Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS1076 - Provider product page
- Provider
- Bioworld Technology, Inc
- Proper citation
- Bioworld Technology Cat#BS1076, RRID:AB_1664012
- Product name
- Cox 2 (T594) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids C-terminus of Human Cox-2.
- Description
- Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate in formation of the prostaglandins. Two prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) are cyclooxygenase-1 and cyclooxygenase-2. Cyclooxygenase-2, or Cox-2, is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. An alternative form of the protein, designated Cox-1, is constitutively expressed in most tissues and is thought to serve in general ¡ùhousekeeping¡ì functions. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatorydrugs, NSAIDs.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of Cox-2 (T594) pAb at 1:500 dilutionLane1:Hela whole cell lysate treated with LPSLane2:Jurkat whole cell lysate treated with LPS Lane3:Raw264.7 whole cell lysate treated with LPSLane3:Rat lung tissue lysate