Zhao Y, Jia C, Zhang P, Li H, Liu Y, Wang Y, Li W, Nie L, Sun X, Li Y, Liu B, Liu H
Frontiers in immunology 2023;14:1171150
Frontiers in immunology 2023;14:1171150
rhFGF-21 accelerates corneal epithelial wound healing through the attenuation of oxidative stress and inflammatory mediators in diabetic mice.
Li L, Wang H, Pang S, Wang L, Fan Z, Ma C, Yang S, Banda J, Hui Q, Lv F, Fan H, Huang T, Zhang X, Wang X
The Journal of biological chemistry 2023 Sep;299(9):105127
The Journal of biological chemistry 2023 Sep;299(9):105127
Liensinine pretreatment reduces inflammation, oxidative stress, apoptosis, and autophagy to alleviate sepsis acute kidney injury.
Zhang W, Chen H, Xu Z, Zhang X, Tan X, He N, Shen J, Dong J
International immunopharmacology 2023 Sep;122:110563
International immunopharmacology 2023 Sep;122:110563
PPM1K mediates metabolic disorder of branched-chain amino acid and regulates cerebral ischemia-reperfusion injury by activating ferroptosis in neurons.
Li T, Zhao L, Li Y, Dang M, Lu J, Lu Z, Huang Q, Yang Y, Feng Y, Wang X, Jian Y, Wang H, Guo Y, Zhang L, Jiang Y, Fan S, Wu S, Fan H, Kuang F, Zhang G
Cell death & disease 2023 Sep 26;14(9):634
Cell death & disease 2023 Sep 26;14(9):634
Novel molecule BBC0901 inhibits BRD4 and acts as a catabolic regulator in the pathogenesis of osteoarthritis.
Lee H, Nam J, Jang H, Park YS, Son MH, Lee IH, Eyun SI, Jeon J, Yang S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115426
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115426
Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1.
Hu T, Zou HX, Le SY, Wang YR, Qiao YM, Yuan Y, Liu JC, Lai SQ, Huang H
International journal of molecular medicine 2023 Nov;52(5)
International journal of molecular medicine 2023 Nov;52(5)
Baicalein Attenuates Neuroinflammation in LPS-Treated BV-2 Cells by Inhibiting Glycolysis via STAT3/c-Myc Pathway.
Gao L, Liu YX, Zhou YZ, Qin XM
Neurochemical research 2023 Nov;48(11):3363-3377
Neurochemical research 2023 Nov;48(11):3363-3377
Role of dysregulated ferroptosis‑related genes in cardiomyocyte ischemia‑reperfusion injury: Experimental verification and bioinformatics analysis.
Hu T, Yu WP, Zou HX, Chai ZH, Le SY, Hu FJ, Wang YC, Huang H, Lai SQ, Liu JC
Experimental and therapeutic medicine 2023 Nov;26(5):534
Experimental and therapeutic medicine 2023 Nov;26(5):534
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
Wang Z, Yang T, Zeng M, Wang Z, Chen Q, Chen J, Christian M, He Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-κB pathway and activation Nrf2 pathway in macrophages.
Shen X, Chen H, Zhang H, Luo L, Wen T, Liu L, Hu Q, Wang L
International immunopharmacology 2023 Nov;124(Pt B):110965
International immunopharmacology 2023 Nov;124(Pt B):110965
Pachymic acid suppresses the inflammatory response of chondrocytes and alleviates the progression of osteoarthritis via regulating the Sirtuin 6/NF-κB signal axis.
Wu Y, Ying J, Zhu X, Xu C, Wu L
International immunopharmacology 2023 Nov;124(Pt A):110854
International immunopharmacology 2023 Nov;124(Pt A):110854
B7H3 increases ferroptosis resistance by inhibiting cholesterol metabolism in colorectal cancer.
Jin H, Zhu M, Zhang D, Liu X, Guo Y, Xia L, Chen Y, Chen Y, Xu R, Liu C, Xi Q, Xia S, Shi T, Zhang G
Cancer science 2023 Nov;114(11):4225-4236
Cancer science 2023 Nov;114(11):4225-4236
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.
Liu X, Li H, Feng Y, Guo H, Li Y, Ke J, Long X
Arthritis research & therapy 2023 Nov 29;25(1):230
Arthritis research & therapy 2023 Nov 29;25(1):230
Kaempferol Improves Breast Cancer-Related Depression through the COX-2/PGE2 Pathway.
Zhu Q, Han Y, He Y, Fu Y, Yang H, Chen Y, Shi Y
Frontiers in bioscience (Landmark edition) 2023 Nov 28;28(11):311
Frontiers in bioscience (Landmark edition) 2023 Nov 28;28(11):311
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells.
Yamashita N, Withers H, Morimoto Y, Bhattacharya A, Haratake N, Daimon T, Fushimi A, Nakashoji A, Thorner AR, Isenhart E, Rosario S, Long MD, Kufe D
iScience 2023 Nov 17;26(11):108168
iScience 2023 Nov 17;26(11):108168
Elsholtzia bodinieri Vaniot ameliorated acute lung injury in mice by regulating pyroptosis, inflammation, oxidative stress and macrophage polarization.
Jiang X, Sun J, Guo S, Zhao Z, Chen Y, Cao J, Liu Y, Cheng G, Tian L, Li Y
Journal of ethnopharmacology 2023 May 10;307:116232
Journal of ethnopharmacology 2023 May 10;307:116232
PPAR-γ Agonist GW1929 Targeted to Macrophages with Dendrimer-Graphene Nanostars Reduces Liver Fibrosis and Inflammation.
Moreno-Lanceta A, Medrano-Bosch M, Simón-Codina B, Barber-González M, Jiménez W, Melgar-Lesmes P
Pharmaceutics 2023 May 10;15(5)
Pharmaceutics 2023 May 10;15(5)
Lnc-17Rik promotes the immunosuppressive function of Myeloid-Derived suppressive cells in esophageal cancer.
Wen J, Xuan B, Gao Y, Liu Y, Wang L, He L, Meng X, Zhou T, Tao Y, Guo K, Wang Y
Cellular immunology 2023 Mar;385:104676
Cellular immunology 2023 Mar;385:104676
Consumption of Nutritionally Enriched Hen Eggs Enhances Endothelium-Dependent Vasodilation via Cyclooxygenase Metabolites in Healthy Young People-A Randomized Study.
Šušnjara P, Mihaljević Z, Stupin A, Kolobarić N, Matić A, Jukić I, Kralik Z, Kralik G, Miloloža A, Pavošević T, Šerić V, Lončarić Z, Kerovec D, Galović O, Drenjančević I
Nutrients 2023 Mar 25;15(7)
Nutrients 2023 Mar 25;15(7)
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment.
Wang Q, Yao S, Yang ZX, Zhou C, Zhang Y, Zhang Y, Zhang L, Li JT, Xu ZJ, Zhu WL, Zhang NX, Ye Y, Feng LY
Acta pharmacologica Sinica 2023 Jun;44(6):1122-1134
Acta pharmacologica Sinica 2023 Jun;44(6):1122-1134
Ent-kauranes and ent-atisanes from Euphorbia wallichii and their anti-inflammatory activity.
Wang Y, Jiang Q, Sun D, Zhang N, Lin Y, Li H, Chen L
Phytochemistry 2023 Jun;210:113643
Phytochemistry 2023 Jun;210:113643
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Yang G, Liu X, Jing X, Wang J, Wang H, Chen F, Wang W, Shao Y, Cui X
International immunopharmacology 2023 Jun;119:110159
International immunopharmacology 2023 Jun;119:110159
Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway.
Wu Y, Duan Z, Qu L, Zhang Y, Zhu C, Fan D
Food & function 2023 Jun 6;14(11):5167-5181
Food & function 2023 Jun 6;14(11):5167-5181
Network Pharmacology Prediction and Experimental Verification for Anti-Ferroptosis of Edaravone After Experimental Intracerebral Hemorrhage.
Cao S, Wei J, Cai Y, Xiong Z, Li J, Jiang Z, Zhou X, Huang B, Zeng J
Molecular neurobiology 2023 Jul;60(7):3633-3649
Molecular neurobiology 2023 Jul;60(7):3633-3649
Long non-coding RNA PVT1 regulates atherosclerosis progression via the microRNA-106b-5p/ACSL4 axis.
Zhang M, Yu Z, Zhao L, Luo H
Biochemical and biophysical research communications 2023 Jul 30;667:170-179
Biochemical and biophysical research communications 2023 Jul 30;667:170-179
Pien Tze Huang attenuated acetaminophen-induced liver injury by autophagy mediated-NLRP3 inflammasome inhibition.
Zhao R, Zhang Q, Liu W, Lin Y, He Y, Chang D, Li S, Xu W, Lin Y, Zheng Y, Zhou X, Huang M
Journal of ethnopharmacology 2023 Jul 15;311:116285
Journal of ethnopharmacology 2023 Jul 15;311:116285
Low-Dose Sodium Salicylate Promotes Ovulation by Regulating Steroids via CYP17A1.
Li T, Ren X, Li T, Yu L, Teng M, Zheng Y, Lei A
International journal of molecular sciences 2023 Jan 30;24(3)
International journal of molecular sciences 2023 Jan 30;24(3)
Antidepression of Xingpijieyu formula targets gut microbiota derived from depressive disorder.
Li Y, Yang L, Li J, Gao W, Zhao Z, Dong K, Duan W, Dai B, Guo R
CNS neuroscience & therapeutics 2023 Feb;29(2):669-681
CNS neuroscience & therapeutics 2023 Feb;29(2):669-681
Iso-seco-tanapartholide induces p62 covalent oligomerization to activate KEAP1-NRF2 redox pathway in rheumatoid arthritis.
Zhu D, Kong M, Chen C, Luo J, Kong L
International immunopharmacology 2023 Feb;115:109689
International immunopharmacology 2023 Feb;115:109689
Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury.
Mohr ME, Li S, Trouten AM, Stairley RA, Roddy PL, Liu C, Zhang M, Sucov HM, Tao G
bioRxiv : the preprint server for biology 2023 Feb 8;
bioRxiv : the preprint server for biology 2023 Feb 8;
The Possibility of IPC to Prevent Ischemic-Reperfusion Injury in Skeletal Muscle in a Rat.
Morikawa T, Shimasaki M, Ichiseki T, Ueda S, Ueda Y, Takahashi K
Journal of clinical medicine 2023 Feb 14;12(4)
Journal of clinical medicine 2023 Feb 14;12(4)
Bisphenol A induced neuronal apoptosis and enhanced autophagy in vitro through Nrf2/HO-1 and Akt/mTOR pathways.
Shen Y, Li X, Wang H, Wang Y, Tao L, Wang P, Zhang H
Toxicology 2023 Dec;500:153678
Toxicology 2023 Dec;500:153678
Ginsenoside Rb1 protects hippocampal neurons in depressed rats based on mitophagy-regulated astrocytic pyroptosis.
Li Y, Li J, Yang L, Ren F, Dong K, Zhao Z, Duan W, Wei W, Guo R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155083
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155083
The ethanol extract of Scutellaria baicalensis Georgi attenuates complete Freund's adjuvant (CFA)-induced inflammatory pain by suppression of P2X3 receptor.
