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- Antibody Data
- Antigen structure
- References [165]
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- Product number
- 27308-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- COX2/ Cyclooxygenase 2/ PTGS2 antibody
- Antibody type
- Polyclonal
- Description
- COX2/ Cyclooxygenase 2/ PTGS2 antibody (Cat. #27308-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Peroxiredoxin 4 suppresses ferroptosis in esophageal squamous cell carcinoma by activating the phosphoinositide 3-kinase signaling pathway.
FXR-mediated transcriptional regulation of KLF11 mitigates contrast-induced acute kidney injury via suppressing JAK2/STAT3 pathway.
Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes ameliorate knee osteoarthritis by promoting cartilage regeneration and alleviating pain in rats.
Curcumin protects against difenoconazole-induced kidney injury in carp by inhibiting ferroptosis through the Nrf2/GPX4 axis.
Shenqi funeng xingnao prescription regulated the TNF/NOD‒like receptor signaling pathway and brain-gut axis dysfunction caused by exercise-induced fatigue.
TRPM7 inhibition alleviates acute gouty arthritis in mice by suppressing M1 polarization through the EDN1/EDNRB axis.
Discovery of novel HDAC6 inhibitors based on the diphenyl-1,2,4-oxadiazole scaffold with potential efficacy in alleviating inflammation- and chemotherapy- associated mechanical hypersensitivity.
Methyl 3-chloroasterric acid exerted anti-neuroinflammatory and antidepressant effects through the downregulation of P2Y1R.
Overexpression of mitofusin 2 ameliorates inflammation and oxidative stress in lipopolysaccharide-induced mastitis model by regulating phosphofurin acidic cluster sorting protein 2.
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Thymoquinone Protects Against Cardiac Hypertrophy via PPAR-γ/PI3K/Akt Pathway.
Oxysophoridine promotes osteoarthritis repair via GSH system activation and ROS suppression.
ROS-Scavenging Bamboo-Derived Carbon Dot-Methotrexate Nanocomposite Ameliorates Rheumatoid Arthritis through Dual Therapeutic Mechanisms.
The protective up-regulation of metallothionein-2A in intervertebral disc degeneration inhibits nucleus pulposus cell ferroptosis through activation of the PI3K/AKT/mTOR pathway.
FADS1 contributes to anesthesia/surgery-induced cognitive impairment by aggravating omega-6 fatty acid metabolic disruption in aged mice.
Acid neutralization and metal-phenolic nanomedicine on-demand release microspheres for reversing cartilage degeneration.
Tussilagone attenuated cigarette smoke-induced chronic obstructive pulmonary disease through regulating Nrf2 and NF-κB/NLRP3 inflammasome via directly targeting cysteine 434 of KEAP1.
NUPR1 and LCN2: Potential Therapeutic Targets for Colorectal Cancer Via Modulating Cell Viability, Migration, and Ferroptosis-Related Pathways.
Sequential delivery of sinigrin and dabigatran by an in situ self-stabilizing dynamic hydrogel attenuates intervertebral disc degeneration.
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polarization via mitophagy.
Apigenin-5-O-glucoside alleviates hepatic fibrosis through NOX4-mediated ferroptosis in zebrafish.
O-GlcNAc Modification Orchestrates HUWE1-Mediated Ubiquitination of TfR1 to Regulate Ferroptosis and Trophoblast Syncytialization in Preeclampsia.
Lycium Barbarum Polysaccharide Attenuates Staphylococcus aureus-Induced Mastitis via the Gut Microbiota-Derived Indole-3-Propionic Acid/AhR-IL-22-STAT3 Axis.
Targeting Reactive Oxygen Species and Inflammation in Sepsis-Induced Liver Injury with Naturally Derived Superoxide Dismutase-Mimicking Carbon Dots.
Atorvastatin Alleviates Sepsis-Induced Cardiomyopathy by Targeting the METTL3/IGF2BP1/CXCL2 Pathway.
Semaphorin 6D Alleviates Osteoarthritis by Inhibiting NLRP3 Inflammasome Activation and Endoplasmic Reticulum Stress.
TYMS Enhances Colorectal Cell Antioxidant Capacity Via the KEAP1-NRF2 Pathway to Resist Ferroptosis.
IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis.
Neonatal supplementation of oleamide during suckling ameliorates maternal postpartum sleep interruption-induced neural impairment and endocannabinoid dysfunction in early adolescent offspring rats.
Kaempferol Suppresses Mesothelial-Mesenchymal Transition and Attenuates Postoperative Peritoneal Adhesions by Blocking the TNF-α/COX2 Signalling Pathway.
miR-210-3p Ameliorates Metabolic Dysfunction-Associated Steatohepatitis-Related Fibrosis by Targeting ISCU and Induces Ferroptosis.
Coptisine Improves Liver Inflammation in Sepsis by Regulating STAT1/IRF1/GPX4 Signaling-Mediated Kupffer Cells Ferroptosis.
Self-assembled cyanidin-3-O-glucoside nanoparticles alleviate inflammation and ferroptosis induced by PRRSV infection.
Therapeutic targeting of Nrf2/HO-1/NF-κB signaling axis with casticin mitigates intervertebral disc degeneration: in vitro and in vivo investigations.
Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species-mediated activation of the NLRP3 inflammasome.
Elucidating the mechanism by which Aloe-emodin from Cassiae semen treats diabetic retinopathy via network pharmacology and experimental verification.
Microglia-Derived Exosomal miR-223-3p Targets the RhoB-NF-κB-CCL11 Axis in Astrocytes and Relieves Neuronal Damage in Subarachnoid Hemorrhage.
Vilazodone ameliorates senescence-related Alzheimer's disease like symptoms by targeting Plau to induce autophagy in senescent cells.
Atraric acid attenuates chronic intermittent hypoxia-induced lung injury by inhibiting ferroptosis through activation of the NRF2 pathway.
Xiaoyao San against depression via glia-mediated neuroinflammation using network pharmacology and experimental validation.
Leptomonines A and B, two novel rare benzyltetrahydroisoquinoline N-oxides from the aerial parts of Leptopyrum fumarioides as potential COX-2 inhibitors: in vitro and in silico studies.
Flammulina velutipes polysaccharide exerts immunomodulatory function involving RSAD2 to regulate the NF-κB/MAPK signaling pathway in RAW264.7 macrophage cells and in mouse spleen cells.
Macrolide sesquiterpene pyridine alkaloids from the roots of Tripterygium regelii and their anti-inflammatory activity.
Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration.
Benzyl butyl phthalate promotes ferroptosis in Sertoli cells via disrupting ceruloplasmin-mediated iron balance.
The dopamine receptor agonist rotigotine attenuated indomethacin-induced enteropathy in the small intestinal mucosa of mice.
Environmental responsive dual-drug synergistic and dual-targeted polymer micelles based on chondroitin sulfate for treatment of breast cancer.
Scutellaria baicalensis Extracts Restrict Intestinal Epithelial Cell Ferroptosis by Regulating Lipid Peroxidation and GPX4/ACSL4 in Colitis.
Tanshinone IIA promotes ferroptosis in cutaneous melanoma via STAT1-mediated upregulation of PTGS2 expression.
Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury.
Marsdenia tenacissima extract accelerates ferroptosis of osteosarcoma cells by upregulating HO-1 and activating mitophagy.
Pharmacological effects and mechanisms of alkamides DDA-E and DDA-Z from Asari Radix et Rhizoma in migraine: Insights from serum pharmacochemistry, network pharmacology, and experimental validation.
Periplocin targets LRP4 to regulate metabolic homeostasis and anti-inflammation for the treatment of IVDD.
Znhit1 alleviates nitroglycerin-induced hyperalgesia in migraine mice via the inhibition of NOD-like receptor signaling pathway.
Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway.
Network pharmacology-based strategy to reveal Acacetin against lipopolysaccharide-induced lung injury.
Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease.
Protein kinase a suppresses antiproliferative effect of interferon-α in hepatocellular carcinoma by activation of protein tyrosine phosphatase SHP2.
Oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cells.
Phillyrin ameliorates DSS-induced colitis in mice via modulating the gut microbiota and inhibiting the NF-κB/MLCK pathway.
Regulation of macrophage-mediated osteogenesis by kaempferol liposomes in trauma-induced heterotopic ossification.
USP36 suppresses breast cancer cell ferroptosis by regulating the ubiquitination and stability of KIF2C.
Lysophosphatidylcholine Acyltransferase 1-Phosphatidylcholine Axis Protects Nucleus Pulposus Cells From Ferroptosis by Facilitating Lysosomal Repair via Interaction With the Endoplasmic Reticulum.
IRF7 orchestrates proinflammatory macrophage polarization and joint destruction in rheumatoid arthritis.
CircZNF418 Prevents Intervertebral Disc Degeneration by Targeting the HuR/SIRT6 Axis to Protect Against Oxidative Stress-Induced Ferroptosis and Senescence.
Knockdown of FSTL1 attenuates sepsis-induced acute lung injury by inhibiting inflammation and ferroptosis.
F-box only protein 10 protects against kidney tubulointerstitial fibrosis by inhibiting ACSL4-mediated lipid peroxidation and ferroptosis.
BAOXIN granules reverse ferroptosis through the solute carrier family 7 member -glutathione-glutathione peroxidase 4 axis in ischemia-induced heart failure in rats.
Whole-gene CRISPR/cas9 library screen revealed targeting STAT6 increased the sensitivity of liver cancer to celecoxib via inhibiting arachidonic acid shunting.
CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.
Systemic Lupus Erythematosus Exacerbates Hip Arthritis by Promoting Chondrocyte Pyroptosis in the Femoral Head via Activating the NF-κB Pathway.
Targeting ceramide-induced microglial pyroptosis: Icariin is a promising therapy for Alzheimer's disease.
Nanomedicine Penetrating Blood-Pancreas Barrier for Effective Treatment of Acute Pancreatitis.
Quercetin-primed MSC exosomes synergistically attenuate osteoarthritis progression.
Oxalate stimulates macrophage secretion of prostaglandin E2 to promote renal tubular epithelial cell osteogenesis.
Transferrin-Modified Carprofen Platinum(IV) Nanoparticles as Antimetastasis Agents with Tumor Targeting, Inflammation Inhibition, Epithelial-Mesenchymal Transition Suppression, and Immune Activation Properties.
Anti-colorectal cancer activity of mannatide from spent brewer's yeast by regulating immune cells and immune function in the tumor microenvironment.
Ellagic acid improves osteoarthritis by inhibiting PGE2 production in M1 macrophages via targeting PTGS2.
LysoPE mediated by respiratory microorganism Aeromicrobium camelliae alleviates H9N2 challenge in mice.
Ursodeoxycholic Acid Platinum(IV) Conjugates as Antiproliferative and Antimetastatic Agents: Remodel the Tumor Microenvironment through Suppressing JAK2/STAT3 Signaling.
Unveiling the crucial role of ferroptosis in host resistance to streptococcus agalactiae infection.
Unveiling Smyd-2's Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion.
TIMP1 regulates ferroptosis in osteoblasts by inhibiting TFRC ubiquitination: an in vitro and in vivo study.
Restoration of ARA metabolic disorders in vascular smooth muscle cells alleviates intimal hyperplasia.
An integrated network pharmacology, molecular docking and experiment validation study to investigate the potential mechanism of Isobavachalcone in the treatment of osteoarthritis.
Resveratrol protects cardiomyocytes against ischemia/reperfusion-induced ferroptosis via inhibition of the VDAC1/GPX4 pathway.
Pentraxin 3 exacerbates psoriasiform dermatitis through regulation of macrophage polarization.
Exposure to nicotine regulates prostaglandin E2 secretion and autophagy of granulosa cells to retard follicular maturation in mammals.
Nonswellable Hydrogel Patch with Tissue-Mimetic Mechanical Characteristics Remodeling In Vivo Microenvironment for Effective Adhesion Prevention.
Activation of PPAR-α attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis and mitochondrial injury via upregulating 14-3-3η.
COL6A3 enhances the osteogenic differentiation potential of BMSCs by promoting mitophagy in the osteoporotic microenvironment.
The protective effect of Ergolide in osteoarthritis: In vitro and in vivo studies.
Discovery from Hypericum elatoides and synthesis of hyperelanitriles as α-aminopropionitrile-containing polycyclic polyprenylated acylphloroglucinols.
Comparison of the inhibition effects of naringenin and its glycosides on LPS-induced inflammation in RAW 264.7 macrophages.
Mechanism of lysine oxidase-like 1 promoting synovial inflammation mediating rheumatoid arthritis development.
Identification of differentially expressed genes associated with ferroptosis in Crohn's disease.
In vitro and in vivo biological evaluation of Lappaconitine derivatives as potential anti-inflammatory agents.
Arteannuin B, a sesquiterpene lactone from Artemisia annua, attenuates inflammatory response by inhibiting the ubiquitin-conjugating enzyme UBE2D3-mediated NF-κB activation.
Chronic exposure to polystyrene microplastics induces renal fibrosis via ferroptosis.
Engineering of phosphatidylserine-targeting ROS-responsive polymeric prodrug for the repair of ischemia-reperfusion-induced acute kidney injury.
Puerarin Protects Myocardium From Ischaemia/Reperfusion Injury by Inhibiting Ferroptosis Through Downregulation of VDAC1.
Baliosperoid A attenuates lipopolysaccharide-induced acute lung injury by targeting SHP2 to inhibit inflammation and oxidative stress.
Biologically active franchetine-type diterpenoid alkaloids: Isolation, synthesis, anti-inflammatory, agalgesic activities, and molecular docking.
To explore the protective mechanism of promethazine against hippocampal neuron injury based on network pharmacology and experimental verification.
Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro.
Chronic microcystin-leucine-arginine exposure induces osteoporosis by breaking the balance of osteoblasts and osteoclasts.
Mechanism of Xing 9 ling tablet candy for alcoholic liver disease based on network pharmacology.
Auraptene Mitigates Colitis Induced by Dextran Sulfate Sodium in Mice by Regulating Specific Intestinal Flora and Repairing the Intestinal Barrier.
Microgel-based carriers enhance skeletal stem cell reprogramming towards immunomodulatory phenotype in osteoarthritic therapy.
Suspected renal interstitial cell tumor causing polycythemia in two dogs.
Active metabolites and potential mechanisms of Notopterygium incisum against obstructive sleep apnea Syndrome (OSAS): network analysis and experimental assessment.
Diabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and in vitro validation.
Dietary emodin alleviates lipopolysaccharide-induced intestinal mucosal barrier injury by regulating gut microbiota in piglets.
IL-38 suppresses macrophage M1 polarization to ameliorate synovial inflammation in the TMJ via GLUT-1 inhibition.
Maslinic acid alleviates LPS-induced mice mastitis by inhibiting inflammatory response, maintaining the integrity of the blood-milk barrier and regulating intestinal flora.
Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway.
δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis.
Integrating UPLC-Q-Exactive Orbitrap/MS, network pharmacology and experimental validation to reveal the potential mechanism of Tibetan medicine Rhodiola granules in improving myocardial ischemia-reperfusion injury.
Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease.
The extract from Portulaca oleracea L. rehabilitates skin photoaging via adjusting miR-138-5p/Sirt1-mediated inflammation and oxidative stress.
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Isobavachalcone ameliorates the progression of osteoarthritis by suppressing NF-κB signaling pathway.
Silibinin alleviates ferroptosis of rat islet β cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy.
Huc-MSCs-derived exosomes attenuate neuropathic pain by inhibiting activation of the TLR2/MyD88/NF-κB signaling pathway in the spinal microglia by targeting Rsad2.
Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice.
Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress.
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6.
M2 Macrophage Membrane-Mediated Biomimetic-Nanoparticle Carrying COX-siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation.
Taxifolin Reduces Blood Pressure via Improvement of Vascular Function and Mitigating the Vascular Inflammatory Response in Spontaneously Hypertensive Rats.
MEN1 is a regulator of alternative splicing and prevents R-loop-induced genome instability through suppression of RNA polymerase II elongation.
PET117 assembly factor stabilizes translation activator TACO1 thereby upregulates mitochondria-encoded cytochrome C oxidase 1 synthesis.
Overexpression of GPX4 attenuates cognitive dysfunction through inhibiting hippocampus ferroptosis and neuroinflammation after traumatic brain injury.
Cardamonin alleviates chondrocytes inflammation and cartilage degradation of osteoarthritis by inhibiting ferroptosis via p53 pathway.
EPC-exosomal miR-26a-5p improves airway remodeling in COPD by inhibiting ferroptosis of bronchial epithelial cells via PTGS2/PGE2 signaling pathway.
The Protective Effect of Sulforaphane on Dextran Sulfate Sodium-Induced Colitis Depends on Gut Microbial and Nrf2-Related Mechanism.
MiR-205-5p Functions as a Tumor Suppressor in Gastric Cancer Cells through Downregulating FAM84B.
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
Atorvastatin attenuates ferroptosis-dependent myocardial injury and inflammation following coronary microembolization via the Hif1a/Ptgs2 pathway.
Network analysis and experimental pharmacology study explore the protective effects of Isoliquiritigenin on 5-fluorouracil-Induced intestinal mucositis.
Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation.
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury.
Oxybaphus himalaicus Mitigates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting TLR4/MD2 Complex Formation.
α-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease.
Golgi Phosphoprotein 3 Mediates Radiation-Induced Bystander Effect via ERK/EGR1/TNF-α Signal Axis.
Combination of mitochondria impairment and inflammation blockade to combat metastasis.
Morphological changes of macrophages and their potential contribution to tendon healing.
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.
Enhancement of the functionality of attenuating acute lung injury by a microemulsion formulation with volatile oil of Angelicae Sinensis Radix and Ligusticum Chuanxiong Rhizoma encapsulated.
Burdock (Arctium lappa L.) leaf flavonoids rich in morin and quercetin 3-O-rhamnoside ameliorate lipopolysaccharide-induced inflammation and oxidative stress in RAW264.7 cells.
The licorice flavonoid isoliquiritigenin attenuates Mycobacterium tuberculosis-induced inflammation through Notch1/NF-κB and MAPK signaling pathways.
Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin.
Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism.
hsa-miR-15b-5p regulates the proliferation and apoptosis of human vascular smooth muscle cells by targeting the ACSS2/PTGS2 axis.
Programmable Polymeric Microneedles for Combined Chemotherapy and Antioxidative Treatment of Rheumatoid Arthritis.
Protective effect of scorpion venom heat-resistant synthetic peptide against PM(2.5)-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway.
