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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [25]
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- Validations
- Western blot [1]
- Immunohistochemistry [3]
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- Product number
- NB100-689 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-689, RRID:AB_10001091
- Product name
- Rabbit Polyclonal COX-2 Antibody
- Antibody type
- Polyclonal
- Description
- Affinity purified. This reacts with the 70 kDa protein.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.5 ml
- Storage
- Store at 4C. Do not freeze.
Submitted references Prevention of multiple system atrophy using human bone marrow-derived mesenchymal stem cells by reducing polyamine and cholesterol-induced neural damages.
Galectin-1 exhibits a protective effect against hepatotoxicity induced by dextran sulfate sodium in mice.
Bee venom phospholipase A2 ameliorates amyloidogenesis and neuroinflammation through inhibition of signal transducer and activator of transcription-3 pathway in Tg2576 mice.
Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation.
(E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates MPTP-Induced Dopaminergic Neurodegeneration by Inhibiting the STAT3 Pathway.
Retinal arteriole reactivity in mice lacking the endothelial nitric oxide synthase (eNOS) gene.
Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease.
Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats.
Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice.
Loss of Parkin reduces inflammatory arthritis by inhibiting p53 degradation.
TLR7 and TLR8 expression increases tumor cell proliferation and promotes chemoresistance in human pancreatic cancer.
Polymorphisms in cyclooxygenase-2 gene in endometrial cancer patients.
A cyclooxygenase-2-dependent prostaglandin E2 biosynthetic system in the Golgi apparatus.
Anti-inflammatory and immunomodulatory effects of Spirulina platensis in comparison to Dunaliella salina in acetic acid-induced rat experimental colitis.
Iron-ascorbate-mediated lipid peroxidation causes epigenetic changes in the antioxidant defense in intestinal epithelial cells: impact on inflammation.
Apple peel polyphenols and their beneficial actions on oxidative stress and inflammation.
Cholera toxin induces a shift from inactive to active cyclooxygenase 2 in alveolar macrophages activated by Mycobacterium bovis BCG.
Role of PPARγ in COX-2 activation in mycobacterial pulmonary inflammation.
2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes.
Early induction of cytokines/cytokine receptors and Cox2, and activation of NF-κB in 4-nitroquinoline 1-oxide-induced murine oral cancer model.
Effect of cyclooxygenase genotype and dietary fish oil on colonic eicosanoids in mice.
Two pathways for cyclooxygenase-2 protein degradation in vivo.
Deletion of the FHL2 gene attenuating neovascularization after corneal injury.
Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis.
Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis.
Park KR, Hwang CJ, Yun HM, Yeo IJ, Choi DY, Park PH, Kim HS, Lee JT, Jung YS, Han SB, Hong JT
Stem cell research & therapy 2020 Mar 4;11(1):63
Stem cell research & therapy 2020 Mar 4;11(1):63
Galectin-1 exhibits a protective effect against hepatotoxicity induced by dextran sulfate sodium in mice.
Arda-Pirincci P, Sacan O, Ozal-Coskun C, Aykol-Celik G, Karabulut-Bulan O, Yanardag R, Bolkent S
Human & experimental toxicology 2020 Apr;39(4):423-432
Human & experimental toxicology 2020 Apr;39(4):423-432
Bee venom phospholipase A2 ameliorates amyloidogenesis and neuroinflammation through inhibition of signal transducer and activator of transcription-3 pathway in Tg2576 mice.
Ham HJ, Han SB, Yun J, Yeo IJ, Ham YW, Kim SH, Park PH, Choi DY, Hong JT
Translational neurodegeneration 2019;8:26
Translational neurodegeneration 2019;8:26
Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation.
Dileepan M, Rastle-Simpson S, Greenberg Y, Wijesinghe DS, Kumar NG, Yang J, Hwang SH, Hammock BD, Sriramarao P, Rao SP
Frontiers in pharmacology 2019;10:1118
Frontiers in pharmacology 2019;10:1118
(E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates MPTP-Induced Dopaminergic Neurodegeneration by Inhibiting the STAT3 Pathway.