Gao L, Zhao JX, Qin XM, Zhao J
Journal of ethnopharmacology 2023 Dec 5;317:116762
Journal of ethnopharmacology 2023 Dec 5;317:116762
Anti-inflammatory iridoid glycosides from Paederia scandens (Lour.) Merrill.
Xu Y, Zeng J, Wang L, Xu J, He X, Wang Y
Phytochemistry 2023 Aug;212:113705
Phytochemistry 2023 Aug;212:113705
Role of omentin-1 in susceptibility to anxiety and depression like behaviors.
Ji L, Zhang L, Liang Z, Zhong S, Liu X, Liu Z, Poon WS, Song Y, Chen B, Wang R
Molecular and cellular endocrinology 2023 Aug 20;574:111990
Molecular and cellular endocrinology 2023 Aug 20;574:111990
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Shen Y, Teng L, Qu Y, Huang Y, Peng Y, Tang M, Fu Q
Inflammation 2023 Apr;46(2):655-678
Inflammation 2023 Apr;46(2):655-678
Altered trafficking of miRNAs at mitochondria modulates mitochondrial functions and cell death in brain ischemia.
Gohel D, Shukla S, Rajan WD, Wojtas B, Kaminska B, Singh R
Free radical biology & medicine 2023 Apr;199:26-33
Free radical biology & medicine 2023 Apr;199:26-33
Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma.
Wu X, Wu Q, Wang Y, Liu Y, Li Z, Liu Q, Huang Z, Li M, Zhang B, Zhan Q
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 2023 Apr 30;35(2):176-190
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 2023 Apr 30;35(2):176-190
Inhibition effect of 1-acetoxy-6α-(2-methylbutyryl)eriolanolide toward soluble epoxide hydrolase: Multispectral analysis, molecular dynamics simulation, biochemical, and in vitro cell-based studies.
Zhang J, Yang FY, Zhu QM, Zhang WH, Zhang M, Yi J, Wang Y, Zhang HL, Liang GB, Yan JK, Sun CP
International journal of biological macromolecules 2023 Apr 30;235:123911
International journal of biological macromolecules 2023 Apr 30;235:123911
Synergistic effect of constituent drugs of Baibutang on improving Yin-deficiency pulmonary fibrosis in rats.
Fu S, Song X, Tang X, Qian X, Du Z, Hu Y, Xu X, Zhang M
Journal of ethnopharmacology 2023 Apr 24;306:116050
Journal of ethnopharmacology 2023 Apr 24;306:116050
Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer.
Mukhopadhyay S, Encarnación-Rosado J, Lin EY, Sohn ASW, Zhang H, Mancias JD, Kimmelman AC
Science advances 2023 Apr 21;9(16):eadf9284
Science advances 2023 Apr 21;9(16):eadf9284
1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model.
Slater K, Bosch R, Smith KF, Jahangir CA, Garcia-Mulero S, Rahman A, O'Connell F, Piulats JM, O'Neill V, Horgan N, Coupland SE, O'Sullivan J, Gallagher WM, Villanueva A, Kennedy BN
Frontiers in medicine 2022;9:1036322
Frontiers in medicine 2022;9:1036322
Experimental Periodontitis Deteriorates Cognitive Function and Impairs Insulin Signaling in a Streptozotocin-Induced Alzheimer's Disease Rat Model.
Duan L, Qian X, Wang Q, Huang L, Ge S
Journal of Alzheimer's disease : JAD 2022;88(1):57-74
Journal of Alzheimer's disease : JAD 2022;88(1):57-74
Betaine Inhibits NLRP3 Inflammasome Hyperactivation and Regulates Microglial M1/M2 Phenotypic Differentiation, Thereby Attenuating Lipopolysaccharide-Induced Depression-Like Behavior.
Zhang M, Wang XL, Shi H, Meng LQ, Quan HF, Yan L, Yang HF, Peng XD
Journal of immunology research 2022;2022:9313436
Journal of immunology research 2022;2022:9313436
LXR agonist inhibits inflammation through regulating MyD88 mRNA alternative splicing.
Li N, Li Y, Han X, Zhang J, Han J, Jiang X, Wang W, Xu Y, Xu Y, Fu Y, Si S
Frontiers in pharmacology 2022;13:973612
Frontiers in pharmacology 2022;13:973612
Mechanism of Tripterygium wilfordii Hook.F.- Trichosanthes kirilowii Maxim decoction in treatment of diabetic kidney disease based on network pharmacology and molecular docking.
Lu L, Peng J, Wan P, Peng H, Lu J, Xiong G
Frontiers in pharmacology 2022;13:940773
Frontiers in pharmacology 2022;13:940773
Inhibition of fucosylation by 2-fluorofucose attenuated acetaminophen-induced liver injury via its anti-inflammation and anti-oxidative stress effects.
Liu Z, Tu M, Shi J, Zhou H, Meng G, Gu J, Wang Y
Frontiers in pharmacology 2022;13:939317
Frontiers in pharmacology 2022;13:939317
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Shao Y, Sun L, Yang G, Wang W, Liu X, Du T, Chen F, Jing X, Cui X
Frontiers in pharmacology 2022;13:937502
Frontiers in pharmacology 2022;13:937502
Dehydrocostus Lactone Suppresses Dextran Sulfate Sodium-Induced Colitis by Targeting the IKKα/β-NF-κB and Keap1-Nrf2 Signalling Pathways.
Yuan Y, Hu Q, Liu L, Xie F, Yang L, Li Y, Zhang C, Chen H, Tang J, Shen X
Frontiers in pharmacology 2022;13:817596
Frontiers in pharmacology 2022;13:817596
Naoluo Xintong Decoction in the Treatment of Ischemic Stroke: A Network Analysis of the Mechanism of Action.
Wang N, Chu F, Fei C, Pan L, Wang Y, Chen W, Peng D, Duan X, He L
Frontiers in pharmacology 2022;13:809505
Frontiers in pharmacology 2022;13:809505
PLA2G6 Silencing Suppresses Melanoma Progression and Affects Ferroptosis Revealed by Quantitative Proteomics.
Wang Y, Song H, Miao Q, Wang Y, Qi J, Xu X, Sun J
Frontiers in oncology 2022;12:819235
Frontiers in oncology 2022;12:819235
Serum-derived exosomes from SD rats induce inflammation in macrophages through the mTOR pathway.
Wang Y, Liu YP, Sun ZB, Deng WH, Yuan XY, Lei YD, Cai Y, Huang L, Zhang ZH
Journal of applied toxicology : JAT 2022 Sep;42(9):1524-1532
Journal of applied toxicology : JAT 2022 Sep;42(9):1524-1532
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Shen Y, Fan X, Qu Y, Tang M, Huang Y, Peng Y, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.
Cabral VLF, Wang F, Peng X, Gao J, Zhou Z, Sun R, Bao J, Wu X
Archives of gerontology and geriatrics 2022 Sep-Oct;102:104748
Archives of gerontology and geriatrics 2022 Sep-Oct;102:104748
Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control.
Wu M, Zhao A, Yan X, Gao H, Zhang C, Liu X, Luo Q, Xie F, Liu S, Shi D
eLife 2022 Sep 26;11
eLife 2022 Sep 26;11
Quercetin in Tonglong Qibi decoction ameliorates testosterone-induced benign prostatic hyperplasia in rats by regulating Nrf2 signalling pathways and oxidative stress.
Fu W, Chen S, Zhang Z, Chen Y, You X, Li Q
Andrologia 2022 Oct;54(9):e14502
Andrologia 2022 Oct;54(9):e14502
BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency.
Wang F, Liu Y, Ni F, Jin J, Wu Y, Huang Y, Ye X, Shen X, Ying Y, Chen J, Chen R, Zhang Y, Sun X, Wang S, Xu X, Chen C, Guo J, Zhang D
Nature communications 2022 Oct 5;13(1):5871
Nature communications 2022 Oct 5;13(1):5871
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes.
Wang X, Liu Z, Peng P, Gong Z, Huang J, Peng H
Chemico-biological interactions 2022 Oct 1;366:110148
Chemico-biological interactions 2022 Oct 1;366:110148
Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.
Sun W, Xie W, Huang D, Cui Y, Yue J, He Q, Jiang L, Xiong J, Sun W, Yi Q
International journal of molecular medicine 2022 Nov;50(5)
International journal of molecular medicine 2022 Nov;50(5)
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling.
Chen J, Liu G, Wang X, Hong H, Li T, Li L, Wang H, Xie J, Li B, Li T, Lu D, Zhang Y, Zhao H, Yao C, Wen K, Li T, Chen J, Wu S, He K, Zhang WN, Zhao J, Wang N, Han Q, Xia Q, Qi J, Chen J, Zhou T, Man J, Zhang XM, Li AL, Pan X
Cell stem cell 2022 Nov 3;29(11):1531-1546.e7
Cell stem cell 2022 Nov 3;29(11):1531-1546.e7
Orally Administered Ginkgolide C Attenuates DSS-Induced Colitis by Maintaining Gut Barrier Integrity, Inhibiting Inflammatory Responses, and Regulating Intestinal Flora.
Xu D, Zhuang L, Gao S, Ma H, Cheng J, Liu J, Liu D, Fu S, Hu G
Journal of agricultural and food chemistry 2022 Nov 23;70(46):14718-14731
Journal of agricultural and food chemistry 2022 Nov 23;70(46):14718-14731
Recombinant porcine beta defensin 2 alleviates inflammatory responses induced by Escherichia coli in IPEC-J2 cells.
Zhang K, Lian S, Shen X, Zhao X, Zhao W, Li C
International journal of biological macromolecules 2022 May 31;208:890-900
International journal of biological macromolecules 2022 May 31;208:890-900
Preconception exposure to dibutyl phthalate (DBP) impairs spermatogenesis by activating NF-κB/COX-2/RANKL signaling in Sertoli cells.
Xie Z, Liu S, Hua S, Wu L, Zhang Y, Zhu Y, Shi F, Jiang J
Toxicology 2022 May 30;474:153213
Toxicology 2022 May 30;474:153213
Induction of COX-2 by feline calicivirus via activation of the MEK1-ERK1/2 pathway, and attenuation of feline lung inflammation and injury by MEK1 inhibitor AZD6244 (selumetinib).
Liu Y, Shi WD, Xie QQ, Wang JG, Gu CC, Ji ZH, Xiao J, Liu WQ
Biochemical and biophysical research communications 2022 May 14;604:8-13
Biochemical and biophysical research communications 2022 May 14;604:8-13
Neutrophil membrane-mimicking nanodecoys with intrinsic anti-inflammatory properties alleviate sepsis-induced acute liver injury and lethality in a mouse endotoxemia model.
Xiao Y, Ren C, Chen G, Shang P, Song X, You G, Yan S, Yao Y, Zhou H
Materials today. Bio 2022 Mar;14:100244
Materials today. Bio 2022 Mar;14:100244
Lipoxin A(4) and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.
Xu F, Zhang J, Zhou X, Hao H
Experimental cell research 2022 Mar 1;412(1):113025
Experimental cell research 2022 Mar 1;412(1):113025
Zuojin Pill attenuates Helicobacter pylori-induced chronic atrophic gastritis in rats and improves gastric epithelial cells function in GES-1 cells.
Wen J, Wu S, Ma X, Zhao Y
Journal of ethnopharmacology 2022 Mar 1;285:114855
Journal of ethnopharmacology 2022 Mar 1;285:114855
Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization.
