Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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Validation data
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- Product number
- MAB6635 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Rat Monoclonal LBP Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects mouse LBP in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human LBP is observed.
- Reactivity
- Mouse
- Host
- Rat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 500 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex.
Okamoto N, Mizote K, Honda H, Saeki A, Watanabe Y, Yamaguchi-Miyamoto T, Fukui R, Tanimura N, Motoi Y, Akashi-Takamura S, Kato T, Fujishita S, Kimura T, Ohto U, Shimizu T, Hirokawa T, Miyake K, Fukase K, Fujimoto Y, Nagai Y, Takatsu K
The Journal of biological chemistry 2017 Sep 15;292(37):15378-15394
The Journal of biological chemistry 2017 Sep 15;292(37):15378-15394
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
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- Experimental details
- Cell Il-8 Secretion Induced by LBP and Neutralization by Mouse LBP Antibody. Recombinant Mouse LBP induces IL-8 secretion in the THP-1 human acute monocytic leukemia cell line in the presence of 5 ng/mL LPS in a dose-dependent manner (orange line), as measured by the Human IL-8 Quantikine kit (Catalog # D8000C). Under these conditions, IL-8 secretion elicited by LBP is neutralized (green line) by increasing concentrations of Rat Anti-Mouse LBP Monoclonal Antibody (Catalog # MAB6635). The ND50 is typically 1-5 μg/mL.