Choi JY, Yun J, Hwang CJ, Lee HP, Kim HD, Chun H, Park PH, Choi DY, Han SB, Hong JT
International journal of molecular sciences 2019 May 29;20(11)
International journal of molecular sciences 2019 May 29;20(11)
Retinal arteriole reactivity in mice lacking the endothelial nitric oxide synthase (eNOS) gene.
Gericke A, Wolff I, Musayeva A, Zadeh JK, Manicam C, Pfeiffer N, Li H, Xia N
Experimental eye research 2019 Apr;181:150-156
Experimental eye research 2019 Apr;181:150-156
Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease.
Suyama K, Sakai D, Hirayama N, Nakamura Y, Matsushita E, Terayama H, Qu N, Tanaka O, Sakabe K, Watanabe M
Journal of cellular and molecular medicine 2018 Nov;22(11):5539-5551
Journal of cellular and molecular medicine 2018 Nov;22(11):5539-5551
Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats.
Fong LY, Jing R, Smalley KJ, Wang ZX, Taccioli C, Fan S, Chen H, Alder H, Huebner K, Farber JL, Fiehn O, Croce CM
Proceedings of the National Academy of Sciences of the United States of America 2018 Nov 20;115(47):E11091-E11100
Proceedings of the National Academy of Sciences of the United States of America 2018 Nov 20;115(47):E11091-E11100
Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice.
Boisvert NC, Holterman CE, Thibodeau JF, Nasrallah R, Kamto E, Comin CH, Costa LDF, Carter A, Hébert RL, Gutsol A, Cron GO, Lacoste B, Gray DA, Kennedy CR
Clinical science (London, England : 1979) 2018 Jul 18;132(13):1453-1470
Clinical science (London, England : 1979) 2018 Jul 18;132(13):1453-1470
Loss of Parkin reduces inflammatory arthritis by inhibiting p53 degradation.
Jung YY, Son DJ, Lee HL, Kim DH, Song MJ, Ham YW, Kim Y, Han SB, Park MH, Hong JT
Redox biology 2017 Aug;12:666-673
Redox biology 2017 Aug;12:666-673
TLR7 and TLR8 expression increases tumor cell proliferation and promotes chemoresistance in human pancreatic cancer.
Grimmig T, Matthes N, Hoeland K, Tripathi S, Chandraker A, Grimm M, Moench R, Moll EM, Friess H, Tsaur I, Blaheta RA, Germer CT, Waaga-Gasser AM, Gasser M
International journal of oncology 2015 Sep;47(3):857-66
International journal of oncology 2015 Sep;47(3):857-66
Polymorphisms in cyclooxygenase-2 gene in endometrial cancer patients.
Torricelli F, Mandato VD, Farnetti E, Abrate M, Casali B, Ciarlini G, Pirillo D, Gelli MC, Costagliola L, Nicoli D, Palomba S, La Sala GB
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Sep;36(10):7423-30
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Sep;36(10):7423-30
A cyclooxygenase-2-dependent prostaglandin E2 biosynthetic system in the Golgi apparatus.
Yuan C, Smith WL
The Journal of biological chemistry 2015 Feb 27;290(9):5606-20
The Journal of biological chemistry 2015 Feb 27;290(9):5606-20
Anti-inflammatory and immunomodulatory effects of Spirulina platensis in comparison to Dunaliella salina in acetic acid-induced rat experimental colitis.
Abdel-Daim MM, Farouk SM, Madkour FF, Azab SS
Immunopharmacology and immunotoxicology 2015 Apr;37(2):126-39
Immunopharmacology and immunotoxicology 2015 Apr;37(2):126-39
Iron-ascorbate-mediated lipid peroxidation causes epigenetic changes in the antioxidant defense in intestinal epithelial cells: impact on inflammation.