Wang G, Li X, Li N, Wang X, He S, Li W, Fan W, Li R, Liu J, Hou S
Redox biology 2022 Jun;52:102297
Redox biology 2022 Jun;52:102297
Methionine strengthens anti-inflammation of rice protein via depressing NF-κB activation and stimulating Msr expression in rats fed cholesterol-enriched diets.
Wang Z, Liang M, Liu B, Yang L
Food science and biotechnology 2022 Jun;31(6):745-758
Food science and biotechnology 2022 Jun;31(6):745-758
DEHP induces ferroptosis in testes via p38α-lipid ROS circulation and destroys the BTB integrity.
Yang L, Jiang L, Sun X, Li J, Wang N, Liu X, Yao X, Zhang C, Deng H, Wang S, Yang G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113046
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113046
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2.
Nguyen V, Zhang Y, Gao C, Cao X, Tian Y, Carver W, Kiaris H, Cui T, Tan W
Cells 2022 Jun 14;11(12)
Cells 2022 Jun 14;11(12)
Effects of black tea and black brick tea with fungal growth on lowering uric acid levels in hyperuricemic mice.
Yuan D, Lin L, Peng Y, Zhou Y, Li L, Xiao W, Gong Z
Journal of food biochemistry 2022 Jul;46(7):e14140
Journal of food biochemistry 2022 Jul;46(7):e14140
Construction and comprehensive analysis of a lncRNA-mRNA interactive network to reveal a potential lncRNA for hepatic encephalopathy development.
Zhang C, Ni W, Zhu Y, Lin J, Li H, Zhao Z, Wang K, Huo H, Luo M
Human cell 2022 Jul;35(4):1060-1070
Human cell 2022 Jul;35(4):1060-1070
Cortistatin attenuates titanium particle-induced osteolysis through regulation of TNFR1-ROS-caspase-3 signaling in osteoblasts.
Cao J, Ma X, Liu L, Zhang G, Wu Y, Fu Y, Gong A, Yang Z, Zhao Y, Zhang L, Li Y
Annals of the New York Academy of Sciences 2022 Jul;1513(1):140-152
Annals of the New York Academy of Sciences 2022 Jul;1513(1):140-152
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Zhu W, Tang H, Cao L, Zhang J, Li J, Ma D, Guo C
Chemical biology & drug design 2022 Jul;100(1):108-120
Chemical biology & drug design 2022 Jul;100(1):108-120
COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR.
Zhang CY, Tan XH, Yang HH, Jin L, Hong JR, Zhou Y, Huang XT
International journal of molecular sciences 2022 Jul 27;23(15)
International journal of molecular sciences 2022 Jul 27;23(15)
Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrin α5.
Zhao D, Hua R, Riquelme MA, Cheng H, Guda T, Xu H, Gu S, Jiang JX
Bone research 2022 Jul 18;10(1):49
Bone research 2022 Jul 18;10(1):49
Efficacy of auranofin as an inhibitor of desmoid progression.
Ito K, Nishida Y, Hamada S, Shimizu K, Sakai T, Ohkawara B, Alman BA, Enomoto A, Ikuta K, Koike H, Zhang J, Ohno K, Imagama S
Scientific reports 2022 Jul 13;12(1):11918
Scientific reports 2022 Jul 13;12(1):11918
Synthesis compound XCR-7a ameliorates LPS-induced inflammatory response by inhibiting the phosphorylation of c-Fos.
Tang H, Roy P, Di Q, Ma X, Xiao Y, Wu Z, Quan J, Zhao J, Xiao W, Chen W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jan;145:112468
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jan;145:112468
Effect of oridonin on oxylipins in the livers of mice with acute liver injury induced by D-galactosamine and lipopolysaccharide.
Zhan Z, Zhang T, Dai F, Wen X, Chen Y, Jiang H, Gu T, Cheng Y, Tang L
International immunopharmacology 2022 Jan;102:108387
International immunopharmacology 2022 Jan;102:108387
Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer.
Liu Y, Shang W, Liu H, Hui H, Wu J, Zhang W, Gao P, Guo K, Guo Y, Tian J
Journal of nanobiotechnology 2022 Jan 24;20(1):48
Journal of nanobiotechnology 2022 Jan 24;20(1):48
Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells.
Zhang X, Jiang L, Chen H, Wei S, Yao K, Sun X, Yang G, Jiang L, Zhang C, Wang N, Wang Y, Liu X
Toxicology 2022 Jan 15;465:153048
Toxicology 2022 Jan 15;465:153048
Evaluation of the therapeutic efficacy of human bone marrow mesenchymal stem cells with COX-2 silence and TGF-β3 overexpression in rabbits with antigen-induced arthritis.
He T, Sun S
Experimental cell research 2022 Jan 1;410(1):112945
Experimental cell research 2022 Jan 1;410(1):112945
Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice.
Yang Q, Song D, Xie Z, He G, Zhao J, Wang Z, Dong Z, Zhang H, Yang L, Jiang M, Wu Y, Shi Q, Li J, Yang J, Bai Z, Quan Z, Qing H
Progress in neurobiology 2022 Feb;209:102209
Progress in neurobiology 2022 Feb;209:102209
TNF signaling pathway-mediated microglial activation in the PFC underlies acute paradoxical sleep deprivation-induced anxiety-like behaviors in mice.
Liu H, Huang X, Li Y, Xi K, Han Y, Mao H, Ren K, Wang W, Wu Z
Brain, behavior, and immunity 2022 Feb;100:254-266
Brain, behavior, and immunity 2022 Feb;100:254-266
Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading.
Zhao D, Riquelme MA, Guda T, Tu C, Xu H, Gu S, Jiang JX
eLife 2022 Feb 8;11
eLife 2022 Feb 8;11
Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury.
He R, Liu B, Xiong R, Geng B, Meng H, Lin W, Hao B, Zhang L, Wang W, Jiang W, Li N, Geng Q
Cell death discovery 2022 Feb 2;8(1):43
Cell death discovery 2022 Feb 2;8(1):43
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.
Zhang P, He Q, Wang Y, Zhou G, Chen Y, Tang L, Zhang Y, Hong X, Mao Y, He Q, Yang X, Liu N, Ma J
Signal transduction and targeted therapy 2022 Feb 16;7(1):46
Signal transduction and targeted therapy 2022 Feb 16;7(1):46
METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice.
Yang L, Wu G, Wu Q, Peng L, Yuan L
Cell death discovery 2022 Feb 14;8(1):62
Cell death discovery 2022 Feb 14;8(1):62
Multi-omics profiling reveals Chitinase-3-like protein 1 as a key mediator in the crosstalk between sarcopenia and liver cancer.
Lu D, Lin Z, Wang R, Chen Z, Zhuo J, Xu L, Pan L, Li H, Yang X, He C, Shen W, Yang M, Li H, Chen H, Tan W, Wei X, Zheng S, Xu X
Redox biology 2022 Dec;58:102538
Redox biology 2022 Dec;58:102538
L-Methionine inhibits 4-hydroxy-2-nonenal accumulation and suppresses inflammation in growing rats.
Wang Z, Liang M, Li H, Liu B, Yang L
Nutrition research and practice 2022 Dec;16(6):729-744
Nutrition research and practice 2022 Dec;16(6):729-744
Elsholtzia bodinieri Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses.
Sun J, Jiang X, Chen Y, Guo S, Zhao Z, Cao J, Liu Y, Cheng G, Li Y, Tian L
International journal of molecular sciences 2022 Dec 9;23(24)
International journal of molecular sciences 2022 Dec 9;23(24)
Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis.
Yang X, Zeng H, Wang L, Luo S, Zhou Y
Cell & bioscience 2022 Dec 5;12(1):197
Cell & bioscience 2022 Dec 5;12(1):197
Contribution of cyclooxygenase-2 overexpression to enhancement in tonically active glutamatergic inputs to the rostral ventrolateral medulla in hypertension.
Fan JF, Wang W, Tan X, Ye P, Li JK, Niu LY, Li WY, Wang WZ, Wang YK
Journal of hypertension 2022 Dec 1;40(12):2394-2405
Journal of hypertension 2022 Dec 1;40(12):2394-2405
The effects of Jiawei Duhuo Jisheng mixture on Wnt/β-catenin signaling pathway in the synovium inflamed by knee osteoarthritis: An in vitro and in vivo experiment.
Shi Q, Huang L, Duan J, Kuang G, Lu M, Tan X
Journal of ethnopharmacology 2022 Aug 10;294:115363
Journal of ethnopharmacology 2022 Aug 10;294:115363
Rice protein suppresses 4-hydroxy-2-nonenal-induced inflammation owing to methionine availability.
Wang Z, Liang M, Li H, Liu B, Yang L
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Aug 1;47(8):826-838
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Aug 1;47(8):826-838
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Zhu W, Tang H, Li J, Guedes RM, Cao L, Guo C
Bioengineered 2022 Apr;13(4):9233-9247
Bioengineered 2022 Apr;13(4):9233-9247
Mechanism exploration of ancient pharmaceutic processing (Paozhi) improving the gastroprotective efficacy of Aucklandiae Radix.
Song S, Qiu R, Jin X, Zhou Z, Yan J, Ou Q, Liu X, Li W, Mao Y, Yao W, Lu T
Journal of ethnopharmacology 2022 Apr 6;287:114911
Journal of ethnopharmacology 2022 Apr 6;287:114911
Ferroptosis is involved in PGPS-induced otitis media in C57BL/6 mice.
Yan B, Xie D, Wu Y, Wang S, Zhang X, Zhao T, Liu L, Ma P, Li G, Yang Y, Zhao Y, Zheng T, Geng R, Li B, Zheng Q
Cell death discovery 2022 Apr 21;8(1):217
Cell death discovery 2022 Apr 21;8(1):217
Harmine Alleviated Sepsis-Induced Cardiac Dysfunction by Modulating Macrophage Polarization via the STAT/MAPK/NF-κB Pathway.
Ruan W, Ji X, Qin Y, Zhang X, Wan X, Zhu C, Lv C, Hu C, Zhou J, Lu L, Guo X
Frontiers in cell and developmental biology 2021;9:792257
Frontiers in cell and developmental biology 2021;9:792257
Tributyltin Oxide Exposure During in vitro Maturation Disrupts Oocyte Maturation and Subsequent Embryonic Developmental Competence in Pigs.
Xiao Y, Yuan B, Hu W, Qi J, Jiang H, Sun B, Zhang J, Liang S
Frontiers in cell and developmental biology 2021;9:683448
Frontiers in cell and developmental biology 2021;9:683448
Periodontitis Deteriorates Cognitive Function and Impairs Neurons and Glia in a Mouse Model of Alzheimer's Disease.
Qian X, Zhang S, Duan L, Yang F, Zhang K, Yan F, Ge S
Journal of Alzheimer's disease : JAD 2021;79(4):1785-1800
Journal of Alzheimer's disease : JAD 2021;79(4):1785-1800
Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD.
Zuo Y, Xie J, Li X, Li Y, Thirupathi A, Zhang J, Yu P, Gao G, Chang Y, Shi Z
Oxidative medicine and cellular longevity 2021;2021:9961628
Oxidative medicine and cellular longevity 2021;2021:9961628
Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.