TFAM knockdown-triggered mtDNA-nucleoid aggregation and a decrease in mtDNA copy number induce the reorganization of nucleoid populations and mitochondria-associated ER-membrane contacts.
Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.
Silencing of PTX3 alleviates LPS-induced inflammatory pain by regulating TLR4/NF-κB signaling pathway in mice.
Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells.
Ajudecumin A from Ajuga ovalifolia var. calantha exhibits anti-inflammatory activity in lipopolysaccharide-activated RAW264.7 murine macrophages and animal models of acute inflammation.
Li K, Xu S, Liu H, Fan T, Li Y, Ren R, Xu Y, Li S, Liu Y
Biomedical reports 2026 May;24(5):60
Biomedical reports 2026 May;24(5):60
FXR-mediated transcriptional regulation of KLF11 mitigates contrast-induced acute kidney injury via suppressing JAK2/STAT3 pathway.
Su BW, Yang HX, Wang WH, Wen L, Cui XH, Bao YN, Ren HW, Wang GY, Hu WJ, Yuan RQ, Wen RK, Luan ZL
International immunopharmacology 2026 May 15;177:116494
International immunopharmacology 2026 May 15;177:116494
Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes ameliorate knee osteoarthritis by promoting cartilage regeneration and alleviating pain in rats.
Zhang B, Lu C, Dou B, Gu W, Li K
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Regenerative therapy 2026 Mar;31:101049
Curcumin protects against difenoconazole-induced kidney injury in carp by inhibiting ferroptosis through the Nrf2/GPX4 axis.
Zhang S, Li X, Gao Y, Dong Q, Jin X, Shi P, Dong J
Fish physiology and biochemistry 2026 Mar 5;52(2)
Fish physiology and biochemistry 2026 Mar 5;52(2)
Shenqi funeng xingnao prescription regulated the TNF/NOD‒like receptor signaling pathway and brain-gut axis dysfunction caused by exercise-induced fatigue.
Xu D, Zhang W, Tao XR, Gao K, Zhao MN, Wang JW
Journal of ethnopharmacology 2026 Mar 1;358:121035
Journal of ethnopharmacology 2026 Mar 1;358:121035
TRPM7 inhibition alleviates acute gouty arthritis in mice by suppressing M1 polarization through the EDN1/EDNRB axis.
Wu S, Zhang Y, Jiang C, Zhang Y, Yu P, Zhao W, Wang Z, Chen Y, Cheng Y, Ding J, Xu Y, Zhao Y, Zhou R, Hu W
International immunopharmacology 2026 Jun 15;179:116624
International immunopharmacology 2026 Jun 15;179:116624
Discovery of novel HDAC6 inhibitors based on the diphenyl-1,2,4-oxadiazole scaffold with potential efficacy in alleviating inflammation- and chemotherapy- associated mechanical hypersensitivity.
Yin L, Yin M, Fan Z, Shi Y, Shan J, Wang L, Chen Y, Hao C, Zhuang T, Liu T, Cao X
Bioorganic chemistry 2026 Jul 5;175:109785
Bioorganic chemistry 2026 Jul 5;175:109785
Methyl 3-chloroasterric acid exerted anti-neuroinflammatory and antidepressant effects through the downregulation of P2Y1R.
Zhang Y, Sun M, Zhang Z, Jia Y, Xiao H, Xu X, Pan X, Li Z
International immunopharmacology 2026 Jul 15;181:116689
International immunopharmacology 2026 Jul 15;181:116689
Overexpression of mitofusin 2 ameliorates inflammation and oxidative stress in lipopolysaccharide-induced mastitis model by regulating phosphofurin acidic cluster sorting protein 2.
Zhou X, Zhang Y, Ma H, Fu S, Liu J, Guo W, Tian X, Huang B
Animal models and experimental medicine 2026 Jan;9(1):154-167
Animal models and experimental medicine 2026 Jan;9(1):154-167
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Li M, Peng Y, Xiao Q, Chen S, Zhang C, Chen H, Zhao Y, Chang S, Qiu L, Zhang L, Guo X, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Thymoquinone Protects Against Cardiac Hypertrophy via PPAR-γ/PI3K/Akt Pathway.
Qiu RB, Wu ZM, Xu ZQ, Hu LJ, Zhao ST, Zeng RY, Qiu ZC, Zhou LF, Lai SQ, Wang WJ, Wan L
Journal of cellular and molecular medicine 2026 Feb;30(3):e70911
Journal of cellular and molecular medicine 2026 Feb;30(3):e70911
Oxysophoridine promotes osteoarthritis repair via GSH system activation and ROS suppression.
Tu J, Peng Z, Sun X, Liu H, Zhao J, Xu B, Zhu X, Liu B
Scientific reports 2026 Feb 3;16(1):7092
Scientific reports 2026 Feb 3;16(1):7092
ROS-Scavenging Bamboo-Derived Carbon Dot-Methotrexate Nanocomposite Ameliorates Rheumatoid Arthritis through Dual Therapeutic Mechanisms.
Hu XR, Wang F, Zhao BF, Xu F, Wang Y
ACS omega 2026 Feb 3;11(4):5853-5864
ACS omega 2026 Feb 3;11(4):5853-5864
The protective up-regulation of metallothionein-2A in intervertebral disc degeneration inhibits nucleus pulposus cell ferroptosis through activation of the PI3K/AKT/mTOR pathway.
Cai H, Zheng HL, Chen QZ, Song SK, Yang BY, Wang Y, Deng H, Mardan M, Lu ZY, Chen PB, Xu QY, Li B, Jiang LS, Zheng XF, Jiang SD
Cell death discovery 2026 Feb 25;12(1)
Cell death discovery 2026 Feb 25;12(1)
FADS1 contributes to anesthesia/surgery-induced cognitive impairment by aggravating omega-6 fatty acid metabolic disruption in aged mice.
Chen Z, Wu Q, Ma J, Shi Y, Zhang Q, Wu H, Zhang Y, Li Z, Ruan X, Xiong L, Cong P, Tian L
Journal of neuroinflammation 2026 Feb 11;23(1)
Journal of neuroinflammation 2026 Feb 11;23(1)
Acid neutralization and metal-phenolic nanomedicine on-demand release microspheres for reversing cartilage degeneration.
Wang S, Gao Y, Dong L, Shu J, Feng F, Ren L, Hu X, Yang L, Lei M, Chen X, Pan L, Wang X, Xu K, Wang C
Journal of controlled release : official journal of the Controlled Release Society 2026 Feb 10;390:114523
Journal of controlled release : official journal of the Controlled Release Society 2026 Feb 10;390:114523
Tussilagone attenuated cigarette smoke-induced chronic obstructive pulmonary disease through regulating Nrf2 and NF-κB/NLRP3 inflammasome via directly targeting cysteine 434 of KEAP1.
Xu LT, Han QT, Xu ZP, Wang XN, Zhang H, Shen T
Journal of advanced research 2026 Apr;82:1149-1162
Journal of advanced research 2026 Apr;82:1149-1162
NUPR1 and LCN2: Potential Therapeutic Targets for Colorectal Cancer Via Modulating Cell Viability, Migration, and Ferroptosis-Related Pathways.
Luo D, Luo X, Qian S, Liu J
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70809
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70809
Sequential delivery of sinigrin and dabigatran by an in situ self-stabilizing dynamic hydrogel attenuates intervertebral disc degeneration.
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Materials today. Bio 2026 Apr;37:102827
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Kakkalide promotes spinal cord injury repair by regulating microglial M2 polarization via mitophagy.
You T, Dai B, Ding X, He Z, Peng J, Tao S, Ye L, Song T, Fan Z, Chen N
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157985
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157985
Apigenin-5-O-glucoside alleviates hepatic fibrosis through NOX4-mediated ferroptosis in zebrafish.
Li M, Deng K, Cheng J, Shi H, Li Y, Wang Y, Wen J, Lv Z, Huang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157956
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157956
O-GlcNAc Modification Orchestrates HUWE1-Mediated Ubiquitination of TfR1 to Regulate Ferroptosis and Trophoblast Syncytialization in Preeclampsia.
Zhang H, Li M, Zhang J, Sun Q, Jin X, Liu R, Li X, Chen X, Wang A, Luo Z, Shang Y, Kong Y
Free radical biology & medicine 2026 Apr 8;
Free radical biology & medicine 2026 Apr 8;
Lycium Barbarum Polysaccharide Attenuates Staphylococcus aureus-Induced Mastitis via the Gut Microbiota-Derived Indole-3-Propionic Acid/AhR-IL-22-STAT3 Axis.
Li K, Ran X, Ding H, Han J, Zhang L, Wang X, Guo W, Li Y, Fu S, Bi J
Journal of agricultural and food chemistry 2026 Apr 22;74(15):12038-12053
Journal of agricultural and food chemistry 2026 Apr 22;74(15):12038-12053
Targeting Reactive Oxygen Species and Inflammation in Sepsis-Induced Liver Injury with Naturally Derived Superoxide Dismutase-Mimicking Carbon Dots.
Zhong C, Song N, Huang P, Han L, Zhang J, Lu Z, Wang L
Biomaterials research 2025;29:0249
Biomaterials research 2025;29:0249
Atorvastatin Alleviates Sepsis-Induced Cardiomyopathy by Targeting the METTL3/IGF2BP1/CXCL2 Pathway.