Yara S, Lavoie JC, Beaulieu JF, Delvin E, Amre D, Marcil V, Seidman E, Levy E
PloS one 2013;8(5):e63456
PloS one 2013;8(5):e63456
Apple peel polyphenols and their beneficial actions on oxidative stress and inflammation.
Denis MC, Furtos A, Dudonné S, Montoudis A, Garofalo C, Desjardins Y, Delvin E, Levy E
PloS one 2013;8(1):e53725
PloS one 2013;8(1):e53725
Cholera toxin induces a shift from inactive to active cyclooxygenase 2 in alveolar macrophages activated by Mycobacterium bovis BCG.
Kogiso M, Shinohara T, Dorey CK, Shibata Y
Infection and immunity 2013 Jan;81(1):373-80
Infection and immunity 2013 Jan;81(1):373-80
Role of PPARγ in COX-2 activation in mycobacterial pulmonary inflammation.
Kogiso M, Shinohara T, Dorey CK, Shibata Y
Inflammation 2012 Oct;35(5):1685-95
Inflammation 2012 Oct;35(5):1685-95
2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes.
Wu MR, Hou MH, Lin YL, Kuo CF
Journal of agricultural and food chemistry 2012 Jul 25;60(29):7262-9
Journal of agricultural and food chemistry 2012 Jul 25;60(29):7262-9
Early induction of cytokines/cytokine receptors and Cox2, and activation of NF-κB in 4-nitroquinoline 1-oxide-induced murine oral cancer model.
Liu YC, Ho HC, Lee MR, Lai KC, Yeh CM, Lin YM, Ho TY, Hsiang CY, Chung JG
Toxicology and applied pharmacology 2012 Jul 15;262(2):107-16
Toxicology and applied pharmacology 2012 Jul 15;262(2):107-16
Effect of cyclooxygenase genotype and dietary fish oil on colonic eicosanoids in mice.
Neilson AP, Djuric Z, Ren J, Hong YH, Sen A, Lager C, Jiang Y, Reuven S, Smith WL, Brenner DE
The Journal of nutritional biochemistry 2012 Aug;23(8):966-76
The Journal of nutritional biochemistry 2012 Aug;23(8):966-76
Two pathways for cyclooxygenase-2 protein degradation in vivo.
Wada M, Saunders TL, Morrow J, Milne GL, Walker KP, Dey SK, Brock TG, Opp MR, Aronoff DM, Smith WL
The Journal of biological chemistry 2009 Nov 6;284(45):30742-53
The Journal of biological chemistry 2009 Nov 6;284(45):30742-53
Deletion of the FHL2 gene attenuating neovascularization after corneal injury.
Chu PH, Yeh LK, Lin HC, Jung SM, Ma DH, Wang IJ, Wu HH, Shiu TF, Chen J
Investigative ophthalmology & visual science 2008 Dec;49(12):5314-8
Investigative ophthalmology & visual science 2008 Dec;49(12):5314-8
Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis.
Paiotti AP, Artigiani Neto R, Forones NM, Oshima CT, Miszputen SJ, Franco M
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2007 Jul;40(7):911-8
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2007 Jul;40(7):911-8
Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis.
Paiotti AP, Artigiani Neto R, Forones NM, Oshima CT, Miszputen SJ, Franco M
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2007 Jul;40(7):911-8
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2007 Jul;40(7):911-8
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Simple Western: COX-2 Antibody [NB100-689] - Simple Western lane view shows a specific band for COX2 in 1.0 mg/ml of Rat Brain at an antibody concentration of 1:100. This experiment was performed under reducing conditions using the 12-230 kDa separation system. Image provided through customer review.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: COX-2 Antibody [NB100-689] - Formalin fixed paraffin embedded human colon carcinoma stained with COX2 antibody.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: COX-2 Antibody [NB100-689] - Formalin fixed paraffin embedded human colon carcinoma stained with COX2 antibody.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: COX-2 Antibody [NB100-689] - Formalin fixed paraffin embedded colon carcinoma stained with COX-2 antibody (NB100-689).