Zhang M, Luo C, Lin D, Cui K, Chen Z, Liu J
Oxidative medicine and cellular longevity 2021;2021:8877540
Oxidative medicine and cellular longevity 2021;2021:8877540
GPX4-Regulated Ferroptosis Mediates S100-Induced Experimental Autoimmune Hepatitis Associated with the Nrf2/HO-1 Signaling Pathway.
Zhu L, Chen D, Zhu Y, Pan T, Xia D, Cai T, Lin H, Lin J, Jin X, Wu F, Yu S, Zhu K, Xu L, Chen Y
Oxidative medicine and cellular longevity 2021;2021:6551069
Oxidative medicine and cellular longevity 2021;2021:6551069
A Novel Hydrogen Sulfide Donor Reduces Pilocarpine-Induced Status Epilepticus and Regulates Microglial Inflammatory Profile.
Liu Z, Zhu Z, He Y, Kang Q, Li F, Zhang W, He Y, Lin Y, Huang B, Mo M, Xu P, Zhu X
Frontiers in cellular neuroscience 2021;15:780447
Frontiers in cellular neuroscience 2021;15:780447
Active-Ingredient Screening and Synergistic Action Mechanism of Shegan Mixture for Anti-Asthma Effects Based on Network Pharmacology in a Mouse Model of Asthma.
Ye Q, Zhang Q, Yao H, Xu A, Liu Y, Qi J, Zhang H, Zhang J
Drug design, development and therapy 2021;15:1765-1777
Drug design, development and therapy 2021;15:1765-1777
Activation of α7nAChR Protects Against Gastric Inflammation and Dysmotility in Parkinson's Disease Rats.
Zhou L, Zheng LF, Zhang XL, Wang ZY, Yao YS, Xiu XL, Liu CZ, Zhang Y, Feng XY, Zhu JX
Frontiers in pharmacology 2021;12:793374
Frontiers in pharmacology 2021;12:793374
Berberine Improves Irinotecan-Induced Intestinal Mucositis Without Impairing the Anti-colorectal Cancer Efficacy of Irinotecan by Inhibiting Bacterial β-glucuronidase.
Yue B, Gao R, Lv C, Yu Z, Wang H, Geng X, Wang Z, Dou W
Frontiers in pharmacology 2021;12:774560
Frontiers in pharmacology 2021;12:774560
Pseudomonas aeruginosa PcrV Enhances the Nitric Oxide-Mediated Tumoricidal Activity of Tumor-Associated Macrophages via a TLR4/PI3K/AKT/mTOR-Glycolysis-Nitric Oxide Circuit.
Yu H, Bai Y, Qiu J, He X, Xiong J, Dai Q, Wang X, Li Y, Sheng H, Xin R, Jiang L, Li Q, Li D, Zhang H, Zhang L, Chen Q, Peng J, Hu X, Zhang K
Frontiers in oncology 2021;11:736882
Frontiers in oncology 2021;11:736882
Targeting cancer cell plasticity by HDAC inhibition to reverse EBV-induced dedifferentiation in nasopharyngeal carcinoma.
Xie J, Wang Z, Fan W, Liu Y, Liu F, Wan X, Liu M, Wang X, Zeng D, Wang Y, He B, Yan M, Zhang Z, Zhang M, Hou Z, Wang C, Kang Z, Fang W, Zhang L, Lam EW, Guo X, Yan J, Zeng Y, Chen M, Liu Q
Signal transduction and targeted therapy 2021 Sep 4;6(1):333
Signal transduction and targeted therapy 2021 Sep 4;6(1):333
Circulating prostaglandin E(2): a novel potential prognostic biomarker in patients with hepatocellular carcinoma.
Pelizzaro F, Kitenge MP, Cardin R, Ponzoni A, Cillo U, Vitale A, Businello G, Munari G, Fassan M, Farinati F
Clinical and experimental medicine 2021 Nov;21(4):675-682
Clinical and experimental medicine 2021 Nov;21(4):675-682
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Zhang Y, Sun J, Dong Y, Shen X, Zhang Z
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22680
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22680
PARP-1 involves in UVB-induced inflammatory response in keratinocytes and skin injury via regulation of ROS-dependent EGFR transactivation and p38 signaling.
Chiu LY, Wu NL, Hung CF, Bai P, Dai YS, Lin WW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Mar;35(3):e21393
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Mar;35(3):e21393
Micro-RNA miR-542-3p suppresses decidualization by targeting ILK pathways in human endometrial stromal cells.
Qu X, Fang Y, Zhuang S, Zhang Y
Scientific reports 2021 Mar 30;11(1):7186
Scientific reports 2021 Mar 30;11(1):7186
Inhibition of chikusetsusaponin IVa on inflammatory responses in RAW264.7 cell line via MAPK pathway.
Xu G, Lei H, Yuan Q, Chen H, Su J
Zeitschrift fur Naturforschung. C, Journal of biosciences 2021 Mar 26;76(3-4):103-110
Zeitschrift fur Naturforschung. C, Journal of biosciences 2021 Mar 26;76(3-4):103-110
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Xie C, Ma H, Shi Y, Li J, Wu H, Wang B, Shao Z, Huang C, Chen J, Sun L, Zhou Y, Tian N, Wu Y, Gao W, Wu A, Wang X, Zhang X
Food & function 2021 Mar 21;12(6):2703-2714
Food & function 2021 Mar 21;12(6):2703-2714
Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway.
Fu P, Zhu R, Jia J, Hu Y, Wu C, Cieszczyk P, Holmberg HC, Gong L
Nutrition & metabolism 2021 Jun 3;18(1):56
Nutrition & metabolism 2021 Jun 3;18(1):56
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury.
Dai C, Li H, Wang Y, Tang S, Velkov T, Shen J
Antioxidants (Basel, Switzerland) 2021 Jun 18;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 18;10(6)
Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.
Zhu Z, Hu R, Li J, Xing X, Chen J, Zhou Q, Sun J
International immunopharmacology 2021 Jul;96:107660
International immunopharmacology 2021 Jul;96:107660
Effects of medicine food Fructus Gardeniae on liver and kidney functions after oral administration to rats for 12 weeks.
Li C, Gao X, Gao X, Lv J, Bian X, Lv J, Sun J, Luo G, Zhang H
Journal of food biochemistry 2021 Jul;45(7):e13752
Journal of food biochemistry 2021 Jul;45(7):e13752
α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice.
Zhang H, Li S, Lu J, Jin J, Zhu G, Wang L, Yan Y, He L, Wang B, Wang X, Yu H
Aging 2021 Jul 8;13(13):17690-17706
Aging 2021 Jul 8;13(13):17690-17706
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Chen C, Gu J, Wang J, Wu Y, Yang A, Chen T, Zhou T, Liu Z
International immunopharmacology 2021 Jan;90:107206
International immunopharmacology 2021 Jan;90:107206
Echinacea polysaccharide attenuates lipopolysaccharide‑induced acute kidney injury via inhibiting inflammation, oxidative stress and the MAPK signaling pathway.
Shi Q, Lang W, Wang S, Li G, Bai X, Yan X, Zhang H
International journal of molecular medicine 2021 Jan;47(1):243-255
International journal of molecular medicine 2021 Jan;47(1):243-255
Myricetin ameliorates sepsis-associated acute lung injury in a murine sepsis model.
Xu H, Qi Q, Yan X
Naunyn-Schmiedeberg's archives of pharmacology 2021 Jan;394(1):165-175
Naunyn-Schmiedeberg's archives of pharmacology 2021 Jan;394(1):165-175
Maltol prevents the progression of osteoarthritis by targeting PI3K/Akt/NF-κB pathway: In vitro and in vivo studies.
Lu H, Fu C, Kong S, Wang X, Sun L, Lin Z, Luo P, Jin H
Journal of cellular and molecular medicine 2021 Jan;25(1):499-509
Journal of cellular and molecular medicine 2021 Jan;25(1):499-509
Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation.
Wang R, Wu G, Dai T, Lang Y, Chi Z, Yang S, Dong D
Experimental and therapeutic medicine 2021 Jan;21(1):66
Experimental and therapeutic medicine 2021 Jan;21(1):66
miR-34a-5p up-regulates the IL-1β/COX2/PGE2 inflammation pathway and induces the release of CGRP via inhibition of SIRT1 in rat trigeminal ganglion neurons.
Zhang H, Zhang XM, Zong DD, Ji XY, Jiang H, Zhang FZ, He SD
FEBS open bio 2021 Jan;11(1):300-311
FEBS open bio 2021 Jan;11(1):300-311
Pro-Inflammatory Effects of Indoxyl Sulfate in Mice: Impairment of Intestinal Homeostasis and Immune Response.
Rapa SF, Prisco F, Popolo A, Iovane V, Autore G, Di Iorio BR, Dal Piaz F, Paciello O, Nishijima F, Marzocco S
International journal of molecular sciences 2021 Jan 24;22(3)
International journal of molecular sciences 2021 Jan 24;22(3)
BML-111, the lipoxin A(4) agonist, modulates VEGF or CoCl(2)-induced migration, angiogenesis and permeability in tumor-derived endothelial cells.
Lin L, Wang Q, Xu F, Luo X, Xu J, Yan L, Li Q, Hao H
Immunology letters 2021 Feb;230:27-35
Immunology letters 2021 Feb;230:27-35
Annexin A1 Attenuates Neutrophil Migration and IL-6 Expression through Fpr2 in a Mouse Model of Streptococcus suis-Induced Meningitis.
Ni C, Gao S, Zheng Y, Liu P, Zhai Y, Huang W, Jiang H, Lv Q, Kong D, Jiang Y
Infection and immunity 2021 Feb 16;89(3)
Infection and immunity 2021 Feb 16;89(3)
Compound Kushen Injection intervenes metabolic reprogramming and epithelial-mesenchymal transition of HCC via regulating β-catenin/c-Myc signaling.
Wang KX, Du GH, Qin XM, Gao L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153781
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153781
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Song Z, Gao C, Jiang Q, Xu J, Xiong L, Liu K, Sun D, Li H, Chen L
Phytochemistry 2021 Dec;192:112971
Phytochemistry 2021 Dec;192:112971
Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells.
Qin X, Zhang J, Wang B, Xu G, Yang X, Zou Z, Yu C
Autophagy 2021 Dec;17(12):4266-4285
Autophagy 2021 Dec;17(12):4266-4285
The expression profile and bioinformatics analysis of microRNAs in human bronchial epithelial cells treated by beryllium sulfate.
Yi S, Liu YP, Li XY, Yuan XY, Wang Y, Cai Y, Lei YD, Huang L, Zhang ZH
Journal of applied toxicology : JAT 2021 Aug;41(8):1275-1285
Journal of applied toxicology : JAT 2021 Aug;41(8):1275-1285
Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis.
Yang RZ, Xu WN, Zheng HL, Zheng XF, Li B, Jiang LS, Jiang SD
Journal of cellular physiology 2021 Apr;236(4):2725-2739
Journal of cellular physiology 2021 Apr;236(4):2725-2739
Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues.
Tian S, Liao L, Zhou Q, Huang X, Zheng P, Guo Y, Deng T, Tian X
Oncology letters 2021 Apr;21(4):286
Oncology letters 2021 Apr;21(4):286
Angiotensin II type 1 receptor is involved in flow-induced vasomotor responses of isolated middle cerebral arteries: role of oxidative stress.