Zhang L, Yin Y, Zheng L, Wang Y, Zhao J, Mu F, Jin F, Gong R, Wang J
Journal of inflammation research 2025;18:14609-14628
Journal of inflammation research 2025;18:14609-14628
Semaphorin 6D Alleviates Osteoarthritis by Inhibiting NLRP3 Inflammasome Activation and Endoplasmic Reticulum Stress.
Zhang W, Li C, Yao J, Xu Z, Huang Y, Lu Y, Lin X, Guo Z, Zhou X
Journal of inflammation research 2025;18:13909-13924
Journal of inflammation research 2025;18:13909-13924
TYMS Enhances Colorectal Cell Antioxidant Capacity Via the KEAP1-NRF2 Pathway to Resist Ferroptosis.
Chen J, Wu W, Wang L, Zhang J, Che X, Zhai L, Zhao Z, Li Y
Journal of Cancer 2025;16(2):417-429
Journal of Cancer 2025;16(2):417-429
IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis.
Deng J, Gu J, Gong X, Tang H, Cai Y, Yang Y, Dong S, Zhao C
Frontiers in immunology 2025;16:1630253
Frontiers in immunology 2025;16:1630253
Neonatal supplementation of oleamide during suckling ameliorates maternal postpartum sleep interruption-induced neural impairment and endocannabinoid dysfunction in early adolescent offspring rats.
Qian L, Zheng T, Zhao B, Wang W, Wu Y
Frontiers in nutrition 2025;12:1566182
Frontiers in nutrition 2025;12:1566182
Kaempferol Suppresses Mesothelial-Mesenchymal Transition and Attenuates Postoperative Peritoneal Adhesions by Blocking the TNF-α/COX2 Signalling Pathway.
Zhang L, Li G, Ren Y, Sun Y, Deng K, Cai L, Li E, Shen T, Li X, Zhou C
Clinical and experimental pharmacology & physiology 2025 Sep;52(9):e70061
Clinical and experimental pharmacology & physiology 2025 Sep;52(9):e70061
miR-210-3p Ameliorates Metabolic Dysfunction-Associated Steatohepatitis-Related Fibrosis by Targeting ISCU and Induces Ferroptosis.
Dai Z, Sun Z, Chen Q, Li Y, Sun Y, Jiao M, Yin X, Liu R, Liang H, Zhu C
Liver international : official journal of the International Association for the Study of the Liver 2025 Sep;45(9):e70282
Liver international : official journal of the International Association for the Study of the Liver 2025 Sep;45(9):e70282
Coptisine Improves Liver Inflammation in Sepsis by Regulating STAT1/IRF1/GPX4 Signaling-Mediated Kupffer Cells Ferroptosis.
Zhu B, Sun C, Luo D, Liang Y, Jiang A, Jiang Z, Luo H, Yuan G, Huang C, Liu S, Li L, Jiang Y
Phytotherapy research : PTR 2025 Sep;39(9):4308-4326
Phytotherapy research : PTR 2025 Sep;39(9):4308-4326
Self-assembled cyanidin-3-O-glucoside nanoparticles alleviate inflammation and ferroptosis induced by PRRSV infection.
Chen X, Pang Y, Amona FM, Liu Z, Wang F, Liang Y, Yang J, Zhang W, Fang X, Chen X
Journal of virology 2025 Sep 23;99(9):e0095425
Journal of virology 2025 Sep 23;99(9):e0095425
Therapeutic targeting of Nrf2/HO-1/NF-κB signaling axis with casticin mitigates intervertebral disc degeneration: in vitro and in vivo investigations.
Wu L, Wang Z, Wu Z, Wu Y
In vitro cellular & developmental biology. Animal 2025 Oct;61(9):1120-1136
In vitro cellular & developmental biology. Animal 2025 Oct;61(9):1120-1136
Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species-mediated activation of the NLRP3 inflammasome.
Peng Y, Huang YH, Luo X, Li MC, Xiao QQ, Qiu L, Fu Q
Journal of Asian natural products research 2025 Oct;27(10):1528-1549
Journal of Asian natural products research 2025 Oct;27(10):1528-1549
Elucidating the mechanism by which Aloe-emodin from Cassiae semen treats diabetic retinopathy via network pharmacology and experimental verification.
Chen J, Zhou D, Zhang L, Zhang X, Lv Z, He N, Bao J
Scientific reports 2025 Oct 31;15(1):38137
Scientific reports 2025 Oct 31;15(1):38137
Microglia-Derived Exosomal miR-223-3p Targets the RhoB-NF-κB-CCL11 Axis in Astrocytes and Relieves Neuronal Damage in Subarachnoid Hemorrhage.
Zeng F, Liao Z, Li L, Yang B, Lin J
Neurochemical research 2025 Oct 14;50(5):326
Neurochemical research 2025 Oct 14;50(5):326
Vilazodone ameliorates senescence-related Alzheimer's disease like symptoms by targeting Plau to induce autophagy in senescent cells.
Sun W, Sheng X, Li R, Li P, Lin H, Gong Y
International immunopharmacology 2025 Oct 10;163:115251
International immunopharmacology 2025 Oct 10;163:115251
Atraric acid attenuates chronic intermittent hypoxia-induced lung injury by inhibiting ferroptosis through activation of the NRF2 pathway.
Chen J, Zhou L, Li M, Wang J, Chen Y, Xia J, Lin Y, Chen H, Dong Z
Toxicology and applied pharmacology 2025 Nov;504:117540
Toxicology and applied pharmacology 2025 Nov;504:117540
Xiaoyao San against depression via glia-mediated neuroinflammation using network pharmacology and experimental validation.
Liu XY, Yan YZ, Jiang AJ, He WY, Fang YY, Li CH, Deng MF, Tan SJ, Zeng P
Scientific reports 2025 Nov 12;15(1):39708
Scientific reports 2025 Nov 12;15(1):39708
Leptomonines A and B, two novel rare benzyltetrahydroisoquinoline N-oxides from the aerial parts of Leptopyrum fumarioides as potential COX-2 inhibitors: in vitro and in silico studies.
Solongo T, Huong TT, Purevdorj E, Solongo A, Bayasgalan B, Loc VT, Ha NX, Ha VT, Hung NP, Thao DT, Nga NT, The HP, Stark P, Cuong NM
Journal of natural medicines 2025 May;79(3):517-529
Journal of natural medicines 2025 May;79(3):517-529
Flammulina velutipes polysaccharide exerts immunomodulatory function involving RSAD2 to regulate the NF-κB/MAPK signaling pathway in RAW264.7 macrophage cells and in mouse spleen cells.
Wang Q, Wang S, Cui L, Zhang Y, Waterhouse GIN, Sun-Waterhouse D, Ma C, Kang W
International journal of biological macromolecules 2025 May;309(Pt 3):142985
International journal of biological macromolecules 2025 May;309(Pt 3):142985
Macrolide sesquiterpene pyridine alkaloids from the roots of Tripterygium regelii and their anti-inflammatory activity.
Li D, Jia Q, Zhao Q, Sun J, Yu J, Chen H, Sui L, Leng A, Guo P, Wang C
Bioorganic chemistry 2025 May;158:108330
Bioorganic chemistry 2025 May;158:108330
Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration.
Chen J, Gan X, Su S, Jiao S, Gong Z, Liu Z, Wu X, Jiang J, Zhang J, Wan J
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113556
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113556
Benzyl butyl phthalate promotes ferroptosis in Sertoli cells via disrupting ceruloplasmin-mediated iron balance.
Dong Y, Shu S, Yu X, Chen X, Li Q, Shen X, Yu Y
Toxicology 2025 Mar;512:154078
Toxicology 2025 Mar;512:154078
The dopamine receptor agonist rotigotine attenuated indomethacin-induced enteropathy in the small intestinal mucosa of mice.
Su T, Zhou L, Peng B, Du W, Liu X, Li Z, Zhao Y, Han X, Liu C, Wang Z
Molecular biology reports 2025 Mar 24;52(1):335
Molecular biology reports 2025 Mar 24;52(1):335
Environmental responsive dual-drug synergistic and dual-targeted polymer micelles based on chondroitin sulfate for treatment of breast cancer.
Hu L, Ma H, Yang C, Wang K, Ji X, Xu T, Xu H, Zhao Y, Zhen Y
International journal of biological macromolecules 2025 Jun;311(Pt 4):144083
International journal of biological macromolecules 2025 Jun;311(Pt 4):144083
Scutellaria baicalensis Extracts Restrict Intestinal Epithelial Cell Ferroptosis by Regulating Lipid Peroxidation and GPX4/ACSL4 in Colitis.
Zhang J, Tan B, Wu H, Han T, Fang D, Cai H, Hu B, Kang A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156708
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156708
Tanshinone IIA promotes ferroptosis in cutaneous melanoma via STAT1-mediated upregulation of PTGS2 expression.
Chen S, Li P, Shi K, Tang S, Zhang W, Peng C, Li T, Xie H, Liu C, Zhou J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156702
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156702
Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury.
Zhuang X, Shi S, Liu S, Jiao Y, Huang B, Yang Y, Yang L, Yang X, Wang H, Liang C, Song D, Yu H, Zou D, Sun Q, Yang S, Yin C, Li J, Liu Y, Min J, Wang F, Nian Y, Du L, Chu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(23):e2500566
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(23):e2500566
Marsdenia tenacissima extract accelerates ferroptosis of osteosarcoma cells by upregulating HO-1 and activating mitophagy.