Jukic I, Mihaljevic Z, Matic A, Mihalj M, Kozina N, Selthofer-Relatic K, Mihaljevic D, Koller A, Tartaro Bujak I, Drenjancevic I
American journal of physiology. Heart and circulatory physiology 2021 Apr 1;320(4):H1609-H1624
American journal of physiology. Heart and circulatory physiology 2021 Apr 1;320(4):H1609-H1624
Chronic intermittent hypoxia vs chronic continuous hypoxia: Effects on vascular endothelial function and myocardial contractility.
Zhu J, Kang J, Li X, Wang M, Shang M, Luo Y, Xiong M, Hu K
Clinical hemorheology and microcirculation 2020;74(4):417-427
Clinical hemorheology and microcirculation 2020;74(4):417-427
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-κB Pathway.
Wu J, Yang CL, Sha YK, Wu Y, Liu ZY, Yuan ZH, Sun ZL
The American journal of Chinese medicine 2020;48(1):127-142
The American journal of Chinese medicine 2020;48(1):127-142
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
Almoiliqy M, Wen J, Qaed E, Sun Y, Lian M, Mousa H, Al-Azab M, Zaky MY, Chen D, Wang L, Al-Sharabi A, Liu Z, Sun P, Lin Y
Oxidative medicine and cellular longevity 2020;2020:4196548
Oxidative medicine and cellular longevity 2020;2020:4196548
Phenylethanol Glycosides Protect Myocardial Hypertrophy Induced by Abdominal Aortic Constriction via ECE-1 Demethylation Inhibition and PI3K/PKB/eNOS Pathway Enhancement.
Fan QL, Wang JW, Zhang SL, Liu T, Zhao J, You SP
Evidence-based complementary and alternative medicine : eCAM 2020;2020:2957094
Evidence-based complementary and alternative medicine : eCAM 2020;2020:2957094
miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition.
Lin L, Wang D, Qu S, Zhao H, Lin Y
Drug design, development and therapy 2020;14:1127-1141
Drug design, development and therapy 2020;14:1127-1141
Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo.
Wu Y, Wang Z, Lin Z, Fu X, Zhan J, Yu K
Frontiers in pharmacology 2020;11:682
Frontiers in pharmacology 2020;11:682
A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation.
Yang HH, Duan JX, Liu SK, Xiong JB, Guan XX, Zhong WJ, Sun CC, Zhang CY, Luo XQ, Zhang YF, Chen P, Hammock BD, Hwang SH, Jiang JX, Zhou Y, Guan CX
Theranostics 2020;10(11):4749-4761
Theranostics 2020;10(11):4749-4761
Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies.
Wu Y, Wang Z, Fu X, Lin Z, Yu K
International immunopharmacology 2020 Sep;86:106713
International immunopharmacology 2020 Sep;86:106713
Arachidonic Acid Metabolites of CYP450 Enzymes and HIF-1α Modulate Endothelium-Dependent Vasorelaxation in Sprague-Dawley Rats under Acute and Intermittent Hyperbaric Oxygenation.
Mihaljević Z, Matić A, Stupin A, Frkanec R, Tavčar B, Kelava V, Tartaro Bujak I, Kolobarić N, Kibel A, Drenjančević I
International journal of molecular sciences 2020 Sep 1;21(17)
International journal of molecular sciences 2020 Sep 1;21(17)
Simvastatin Improves Behavioral Disorders and Hippocampal Inflammatory Reaction by NMDA-Mediated Anti-inflammatory Function in MPTP-Treated Mice.
Yan J, Liu A, Fan H, Qiao L, Wu J, Shen M, Lai X, Huang J
Cellular and molecular neurobiology 2020 Oct;40(7):1155-1164
Cellular and molecular neurobiology 2020 Oct;40(7):1155-1164
TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice.
Liu X, Cai HX, Cao PY, Feng Y, Jiang HH, Liu L, Ke J, Long X
Journal of cellular and molecular medicine 2020 Oct;24(19):11489-11499
Journal of cellular and molecular medicine 2020 Oct;24(19):11489-11499
Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.
Zou C, Yang H, Cui L, Cao X, Huang H, Chen T
Molecular medicine reports 2020 Oct;22(4):3213-3224
Molecular medicine reports 2020 Oct;22(4):3213-3224
The TGF-β1/COX-2-dependant pathway serves a key role in the generation of OKC-induced M2-polarized macrophage-like cells and angiogenesis.
Cheng G, Gao J, Wang L, Ding Y, Wu Q, Wang Q, Xiao J, Wang S
Oncology letters 2020 Oct;20(4):39
Oncology letters 2020 Oct;20(4):39
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Yuan L, Qu Y, Li Q, An T, Chen Z, Chen Y, Deng X, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
(-)-Hydroxycitric Acid Alleviates Oleic Acid-Induced Steatosis, Oxidative Stress, and Inflammation in Primary Chicken Hepatocytes by Regulating AMP-Activated Protein Kinase-Mediated Reactive Oxygen Species Levels.
Li L, Chu X, Yao Y, Cao J, Li Q, Ma H
Journal of agricultural and food chemistry 2020 Oct 7;68(40):11229-11241
Journal of agricultural and food chemistry 2020 Oct 7;68(40):11229-11241
OPA1 and MICOS Regulate mitochondrial crista dynamics and formation.
Hu C, Shu L, Huang X, Yu J, Li L, Gong L, Yang M, Wu Z, Gao Z, Zhao Y, Chen L, Song Z
Cell death & disease 2020 Oct 31;11(10):940
Cell death & disease 2020 Oct 31;11(10):940
Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.
Huang H, Cai H, Zhang L, Hua Z, Shi J, Wei Y
International immunopharmacology 2020 Mar;80:106123
International immunopharmacology 2020 Mar;80:106123
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
Lin Z, Fu C, Yan Z, Wu Y, Zhan J, Lou Z, Liao X, Pan J
Food & function 2020 Mar 26;11(3):2654-2666
Food & function 2020 Mar 26;11(3):2654-2666
Inhibitory Effects of Bound Polyphenol from Foxtail Millet Bran on Colitis-Associated Carcinogenesis by the Restoration of Gut Microbiota in a Mice Model.
Yang R, Shan S, Zhang C, Shi J, Li H, Li Z
Journal of agricultural and food chemistry 2020 Mar 18;68(11):3506-3517
Journal of agricultural and food chemistry 2020 Mar 18;68(11):3506-3517
Hispidulin Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia and Attenuates the Activation of Akt, NF-κB, and STAT3 Pathway.
Yu CI, Cheng CI, Kang YF, Chang PC, Lin IP, Kuo YH, Jhou AJ, Lin MY, Chen CY, Lee CH
Neurotoxicity research 2020 Jun;38(1):163-174
Neurotoxicity research 2020 Jun;38(1):163-174
The Activation of Heat-Shock Protein After Copper(II) and/or Arsenic(III)-Induced Imbalance of Homeostasis, Inflammatory Response in Chicken Rectum.
Yang X, Zhao H, Wang Y, Liu J, Guo M, Fei D, Mu M, Xing M
Biological trace element research 2020 Jun;195(2):613-623
Biological trace element research 2020 Jun;195(2):613-623
MGP Promotes Colon Cancer Proliferation by Activating the NF-κB Pathway through Upregulation of the Calcium Signaling Pathway.
Li X, Wei R, Wang M, Ma L, Zhang Z, Chen L, Guo Q, Guo S, Zhu S, Zhang S, Min L
Molecular therapy oncolytics 2020 Jun 26;17:371-383
Molecular therapy oncolytics 2020 Jun 26;17:371-383
10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells.
You M, Miao Z, Sienkiewicz O, Jiang X, Zhao X, Hu F
International immunopharmacology 2020 Jul;84:106501
International immunopharmacology 2020 Jul;84:106501
miR-211-5p alleviates focal cerebral ischemia-reperfusion injury in rats by down-regulating the expression of COX2.
Peng Z, Li M, Tan X, Xiang P, Wang H, Luo Y, Yang Y, Huang H, Chen Z, Xia H, Li Y, Zhang J, Gu C, Liu M, Wang Q, Chen M, Yang J
Biochemical pharmacology 2020 Jul;177:113983
Biochemical pharmacology 2020 Jul;177:113983
Resveratrol slows the tumourigenesis of pancreatic cancer by inhibiting NFκB activation.
Qian W, Xiao Q, Wang L, Qin T, Xiao Y, Li J, Yue Y, Zhou C, Duan W, Ma Q, Ma J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110116
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110116
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload.
Wang J, Deng B, Liu Q, Huang Y, Chen W, Li J, Zhou Z, Zhang L, Liang B, He J, Chen Z, Yan C, Yang Z, Xian S, Wang L
Cell death & disease 2020 Jul 24;11(7):574
Cell death & disease 2020 Jul 24;11(7):574
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Xie C, Ge M, Jin J, Xu H, Mao L, Geng S, Wu J, Zhu J, Li X, Zhong C
Journal of hazardous materials 2020 Jul 15;394:122549
Journal of hazardous materials 2020 Jul 15;394:122549
Karyopherin α 2 promotes proliferation, migration and invasion through activating NF-κB/p65 signaling pathways in melanoma cells.
Yang F, Li S, Cheng Y, Li J, Han X
Life sciences 2020 Jul 1;252:117611
Life sciences 2020 Jul 1;252:117611
Baicalein attenuates the neuroinflammation in LPS-activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2/NF-κB expressions and regulation of metabolic abnormality.
Yan JJ, Du GH, Qin XM, Gao L
International immunopharmacology 2020 Feb;79:106092
International immunopharmacology 2020 Feb;79:106092
Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1/2 in polycystic ovary syndrome.
Zhou R, Li S, Liu J, Wu H, Yao G, Sun Y, Chen ZJ, Li W, Du Y
EBioMedicine 2020 Feb;52:102635
EBioMedicine 2020 Feb;52:102635
Elevated levels of arachidonic acid metabolites in follicular fluid of PCOS patients.
Li S, Qi J, Tao Y, Zhu Q, Huang R, Liao Y, Yue J, Liu W, Zhao H, Yin H, Sun Y
Reproduction (Cambridge, England) 2020 Feb;159(2):159-169
Reproduction (Cambridge, England) 2020 Feb;159(2):159-169
MiRNA-192-5p attenuates airway remodeling and autophagy in asthma by targeting MMP-16 and ATG7.
Lou L, Tian M, Chang J, Li F, Zhang G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Feb;122:109692
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Feb;122:109692
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Liu H, Zhu Y, Gao Y, Qi D, Zhao L, Zhao L, Liu C, Tao T, Zhou C, Sun X, Guo F, Xiao J
Cell death & disease 2020 Feb 18;11(2):129
Cell death & disease 2020 Feb 18;11(2):129
Autotaxin stimulates LPA2 receptor in macrophages and exacerbates dextran sulfate sodium-induced acute colitis.
Wang Z, Shi W, Tian D, Qin H, Vallance BA, Yang H, Yu HB, Yu Q
Journal of molecular medicine (Berlin, Germany) 2020 Dec;98(12):1781-1794
Journal of molecular medicine (Berlin, Germany) 2020 Dec;98(12):1781-1794
Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.
Zhang C, Shao Z, Hu X, Chen Z, Li B, Jiang R, Bsoul N, Chen J, Xu C, Gao W
International immunopharmacology 2020 Dec;89(Pt B):107079
International immunopharmacology 2020 Dec;89(Pt B):107079
Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer.
Liu Q, Xie Z, Qiu M, Shim I, Yang Y, Xie S, Yang Q, Wang D, Chen S, Fan T, Ding B, Guo Z, Adah D, Yao X, Zhang Y, Wu H, Wu Z, Wei C, Wang H, Kim HS, Zou Q, Yan Q, Cai Z, Kim JS, Liu LP, Zhang H, Cao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2020 Dec;7(24):2001191
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2020 Dec;7(24):2001191
Protective effect of hydroxysafflor yellow A on dopaminergic neurons against 6-hydroxydopamine, activating anti-apoptotic and anti-neuroinflammatory pathways.
Yang X, Li Y, Chen L, Xu M, Wu J, Zhang P, Nel D, Sun B
Pharmaceutical biology 2020 Dec;58(1):686-694
Pharmaceutical biology 2020 Dec;58(1):686-694
Analysis of Cyclooxygenase 2, Programmed Cell Death Ligand 1, and Arginase 1 Expression in Human Pituitary Adenoma.
Zhao G, Chen W, He J, Cui C, Zhao L, Zhao Y, Sun C, Nie D, Jin F, Kong L
World neurosurgery 2020 Dec;144:e660-e673
World neurosurgery 2020 Dec;144:e660-e673
Arsenic nano complex induced degradation of YAP sensitized ESCC cancer cells to radiation and chemotherapy.
Zhou W, Liu M, Li X, Zhang P, Li J, Zhao Y, Sun G, Mao W
Cell & bioscience 2020 Dec 22;10(1):146
Cell & bioscience 2020 Dec 22;10(1):146
Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice.
Gu M, Jin J, Ren C, Chen X, Gao W, Wang X, Wu Y, Tian N, Pan Z, Wu A, Zhou Y, Zhang X
Food & function 2020 Dec 1;11(12):10852-10863
Food & function 2020 Dec 1;11(12):10852-10863
Inhibitory Effects of Peroxidase from Foxtail Millet Bran on Colitis-Associated Colorectal Carcinogenesis by the Blockage of Glycerophospholipid Metabolism.
Shan S, Wu C, Shi J, Zhang X, Niu J, Li H, Li Z
Journal of agricultural and food chemistry 2020 Aug 5;68(31):8295-8307
Journal of agricultural and food chemistry 2020 Aug 5;68(31):8295-8307
Anti-inflammatory effect of Ganluyin, a Chinese classic prescription, in chronic pharyngitis rat model.
Chen YH, Luo R, Lei SS, Li B, Zhou FC, Wang HY, Chen X, He X, Wang YZ, Zhan LH, Lu TT, Su J, Yu QX, Li B, Lv GY, Chen SH
BMC complementary medicine and therapies 2020 Aug 28;20(1):265
BMC complementary medicine and therapies 2020 Aug 28;20(1):265
Berberine combined with cyclosporine A alleviates acute graft-versus-host disease in murine models.
Wang M, Zhang J, Zhao H, Wan D, Jiang Z
International immunopharmacology 2020 Apr;81:106205
International immunopharmacology 2020 Apr;81:106205
Wogonoside inhibits inflammatory cytokine production in lipopolysaccharide-stimulated macrophage by suppressing the activation of the JNK/c-Jun signaling pathway.
Yu X, Chen D, Wang L, Li J, Khan K, Chen H, Liang Y, Luo H, Qiu C
Annals of translational medicine 2020 Apr;8(8):532
Annals of translational medicine 2020 Apr;8(8):532
4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease.
Yang WJ, Chen XM, Wang SQ, Hu HX, Cheng XP, Xu LT, Ren DM, Wang XN, Zhao BB, Lou HX, Shen T
Journal of natural products 2020 Apr 24;83(4):1217-1228
Journal of natural products 2020 Apr 24;83(4):1217-1228
Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease.
Zhao J, Gao W, Cai X, Xu J, Zou D, Li Z, Hu B, Zheng Y
Theranostics 2019;9(10):2843-2855
Theranostics 2019;9(10):2843-2855
C-Phycocyanin Alleviates Bladder Inflammation and Dysfunction in Cyclophosphamide-Induced Cystitis in a Mouse Model by Inhibiting COX-2 and EP4.
Bao XQ, Huang YC, Chen F
Evidence-based complementary and alternative medicine : eCAM 2019;2019:8424872
Evidence-based complementary and alternative medicine : eCAM 2019;2019:8424872
Role of Antioxidants in the Protection from Aging-Related Diseases.
Monti DM, Rigano MM, Monti SM, Peixoto HS
Oxidative medicine and cellular longevity 2019;2019:7450693
Oxidative medicine and cellular longevity 2019;2019:7450693
Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression.
Zhang P, He D, Song E, Jiang M, Song Y
PloS one 2019;14(10):e0223760
PloS one 2019;14(10):e0223760
Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice.
Lin Z, Wu D, Huang L, Jiang C, Pan T, Kang X, Pan J
Frontiers in pharmacology 2019;10:570
Frontiers in pharmacology 2019;10:570
Neferine Attenuates Acute Kidney Injury by Inhibiting NF-κB Signaling and Upregulating Klotho Expression.
Li H, Chen W, Chen Y, Zhou Q, Xiao P, Tang R, Xue J
Frontiers in pharmacology 2019;10:1197
Frontiers in pharmacology 2019;10:1197
TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats.
Zhong X, Xiao Q, Liu Z, Wang W, Lai CH, Yang W, Yue P, Ye Q, Xiao J
Molecular medicine reports 2019 Sep;20(3):2101-2110
Molecular medicine reports 2019 Sep;20(3):2101-2110
Melatonin inhibits lung metastasis of gastric cancer in vivo.
Wang X, Wang B, Zhan W, Kang L, Zhang S, Chen C, Hou D, You R, Huang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109018
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109018
Pentamidine protects mice from cecal ligation and puncture-induced brain damage via inhibiting S100B/RAGE/NF-κB.
Huang L, Zhang L, Liu Z, Zhao S, Xu D, Li L, Peng Q, Ai Y
Biochemical and biophysical research communications 2019 Sep 17;517(2):221-226
Biochemical and biophysical research communications 2019 Sep 17;517(2):221-226
Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways.
Wu Y, Lin Z, Yan Z, Wang Z, Fu X, Yu K
International immunopharmacology 2019 Oct;75:105715
International immunopharmacology 2019 Oct;75:105715
Dioscin attenuates Bleomycin-Induced acute lung injury via inhibiting the inflammatory response in mice.
Wu ZL, Wang J
Experimental lung research 2019 Oct;45(8):236-244
Experimental lung research 2019 Oct;45(8):236-244
Therapeutic effect of yttrium oxide nanoparticles for the treatment of fulminant hepatic failure.
Song X, Shang P, Sun Z, Lu M, You G, Yan S, Chen G, Zhou H
Nanomedicine (London, England) 2019 Oct;14(19):2519-2533
Nanomedicine (London, England) 2019 Oct;14(19):2519-2533
Dehydroepiandrosterone alleviates E. Coli O157:H7-induced inflammation by preventing the activation of p38 MAPK and NF-κB pathways in mice peritoneal macrophages.
Zhao J, Cao J, Yu L, Ma H
Molecular immunology 2019 Oct;114:114-122
Molecular immunology 2019 Oct;114:114-122
Polysaccharides isolated from Nostoc commune Vaucher inhibit colitis-associated colon tumorigenesis in mice and modulate gut microbiota.
Guo M, Li Z
Food & function 2019 Oct 16;10(10):6873-6881
Food & function 2019 Oct 16;10(10):6873-6881
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Shu G, Qiu Y, Hao J, Fu Q, Deng X
Food & function 2019 Oct 16;10(10):6858-6872
Food & function 2019 Oct 16;10(10):6858-6872
The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic agent-damaged mitosis.
Chen P, Wang B, Mo Q, Wu P, Fang Y, Tian Y, Jin X, Gao Y, Wu Y, Cao Y, Zhang Y, Xi L, Wang S, Hu J, Ma D, Zhou J, Gao Q, Chen G
EBioMedicine 2019 Nov;49:26-39
EBioMedicine 2019 Nov;49:26-39
SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia.
Mo Y, Deng S, Zhang L, Huang Y, Li W, Peng Q, Liu Z, Ai Y
Biochemical and biophysical research communications 2019 Nov 26;520(1):171-178
Biochemical and biophysical research communications 2019 Nov 26;520(1):171-178
β-arrestin 2 negatively regulates NOD2 signalling pathway through association with TRAF6 in microglia after cerebral ischaemia/reperfusion injury.
Chen L, Kong L, Wei X, Wang Y, Wang B, Zhang X, Sun J, Liu H
Journal of cellular and molecular medicine 2019 May;23(5):3325-3335
Journal of cellular and molecular medicine 2019 May;23(5):3325-3335
Nano hydroxyapatite induces glioma cell apoptosis by suppressing NF-κB signaling pathway.
Guo G, Tian A, Lan X, Fu C, Yan Z, Wang C
Experimental and therapeutic medicine 2019 May;17(5):4080-4088
Experimental and therapeutic medicine 2019 May;17(5):4080-4088
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, Ye X, Li X, Zhang B
International immunopharmacology 2019 Mar;68:171-178
International immunopharmacology 2019 Mar;68:171-178
In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways.
Zhang C, Li C, Jia X, Wang K, Tu Y, Wang R, Liu K, Lu T, He C
Molecules (Basel, Switzerland) 2019 Mar 1;24(5)
Molecules (Basel, Switzerland) 2019 Mar 1;24(5)
Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis.
Wang Y, Ai L, Hai B, Cao Y, Li R, Li H, Li Y
Physiological research 2019 Jun 30;68(3):445-455
Physiological research 2019 Jun 30;68(3):445-455
Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb.
Yu HH, Lin Y, Zeng R, Li X, Zhang T, Tasneem S, Chen C, Qiu YX, Li B, Liao J, Wang YH, Cai X, Wang W
Journal of ethnopharmacology 2019 Jun 28;238:111902
Journal of ethnopharmacology 2019 Jun 28;238:111902
BG-4 from Bitter Gourd (Momordica charantia) Differentially Affects Inflammation In Vitro and In Vivo.
Nieto-Veloza A, Wang Z, Zhong Q, Krishnan HB, Dia VP
Antioxidants (Basel, Switzerland) 2019 Jun 14;8(6)
Antioxidants (Basel, Switzerland) 2019 Jun 14;8(6)
Clearance of apoptotic cells by mesenchymal stem cells contributes to immunosuppression via PGE2.
Zhang Z, Huang S, Wu S, Qi J, Li W, Liu S, Cong Y, Chen H, Lu L, Shi S, Wang D, Chen W, Sun L
EBioMedicine 2019 Jul;45:341-350
EBioMedicine 2019 Jul;45:341-350
Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway.
Fan H, Yu X, Zou Z, Zheng W, Deng X, Guo L, Jiang W, Zhan Q, Lu SH
Carcinogenesis 2019 Jul 4;40(5):669-679
Carcinogenesis 2019 Jul 4;40(5):669-679
The profiling of bioactives in Akebia trifoliata pericarp and metabolites, bioavailability and in vivo anti-inflammatory activities in DSS-induced colitis mice.