Xiang D, Zhang X, Xue X, Liang H, Meng J, Zhao S, Yang J, Zhou Y, Hu Y, Xu L, Shi M, Zhang J, Wang M, Chen J, Han Y
Journal of ethnopharmacology 2025 Jun 26;350:120055
Journal of ethnopharmacology 2025 Jun 26;350:120055
Pharmacological effects and mechanisms of alkamides DDA-E and DDA-Z from Asari Radix et Rhizoma in migraine: Insights from serum pharmacochemistry, network pharmacology, and experimental validation.
Cai F, Wang H, Liu H, Liu W, Hu X, Zhang S, Wang J, Zheng M, Dang R, Bahatijiang M, Guan H, Cheng X, Wang C
Journal of ethnopharmacology 2025 Jun 12;349:119978
Journal of ethnopharmacology 2025 Jun 12;349:119978
Periplocin targets LRP4 to regulate metabolic homeostasis and anti-inflammation for the treatment of IVDD.
Liu Z, Qiao F, Liu D, Kong X, Liu K, Gu H, Zhang Y, Meng Q, Cheng L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156885
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156885
Znhit1 alleviates nitroglycerin-induced hyperalgesia in migraine mice via the inhibition of NOD-like receptor signaling pathway.
Wang X, Tang J, Hou Y, Sui C
Molecular pain 2025 Jan-Dec;21:17448069251389420
Molecular pain 2025 Jan-Dec;21:17448069251389420
Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway.
Zhong X, Sun Y, Lin Y, Deng S, Wang H, Zhou X, Lu J, Zheng Y, Luo R, Huang M, Song J
Scientific reports 2025 Jan 28;15(1):3569
Scientific reports 2025 Jan 28;15(1):3569
Network pharmacology-based strategy to reveal Acacetin against lipopolysaccharide-induced lung injury.
Wang Z, Zhang Z, Yan T, Wang Y, Li L, Li J, Zhou W
International immunopharmacology 2025 Jan 27;146:113843
International immunopharmacology 2025 Jan 27;146:113843
Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease.
Shi Y, Hong R, Fan Z, Huan R, Gao Y, Ma M, Liu T, Pan C
Toxicology 2025 Feb;511:154067
Toxicology 2025 Feb;511:154067
Protein kinase a suppresses antiproliferative effect of interferon-α in hepatocellular carcinoma by activation of protein tyrosine phosphatase SHP2.
Sheng Y, Lin Y, Qiang Z, Shen X, He Y, Li L, Li S, Zhang G, Wang F
The Journal of biological chemistry 2025 Feb;301(2):108195
The Journal of biological chemistry 2025 Feb;301(2):108195
Oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cells.
Nie B, Zhang D, Liu X, Lei C, Li Z, Zhang N, Zhang S, Wei Y, Zhang J
Ecotoxicology and environmental safety 2025 Feb;291:117845
Ecotoxicology and environmental safety 2025 Feb;291:117845
Phillyrin ameliorates DSS-induced colitis in mice via modulating the gut microbiota and inhibiting the NF-κB/MLCK pathway.
Li T, Hu G, Fu S, Qin D, Song Z
Microbiology spectrum 2025 Feb 4;13(2):e0200624
Microbiology spectrum 2025 Feb 4;13(2):e0200624
Regulation of macrophage-mediated osteogenesis by kaempferol liposomes in trauma-induced heterotopic ossification.
Zhang D, Qu X, Chu F, Wang Z, Mou J, Yuan F
International journal of pharmaceutics 2025 Feb 25;671:125226
International journal of pharmaceutics 2025 Feb 25;671:125226
USP36 suppresses breast cancer cell ferroptosis by regulating the ubiquitination and stability of KIF2C.
Chen Y, Hong S, Wu F, Xu S, Yang Y, Xu J
Biochemical pharmacology 2025 Dec;242(Pt 2):117196
Biochemical pharmacology 2025 Dec;242(Pt 2):117196
Lysophosphatidylcholine Acyltransferase 1-Phosphatidylcholine Axis Protects Nucleus Pulposus Cells From Ferroptosis by Facilitating Lysosomal Repair via Interaction With the Endoplasmic Reticulum.
Li C, Jiang J, Tu S, Dong Y, Zhang W, Chen X
Neurospine 2025 Dec;22(4):953-973
Neurospine 2025 Dec;22(4):953-973
IRF7 orchestrates proinflammatory macrophage polarization and joint destruction in rheumatoid arthritis.
Liu H, Wu C, Li G, Peng X, Zhang Z, Su Z, Lin J, Wang X, Shen H, Wu Y, Liu W, Wang P, Zheng G
Arthritis research & therapy 2025 Dec 8;28(1):10
Arthritis research & therapy 2025 Dec 8;28(1):10
CircZNF418 Prevents Intervertebral Disc Degeneration by Targeting the HuR/SIRT6 Axis to Protect Against Oxidative Stress-Induced Ferroptosis and Senescence.
Wei K, Feng D, Fan D, Chen J, Du Q, Xue J, Zhong G, Chen J
IUBMB life 2025 Aug;77(8):e70049
IUBMB life 2025 Aug;77(8):e70049
Knockdown of FSTL1 attenuates sepsis-induced acute lung injury by inhibiting inflammation and ferroptosis.
Zhou X, Gao B, Li K, Fu H, Hao Y, Lan A, Zhou F
Molecular immunology 2025 Aug;184:213-223
Molecular immunology 2025 Aug;184:213-223
F-box only protein 10 protects against kidney tubulointerstitial fibrosis by inhibiting ACSL4-mediated lipid peroxidation and ferroptosis.
Hu J, Ma F, Chen X, Lu X, Lu Y, Jiang Y
Cellular signalling 2025 Aug;132:111841
Cellular signalling 2025 Aug;132:111841
BAOXIN granules reverse ferroptosis through the solute carrier family 7 member -glutathione-glutathione peroxidase 4 axis in ischemia-induced heart failure in rats.
Xu J, Li Y, Pan F, Cao S, Wang M, Chen Y, Wang Y, Yang Y, Wu H, Huang Y, Tian J
Journal of ethnopharmacology 2025 Aug 29;352:120119
Journal of ethnopharmacology 2025 Aug 29;352:120119
Whole-gene CRISPR/cas9 library screen revealed targeting STAT6 increased the sensitivity of liver cancer to celecoxib via inhibiting arachidonic acid shunting.
Hu C, Zeng Z, Bao X, Li D, Tai H, Zeng H, Luo C, Tang L, Chen T, Zuo S
Cell communication and signaling : CCS 2025 Aug 28;23(1):384
Cell communication and signaling : CCS 2025 Aug 28;23(1):384
CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.
Xu Q, Chen Y, Zhang H, Zhou K, Zhao Y, Deng W, Wang Z, Guo L, Liu H, Ren Z, Liu L, Tang Z, Jiang Z
Free radical biology & medicine 2025 Aug 16;236:188-203
Free radical biology & medicine 2025 Aug 16;236:188-203
Systemic Lupus Erythematosus Exacerbates Hip Arthritis by Promoting Chondrocyte Pyroptosis in the Femoral Head via Activating the NF-κB Pathway.
Fang X, Zhang H, Zhou H, Shen S, Lao Z, Zhang Z, Bian Y, Zhou C, Jin H, Tong P, Huang Y, Zhou H, Zeng H, Fu F, Wu C, Zheng W, Ruan H
Journal of cellular and molecular medicine 2025 Apr;29(7):e70531
Journal of cellular and molecular medicine 2025 Apr;29(7):e70531
Targeting ceramide-induced microglial pyroptosis: Icariin is a promising therapy for Alzheimer's disease.
Li H, Xiao Q, Zhu L, Kang J, Zhan Q, Peng W
Journal of pharmaceutical analysis 2025 Apr;15(4):101106
Journal of pharmaceutical analysis 2025 Apr;15(4):101106
Nanomedicine Penetrating Blood-Pancreas Barrier for Effective Treatment of Acute Pancreatitis.
Wang D, Wang S, Liu J, Shi X, Xiong T, Li R, Wei W, Ji L, Huang Q, Gong X, Ai K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2413925
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2413925
Quercetin-primed MSC exosomes synergistically attenuate osteoarthritis progression.
Lu M, Lou A, Gao J, Li S, He L, Fan W, Zhao L
Journal of orthopaedic surgery and research 2025 Apr 15;20(1):373
Journal of orthopaedic surgery and research 2025 Apr 15;20(1):373
Oxalate stimulates macrophage secretion of prostaglandin E2 to promote renal tubular epithelial cell osteogenesis.
Song Q, Chen X, Jiang Q, He Z, Su X, Dong C, Xiang H, Song C, Xiong Y, Yang S
Life sciences 2025 Apr 1;366-367:123476
Life sciences 2025 Apr 1;366-367:123476
Transferrin-Modified Carprofen Platinum(IV) Nanoparticles as Antimetastasis Agents with Tumor Targeting, Inflammation Inhibition, Epithelial-Mesenchymal Transition Suppression, and Immune Activation Properties.
Zhang M, Chen Y, Feng S, He Y, Liu Z, Zhang N, Wang Q
Journal of medicinal chemistry 2024 Sep 26;67(18):16416-16434
Journal of medicinal chemistry 2024 Sep 26;67(18):16416-16434
Anti-colorectal cancer activity of mannatide from spent brewer's yeast by regulating immune cells and immune function in the tumor microenvironment.