Wang X, Yu N, Peng H, Hu Z, Sun Y, Zhu X, Jiang L, Xiong H
Food & function 2019 Jul 17;10(7):3977-3991
Food & function 2019 Jul 17;10(7):3977-3991
Melatonin therapy protects against renal injury before and after release of bilateral ureteral obstruction in rats.
Li Z, Wang Y, Sun N, Liu X, Song E, Zhang Z, Wen J, Zheng T
Life sciences 2019 Jul 15;229:104-115
Life sciences 2019 Jul 15;229:104-115
Endothelial cell transient receptor potential channel C5 (TRPC5) is essential for endothelium-dependent contraction in mouse carotid arteries.
Liang C, Zhang Y, Zhuo D, Lo CY, Yu L, Lau CW, Kwan YW, Tse G, Huang Y, Yao X
Biochemical pharmacology 2019 Jan;159:11-24
Biochemical pharmacology 2019 Jan;159:11-24
Semaphoring 4D is required for the induction of antioxidant stress and anti-inflammatory effects of dihydromyricetin in colon cancer.
Liang J, Wu J, Wang F, Zhang P, Zhang X
International immunopharmacology 2019 Feb;67:220-230
International immunopharmacology 2019 Feb;67:220-230
MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4.
Wu J, Miao J, Ding Y, Zhang Y, Huang X, Zhou X, Tang R
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Dec;97(6):722-730
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Dec;97(6):722-730
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Hu Y, Gui Z, Zhou Y, Xia L, Lin K, Xu Y
Free radical biology & medicine 2019 Dec;145:146-160
Free radical biology & medicine 2019 Dec;145:146-160
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Wang Z, Liang M, Li H, Cai L, Yang L
International journal of molecular sciences 2019 Dec 6;20(24)
International journal of molecular sciences 2019 Dec 6;20(24)
Trans-10-hydroxy-2-decenoic acid alleviates LPS-induced blood-brain barrier dysfunction by activating the AMPK/PI3K/AKT pathway.
You M, Miao Z, Pan Y, Hu F
European journal of pharmacology 2019 Dec 15;865:172736
European journal of pharmacology 2019 Dec 15;865:172736
Total flavonoids from sea buckthorn ameliorates lipopolysaccharide/cigarette smoke-induced airway inflammation.
Ren QC, Li XH, Li QY, Yang HL, Wang HL, Zhang H, Zhao L, Jiang-Yong SL, Meng XL, Zhang Y, Shen XF
Phytotherapy research : PTR 2019 Aug;33(8):2102-2117
Phytotherapy research : PTR 2019 Aug;33(8):2102-2117
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2019 Aug 1;10(8):5240-5241
Food & function 2019 Aug 1;10(8):5240-5241
MicroRNA-204-5p suppresses IL6-mediated inflammatory response and chemokine generation in HK-2 renal tubular epithelial cells by targeting IL6R.
Li H, Wang J, Liu X, Cheng Q
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Apr;97(2):109-117
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Apr;97(2):109-117
ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS.
Di F, Liu J, Li S, Yao G, Hong Y, Chen ZJ, Li W, Du Y
Frontiers in endocrinology 2018;9:669
Frontiers in endocrinology 2018;9:669
High Concentration of Aspirin Induces Apoptosis in Rat Tendon Stem Cells via Inhibition of the Wnt/β-Catenin Pathway.
Wang Y, Tang H, He G, Shi Y, Kang X, Lyu J, Zhou M, Zhu M, Zhang J, Tang K
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(6):2046-2059
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(6):2046-2059
Flavonoid-Rich Ethanol Extract from the Leaves of Diospyros kaki Attenuates D-Galactose-Induced Oxidative Stress and Neuroinflammation-Mediated Brain Aging in Mice.
Ma Y, Ma B, Shang Y, Yin Q, Wang D, Xu S, Hong Y, Hou X, Liu X
Oxidative medicine and cellular longevity 2018;2018:8938207
Oxidative medicine and cellular longevity 2018;2018:8938207
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
Li YR, Li GH, Sun L, Li L, Liu Y, Kong DG, Wang SQ, Ren DM, Wang XN, Lou HX, Shen T
Oxidative medicine and cellular longevity 2018;2018:7616852
Oxidative medicine and cellular longevity 2018;2018:7616852
Anti-Inflammatory and Antioxidant Effects of Kelong-Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats.
Zhang L, Fan XR, Xie H, He QH, Nie YS, Zhang M, Yan M
Evidence-based complementary and alternative medicine : eCAM 2018;2018:5290514
Evidence-based complementary and alternative medicine : eCAM 2018;2018:5290514
Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and Autophagy.
Sun RZ, Fan Y, Liang X, Gong TT, Wang Q, Liu H, Shan ZY, Lei L
BioMed research international 2018;2018:1010248
BioMed research international 2018;2018:1010248
Combination Treatment of Icariin and L-DOPA Against 6-OHDA-Lesioned Dopamine Neurotoxicity.
Lu DS, Chen C, Zheng YX, Li DD, Wang GQ, Liu J, Shi J, Zhang F
Frontiers in molecular neuroscience 2018;11:155
Frontiers in molecular neuroscience 2018;11:155
GABAB receptor mediate hippocampal neuroinflammation in adolescent male and female mice after cold expose.
Xu B, Lian S, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM
Brain research bulletin 2018 Sep;142:163-175
Brain research bulletin 2018 Sep;142:163-175
Impacts of simultaneous exposure to arsenic (III) and copper (II) on inflammatory response, immune homeostasis, and heat shock response in chicken thymus.
Liu J, Zhao H, Wang Y, Shao Y, Zhang L, Xing M
International immunopharmacology 2018 Nov;64:60-68
International immunopharmacology 2018 Nov;64:60-68
HMGB1 knock-down promoting tumor cells viability and arrest pro-apoptotic proteins via Stat3/NFκB in HepG2 cells.
Alduais S, Alduais Y, Wu X, Li H, Mao J
BioFactors (Oxford, England) 2018 Nov;44(6):570-576
BioFactors (Oxford, England) 2018 Nov;44(6):570-576
Enhancement of glyoxalase 1, a polyfunctional defense enzyme, by quercetin in the brain in streptozotocin-induced diabetic rats.
Zhu X, Cheng YQ, Lu Q, Du L, Yin XX, Liu YW
Naunyn-Schmiedeberg's archives of pharmacology 2018 Nov;391(11):1237-1245
Naunyn-Schmiedeberg's archives of pharmacology 2018 Nov;391(11):1237-1245
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Liu Y, Fan D
Food & function 2018 Nov 14;9(11):5513-5527
Food & function 2018 Nov 14;9(11):5513-5527
Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity.
Li S, Niu H, Qiao Y, Zhu R, Sun Y, Ren Z, Yuan H, Gao Y, Li Y, Chen W, Zhou J, Lou H
Bioorganic & medicinal chemistry 2018 May 15;26(9):2392-2400
Bioorganic & medicinal chemistry 2018 May 15;26(9):2392-2400
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K, Peng J
Toxicology letters 2018 Mar 1;284:37-45
Toxicology letters 2018 Mar 1;284:37-45
Alterations of antioxidant indexes and inflammatory cytokine expression aggravated hepatocellular apoptosis through mitochondrial and death receptor-dependent pathways in Gallus gallus exposed to arsenic and copper.
Liu J, Zhao H, Wang Y, Shao Y, Li J, Xing M
Environmental science and pollution research international 2018 Jun;25(16):15462-15473
Environmental science and pollution research international 2018 Jun;25(16):15462-15473
Copper and arsenic-induced oxidative stress and immune imbalance are associated with activation of heat shock proteins in chicken intestines.
Wang Y, Zhao H, Liu J, Shao Y, Li J, Luo L, Xing M
International immunopharmacology 2018 Jul;60:64-75
International immunopharmacology 2018 Jul;60:64-75
HPV16 E7 increases COX-2 expression and promotes the proliferation of breast cancer.
Wang YX, Zhang ZY, Wang JQ, Qian XL, Cui J
Oncology letters 2018 Jul;16(1):317-325
Oncology letters 2018 Jul;16(1):317-325
Peroxisome Proliferator-Activated Receptor (PPARγ) Plays a Protective Role in Cigarette Smoking-Induced Inflammation via AMP-Activated Protein Kinase (AMPK) Signaling.
Wang L, Yin Y, Hou G, Kang J, Wang Q
Medical science monitor : international medical journal of experimental and clinical research 2018 Jul 25;24:5168-5177
Medical science monitor : international medical journal of experimental and clinical research 2018 Jul 25;24:5168-5177
Investigation of constituents from Cinnamomum camphora (L.) J. Presl and evaluation of their anti-inflammatory properties in lipopolysaccharide-stimulated RAW 264.7 macrophages.
Li YR, Fu CS, Yang WJ, Wang XL, Feng D, Wang XN, Ren DM, Lou HX, Shen T
Journal of ethnopharmacology 2018 Jul 15;221:37-47
Journal of ethnopharmacology 2018 Jul 15;221:37-47
Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
He J, Lu X, Wei T, Dong Y, Cai Z, Tang L, Liu M
International journal of molecular sciences 2018 Jul 12;19(7)
International journal of molecular sciences 2018 Jul 12;19(7)
Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis.
Zhao XC, Yang SH, Yan YQ, Zhang X, Zhang L, Jiao B, Jiang S, Yu ZB
BMC medical genomics 2018 Jul 11;11(1):59
BMC medical genomics 2018 Jul 11;11(1):59
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K, Peng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
Dai C, Ciccotosto GD, Cappai R, Tang S, Li D, Xie S, Xiao X, Velkov T
Molecular neurobiology 2018 Jan;55(1):421-434
Molecular neurobiology 2018 Jan;55(1):421-434
The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.
Lorenzi I, Oeljeklaus S, Aich A, Ronsör C, Callegari S, Dudek J, Warscheid B, Dennerlein S, Rehling P
Biochimica et biophysica acta. Molecular cell research 2018 Feb;1865(2):323-333
Biochimica et biophysica acta. Molecular cell research 2018 Feb;1865(2):323-333
Arachidonic acid induces macrophage cell cycle arrest through the JNK signaling pathway.
Shen Z, Ma Y, Ji Z, Hao Y, Yan X, Zhong Y, Tang X, Ren W
Lipids in health and disease 2018 Feb 9;17(1):26
Lipids in health and disease 2018 Feb 9;17(1):26
Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
He J, Li J, Liu H, Yang Z, Zhou F, Wei T, Dong Y, Xue H, Tang L, Liu M
International journal of molecular sciences 2018 Feb 3;19(2)
International journal of molecular sciences 2018 Feb 3;19(2)
Loganin prevents BV-2 microglia cells from Aβ(1-42) -induced inflammation via regulating TLR4/TRAF6/NF-κB axis.
Cui Y, Wang Y, Zhao D, Feng X, Zhang L, Liu C
Cell biology international 2018 Dec;42(12):1632-1642
Cell biology international 2018 Dec;42(12):1632-1642
Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress.
Wang Y, Hai B, Ai L, Cao Y, Li R, Li H, Li Y
Iranian journal of basic medical sciences 2018 Dec;21(12):1238-1244
Iranian journal of basic medical sciences 2018 Dec;21(12):1238-1244
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.
Yang WJ, Li YR, Gao H, Wu XY, Wang XL, Wang XN, Xiang L, Ren DM, Lou HX, Shen T
Journal of ethnopharmacology 2018 Dec 5;227:166-175
Journal of ethnopharmacology 2018 Dec 5;227:166-175
Proteomic profiling of human decidual immune proteins during Toxoplasma gondii infection.
Zhang D, Sun X, Ren L, Yang C, Liu X, Zhang H, Jiang Y, Hu X
Journal of proteomics 2018 Aug 30;186:28-37
Journal of proteomics 2018 Aug 30;186:28-37
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.
Cheng L, Chen L, Wei X, Wang Y, Ren Z, Zeng S, Zhang X, Wen H, Gao C, Liu H
Journal of neuroinflammation 2018 Aug 29;15(1):243
Journal of neuroinflammation 2018 Aug 29;15(1):243
Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.
Xu W, Li F, Xu Z, Sun B, Cao J, Liu Y
Cellular and molecular neurobiology 2018 Apr;38(3):735-745
Cellular and molecular neurobiology 2018 Apr;38(3):735-745
Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity.
Zheng X, Ma W, Sun R, Yin H, Lin F, Liu Y, Xu W, Zeng H
Redox biology 2018 Apr;14:237-249
Redox biology 2018 Apr;14:237-249
Localized delivery of miRNAs targets cyclooxygenases and reduces flexor tendon adhesions.
Zhou YL, Yang QQ, Yan YY, Zhu C, Zhang L, Tang JB
Acta biomaterialia 2018 Apr 1;70:237-248
Acta biomaterialia 2018 Apr 1;70:237-248
HPV16 E6 Promotes Breast Cancer Proliferation via Upregulation of COX-2 Expression.
Wang YX, Li YZ, Zhang ZY, Wang JQ, Cui J, Qian XL
BioMed research international 2017;2017:2948467
BioMed research international 2017;2017:2948467
Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra.
Huang C, Zhu L, Li H, Shi FG, Wang GQ, Wei YZ, Liu J, Zhang F
Frontiers in molecular neuroscience 2017;10:131
Frontiers in molecular neuroscience 2017;10:131
Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice.
Kawakita F, Fujimoto M, Liu L, Nakano F, Nakatsuka Y, Suzuki H
Molecular neurobiology 2017 Oct;54(8):6624-6633
Molecular neurobiology 2017 Oct;54(8):6624-6633
Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice.
Chen G, Deng H, Song X, Lu M, Zhao L, Xia S, You G, Zhao J, Zhang Y, Dong A, Zhou H
Biomaterials 2017 Nov;144:30-41
Biomaterials 2017 Nov;144:30-41
Copper or/and arsenic induce oxidative stress-cascaded, nuclear factor kappa B-dependent inflammation and immune imbalance, trigging heat shock response in the kidney of chicken.
Wang Y, Zhao H, Shao Y, Liu J, Li J, Xing M
Oncotarget 2017 Nov 17;8(58):98103-98116
Oncotarget 2017 Nov 17;8(58):98103-98116
Effect of ART1 on the proliferation and migration of mouse colon carcinoma CT26 cells in vivo.
Xu JX, Xiong W, Zeng Z, Tang Y, Wang YL, Xiao M, Li M, Li QS, Song GL, Kuang J
Molecular medicine reports 2017 Mar;15(3):1222-1228
Molecular medicine reports 2017 Mar;15(3):1222-1228
EpCAM and COX‑2 expression are positively correlated in human breast cancer.
Gao S, Sun Y, Liu X, Zhang D, Yang X
Molecular medicine reports 2017 Jun;15(6):3755-3760
Molecular medicine reports 2017 Jun;15(6):3755-3760
High soluble endoglin levels do not induce changes in structural parameters of mouse heart.
Rathouska J, Fikrova P, Mrkvicova A, Blazickova K, Varejckova M, Dolezelova E, Nemeckova I, Vitverova B, Peslova L, Gallardo-Vara E, Pericacho M, Nachtigal P
Heart and vessels 2017 Aug;32(8):1013-1024
Heart and vessels 2017 Aug;32(8):1013-1024
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model.
Gamallat Y, Meyiah A, Kuugbee ED, Hago AM, Chiwala G, Awadasseid A, Bamba D, Zhang X, Shang X, Luo F, Xin Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:536-541
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:536-541
Gx-50 reduces β-amyloid-induced TNF-α, IL-1β, NO, and PGE2 expression and inhibits NF-κB signaling in a mouse model of Alzheimer's disease.
Shi S, Liang D, Chen Y, Xie Y, Wang Y, Wang L, Wang Z, Qiao Z
European journal of immunology 2016 Mar;46(3):665-76
European journal of immunology 2016 Mar;46(3):665-76
Ibuprofen attenuates nephropathy in streptozotocin‑induced diabetic rats.
Liu YW, Zhu X, Cheng YQ, Lu Q, Zhang F, Guo H, Yin XX
Molecular medicine reports 2016 Jun;13(6):5326-34
Molecular medicine reports 2016 Jun;13(6):5326-34
A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways.
Yan T, Yu X, Sun X, Meng D, Jia JM
Fitoterapia 2016 Dec;115:37-45
Fitoterapia 2016 Dec;115:37-45
The modulatory effect of anandamide on nitroglycerin-induced sensitization in the trigeminal system of the rat.
Nagy-Grócz G, Tar L, Bohár Z, Fejes-Szabó A, Laborc KF, Spekker E, Vécsei L, Párdutz Á
Cephalalgia : an international journal of headache 2016 Aug;36(9):849-61
Cephalalgia : an international journal of headache 2016 Aug;36(9):849-61
Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice.
Yuan L, Liu S, Bai X, Gao Y, Liu G, Wang X, Liu D, Li T, Hao A, Wang Z
Journal of neuroinflammation 2016 Apr 13;13(1):77
Journal of neuroinflammation 2016 Apr 13;13(1):77
Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth.
Zhang L, Tong Y, Zhang X, Pan M, Chen S
Drug design, development and therapy 2015;9:5851-62
Drug design, development and therapy 2015;9:5851-62
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Dong D, Yin L, Qi Y, Xu L, Peng J
Nutrients 2015 Jun 15;7(6):4829-50
Nutrients 2015 Jun 15;7(6):4829-50
Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study.
Aziz F, Yang X, Wang X, Yan Q
Journal of cancer research and clinical oncology 2015 Jul;141(7):1221-35
Journal of cancer research and clinical oncology 2015 Jul;141(7):1221-35
Cerebral ischemia increases bone marrow CD4+CD25+FoxP3+ regulatory T cells in mice via signals from sympathetic nervous system.
Wang J, Yu L, Jiang C, Fu X, Liu X, Wang M, Ou C, Cui X, Zhou C, Wang J
Brain, behavior, and immunity 2015 Jan;43:172-83
Brain, behavior, and immunity 2015 Jan;43:172-83
MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.
Aras S, Bai M, Lee I, Springett R, Hüttemann M, Grossman LI
Mitochondrion 2015 Jan;20:43-51
Mitochondrion 2015 Jan;20:43-51
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
Mangiferin attenuates renal fibrosis through down-regulation of osteopontin in diabetic rats.
Zhu X, Cheng YQ, Du L, Li Y, Zhang F, Guo H, Liu YW, Yin XX
Phytotherapy research : PTR 2015 Feb;29(2):295-302
Phytotherapy research : PTR 2015 Feb;29(2):295-302
Potent effects of the total saponins from Dioscorea nipponica Makino against streptozotocin-induced type 2 diabetes mellitus in rats.
Yu H, Zheng L, Xu L, Yin L, Lin Y, Li H, Liu K, Peng J
Phytotherapy research : PTR 2015 Feb;29(2):228-40
Phytotherapy research : PTR 2015 Feb;29(2):228-40
Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice.
Wang HL, Li YX, Niu YT, Zheng J, Wu J, Shi GJ, Ma L, Niu Y, Sun T, Yu JQ
Inflammation 2015 Dec;38(6):2269-78
Inflammation 2015 Dec;38(6):2269-78
Anti-inflammation Effects of Oxysophoridine on Cerebral Ischemia-Reperfusion Injury in Mice.
Wang YS, Li YX, Zhao P, Wang HB, Zhou R, Hao YJ, Wang J, Wang SJ, Du J, Ma L, Sun T, Yu JQ
Inflammation 2015 Dec;38(6):2259-68
Inflammation 2015 Dec;38(6):2259-68
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Celecoxib ameliorates non-alcoholic steatohepatitis in type 2 diabetic rats via suppression of the non-canonical Wnt signaling pathway expression.
Tian F, Zhang YJ, Li Y, Xie Y
PloS one 2014;9(1):e83819
PloS one 2014;9(1):e83819
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Tao X, Wan X, Xu Y, Xu L, Qi Y, Yin L, Han X, Lin Y, Peng J
Transplantation 2014 Sep 27;98(6):604-11
Transplantation 2014 Sep 27;98(6):604-11
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
Xu D, Hu L, Su C, Xia X, Zhang P, Fu J, Wang W, Xu D, Du H, Hu Q, Song E, Song Y
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells.
Kuang J, Wang YL, Xiao M, Tang Y, Chen WW, Song GL, Yang X, Li M
Oncology reports 2014 May;31(5):2335-43
Oncology reports 2014 May;31(5):2335-43
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Dong D, Xu L, Han X, Qi Y, Xu Y, Yin L, Liu K, Peng J
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats.
Liu YW, Zhu X, Zhang L, Lu Q, Zhang F, Guo H, Yin XX
Pharmacology, biochemistry, and behavior 2014 Feb;117:128-36
Pharmacology, biochemistry, and behavior 2014 Feb;117:128-36
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075
Food & function 2014 Dec;5(12):3065-3075
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Liu M, Xu Y, Han X, Liang C, Yin L, Xu L, Qi Y, Zhao Y, Peng J, Sun C
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation.
Yu H, Zheng L, Yin L, Xu L, Qi Y, Han X, Xu Y, Liu K, Peng J
International immunopharmacology 2014 Apr;19(2):233-44
International immunopharmacology 2014 Apr;19(2):233-44
Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation.
Zhang S, Qi Y, Xu Y, Han X, Peng J, Liu K, Sun CK
Neurochemistry international 2013 Nov;63(5):522-32
Neurochemistry international 2013 Nov;63(5):522-32
Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.
Ding QH, Cheng Y, Chen WP, Zhong HM, Wang XH
European journal of pharmacology 2013 May 15;708(1-3):1-7
European journal of pharmacology 2013 May 15;708(1-3):1-7
Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
Dong D, Zhang S, Yin L, Tang X, Xu Y, Han X, Qi Y, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:120-30
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:120-30
Akebia Saponin D attenuates amyloid β-induced cognitive deficits and inflammatory response in rats: involvement of Akt/NF-κB pathway.
Yu X, Wang LN, Du QM, Ma L, Chen L, You R, Liu L, Ling JJ, Yang ZL, Ji H
Behavioural brain research 2012 Dec 1;235(2):200-9
Behavioural brain research 2012 Dec 1;235(2):200-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- LPS treated HEK-293 cells were subjected to SDS PAGE followed by western blot with 12375-1-AP(PTGS2 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The COX2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human COX2. This antibody recognizes human,mouse,rat antigen. The COX2 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary using 12375-1-AP(PTGS2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary using 12375-1-AP(PTGS2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