Li F, Sun X, Gao X, Zhao S, Tavakoli S, Du Z, Wei Y
International journal of biological macromolecules 2024 Sep 11;280(Pt 1):135531
International journal of biological macromolecules 2024 Sep 11;280(Pt 1):135531
Ellagic acid improves osteoarthritis by inhibiting PGE2 production in M1 macrophages via targeting PTGS2.
Zhang C, Li X, Wen P, Li Y
Clinical and experimental pharmacology & physiology 2024 Oct;51(10):e13918
Clinical and experimental pharmacology & physiology 2024 Oct;51(10):e13918
LysoPE mediated by respiratory microorganism Aeromicrobium camelliae alleviates H9N2 challenge in mice.
Yan Q, Xing J, Zou R, Sun M, Zou B, Wang Y, Niu T, Yu T, Huang H, Yang W, Shi C, Yang G, Wang C
Veterinary research 2024 Oct 11;55(1):136
Veterinary research 2024 Oct 11;55(1):136
Ursodeoxycholic Acid Platinum(IV) Conjugates as Antiproliferative and Antimetastatic Agents: Remodel the Tumor Microenvironment through Suppressing JAK2/STAT3 Signaling.
Chen Y, Zhang M, Liu Z, Zhang N, Wang Q
Journal of medicinal chemistry 2024 Oct 10;67(19):17551-17567
Journal of medicinal chemistry 2024 Oct 10;67(19):17551-17567
Unveiling the crucial role of ferroptosis in host resistance to streptococcus agalactiae infection.
Yi JX, Sun ZY, Liu P, Wang YH, Liu H, Lv QY, Kong DC, Huang WH, Ren YH, Li Q, Jiang YQ, Li J, Jiang H
Cell death discovery 2024 Oct 1;10(1):423
Cell death discovery 2024 Oct 1;10(1):423
Unveiling Smyd-2's Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion.
Liu D, Zhu Y
Cells 2024 Nov 28;13(23)
Cells 2024 Nov 28;13(23)
TIMP1 regulates ferroptosis in osteoblasts by inhibiting TFRC ubiquitination: an in vitro and in vivo study.
Peng B, Feng Z, Yang A, Liu J, He J, Xu L, Tian C, Sheng X, Wang Y, Chen R, Wang X, Ren X, Geng B, Xia Y
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):226
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):226
Restoration of ARA metabolic disorders in vascular smooth muscle cells alleviates intimal hyperplasia.
Wu H, Li D, Zhang CY, Huang LL, Zeng YJ, Chen TG, Yu K, Meng JW, Lin YX, Guo R, Zhou Y, Gao G
European journal of pharmacology 2024 Nov 15;983:176824
European journal of pharmacology 2024 Nov 15;983:176824
An integrated network pharmacology, molecular docking and experiment validation study to investigate the potential mechanism of Isobavachalcone in the treatment of osteoarthritis.
Fan Y, Yin L, Zhong X, He Z, Meng X, Chai F, Kong M, Zhang Q, Xia C, Tong Y, Bi Q
Journal of ethnopharmacology 2024 May 23;326:117827
Journal of ethnopharmacology 2024 May 23;326:117827
Resveratrol protects cardiomyocytes against ischemia/reperfusion-induced ferroptosis via inhibition of the VDAC1/GPX4 pathway.
Hu T, Zou HX, Zhang ZY, Wang YC, Hu FJ, Huang WX, Liu JC, Lai SQ, Huang H
European journal of pharmacology 2024 May 15;971:176524
European journal of pharmacology 2024 May 15;971:176524
Pentraxin 3 exacerbates psoriasiform dermatitis through regulation of macrophage polarization.
Liu J, Qiu C, Zhou Z, Li J, Zhen Y, Wang R, Zhuang Y, Zhang F
International immunopharmacology 2024 Mar 30;130:111805
International immunopharmacology 2024 Mar 30;130:111805
Exposure to nicotine regulates prostaglandin E2 secretion and autophagy of granulosa cells to retard follicular maturation in mammals.
Zhou X, He Y, Quan H, Yang J, Li S, Jiang Y, Li J, Yuan X
Ecotoxicology and environmental safety 2024 Jun 1;277:116358
Ecotoxicology and environmental safety 2024 Jun 1;277:116358
Nonswellable Hydrogel Patch with Tissue-Mimetic Mechanical Characteristics Remodeling In Vivo Microenvironment for Effective Adhesion Prevention.
Liu X, Qiu X, Nie L, Zhou B, Bu P, Li Y, Xue X, Tang B, Feng Q, Cai K
ACS nano 2024 Jul 9;18(27):17651-17671
ACS nano 2024 Jul 9;18(27):17651-17671
Activation of PPAR-α attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis and mitochondrial injury via upregulating 14-3-3η.
Hu T, Yu WP, Wang XQ, Wang ZY, Xu ZQ, Hu FJ, Liu JC, Yu F, Wang LJ
Scientific reports 2024 Jul 2;14(1):15246
Scientific reports 2024 Jul 2;14(1):15246
COL6A3 enhances the osteogenic differentiation potential of BMSCs by promoting mitophagy in the osteoporotic microenvironment.
Wang K, Peng X, Zhang R, Wu X, Mao L
Molecular biology reports 2024 Jan 25;51(1):206
Molecular biology reports 2024 Jan 25;51(1):206
The protective effect of Ergolide in osteoarthritis: In vitro and in vivo studies.
Meng X, Sun L, Meng X, Bi Q
International immunopharmacology 2024 Jan 25;127:111355
International immunopharmacology 2024 Jan 25;127:111355
Discovery from Hypericum elatoides and synthesis of hyperelanitriles as α-aminopropionitrile-containing polycyclic polyprenylated acylphloroglucinols.
Xie JY, Li P, Yan XT, Gao JM
Communications chemistry 2024 Jan 2;7(1):1
Communications chemistry 2024 Jan 2;7(1):1
Comparison of the inhibition effects of naringenin and its glycosides on LPS-induced inflammation in RAW 264.7 macrophages.
Cho SC, Shaw SY
Molecular biology reports 2024 Jan 2;51(1):56
Molecular biology reports 2024 Jan 2;51(1):56
Mechanism of lysine oxidase-like 1 promoting synovial inflammation mediating rheumatoid arthritis development.
Hu J, Liu X, Xu Q, Zhu M, Wang S, Quan K, Dai M, Mo F, Zhan H
Aging 2024 Jan 12;16(1):928-947
Aging 2024 Jan 12;16(1):928-947
Identification of differentially expressed genes associated with ferroptosis in Crohn's disease.
Zhang W, Li Z, Li H, Zhang D
Experimental and therapeutic medicine 2024 Feb;27(2):89
Experimental and therapeutic medicine 2024 Feb;27(2):89
In vitro and in vivo biological evaluation of Lappaconitine derivatives as potential anti-inflammatory agents.
Xiao Y, Han M, Chen Y, Li YZ, Zhang YY, Chen L, Huang S, Zhou XL
Chemistry & biodiversity 2024 Feb;21(2):e202301761
Chemistry & biodiversity 2024 Feb;21(2):e202301761
Arteannuin B, a sesquiterpene lactone from Artemisia annua, attenuates inflammatory response by inhibiting the ubiquitin-conjugating enzyme UBE2D3-mediated NF-κB activation.
Chen H, Hu Q, Wen T, Luo L, Liu L, Wang L, Shen X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155263
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155263
Chronic exposure to polystyrene microplastics induces renal fibrosis via ferroptosis.
Hong R, Shi Y, Fan Z, Gao Y, Chen H, Pan C
Toxicology 2024 Dec;509:153996
Toxicology 2024 Dec;509:153996
Engineering of phosphatidylserine-targeting ROS-responsive polymeric prodrug for the repair of ischemia-reperfusion-induced acute kidney injury.
Wang JH, Mao HB, Hu JB, Cheng S, Su H
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:1100-1114
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:1100-1114
Puerarin Protects Myocardium From Ischaemia/Reperfusion Injury by Inhibiting Ferroptosis Through Downregulation of VDAC1.
Hu F, Hu T, He A, Yuan Y, Wang X, Zou C, Qiao Y, Xu H, Liu L, Wang Q, Liu J, Lai S, Huang H
Journal of cellular and molecular medicine 2024 Dec;28(24):e70313
Journal of cellular and molecular medicine 2024 Dec;28(24):e70313
Baliosperoid A attenuates lipopolysaccharide-induced acute lung injury by targeting SHP2 to inhibit inflammation and oxidative stress.
Li Y, Zhao L, Liu Z, Chen Y, Li X, Zhu D, Liu L
Bioorganic chemistry 2024 Dec;153:107982
Bioorganic chemistry 2024 Dec;153:107982
Biologically active franchetine-type diterpenoid alkaloids: Isolation, synthesis, anti-inflammatory, agalgesic activities, and molecular docking.
Xiao Y, Chang Y, Liu YY, Li TT, Qu WR, Yuan C, Chen L, Huang S, Zhou XL
Bioorganic chemistry 2024 Dec;153:107834
Bioorganic chemistry 2024 Dec;153:107834
To explore the protective mechanism of promethazine against hippocampal neuron injury based on network pharmacology and experimental verification.
Bai L, Li F
Medicine 2024 Dec 6;103(49):e40550
Medicine 2024 Dec 6;103(49):e40550
Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro.
Shimasaki M, Ueda S, Sakurai M, Kawahara N, Ueda Y, Ichiseki T
Biomolecules 2024 Dec 20;14(12)
Biomolecules 2024 Dec 20;14(12)
Chronic microcystin-leucine-arginine exposure induces osteoporosis by breaking the balance of osteoblasts and osteoclasts.
Pan C, Wang K, Hong R, Wang X, Zhang Y, Fan Z, Shi Y, Liu T, Chen H
Environmental research 2024 Dec 15;263(Pt 2):120098
Environmental research 2024 Dec 15;263(Pt 2):120098
Mechanism of Xing 9 ling tablet candy for alcoholic liver disease based on network pharmacology.
Zhao X, Qu Q, Zhang Y, Zhao P, Zhang X, Tang Y, Lei X, Wei X, Song X
Analytical biochemistry 2024 Aug;691:115534
Analytical biochemistry 2024 Aug;691:115534
Auraptene Mitigates Colitis Induced by Dextran Sulfate Sodium in Mice by Regulating Specific Intestinal Flora and Repairing the Intestinal Barrier.
Chen T, Jin N, Zhang Q, Li Z, Wang Q, Fang X
Inflammation 2024 Aug;47(4):1127-1141
Inflammation 2024 Aug;47(4):1127-1141
Microgel-based carriers enhance skeletal stem cell reprogramming towards immunomodulatory phenotype in osteoarthritic therapy.
Li PL, Chen DF, Li XT, Hao RC, Zhao ZD, Li ZL, Yin BF, Tang J, Luo YW, Wu CT, Nie JJ, Zhu H
Bioactive materials 2024 Apr;34:204-220
Bioactive materials 2024 Apr;34:204-220
Suspected renal interstitial cell tumor causing polycythemia in two dogs.
Ide K, Katayama M, Mitsui I, Satoh H, Fukushima R, Yamamoto Y, Yamasaki M
The Journal of veterinary medical science 2024 Apr 1;86(4):368-373
The Journal of veterinary medical science 2024 Apr 1;86(4):368-373
Active metabolites and potential mechanisms of Notopterygium incisum against obstructive sleep apnea Syndrome (OSAS): network analysis and experimental assessment.
Liu P, Tang W, Zhao D, Zhou P, Hu K
Frontiers in pharmacology 2023;14:1185100
Frontiers in pharmacology 2023;14:1185100
Diabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and in vitro validation.
Tan Y, Kang J, Li H, Zhong A, Liu Y, Zhang Z, Huang R, Cheng X, Peng W
Frontiers in immunology 2023;14:1149810
Frontiers in immunology 2023;14:1149810
Dietary emodin alleviates lipopolysaccharide-induced intestinal mucosal barrier injury by regulating gut microbiota in piglets.
Xun W, Ji M, Ma Z, Deng T, Yang W, Hou G, Shi L, Cao T
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Sep;14:152-162
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Sep;14:152-162
IL-38 suppresses macrophage M1 polarization to ameliorate synovial inflammation in the TMJ via GLUT-1 inhibition.
Luo P, Du M, Sun Q, Zhao T, He H
International immunopharmacology 2023 Sep;122:110619
International immunopharmacology 2023 Sep;122:110619
Maslinic acid alleviates LPS-induced mice mastitis by inhibiting inflammatory response, maintaining the integrity of the blood-milk barrier and regulating intestinal flora.
Li K, Ran X, Zeng Y, Li S, Hu G, Wang X, Li Y, Yang Z, Liu J, Fu S
International immunopharmacology 2023 Sep;122:110551
International immunopharmacology 2023 Sep;122:110551
Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway.
Zhu A, Duan Z, Chen Y, Zhu C, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154906
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154906
δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis.
He X, Wang D, Yi Y, Tan Y, Wu M, Wang H, Hu W, Chen H, Zhang Q, Wu Y
Cell death discovery 2023 Sep 22;9(1):349
Cell death discovery 2023 Sep 22;9(1):349
Integrating UPLC-Q-Exactive Orbitrap/MS, network pharmacology and experimental validation to reveal the potential mechanism of Tibetan medicine Rhodiola granules in improving myocardial ischemia-reperfusion injury.
Xing N, Qin J, Ren D, Du Q, Li Y, Mi J, Zhang F, Ai L, Zhang S, Zhang Y, Wang S
Journal of ethnopharmacology 2023 Oct 5;314:116572
Journal of ethnopharmacology 2023 Oct 5;314:116572
Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease.
Wang H, He D, Li Z, Gao X, Yang S, Cui M, Ye B, Huang B, Fu S, Liu D
Chemico-biological interactions 2023 Oct 1;384:110726
Chemico-biological interactions 2023 Oct 1;384:110726
The extract from Portulaca oleracea L. rehabilitates skin photoaging via adjusting miR-138-5p/Sirt1-mediated inflammation and oxidative stress.
Qu L, Wang F, Ma X
Heliyon 2023 Nov;9(11):e21955
Heliyon 2023 Nov;9(11):e21955
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Sun W, Yue J, Xu T, Cui Y, Huang D, Shi H, Xiong J, Sun W, Yi Q
Heliyon 2023 Nov;9(11):e21282
Heliyon 2023 Nov;9(11):e21282
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Chen X, Chen J, Miao C, Yin G, Zhang Z, Sun R, Ni S
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
Isobavachalcone ameliorates the progression of osteoarthritis by suppressing NF-κB signaling pathway.
Guo Q, Zhang M, Dong Y, Liu K, Wang D, Zheng J
International immunopharmacology 2023 Jun;119:110102
International immunopharmacology 2023 Jun;119:110102
Silibinin alleviates ferroptosis of rat islet β cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy.
Du Q, Wu X, Ma K, Liu W, Liu P, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T
Archives of biochemistry and biophysics 2023 Jul 15;743:109644
Archives of biochemistry and biophysics 2023 Jul 15;743:109644
Huc-MSCs-derived exosomes attenuate neuropathic pain by inhibiting activation of the TLR2/MyD88/NF-κB signaling pathway in the spinal microglia by targeting Rsad2.
Gao X, Gao LF, Zhang YN, Kong XQ, Jia S, Meng CY
International immunopharmacology 2023 Jan;114:109505
International immunopharmacology 2023 Jan;114:109505
Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice.
Xia Y, Hao L, Li Y, Li Y, Chen J, Li L, Han X, Liu Y, Wang X, Li D
Ecotoxicology and environmental safety 2023 Jan 15;250:114497
Ecotoxicology and environmental safety 2023 Jan 15;250:114497
Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress.
Yang W, Jia C, Liu L, Fu Y, Wu Y, Liu Z, Yu R, Ma X, Gong A, Liu F, Xia Y, Hou Y, Li Y, Zhang L
Inflammation 2023 Feb;46(1):270-284
Inflammation 2023 Feb;46(1):270-284
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
Teng L, Shen Y, Qu Y, Yang L, Yang Y, Jian X, Fan S, Zhang L, Fu Q
Chinese journal of natural medicines 2023 Feb;21(2):99-112
Chinese journal of natural medicines 2023 Feb;21(2):99-112
MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6.
Lou C, Jiang H, Lin Z, Xia T, Wang W, Lin C, Zhang Z, Fu H, Iqbal S, Liu H, Lin J, Wang J, Pan X, Xue X
Journal of nanobiotechnology 2023 Dec 18;21(1):486
Journal of nanobiotechnology 2023 Dec 18;21(1):486
M2 Macrophage Membrane-Mediated Biomimetic-Nanoparticle Carrying COX-siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation.
Sun J, Ju F, Jin J, Wang HL, Li ZJ, Sun YC, Chen QZ, Yang QQ, Tan J, Zhou YL
Small (Weinheim an der Bergstrasse, Germany) 2023 Aug;19(33):e2300326
Small (Weinheim an der Bergstrasse, Germany) 2023 Aug;19(33):e2300326
Taxifolin Reduces Blood Pressure via Improvement of Vascular Function and Mitigating the Vascular Inflammatory Response in Spontaneously Hypertensive Rats.
Liskova S, Cacanyiova S, Cebova M, Berenyiova A, Kluknavsky M, Micurova A, Valachova K, Soltes L, Bernatova I
International journal of molecular sciences 2023 Aug 9;24(16)
International journal of molecular sciences 2023 Aug 9;24(16)
MEN1 is a regulator of alternative splicing and prevents R-loop-induced genome instability through suppression of RNA polymerase II elongation.
Jin B, Zhu J, Pan T, Yang Y, Liang L, Zhou Y, Zhang T, Teng Y, Wang Z, Wang X, Tian Q, Guo B, Li H, Chen T
Nucleic acids research 2023 Aug 25;51(15):7951-7971
Nucleic acids research 2023 Aug 25;51(15):7951-7971
PET117 assembly factor stabilizes translation activator TACO1 thereby upregulates mitochondria-encoded cytochrome C oxidase 1 synthesis.
Sun Q, Shi L, Li S, Li J, Zhang R, Huang X, Shao Y, Feng Z, Peng Y, Yang Z, Liu J, Liu H, Long J
Free radical biology & medicine 2023 Aug 20;205:13-24
Free radical biology & medicine 2023 Aug 20;205:13-24
Overexpression of GPX4 attenuates cognitive dysfunction through inhibiting hippocampus ferroptosis and neuroinflammation after traumatic brain injury.
Fang J, Yuan Q, Du Z, Zhang Q, Yang L, Wang M, Yang W, Yuan C, Yu J, Wu G, Hu J
Free radical biology & medicine 2023 Aug 1;204:68-81
Free radical biology & medicine 2023 Aug 1;204:68-81
Cardamonin alleviates chondrocytes inflammation and cartilage degradation of osteoarthritis by inhibiting ferroptosis via p53 pathway.
Gong Z, Wang Y, Li L, Li X, Qiu B, Hu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113644
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113644
EPC-exosomal miR-26a-5p improves airway remodeling in COPD by inhibiting ferroptosis of bronchial epithelial cells via PTGS2/PGE2 signaling pathway.
Liu C, Lu J, Yuan T, Xie L, Zhang L
Scientific reports 2023 Apr 14;13(1):6126
Scientific reports 2023 Apr 14;13(1):6126
The Protective Effect of Sulforaphane on Dextran Sulfate Sodium-Induced Colitis Depends on Gut Microbial and Nrf2-Related Mechanism.
He C, Gao M, Zhang X, Lei P, Yang H, Qing Y, Zhang L
Frontiers in nutrition 2022;9:893344
Frontiers in nutrition 2022;9:893344
MiR-205-5p Functions as a Tumor Suppressor in Gastric Cancer Cells through Downregulating FAM84B.
Chen X, Zhang L, Geng J, Chen Z, Cui X
Journal of oncology 2022;2022:8267891
Journal of oncology 2022;2022:8267891
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
Wang L, Wang J
Oxidative medicine and cellular longevity 2022;2022:1755608
Oxidative medicine and cellular longevity 2022;2022:1755608
Atorvastatin attenuates ferroptosis-dependent myocardial injury and inflammation following coronary microembolization via the Hif1a/Ptgs2 pathway.
Liu T, Shu J, Liu Y, Xie J, Li T, Li H, Li L
Frontiers in pharmacology 2022;13:1057583
Frontiers in pharmacology 2022;13:1057583
Network analysis and experimental pharmacology study explore the protective effects of Isoliquiritigenin on 5-fluorouracil-Induced intestinal mucositis.
Liao YF, Luo FL, Tang SS, Huang JW, Yang Y, Wang S, Jiang TY, Man Q, Liu S, Wu YY
Frontiers in pharmacology 2022;13:1014160
Frontiers in pharmacology 2022;13:1014160
Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation.
Zhao B, Fu J, Ni H, Xu L, Xu C, He Q, Ni C, Wang Y, Kuang J, Tang M, Shou Q, Yao M
Frontiers in pharmacology 2022;13:1010483
Frontiers in pharmacology 2022;13:1010483
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
He D, Liu Y, Li J, Wang H, Ye B, He Y, Li Z, Gao X, Fu S, Liu D
Cells 2022 Sep 19;11(18)
Cells 2022 Sep 19;11(18)
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Qu Y, Shen Y, Teng L, Huang Y, Yang Y, Jian X, Fan S, Wu P, Fu Q
International immunopharmacology 2022 Oct;111:109129
International immunopharmacology 2022 Oct;111:109129
Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury.
Xia M, Zhang Y, Wu H, Zhang Q, Liu Q, Li G, Zhao T, Liu X, Zheng S, Qian Z, Li H
International immunopharmacology 2022 Oct;111:109120
International immunopharmacology 2022 Oct;111:109120
Oxybaphus himalaicus Mitigates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting TLR4/MD2 Complex Formation.
Zhan H, Pu Q, Long X, Lu W, Wang G, Meng F, Liao Z, Lan X, Chen M
Antioxidants (Basel, Switzerland) 2022 Nov 22;11(12)
Antioxidants (Basel, Switzerland) 2022 Nov 22;11(12)
α-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease.
A A, W C, N N, L M, M D, Zhang DD
Free radical biology & medicine 2022 Nov 1;192:130-140
Free radical biology & medicine 2022 Nov 1;192:130-140
Golgi Phosphoprotein 3 Mediates Radiation-Induced Bystander Effect via ERK/EGR1/TNF-α Signal Axis.
Qin F, Chen G, Yu KN, Yang M, Cao W, Kong P, Peng S, Sun M, Nie L, Han W
Antioxidants (Basel, Switzerland) 2022 Nov 1;11(11)
Antioxidants (Basel, Switzerland) 2022 Nov 1;11(11)
Combination of mitochondria impairment and inflammation blockade to combat metastasis.
Yi X, Yan Y, Li L, Zhou R, Shen X, Huang Y
Journal of controlled release : official journal of the Controlled Release Society 2022 Jan;341:753-768
Journal of controlled release : official journal of the Controlled Release Society 2022 Jan;341:753-768
Morphological changes of macrophages and their potential contribution to tendon healing.
Yang QQ, Zhang L, Zhou YL, Tang JB
Colloids and surfaces. B, Biointerfaces 2022 Jan;209(Pt 1):112145
Colloids and surfaces. B, Biointerfaces 2022 Jan;209(Pt 1):112145
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Xu LT, Wang T, Fang KL, Zhao Y, Wang XN, Ren DM, Shen T
Journal of ethnopharmacology 2022 Jan 30;283:114694
Journal of ethnopharmacology 2022 Jan 30;283:114694
Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.
Chen Y, Qu L, Li Y, Chen C, He W, Shen L, Zhang R
Inflammation 2022 Feb;45(1):253-266
Inflammation 2022 Feb;45(1):253-266
Enhancement of the functionality of attenuating acute lung injury by a microemulsion formulation with volatile oil of Angelicae Sinensis Radix and Ligusticum Chuanxiong Rhizoma encapsulated.
Zhang L, Yan Q, Zhang W, Li X, Zhang X, Du S, Hua X, Lin J, Shu G, Peng G, Tan Z, Fu H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113888
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113888
Burdock (Arctium lappa L.) leaf flavonoids rich in morin and quercetin 3-O-rhamnoside ameliorate lipopolysaccharide-induced inflammation and oxidative stress in RAW264.7 cells.
Cui J, Zong W, Zhao N, Yuan R
Food science & nutrition 2022 Aug;10(8):2718-2726
Food science & nutrition 2022 Aug;10(8):2718-2726
The licorice flavonoid isoliquiritigenin attenuates Mycobacterium tuberculosis-induced inflammation through Notch1/NF-κB and MAPK signaling pathways.
Sun J, Zhang Q, Yang G, Li Y, Fu Y, Zheng Y, Jiang X
Journal of ethnopharmacology 2022 Aug 10;294:115368
Journal of ethnopharmacology 2022 Aug 10;294:115368
Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin.
Jandova J, Snell J, Hua A, Dickinson S, Fimbres J, Wondrak GT
Redox biology 2021 Sep;45:102042
Redox biology 2021 Sep;45:102042
Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism.
Yin D, Jin G, He H, Zhou W, Fan Z, Gong C, Zhao J, Xiong H
Aging 2021 Sep 8;13(17):21268-21282
Aging 2021 Sep 8;13(17):21268-21282
hsa-miR-15b-5p regulates the proliferation and apoptosis of human vascular smooth muscle cells by targeting the ACSS2/PTGS2 axis.
Gan S, Mao J, Pan Y, Tang J, Qiu Z
Experimental and therapeutic medicine 2021 Nov;22(5):1208
Experimental and therapeutic medicine 2021 Nov;22(5):1208
Programmable Polymeric Microneedles for Combined Chemotherapy and Antioxidative Treatment of Rheumatoid Arthritis.
Wu C, Cheng J, Li W, Yang L, Dong H, Zhang X
ACS applied materials & interfaces 2021 Nov 24;13(46):55559-55568
ACS applied materials & interfaces 2021 Nov 24;13(46):55559-55568
Protective effect of scorpion venom heat-resistant synthetic peptide against PM(2.5)-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway.
Xu X, Xu H, Ren F, Huang L, Xu J, Li F
Journal of neuroimmunology 2021 Jun 15;355:577567
Journal of neuroimmunology 2021 Jun 15;355:577567
TFAM knockdown-triggered mtDNA-nucleoid aggregation and a decrease in mtDNA copy number induce the reorganization of nucleoid populations and mitochondria-associated ER-membrane contacts.
Aasumets K, Basikhina Y, Pohjoismäki JL, Goffart S, Gerhold J
Biochemistry and biophysics reports 2021 Dec;28:101142
Biochemistry and biophysics reports 2021 Dec;28:101142
Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.
Wei N, Lu T, Yang L, Dong Y, Liu X
FEBS open bio 2021 Aug;11(8):2118-2126
FEBS open bio 2021 Aug;11(8):2118-2126
Silencing of PTX3 alleviates LPS-induced inflammatory pain by regulating TLR4/NF-κB signaling pathway in mice.
Qi S, Zhao F, Li Z, Liang F, Yu S
Bioscience reports 2020 Feb 28;40(2)
Bioscience reports 2020 Feb 28;40(2)
Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells.
Wang R, Dong Z, Lan X, Liao Z, Chen M
Molecules (Basel, Switzerland) 2019 Mar 1;24(5)
Molecules (Basel, Switzerland) 2019 Mar 1;24(5)
Ajudecumin A from Ajuga ovalifolia var. calantha exhibits anti-inflammatory activity in lipopolysaccharide-activated RAW264.7 murine macrophages and animal models of acute inflammation.
Zhang H, Ren QC, Ren Y, Zhao L, Yang F, Zhang Y, Zhao WJ, Tan YZ, Shen XF
Pharmaceutical biology 2018 Dec;56(1):649-657
Pharmaceutical biology 2018 Dec;56(1):649-657
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